-
1
-
-
79959936188
-
National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants
-
Danaei, G. et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 378, 31-40 (2011).
-
(2011)
Lancet
, vol.378
, pp. 31-40
-
-
Danaei, G.1
-
2
-
-
0036276518
-
Food groups as predictors for short-term weight changes in men and women of the EPIC-Potsdam cohort
-
Schulz, M. et al. Food groups as predictors for short-term weight changes in men and women of the EPIC-Potsdam cohort. J. Nutr. 132, 1335-1340 (2002). (Pubitemid 34606473)
-
(2002)
Journal of Nutrition
, vol.132
, Issue.6
, pp. 1335-1340
-
-
Schulz, M.1
Kroke, A.2
Liese, A.D.3
Hoffmann, K.4
Bergmann, M.M.5
Boeing, H.6
-
3
-
-
33745861300
-
Inflammation and insulin resistance
-
DOI 10.1172/JCI29069
-
Shoelson, S. E., Lee, J. & Goldfine, A. B. Inflammation and insulin resistance. J. Clin. Invest. 116, 1793-1801 (2006). (Pubitemid 44033299)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1793-1801
-
-
Shoelson, S.E.1
Lee, J.2
Goldfine, A.B.3
-
4
-
-
34547602916
-
Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
DOI 10.2337/db06-1595
-
Tsukumo, D. M. et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56, 1986-1998 (2007). (Pubitemid 47195825)
-
(2007)
Diabetes
, vol.56
, Issue.8
, pp. 1986-1998
-
-
Tsukumo, D.M.L.1
Carvalho-Filho, M.A.2
Carvalheira, J.B.C.3
Prada, P.O.4
Hirabara, S.M.5
Schenka, A.A.6
Araujo, E.P.7
Vassallo, J.8
Curi, R.9
Velloso, L.A.10
Saad, M.J.A.11
-
5
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
-
DOI 10.1126/science.1103160
-
Ozcan, U. et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 306, 457-461 (2004). (Pubitemid 39372439)
-
(2004)
Science
, vol.306
, Issue.5695
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.-H.4
Iwakoshi, N.N.5
Ozdelen, E.6
Tuncman, G.7
Gorgun, C.8
Glimcher, L.H.9
Hotamisligil, G.S.10
-
6
-
-
58849149821
-
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
-
Milanski, M. et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J. Neurosci. 29, 359-370 (2009).
-
(2009)
J. Neurosci.
, vol.29
, pp. 359-370
-
-
Milanski, M.1
-
7
-
-
84864657351
-
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
Pal, D. et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat. Med. 18, 1279-1285 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 1279-1285
-
-
Pal, D.1
-
9
-
-
84855605795
-
Endoplasmic reticulum stress, obesity and diabetes
-
Cnop, M., Foufelle, F. & Velloso, L. A. Endoplasmic reticulum stress, obesity and diabetes. Trends Mol. Med. 18, 59-68 (2012).
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 59-68
-
-
Cnop, M.1
Foufelle, F.2
Velloso, L.A.3
-
10
-
-
84878777666
-
Signalling danger: Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation
-
Eizirik, D. L., Miani, M. & Cardozo, A. K. Signalling danger: endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation. Diabetologia 56, 234-241 (2013).
-
(2013)
Diabetologia
, vol.56
, pp. 234-241
-
-
Eizirik, D.L.1
Miani, M.2
Cardozo, A.K.3
-
11
-
-
84857985148
-
The cellular and signaling networks linking the immune system and metabolism in disease
-
Osborn, O. & Olefsky, J. M. The cellular and signaling networks linking the immune system and metabolism in disease. Nat. Med. 18, 363-374 (2012).
-
(2012)
Nat. Med.
, vol.18
, pp. 363-374
-
-
Osborn, O.1
Olefsky, J.M.2
-
12
-
-
67650421494
-
T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes
-
Guarda, G. et al. T cells dampen innate immune responses through inhibition of NLRP1 and NLRP3 inflammasomes. Nature 460, 269-273 (2009).
