-
2
-
-
71949118923
-
Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin- 1 receptor i
-
Boni-Schnetzler M, Boller S, Debray S, et al. Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin- 1 receptor I. Endocrinology 2009; 150:5218-5229.
-
(2009)
Endocrinology
, vol.150
, pp. 5218-5229
-
-
Boni-Schnetzler, M.1
Boller, S.2
Debray, S.3
-
3
-
-
53749100698
-
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta-cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation
-
Boni-Schnetzler M, Thorne J, Parnaud G, et al. Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta-cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab 2008; 93:4065-4074.
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 4065-4074
-
-
Boni-Schnetzler, M.1
Thorne, J.2
Parnaud, G.3
-
4
-
-
2542541353
-
Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets
-
Maedler K, Sergeev P, Ehses JA, et al. Leptin modulates beta cell expression of IL-1 receptor antagonist and release of IL-1beta in human islets. Proc Natl Acad Sci USA 2004; 101:8138-8143.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 8138-8143
-
-
Maedler, K.1
Sergeev, P.2
Ehses, J.A.3
-
5
-
-
0036738398
-
Glucose-induced beta cell production of IL- 1beta contributes to glucotoxicity in human pancreatic islets
-
Maedler K, Sergeev P, Ris F, et al. Glucose-induced beta cell production of IL- 1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002; 110:851-860.
-
(2002)
J Clin Invest
, vol.110
, pp. 851-860
-
-
Maedler, K.1
Sergeev, P.2
Ris, F.3
-
6
-
-
42449110310
-
Thioredoxin-interacting protein: A critical link between glucose toxicity and beta-cell apoptosis
-
Chen J, Saxena G, Mungrue IN, et al. Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes 2008; 57:938-944.
-
(2008)
Diabetes
, vol.57
, pp. 938-944
-
-
Chen, J.1
Saxena, G.2
Mungrue, I.N.3
-
7
-
-
0036720558
-
Oligonucleotide microarray analysis of intact human pancreatic islets: Identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway
-
Shalev A, Pise-Masison CA, Radonovich M, et al. Oligonucleotide microarray analysis of intact human pancreatic islets: identification of glucose-responsive genes and a highly regulated TGFbeta signaling pathway. Endocrinology 2002; 143:3695-3698.
-
(2002)
Endocrinology
, vol.143
, pp. 3695-3698
-
-
Shalev, A.1
Pise-Masison, C.A.2
Radonovich, M.3
-
8
-
-
77955768241
-
Txnip expression associates with hyperglycemia-induced inflammation in human peripheral blood mononuclear cells and adipocytes
-
Koenen TB, Stienstra R, van Tits LJH, et al. Txnip expression associates with hyperglycemia-induced inflammation in human peripheral blood mononuclear cells and adipocytes. Diabetologia 2009; 52 (Suppl):253.
-
(2009)
Diabetologia
, vol.52
, Issue.SUPPL.
, pp. 253
-
-
Koenen, T.B.1
Stienstra, R.2
Van Tits Ljh3
-
9
-
-
0842284799
-
Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes
-
Robertson RP, Harmon J, Tran PO, Poitout V. Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 2004; 53 (Suppl 1):S119-S124.
-
(2004)
Diabetes
, vol.53
, Issue.SUPPL. 1
-
-
Robertson, R.P.1
Harmon, J.2
Tran, P.O.3
Poitout, V.4
-
10
-
-
75649096002
-
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
-
Zhou R, Tardivel A, Thorens B, et al. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 2010; 11:136-140.
-
(2010)
Nat Immunol
, vol.11
, pp. 136-140
-
-
Zhou, R.1
Tardivel, A.2
Thorens, B.3
-
11
-
-
0023201153
-
Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro
-
Dinarello CA, Ikejima T, Warner SJ, et al. Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro. J Immunol 1987; 139:1902-1910.
-
(1987)
J Immunol
, vol.139
, pp. 1902-1910
-
-
Dinarello, C.A.1
Ikejima, T.2
Warner, S.J.3
-
12
-
-
0037083506
-
Autocrine induction of the human pro-IL- 1beta gene promoter by IL-1beta in monocytes
-
Toda Y, Tsukada J, Misago M, et al. Autocrine induction of the human pro-IL- 1beta gene promoter by IL-1beta in monocytes. J Immunol 2002; 168:1984-1991.
