Deletion of tumor necrosis factor-α receptor 1 (TNFR1) protects against diet-induced obesity by means of increased thermogenesis

Journal of Biological Chemistry

Volumn 284, Issue 52, 2009, Pages 36213-36222

  Romanatto, Talita ^a   Roman, Erika A ^a   Arruda, Ana P ^a   Denis, Raphael G ^a   Solon, Carina ^a   Milanski, Marciane ^a   Moraes, Juliana C ^a   Bonfleur, Maria L ^a   Degasperi, Giovanna R ^a   Picardi, Paty K ^a   Hirabara, Sandro ^b   Boschero, Antonio C ^a   Curi, Rui ^b   Velloso, Licio A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTES; ADIPOSE TISSUE; BLOOD CONCENTRATIONS; BODY MASS; DIET-INDUCED OBESITY; FOOD INTAKE; HIGH-FAT DIET; INSULIN RESISTANCE; KNOCK OUTS; RESPIROMETRY; SKELETAL MUSCLE; SKELETAL MUSCLE FIBERS; TUMOR NECROSIS FACTORS;

CHEMICAL CONTAMINATION; ECOLOGY; GLYCOPROTEINS; INSULIN; MACROPHAGES; MUSCLE; SIGNAL TRANSDUCTION; TUMORS;

NUTRITION;

INSULIN; JANUS KINASE 2; LEPTIN; STAT3 PROTEIN; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA RECEPTOR;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY MASS; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; DIETARY INTAKE; FOOD INTAKE; GENE ACTIVATION; GENE DELETION; GENE EXPRESSION; GENE FUNCTION; INSULIN BLOOD LEVEL; LIPID DIET; MOUSE; NEUROTRANSMISSION; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; RESPIROMETRY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; THERMOGENESIS;

ABDOMINAL FAT; ADIPOSE TISSUE, BROWN; ANIMALS; DIET; DIETARY FATS; FORKHEAD TRANSCRIPTION FACTORS; INFLAMMATION; INSULIN; ION CHANNELS; JANUS KINASE 2; LEPTIN; MICE; MICE, KNOCKOUT; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; NERVE TISSUE PROTEINS; OBESITY; OXYGEN CONSUMPTION; RATS; RECEPTORS, TUMOR NECROSIS FACTOR, TYPE I; STAT3 TRANSCRIPTION FACTOR; THERMOGENESIS; TUMOR NECROSIS FACTOR-ALPHA;

MUS; RODENTIA;

EID: 73649094118     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.030874     Document Type: Article

References (33)