-
(2009)
Nature
, vol.460
, pp. 269-273
-
-
Guarda, G.1
-
13
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer, M. et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat. Med. 15, 930-939 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
-
14
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer, S. et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat. Med. 15, 921-929 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 921-929
-
-
Winer, S.1
-
15
-
-
70449164839
-
Chronic thyroiditis and autoimmunization
-
Witebsky, E., Rose, N. R., Terplan, K., Paine, J. R. & Egan, R. W. Chronic thyroiditis and autoimmunization. J. Am. Med. Assoc. 164, 1439-1447 (1957).
-
(1957)
J. Am. Med. Assoc.
, vol.164
, pp. 1439-1447
-
-
Witebsky, E.1
Rose, N.R.2
Terplan, K.3
Paine, J.R.4
Egan, R.W.5
-
16
-
-
77951891703
-
Prediction and pathogenesis in type 1 diabetes
-
Ziegler, A. G. & Nepom, G. T. Prediction and pathogenesis in type 1 diabetes. Immunity 32, 468-478 (2010).
-
(2010)
Immunity
, vol.32
, pp. 468-478
-
-
Ziegler, A.G.1
Nepom, G.T.2
-
17
-
-
33744900639
-
Lessons on autoimmune diabetes from animal models
-
DOI 10.1016/j.cad.2006.02.007
-
Yang, Y. & Santamaria, P. Lessons on autoimmune diabetes from animal models. Clin. Sci. (Lond.) 110, 627-639 (2006). (Pubitemid 43844732)
-
(2006)
Clinical Science
, vol.110
, Issue.6
, pp. 627-639
-
-
Yang, Y.1
Santamaria, P.2
-
18
-
-
82955247941
-
Diabetogenic T lymphocytes in human type 1 diabetes
-
Roep, B. O. & Peakman, M. Diabetogenic T lymphocytes in human type 1 diabetes. Curr. Opin. Immunol. 23, 746-753 (2011).
-
(2011)
Curr. Opin. Immunol.
, vol.23
, pp. 746-753
-
-
Roep, B.O.1
Peakman, M.2
-
19
-
-
84876089704
-
Progress in immune-based therapies for type 1 diabetes
-
von Herrath, M., Peakman, M. & Roep, B. Progress in immune-based therapies for type 1 diabetes. Clin. Exp. Immunol. 172, 186-202 (2013).
-
(2013)
Clin. Exp. Immunol.
, vol.172
, pp. 186-202
-
-
Von Herrath, M.1
Peakman, M.2
Roep, B.3
-
20
-
-
67649364114
-
The role of inflammation in insulitis and β-cell loss in type 1 diabetes
-
Eizirik, D. L., Colli, M. L. & Ortis, F. The role of inflammation in insulitis and β-cell loss in type 1 diabetes. Nat. Rev. Endocrinol. 5, 219-226 (2009).
-
(2009)
Nat. Rev. Endocrinol.
, vol.5
, pp. 219-226
-
-
Eizirik, D.L.1
Colli, M.L.2
Ortis, F.3
-
21
-
-
85027938385
-
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
-
Winer, D. A. et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat. Med. 17, 610-617 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 610-617
-
-
Winer, D.A.1
-
22
-
-
0032940245
-
Cellular immune responses to human islet proteins in antibody-positive type 2 diabetic patients
-
DOI 10.2337/diabetes.48.5.983
-
Brooks-Worrell, B. M., Juneja, R., Minokadeh, A., Greenbaum, C. J. & Palmer, J. P. Cellular immune responses to human islet proteins in antibody-positive type 2 diabetic patients. Diabetes 48, 983-988 (1999). (Pubitemid 29226343)
-
(1999)
Diabetes
, vol.48
, Issue.5
, pp. 983-988
-
-
Brooks-Worrell, B.M.1
Juneja, R.2
Minokadeh, A.3
Greenbaum, C.J.4
Palmer, J.P.5
-
23
-
-
67349199566
-
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
-
Barrett, J. C. et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat. Genet. 41, 703-707 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 703-707
-
-
Barrett, J.C.1
-
24
-
-
75749086085
-
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
-
Dupuis, J. et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat. Genet. 42, 105-116 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 105-116
-
-
Dupuis, J.1
-
25
-
-
55649116393
-
Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes
-
Rafiq, S. et al. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes. Diabetologia 51, 2205-2213 (2008).