-
(2002)
J Immunol
, vol.168
, pp. 1984-1991
-
-
Toda, Y.1
Tsukada, J.2
Misago, M.3
-
13
-
-
77950355734
-
Anti-inflammatory agents: Present and future
-
Dinarello CA. Anti-inflammatory agents: present and future. Cell 2010; 140:935-950.
-
(2010)
Cell
, vol.140
, pp. 935-950
-
-
Dinarello, C.A.1
-
14
-
-
62649139025
-
Immunological and inflammatory functions of the interleukin-1 family
-
Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Ann Rev Immunol 2009; 27:519-550.
-
(2009)
Ann Rev Immunol
, vol.27
, pp. 519-550
-
-
Dinarello, C.A.1
-
15
-
-
34548431826
-
Increased number of islet-associated macrophages in type 2 diabetes
-
Ehses JA, Perren A, Eppler E, et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 2007; 56:2356-2370.
-
(2007)
Diabetes
, vol.56
, pp. 2356-2370
-
-
Ehses, J.A.1
Perren, A.2
Eppler, E.3
-
16
-
-
69549098032
-
IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat
-
Ehses JA, Lacraz G, Giroix MH, et al. IL-1 antagonism reduces hyperglycemia and tissue inflammation in the type 2 diabetic GK rat. Proc Natl Acad Sci USA 2009; 106:13998-14003.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 13998-14003
-
-
Ehses, J.A.1
Lacraz, G.2
Giroix, M.H.3
-
17
-
-
40749139988
-
Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat
-
Weksler-Zangen S, Raz I, Lenzen S, et al. Impaired glucose-stimulated insulin secretion is coupled with exocrine pancreatic lesions in the Cohen diabetic rat. Diabetes 2008; 57:279-287.
-
(2008)
Diabetes
, vol.57
, pp. 279-287
-
-
Weksler-Zangen, S.1
Raz, I.2
Lenzen, S.3
-
18
-
-
0022596377
-
Affinity-purified human interleukin i is cytotoxic to isolated islets of Langerhans
-
Mandrup-Poulsen T, Bendtzen K, Nerup J, et al. Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans. Diabetologia 1986; 29:63-67.
-
(1986)
Diabetologia
, vol.29
, pp. 63-67
-
-
Mandrup-Poulsen, T.1
Bendtzen, K.2
Nerup, J.3
-
19
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
Larsen CM, Faulenbach M, Vaag A, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007; 356:1517-1526.
-
(2007)
N Engl J Med
, vol.356
, pp. 1517-1526
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
-
20
-
-
34848875155
-
Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
-
Gattorno M, Tassi S, Carta S, et al. Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations. Arthritis Rheum 2007; 56:3138-3148.
-
(2007)
Arthritis Rheum
, vol.56
, pp. 3138-3148
-
-
Gattorno, M.1
Tassi, S.2
Carta, S.3
-
21
-
-
66649102432
-
Use of canakinumab in the cryopyrin-associated periodic syndrome
-
Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB, et al. Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med 2009; 360:2416-2425.
-
(2009)
N Engl J Med
, vol.360
, pp. 2416-2425
-
-
Lachmann, H.J.1
Kone-Paut, I.2
Kuemmerle-Deschner, J.B.3
-
22
-
-
66649113371
-
An autoinflammatory disease due to homozygous deletion of the IL1RN locus
-
Reddy S, Jia S, Geoffrey R, et al. An autoinflammatory disease due to homozygous deletion of the IL1RN locus. N Engl J Med 2009; 360: 2438-2444.
-
(2009)
N Engl J Med
, vol.360
, pp. 2438-2444
-
-
Reddy, S.1
Jia, S.2
Geoffrey, R.3
-
23
-
-
66649121678
-
An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist
-
Aksentijevich I, Masters SL, Ferguson PJ, et al. An autoinflammatory disease with deficiency of the interleukin-1-receptor antagonist. N Engl J Med 2009; 360:2426-2437.
-
(2009)
N Engl J Med
, vol.360
, pp. 2426-2437
-
-
Aksentijevich, I.1
Masters, S.L.2
Ferguson, P.J.3
-
24
-
-
66649122286
-
Interleukin-1beta and the autoinflammatory diseases
-
Dinarello CA. Interleukin-1beta and the autoinflammatory diseases. N Engl J Med 2009; 360:2467-2470.
