Fatty acid-induced induction of Toll-like receptor-4/nuclear factor-κB pathway in adipocytes links nutritional signalling with innate immunity

Immunology

Volumn 126, Issue 2, 2009, Pages 233-245

  Schaeffler, Andreas ^a,b   Gross, Philipp ^b   Buettner, Roland ^b   Bollheimer, Cornelius ^b   Buechler, Christa ^b   Neumeier, Markus ^b   Kopp, Andrea ^b   Schoelmerich, Juergen ^b   Falk, Werner ^b  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Adipocyte; Adipokines; Fatty acids; Innate immunity; Metabolism; Toll like receptor 4

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; CARBON 14; FATTY ACID; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGAND; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NEUTRALIZING ANTIBODY; PALMITIC ACID; PALMITOLEIC ACID; RESISTIN; STEARIC ACID; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA;

ABDOMINAL FAT; ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; INNATE IMMUNITY; LIPID DIET; MALE; MOUSE; NONHUMAN; NUTRITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ABDOMINAL FAT; ADIPOCYTES; ADIPONECTIN; ANIMAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINE CCL2; DIET; DIETARY FATS; FATTY ACIDS; IMMUNITY, INNATE; MALE; NF-KAPPA B; RATS; RATS, WISTAR; RESISTIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 58149310977     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2008.02892.x     Document Type: Article

References (36)

1. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, Ferrante AW Jr. Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 2003 112 : 1796 808.
2. Xu H, Barnes GT, Yang Q et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003 112 : 1821 30.
3. Whitehead JP, Richards AA, Hickman IJ, Macdonald GA, Prins JB. Adiponectin - a key adipokine in the metabolic syndrome. Diabetes Obes Metab 2006 8 : 264 80.
4. Okamoto Y, Kihara S, Funahashi T, Matsuzawa Y, Libby P. Adiponectin: a key adipocytokine in metabolic syndrome. Clin Sci (Lond) 2006 110 : 267 78.
5. Vasseur F. Adiponectin and its receptors: partners contributing to the "vicious circle" leading to the metabolic syndrome? Pharmacol Res 2006 53 : 478 81.
6. Rea R, Donnelly R. Resistin: an adipocyte-derived hormone. Has it a role in diabetes and obesity? Diabetes Obes Metab 2004 6 : 163 70.
7. Pang SS, Le YY. Role of resistin in inflammation and inflammation-related diseases. Cell Mol Immunol 2006 3 : 29 34.
8. Arner P. Resistin: yet another adipokine tells us that men are not mice. Diabetologia 2005 48 : 2203 5.
9. Fain JN, Madan AK. Regulation of monocyte chemoattractant protein 1 (MCP-1) release by explants of human visceral adipose tissue. Int J Obes (Lond) 2005 29 : 1299 307.
10. Lehrke M, Lazar MA. Inflamed about obesity. Nat Med 2004 10 : 126 7.
11. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006 116 : 3015 25.
12. Zaitsu H, Serrero G. Pedersen fetuin contains three adipogenic factors with distinct biochemical characteristics. J Cell Physiol 1990 144 : 485 91.
13. Bachmeier M, Loffler G. Adipogenic activities in commercial preparations of fetuin. Horm Metab Res 1994 26 : 92 6.
14. Green H, Kehinde O. Formation of normally differentiated subcutaneous fat pads by an established preadipose cell line. J Cell Physiol 1979 101 : 169 71.
15. Green H, Kehinde O. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 1975 5 : 19 27.
16. Green H, Meuth M. An established pre-adipose cell line and its differentiation in culture. Cell 1974 3 : 127 33.
17. Cornelius P, MacDougald OA, Lane MD. Regulation of adipocyte development. Annu Rev Nutr 1994 14 : 99 129.
18. MacDougald OA, Lane MD. Transcriptional regulation of gene expression during adipocyte differentiation. Annu Rev Biochem 1995 64 : 345 73.
19. Hausmann M, Kiessling S, Mestermann S et al. Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Gastroenterology 2002 122 : 1987 2000.
20. Brandl K, Gluck T, Hartmann P, Salzberger B, Falk W. A designed TLR4/MD-2 complex to capture LPS. J Endotoxin Res 2005 11 : 197 206.
21. Buettner R, Parhofer KG, Woenckhaus M, Wrede CE, Kunz-Schughart LA, Scholmerich J, Bollheimer LC. Defining high-fat-diet rat models: metabolic and molecular effects of different fat types. J Mol Endocrinol 2006 36 : 485 501.
22. Kim HM, Park BS, Kim JI et al. Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 2007 130 : 906 17.
23. Faraj M, Lu HL, Cianflone K. Diabetes, lipids, and adipocyte secretagogues. Biochem Cell Biol 2004 82 : 170 90.
24. Flachs P, Mohamed-Ali V, Horakova O, Rossmeisl M, Hosseinzadeh-Attar MJ, Hensler M, Ruzickova J, Kopecky J. Polyunsaturated fatty acids of marine origin induce adiponectin in mice fed a high-fat diet. Diabetologia 2006 49 : 394 7.
25. Ahn IS, Choi BH, Ha JH, Byun JM, Shin HG, Park KY, Do MS. Isomer-specific effect of conjugated linoleic acid on inflammatory adipokines associated with fat accumulation in 3T3-L1 adipocytes. J Med Food 2006 9 : 307 12.
26. Ide T. Interaction of fish oil and conjugated linoleic acid in affecting hepatic activity of lipogenic enzymes and gene expression in liver and adipose tissue. Diabetes 2005 54 : 412 23.
27. Ort T, Arjona AA, MacDougall JR, Nelson PJ, Rothenberg ME, Wu F, Eisen A, Halvorsen YD. Recombinant human FIZZ3/resistin stimulates lipolysis in cultured human adipocytes, mouse adipose explants, and normal mice. Endocrinology 2005 146 : 2200 9.
28. Bajaj M, Suraamornkul S, Kashyap S, Cusi K, Mandarino L, DeFronzo RA. Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes. J Clin Endocrinol Metab 2004 89 : 4649 55.
29. Juan CC, Au LC, Fang VS et al. Suppressed gene expression of adipocyte resistin in an insulin-resistant rat model probably by elevated free fatty acids. Biochem Biophys Res Commun 2001 289 : 1328 33.
30. Rea R, Donnelly R. Effects of metformin and oleic acid on adipocyte expression of resistin. Diabetes Obes Metab 2006 8 : 105 9.
31. Suganami T, Nishida J, Ogawa Y. A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 2005 25 : 2062 8.
32. Kamei N, Tobe K, Suzuki R et al. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 2006 281 : 26602 14.
33. Pietsch J, Batra A, Stroh T, Fedke I, Glauben R, Okur B, Zeitz M, Siegmund B. Toll-like receptor expression and response to specific stimulation in adipocytes and preadipocytes: on the role of fat in inflammation. Ann N Y Acad Sci 2006 1072 : 407 9.
34. Batra A, Pietsch J, Fedke I, Glauben R, Okur B, Stroh T, Zeitz M, Siegmund B. Leptin-dependent Toll-like receptor expression and responsiveness in preadipocytes and adipocytes. Am J Pathol 2007 170 : 1931 41.
35. Suganami T, Tanimoto-Koyama K, Nishida J et al. Role of the Toll-like receptor 4/NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 2007 27 : 84 91.
36. Schaeffler A, Schoelmerich J, Salzberger B. Toll-like receptors, C1q/TNFs and CTRPs: the adipose tissue as an immunological organ? Trends Immunol 2007 28 : 393 9.