-
(2008)
Diabetologia
, vol.51
, pp. 2205-2213
-
-
Rafiq, S.1
-
26
-
-
84865834692
-
Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes
-
Winkler, C., Raab, J., Grallert, H. & Ziegler, A. G. Lack of association of type 2 diabetes susceptibility genotypes and body weight on the development of islet autoimmunity and type 1 diabetes. PLoS ONE 7, e35410 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Winkler, C.1
Raab, J.2
Grallert, H.3
Ziegler, A.G.4
-
27
-
-
78049337953
-
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
-
Speliotes, E. K. et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat. Genet. 42, 937-948 (2010).
-
(2010)
Nat. Genet.
, vol.42
, pp. 937-948
-
-
Speliotes, E.K.1
-
28
-
-
67651246858
-
Sera from patients with type 2 diabetes contain agonistic autoantibodies against G protein-coupled receptors
-
Hempel, P. et al. Sera from patients with type 2 diabetes contain agonistic autoantibodies against G protein-coupled receptors. Scand. J. Immunol. 70, 159-160 (2009).
-
(2009)
Scand. J. Immunol.
, vol.70
, pp. 159-160
-
-
Hempel, P.1
-
29
-
-
66749138197
-
Autoantibodies in type 2 diabetes induce stress fiber formation and apoptosis in endothelial cells
-
Zimering, M. B. & Pan, Z. Autoantibodies in type 2 diabetes induce stress fiber formation and apoptosis in endothelial cells. J. Clin. Endocrinol. Metab. 94, 2171-2177 (2009).
-
(2009)
J. Clin. Endocrinol. Metab.
, vol.94
, pp. 2171-2177
-
-
Zimering, M.B.1
Pan, Z.2
-
30
-
-
76649133789
-
Interleukin-6 autoantibodies are involved in the pathogenesis of a subset of type 2 diabetes
-
Fosgerau, K. et al. Interleukin-6 autoantibodies are involved in the pathogenesis of a subset of type 2 diabetes. J. Endocrinol. 204, 265-273 (2010).
-
(2010)
J. Endocrinol.
, vol.204
, pp. 265-273
-
-
Fosgerau, K.1
-
31
-
-
33847280286
-
T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity
-
DOI 10.1161/CIRCULATIONAHA.106.638379, PII 0000301720070227000014
-
Wu, H. et al. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation 115, 1029-1038 (2007). (Pubitemid 46328297)
-
(2007)
Circulation
, vol.115
, Issue.8
, pp. 1029-1038
-
-
Wu, H.1
Ghosh, S.2
Perrard, X.D.3
Feng, L.4
Garcia, G.E.5
Perrard, J.L.6
Sweeney, J.F.7
Peterson, L.E.8
Chan, L.9
Smith, C.W.10
Ballantyne, C.M.11
-
32
-
-
33745584658
-
Human subcutaneous adipose cells support complete differentiation but not self-renewal of hematopoietic progenitors
-
DOI 10.1002/jcp.20655
-
Corre, J. et al. Human subcutaneous adipose cells support complete differentiation but not self-renewal of hematopoietic progenitors. J. Cell Physiol. 208, 282-288 (2006). (Pubitemid 43993418)
-
(2006)
Journal of Cellular Physiology
, vol.208
, Issue.2
, pp. 282-288
-
-
Corre, J.1
Barreau, C.2
Cousin, B.3
Chavoin, J.-P.4
Caton, D.5
Fournial, G.6
Penicaud, L.7
Casteilla, L.8
Laharrague, P.9
-
33
-
-
54049086276
-
Interferon-gamma, a Th1 cytokine, regulates fat inflammation: A role for adaptive immunity in obesity
-
Rocha, V. Z. et al. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ. Res. 103, 467-476 (2008).