-
(2009)
N Engl J Med
, vol.360
, pp. 2467-2470
-
-
Dinarello, C.A.1
-
25
-
-
75749090445
-
Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cellspecific interleukin-1 receptor antagonist
-
Lamacchia C, Palmer G, Seemayer CA, et al. Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cellspecific interleukin-1 receptor antagonist. Arthritis Rheum 2010; 62:452-462.
-
(2010)
Arthritis Rheum
, vol.62
, pp. 452-462
-
-
Lamacchia, C.1
Palmer, G.2
Seemayer, C.A.3
-
26
-
-
3042825017
-
Glucose- and interleukin-1beta-induced beta-cell apoptosis requires Ca2 influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/ inwardly rectifying K channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets
-
Maedler K, Storling J, Sturis J, et al. Glucose- and interleukin-1beta- induced beta-cell apoptosis requires Ca2 influx and extracellular signal-regulated kinase (ERK) 1/2 activation and is prevented by a sulfonylurea receptor 1/ inwardly rectifying K channel 6.2 (SUR/Kir6.2) selective potassium channel opener in human islets. Diabetes 2004; 53:1706-1713.
-
(2004)
Diabetes
, vol.53
, pp. 1706-1713
-
-
Maedler, K.1
Storling, J.2
Sturis, J.3
-
27
-
-
68949117166
-
XOMA 052, a potential disease modifying anti1L-1beta antibody, shows sustained HbA1c reductions 3 Months after a single injection with no increases in safety parameters in subjects with type 2 diabetes
-
Donath MY, Weder C, Brunner A, et al. XOMA 052, a potential disease modifying anti1L-1beta antibody, shows sustained HbA1c reductions 3 Months after a single injection with no increases in safety parameters in subjects with type 2 diabetes. Diabetes 2009; 58:A30.
-
(2009)
Diabetes
, vol.58
-
-
Donath, M.Y.1
Weder, C.2
Brunner, A.3
-
28
-
-
69549105888
-
Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes
-
Larsen CM, Faulenbach M, Vaag A, et al. Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diabetes Care 2009; 32:1663-1668.
-
(2009)
Diabetes Care
, vol.32
, pp. 1663-1668
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
-
29
-
-
33746876396
-
Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition
-
Goldbach-Mansky R, Dailey NJ, Canna SW, et al. Neonatal-onset multisystem inflammatory disease responsive to interleukin-1beta inhibition. N Engl J Med 2006; 355:581-592.
-
(2006)
N Engl J Med
, vol.355
, pp. 581-592
-
-
Goldbach-Mansky, R.1
Dailey, N.J.2
Canna, S.W.3
-
30
-
-
18644385243
-
Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade
-
Pascual V, Allantaz F, Arce E, et al. Role of interleukin-1 (IL-1) in the pathogenesis of systemic onset juvenile idiopathic arthritis and clinical response to IL-1 blockade. J Exp Med 2005; 201:1479-1486.
-
(2005)
J Exp Med
, vol.201
, pp. 1479-1486
-
-
Pascual, V.1
Allantaz, F.2
Arce, E.3
-
31
-
-
66049094734
-
Vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes
-
Lachmann HJ, Lowe P, Felix SD, et al. In vivo regulation of interleukin 1beta in patients with cryopyrin-associated periodic syndromes. J Exp Med 2009; 206:1029-1036.
-
(2009)
J Exp Med
, vol.206
, pp. 1029-1036
-
-
Lachmann, H.J.1
Lowe, P.2
Felix, S.D.3
-
32
-
-
0034453105
-
Interferon-gamma induces interleukin- 1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism
-
Karlsen AE, Pavlovic D, Nielsen K, et al. Interferon-gamma induces interleukin- 1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism. J Clin Endocrinol Metab 2000; 85:830-836.
-
(2000)
J Clin Endocrinol Metab
, vol.85
, pp. 830-836
-
-
Karlsen, A.E.1
Pavlovic, D.2
Nielsen, K.3
-
33
-
-
0028830125
-
Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury
-
Mandrup-Poulsen T, Wogensen LD, Jensen M, et al. Circulating interleukin-1 receptor antagonist concentrations are increased in adult patients with thermal injury. Crit Care Med 1995; 23:26-33.
-
(1995)
Crit Care Med
, vol.23
, pp. 26-33
-
-
Mandrup-Poulsen, T.1
Wogensen, L.D.2
Jensen, M.3
-
34
-
-
0025100764
-
Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas
-
Wogensen LD, Kolb-Bachofen V, Christensen P, et al. Functional and morphological effects of interleukin-1 beta on the perfused rat pancreas. Diabetologia 1990; 33:15-23.
