Turning off a viral/lipid sensor improves type 2 diabetes

Diabetes

Volumn 63, Issue 2, 2014, Pages 393-395

  Velloso, Licio A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINOPURINE; DOUBLE STRANDED RNA; GLUCAGON LIKE PEPTIDE 1; HEMOGLOBIN A1C; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INTERLEUKIN 6; LIPID; METFORMIN; PROTEIN KINASE R; STRESS ACTIVATED PROTEIN KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 3; TUMOR NECROSIS FACTOR ALPHA;

BIOSENSOR; BLOOD GLUCOSE MONITORING; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; FAT INTAKE; GENETIC VARIABILITY; GLUCOSE TOLERANCE; HUMAN; INFLAMMATION; INSULIN RELEASE; INSULIN RESISTANCE; LIPOGENESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NOTE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; VIRUS INFECTION; WHITE ADIPOSE TISSUE;

ANIMALS; EIF-2 KINASE; GLUCOSE; IMIDAZOLES; INDOLES; MALE; OBESITY;

EID: 84893154243     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1704     Document Type: Note

References (28)

1. Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006;116:1802-1812
2. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. J Clin Invest 2006;116:1793-1801
3. Schmidt MI, Duncan BB, Sharrett AR, et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet 1999;353:1649-1652
4. Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91
5. Hirosumi J, Tuncman G, Chang L, et al. A central role for JNK in obesity and insulin resistance. Nature 2002;420:333-336
6. Yuan M, Konstantopoulos N, Lee J, et al. Reversal of obesity-and dietinduced insulin resistance with salicylates or targeted disruption of Ikkb. Science 2001;293:1673-1677
7. Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 2008;8:923-934
8. Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011;29:415-445
9. Cnop M, Foufelle F, Velloso LA. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol Med 2012;18:59-68
10. Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004;306:457-461
11. Coope A, Milanski M, Arruda AP, et al. Chaperone insufficiency links TLR4 protein signaling to endoplasmic reticulum stress. J Biol Chem 2012;287: 15580-15589
12. Nakamura T, Furuhashi M, Li P, et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010;140:338-348
13. Samuel CE. Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 1991; 183:1-11
14. Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB. Genetic deletion of PKR abrogates TNF-induced activation of IkBa kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. Oncogene 2007;26:1201-1212
15. Carvalho BM, Oliveira AG, Ueno M, et al. Modulation of double-stranded RNA-activated protein kinase in insulin sensitive tissues of obese humans. Obesity (Silver Spring) 21 March 2013 [Epub ahead of print]
16. Carvalho-Filho MA, Carvalho BM, Oliveira AG, et al. Double-stranded RNAactivated protein kinase is a key modulator of insulin sensitivity in physiological conditions and in obesity in mice. Endocrinology 2012;153:5261-5274
17. Nakamura T, Arduini A, Baccaro B, Furuhashi M, Hotamisligil GS. Smallmolecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice. Diabetes 2014;63:526-534
18. Jammi NV, Whitby LR, Beal PA. Small molecule inhibitors of the RNAdependent protein kinase. Biochem Biophys Res Commun 2003;308:50-57
19. Lu B, Nakamura T, Inouye K, et al. Novel role of PKR in inflammasome activation and HMGB1 release. Nature 2012;488:670-674
20. Hu Y, Conway TW. 2-Aminopurine inhibits the double-stranded RNAdependent protein kinase both in vitro and in vivo. J Interferon Res 1993; 13:323-328
21. American Diabetes Association. Standards of medical care in diabetes- 2013. Diabetes Care 2013;36(Suppl. 1):S11-S66
22. Gupta-Ganguli M, Cox K, Means B, Gerling I, Solomon SS. Does therapy with anti-TNF-aimprove glucose tolerance and control in patients with type 2 diabetes? Diabetes Care 2011;34:e121
23. Rosenvinge A, Krogh-Madsen R, Baslund B, Pedersen BK. Insulin resistance in patients with rheumatoid arthritis: effect of anti-TNFa therapy. Scand J Rheumatol 2007;36:91-96
24. Larsen CM, Faulenbach M, Vaag A, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007;356:1517-1526
25. Targownik LE, Bernstein CN. Infectious and malignant complications of TNF inhibitor therapy in IBD. Am J Gastroenterol 17 September 2013
26. Goldfine AB, Fonseca V, Jablonski KA, et al.; Targeting Inflammation Using Salsalate in Type 2 Diabetes Study Team. Salicylate (salsalate) in patients with type 2 diabetes: a randomized trial. Ann Intern Med 2013; 159:1-12
27. Hii SI, Hardy L, Crough T, et al. Loss of PKR activity in chronic lymphocytic leukemia. Int J Cancer 2004;109:329-335
28. Murad JM, Tone LG, de Souza LR, De Lucca FL. A point mutation in the RNA-binding domain I results in decrease of PKR activation in acute lymphoblastic leukemia. Blood Cells Mol Dis 2005;34:1-5