1. Schwartz, M. W. (2006) Obesity 14, Suppl. 1, 1S-8S
2. Flier, J. S. (2004) Cell 116, 337-350
3. Freire, R. D., Cardoso, M. A., Gimeno, S. G., and Ferreira, S. R. (2005) Diabetes Care 28, 1779-1785
4. Hotamisligil, G. S. (2006) Nature 444, 860-867
5. Velloso, L. A., Araújo, E. P., and de Souza, C. T. (2008) Neuroimmunomodulation 15, 189-193
6. Hehlgans, T., and Pfeffer, K. (2005) Immunology 115, 1-20
7. Locksley, R. M., Killeen, N., and Lenardo, M. J. (2001) Cell 104, 487-501
8. Uysal, K. T., Wiesbrock, S. M., Marino, M. W., and Hotamisligil, G. S. (1997) Nature 389, 610-614
9. Uysal, K. T., Wiesbrock, S. M., and Hotamisligil, G. S. (1998) Endocrinology 139, 4832-4838
10. Schreyer, S. A., Chua, S. C., Jr., and LeBoeuf, R. C. (1998) J. Clin. Invest. 102, 402-411
11. Pfeffer, K., Matsuyama, T., Kündig, T. M., Wakeham, A., Kishihara, K., Shahinian, A., Wiegmann, K., Ohashi, P. S., Krönke, M., and Mak, T. W. (1993) Cell 73, 457-467
12. Romanatto, T., Cesquini, M., Amaral, M. E., Roman, E. A., Moraes, J. C., Torsoni, M. A., Cruz-Neto, A. P., and Velloso, L. A. (2007) Peptides 28, 1050-1058
13. Johnson, A. K., and Epstein, A. N. (1975) Brain Res. 86, 399-418
14. Schenka, A. A., Machado, C. M., Grippo, M. C., Queiroz, L. S., Schenka, N. G., Chagas, C. A., Verinaud, L., Brousset, P., and Vassallo, J. (2005) Cell. Mol. Neurobiol. 25, 929-941
15. Hirabara, S. M., Silveira, L. R., Alberici, L. C., Leandro, C. V., Lambertucci, R. H., Polimeno, G. C., Cury Boaventura, M. F., Procopio, J., Vercesi, A. E., and Curi, R. (2006) Biochim. Biophys. Acta 1757, 57-66
16. Tsukumo, D. M., Carvalho-Filho, M. A., Carvalheira, J. B., Prada, P. O., Hirabara, S. M., Schenka, A. A., Araújo, E. P., Vassallo, J., Curi, R., Velloso, L. A., and Saad, M. J. (2007) Diabetes 56, 1986-1998
17. Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D. E., Tsukumo, D. M., Anhe, G., Amaral, M. E., Takahashi, H. K., Curi, R., Oliveira, H. C., Carvalheira, J. B., Bordin, S., Saad, M. J., and Velloso, L. A. (2009) J. Neurosci. 29, 359-370
18. Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., and Flier, J. S. (2006) J. Clin. Invest. 116, 3015-3025
19. Yang, L., and Hotamisligil, G. S. (2008) Cell 135, 20-22
20. Ozcan, U., Cao, Q., Yilmaz, E., Lee, A. H., Iwakoshi, N. N., Ozdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., and Hotamisligil, G. S. (2004) Science 306, 457-461
21. Caricilli, A. M., Nascimento, P. H., Pauli, J. R., Tsukumo, D. M., Velloso, L. A., Carvalheira, J. B., and Saad, M. J. (2008) J. Endocrinol. 199, 399-406
22. Moraes, J. C., Coope, A., Morari, J., Cintra, D. E., Roman, E. A., Pauli, J. R., Romanatto, T., Carvalheira, J. B., Oliveira, A. L., Saad, M. J., and Velloso, L. A, (2009) PLoS ONE 4, e5045
23. De Souza, C. T., Araujo, E. P., Bordin, S., Ashimine, R., Zollner, R. L., Boschero, A. C., Saad, M. J., and Velloso, L. A. (2005) Endocrinology 146, 4192-4199
24. Araújo, E. P., De Souza, C. T., Ueno, M., Cintra, D. E., Bertolo, M. B., Carvalheira, J. B., Saad, M. J., and Velloso, L. A. (2007) Endocrinology 148, 5991-5997
25. Crawford, M., and Curtis, J. R. (2008) Curr. Rheumatol. Rep. 10, 383-389
26. Myers, M. G., Cowley, M. A., and Münzberg, H. (2008) Annu. Rev. Physiol. 70, 537-556
27. Münzberg, H., Jobst, E. E., Bates, S. H., Jones, J., Villanueva, E., Leshan, R., Björnholm, M., Elmquist, J., Sleeman, M., Cowley, M. A., and Myers, M. G., Jr. (2007) J. Neurosci. 27, 69-74
28. Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., and Low, M. J. (2001) Nature 411, 480-484
29. Münzberg, H., and Myers, M. G., Jr. (2005) Nat. Neurosci. 8, 566-570
30. Lechan, R. M., and Fekete, C. (2006) Prog. Brain Res. 153, 209-235
31. Zanotti, S., Kumar, A., and Kumar, A. (2002) Expert Opin. Investig. Drugs 11, 1061-1075
32. Felig, P., Cunningham, J., Levitt, M., Hendler, R., and Nadel, E. (1983) Am. J. Physiol. 244, E45-51
33. Klir, J. J., McClellan, J. L., Kozak, W., Szelényi, Z., Wong, G. H., and Kluger, M. J. (1995) Am. J. Physiol. 268, R480-486