Free fatty acid levels modulate microvascular function: Relevance for obesity-associated insulin resistance, hypertension, and microangiopathy

Diabetes

Volumn 53, Issue 11, 2004, Pages 2873-2882

  De Jongh, Renate T ^a   Serné, Erik H ^a   Ijzerman, Richard G ^a   De Vries, Greetje ^a   Stehouwer, Coen D A ^a,b  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACIPIMOX; FATTY ACID; HEPARIN; INTRALIPID; NITROPRUSSIDE SODIUM;

ADULT; ARTICLE; BLOOD VESSEL FUNCTION; CAPILLAROSCOPY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM DEPENDENT VASODILATION; ENDOTHELIUM INDEPENDENT VASODILATION; FATTY ACID BLOOD LEVEL; FEMALE; HUMAN; HYPERINSULINEMIA; HYPERTENSION; INSULIN RESISTANCE; INSULIN SENSITIVITY; IONTOPHORESIS; MICROANGIOPATHY; MICROVASCULATURE; MODULATION; OBESITY; PRIORITY JOURNAL; REGRESSION ANALYSIS; SKIN CAPILLARY; VASCULAR ENDOTHELIUM; VASODILATATION;

ACETYLCHOLINE; ADULT; BIOLOGICAL MARKERS; BLOOD PRESSURE; FATTY ACIDS, NONESTERIFIED; FEMALE; HEART RATE; HUMANS; HYPERTENSION; INSULIN RESISTANCE; MICROCIRCULATION; NITROPRUSSIDE; OBESITY; VASODILATION;

EID: 7044269441     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.53.11.2873     Document Type: Article

References (46)

