Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice

Diabetologia

Volumn 57, Issue 11, 2014, Pages 2393-2404

  Jiang, Hongfeng ^a   Westerterp, Marit ^a,b   Wang, Chunjiong ^c   Zhu, Yi ^c   Ai, Ding ^a,c  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

Inflammation; Insulin resistance; mTORC1

Indexed keywords

CRE RECOMBINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INOSITOL; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PALMITIC ACID; PROTEIN KINASE B; RAPAMYCIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; TARGET OF RAPAMYCIN KINASE;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MARROW; CONTROLLED STUDY; FATTY LIVER; GENE EXPRESSION; IN VITRO STUDY; INFLAMMATION; INHIBITION KINETICS; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIVER; MACROPHAGE; MOUSE; MUSCLE; NONHUMAN; PERITONEUM MACROPHAGE; PROMOTER REGION; ANIMAL; CELL CULTURE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; IMMUNOHISTOCHEMISTRY; LIPID DIET; MALE; METABOLISM; MOUSE MUTANT; OBESITY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION;

ANIMALS; CELLS, CULTURED; DIET, HIGH-FAT; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; MACROPHAGES; MALE; MICE; MICE, OBESE; MULTIPROTEIN COMPLEXES; OBESITY; REAL-TIME POLYMERASE CHAIN REACTION; TOR SERINE-THREONINE KINASES;

EID: 84919965563     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3350-5     Document Type: Article

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