-
(1990)
Diabetologia
, vol.33
, pp. 15-23
-
-
Wogensen, L.D.1
Kolb-Bachofen, V.2
Christensen, P.3
-
35
-
-
0026589802
-
Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats
-
Wogensen LD, Reimers J, Nerup J, et al. Repetitive in vivo treatment with human recombinant interleukin-1 beta modifies beta-cell function in normal rats. Diabetologia 1992; 35:331-339.
-
(1992)
Diabetologia
, vol.35
, pp. 331-339
-
-
Wogensen, L.D.1
Reimers, J.2
Nerup, J.3
-
36
-
-
0027932846
-
Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases
-
Reimers JI, Bjerre U, Mandrup-Poulsen T, Nerup J. Interleukin 1 beta induces diabetes and fever in normal rats by nitric oxide via induction of different nitric oxide synthases. Cytokine 1994; 6:512-520.
-
(1994)
Cytokine
, vol.6
, pp. 512-520
-
-
Reimers, J.I.1
Bjerre, U.2
Mandrup-Poulsen, T.3
Nerup, J.4
-
37
-
-
72449150103
-
The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation
-
Kolb H, Mandrup-Poulsen T. The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia 2010; 53:10-20.
-
(2010)
Diabetologia
, vol.53
, pp. 10-20
-
-
Kolb, H.1
Mandrup-Poulsen, T.2
-
38
-
-
64049084303
-
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
-
Netea MG, Nold-Petry CA, Nold MF, et al. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 2009; 113:2324-2335.
-
(2009)
Blood
, vol.113
, pp. 2324-2335
-
-
Netea, M.G.1
Nold-Petry, C.A.2
Nold, M.F.3
-
39
-
-
0025302145
-
Dissociation between interleukin-1b mRNA and protein synthesis in human peripheral blood mononuclear cells
-
Schindler R, Clark BD, Dinarello CA. Dissociation between interleukin-1b mRNA and protein synthesis in human peripheral blood mononuclear cells. J Biol Chem 1990; 265:10232-10237.
-
(1990)
J Biol Chem
, vol.265
, pp. 10232-10237
-
-
Schindler, R.1
Clark, B.D.2
Dinarello, C.A.3
-
40
-
-
77950646650
-
The inflammasome-mediated caspase-1 activation controls apipocyte differentiation and insulin sensitivity
-
(abs)
-
Stienstra R, Joosten LA, Koenen T, et al. The inflammasome-mediated caspase-1 activation controls apipocyte differentiation and insulin sensitivity. Cytokine 2009; 48:134. (abs).
-
(2009)
Cytokine
, vol.48
, pp. 134
-
-
Stienstra, R.1
Joosten, L.A.2
Koenen, T.3
-
41
-
-
33745009509
-
Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
-
Netea MG, Joosten LA, Lewis E, et al. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 2006; 12:650-656.
-
(2006)
Nat Med
, vol.12
, pp. 650-656
-
-
Netea, M.G.1
Joosten, L.A.2
Lewis, E.3
-
42
-
-
34547466569
-
Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency
-
Zorrilla EP, Sanchez-Alavez M, Sugama S, et al. Interleukin-18 controls energy homeostasis by suppressing appetite and feed efficiency. Proc Natl Acad Sci USA 2007; 104:11097-11102.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 11097-11102
-
-
Zorrilla, E.P.1
Sanchez-Alavez, M.2
Sugama, S.3
-
43
-
-
51849099326
-
Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus
-
Zilverschoon GR, Tack CJ, Joosten LA, et al. Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus. Int J Obes (Lond) 2008; 32:1407-1414.
-
(2008)
Int J Obes (Lond)
, vol.32
, pp. 1407-1414
-
-
Zilverschoon, G.R.1
Tack, C.J.2
Joosten, L.A.3
-
44
-
-
0036896760
-
Interleukin-1 receptor antagonist genotype is associated with coronary atherosclerosis in patients with type 2 diabetes
-
Marculescu R, Endler G, Schillinger M, et al. Interleukin-1 receptor antagonist genotype is associated with coronary atherosclerosis in patients with type 2 diabetes. Diabetes 2002; 51:3582-3585.
-
(2002)
Diabetes
, vol.51
, pp. 3582-3585
-
-
Marculescu, R.1
Endler, G.2
Schillinger, M.3
|