1. Hubert HB, Feinleib M, McNamara PM, Castelli WP: Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study. Circulation 67:968-977, 1983
2. Manson JE, Colditz GA, Stampfer MJ, Willett WC, Rosner B, Monson RR, Speizer FE, Hennekens CH: A prospective study of obesity and risk of coronary heart disease in women. N Engl J Med 322:882-889, 1990
3. van Leiden HA, Dekker JM, Moll AC, Nijpels G, Heine RJ, Bouter LM, Stehouwer CD, Polak BC: Blood pressure, lipids, and obesity are associated with retinopathy: the Hoorn study. Diabetes Care 25:1320-1325, 2002
4. de Jong PE, Verhave JC, Pinto-Sietsma SJ, Hillege HL: Obesity and target organ damage: the kidney. Int J Obes Relat Metab Disord 26 (Suppl. 4):S21-S24, 2002
5. Kenchaiah S, Evans JC, Levy D, Wilson PW, Benjamin EJ, Larson MG, Kannel WB, Vasan RS: Obesity and the risk of heart failure. N Engl J Med 347:305-313, 2002
6. Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest 93:2438-2446, 1994
7. Bonadonna RC, Zych K, Boni C, Ferrannini E, DeFronzo RA: Time dependence of the interaction between lipid and glucose in humans. Am J Physiol 257:E49-E56, 1989
8. Steinberg HO, Tarshoby M, Monestel R, Hook G, Cronin J, Johnson A, Bayazeed B, Baron AD: Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 100:1230-1239, 1997
9. Stepniakowski KT, Goodfriend TL, Egan BM: Fatty acids enhance vascular alpha-adrenergic sensitivity. Hypertension 25:774-778, 1995
10. Steinberg HO, Paradisi G, Hook G, Crowder K, Cronin J, Baron AD: Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes 49:1231-1238, 2000
11. Clerk LH, Rattigan S, Clark MG: Lipid infusion impairs physiologic insulin-mediated capillary recruitment and muscle glucose uptake in vivo. Diabetes 51:1138-1145, 2002
12. Clark MG, Wallis MG, Barrett EJ, Vincent MA, Richards SM, Clerk LH, Rattigan S: Blood flow and muscle metabolism: a focus on insulin action. Am J Physiol Endocrinol Metab 284:E241-E258, 2003
13. Youd JM, Rattigan S, Clark MG: Acute impairment of insulin-mediated capillary recruitment and glucose uptake in rat skeletal muscle in vivo by TNF-α. Diabetes 49:1904-1909, 2000
14. Levy BI, Ambrosio G, Pries AR, Struijker-Boudier HA: Microcirculation in hypertension: a new target for treatment? Circulation 104:736-741, 2001
15. Noon JP, Walker BR, Webb DJ, Shore AC, Holton DW, Edwards HV, Watt GC: Impaired microvascular dilatation and capillary rarefaction in young adults with a predisposition to high blood pressure. J Clin Invest 99:1873-1879, 1997
16. Antonios TF, Singer DR, Markandu ND, Mortimer PS, MacGregor GA: Rarefaction of skin capillaries in borderline essential hypertension suggests an early structural abnormality. Hypertension 34:655-658, 1999
17. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus: Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 20:1183-1197, 1997
18. Ferrannini E, Mari A: How to measure insulin sensitivity. J Hypertens 16:895-906, 1998
19. Serné EH, Stehouwer CD, ter Maaten JC, ter Wee PM, Rauwerda JA, Donker AJ, Gans RO: Microvascular function relates to insulin sensitivity and blood pressure in normal subjects. Circulation 99:896-902, 1999
20. Coggins M, Lindner J, Rattigan S, Jahn L, Fasy E, Kaul S, Barrett E: Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment. Diabetes 50:2682-2690, 2001
21. Vincent MA, Dawson D, Clark AD, Lindner JR, Rattigan S, Clark MG, Barrett EJ: Skeletal muscle microvascular recruitment by physiological hyperinsulinemia precedes increases in total blood flow. Diabetes 51:42-48, 2002
22. Serné EH, IJzerman RG, Gans RO, Nijveldt R, de Vries G, Evertz R, Donker AJ, Stehouwer CD: Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia. Diabetes 51:1515-1522, 2002
23. Wallis MG, Wheatley CM, Rattigan S, Barrett EJ, Clark AD, Clark MG: Insulin-mediated hemodynamic changes are impaired in muscle of Zucker obese rats. Diabetes 51:3492-3498, 2002
24. de Jongh RT, Serné EH, IJzerman RG, de Vries G, Stehouwer CD: Impaired microvascular function in obesity: implications for obesity-associated microangiopathy, hypertension, and insulin resistance. Circulation 109: 2529-2535, 2004
25. Roden M, Krssak M, Stingl H, Gruber S, Hofer A, Furnsinn C, Moser E, Waldhausl W: Rapid impairment of skeletal muscle glucose transport/ phosphorylation by free fatty acids in humans. Diabetes 48:358-364, 1999
26. Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, Cline GW, Shulman GI: Mechanism of free fatty acid-induced insulin resistance in humans. J Clin Invest 97:2859-2865, 1996
27. Krebs M, Krssak M, Nowotny P, Weghuber D, Gruber S, Mlynarik V, Bischof M, Stingl H, Furnsinn C, Waldhausl W, Roden M: Free fatty acids inhibit the glucose-stimulated increase of intramuscular glucose-6-phosphate concentration in humans. J Clin Endocrinol Metab 86:2153-2160, 2001
28. Vincent MA, Clerk LH, Lindner JR, Klibanov AL, Clark MG, Rattigan S, Barrett EJ: Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo. Diabetes 53:1418-1423, 2004
29. Ferrannini E, Barrett EJ, Bevilacqua S, DeFronzo RA: Effect of fatty acids on glucose production and utilization in man. J Clin Invest 72:1737-1747, 1983
30. Kelley DE, Mokan M, Simoneau JA, Mandarino LJ: Interaction between glucose and free fatty acid metabolism in human skeletal muscle. J Clin Invest 92:91-98, 1993
31. Homko CJ, Cheung P, Boden G: Effects of free fatty acids on glucose uptake and utilization in healthy women. Diabetes 52:487-491, 2003
32. Zhang L, Vincent MA, Richards SM, Clerk LH, Rattigan S, Clark MG, Barrett EJ: Insulin sensitivity of muscle capillary recruitment in vivo. Diabetes 53:447-453, 2004
33. Dresner A, Laurent D, Marcucci M, Griffin ME, Dufour S, Cline GW, Slezak LA, Andersen DK, Hundal RS, Rothman DL, Petersen KF, Shulman GI: Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity. J Clin Invest 103:253-259, 1999
34. Jiang ZY, Lin YW, Clemont A, Feener EP, Hein KD, Igarashi M, Yamauchi T, White MF, King GL: Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats. J Clin Invest 104:447-457, 1999
35. Lang CH: Rates and tissue sites of noninsulin- and insulin-mediated glucose uptake in diabetic rats. Proc Soc Exp Biol Med 199:81-87, 1992
36. Lang CH, Dobrescu C, Bagby GJ: Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output. Endocrinology 130:43-52, 1992
37. Lang CH: Beta-adrenergic blockade attenuates insulin resistance induced by tumor necrosis factor. Am J Physiol 264:R984-R991, 1993
38. Tooke JE, Lins PE, Ostergren J, Adamson U, Fagrell B: The effects of intravenous insulin infusion on skin microcirculatory flow in type 1 diabetes. Int J Microcirc Clin Exp 4:69-83, 1985
39. Tymms DJ, Tooke JE: The effect of continuous subcutaneous insulin infusion (CSII) on microvascular blood flow in diabetes mellitus. Int J Microcirc Clin Exp 7:347-356, 1988
40. Tuominen JA, Eriksson JG, Koivisto VA: Acute administration of metoprolol and enalaprilat reduces insulin-stimulated thermogenesis and skin blood flow. J Intern Med 239:399-406, 1996
41. Serné EH, Gans RO, ter Maaten JC, ter Wee PM, Donker AJ, Stehouwer CD: Capillary recruitment is impaired in essential hypertension and relates to insulin's metabolic and vascular actions. Cardiovasc Res 49:161-168, 2001
42. Jaap AJ, Shore AC, Tooke JE: Relationship of insulin resistance to microvascular dysfunction in subjects with fasting hyperglycaemia. Diabetologia 40:238-243, 1997
43. Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, King GL, LoGerfo FW, Horton ES, Veves A: Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes 48:1856-1862, 1999
44. Johnson PC: Active and passive determinants of capillary density: a historical perspective. Int J Microcirc Clin Exp 15:218-222, 1995
45. Pan DA, Lillioja S, Kriketos AD, Milner MR, Baur LA, Bogardus C, Jenkins AB, Storlien LH: Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983-988, 1997
46. Phillips DI, Caddy S, Ilic V, Fielding BA, Frayn KN, Borthwick AC, Taylor R: Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45:947-950, 1996