-
(2008)
Circ. Res.
, vol.103
, pp. 467-476
-
-
Rocha, V.Z.1
-
34
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
Nishimura, S. et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat. Med. 15, 914-920 (2009).
-
(2009)
Nat. Med.
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
-
35
-
-
77953110535
-
Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
-
Ilan, Y. et al. Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc. Natl Acad. Sci. USA 107, 9765-9770 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 9765-9770
-
-
Ilan, Y.1
-
36
-
-
77956396699
-
Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: Implications for systemic inflammation and insulin resistance
-
Yang, H. et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J. Immunol. 185, 1836-1845 (2010).
-
(2010)
J. Immunol.
, vol.185
, pp. 1836-1845
-
-
Yang, H.1
-
37
-
-
84867364866
-
Autoinflammatory syndromes and cellular responses to stress: Pathophysiology, diagnosis and new treatment perspectives
-
Savic, S., Dickie, L. J., Wittmann, M. & McDermott, M. F. Autoinflammatory syndromes and cellular responses to stress: pathophysiology, diagnosis and new treatment perspectives. Best Pract. Res. Clin. Rheumatol. 26, 505-533 (2012).
-
(2012)
Best Pract. Res. Clin. Rheumatol.
, vol.26
, pp. 505-533
-
-
Savic, S.1
Dickie, L.J.2
Wittmann, M.3
McDermott, M.F.4
-
38
-
-
36348981083
-
Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes
-
DOI 10.1210/en.2007-0132
-
Araujo, E. P. et al. Infliximab restores glucose homeostasis in an animal model of diet-induced obesity and diabetes. Endocrinology 148, 5991-5997 (2007). (Pubitemid 350146162)
-
(2007)
Endocrinology
, vol.148
, Issue.12
, pp. 5991-5997
-
-
Araujo, E.P.1
De Souza, C.T.2
Ueno, M.3
Cintra, D.E.4
Bertolo, M.B.5
Carvalheira, J.B.6
Saad, M.J.7
Velloso, L.A.8
-
39
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
DOI 10.1056/NEJMoa065213
-
Larsen, C. M. et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N. Engl. J. Med. 356, 1517-1526 (2007). (Pubitemid 46588416)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.15
, pp. 1517-1526
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Volund, A.4
Ehses, J.A.5
Seifert, B.6
Mandrup-Poulsen, T.7
Donath, M.Y.8
-
40
-
-
77950885686
-
The effects of salsalate on glycemic control in patients with type 2 diabetes: A randomized trial
-
Goldfine, A. B. et al. The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial. Ann. Intern. Med. 152, 346-357 (2010).
-
(2010)
Ann. Intern. Med.
, vol.152
, pp. 346-357
-
-
Goldfine, A.B.1
-
41
-
-
33746101818
-
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
-
DOI 10.1073/pnas.0603509103
-
Tuncman, G. et al. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc. Natl Acad. Sci. USA 103, 10741-10746 (2006). (Pubitemid 44078046)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.28
, pp. 10741-10746
-
-
Tuncman, G.1
Hirosumi, J.2
Solinas, G.3
Chang, L.4
Karin, M.5
Hotamisligil, G.S.6
-
42
-
-
0034770292
-
Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle
-
DOI 10.1038/nm1001-1138
-
Perreault, M. & Marette, A. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat. Med. 7, 1138-1143 (2001). (Pubitemid 33010023)
-
(2001)
Nature Medicine
, vol.7
, Issue.10
, pp. 1138-1143
-
-
Perreault, M.1
Marette, A.2
-
43
-
-
84855459760
-
Obesity is associated with hypothalamic injury in rodents and humans
-
Thaler, J. P. et al. Obesity is associated with hypothalamic injury in rodents and humans. J. Clin. Invest. 122, 153-162 (2012).
-
(2012)
J. Clin. Invest.
, vol.122
, pp. 153-162
-
-
Thaler, J.P.1
-
44
-
-
84856450553
-
Altered hypothalamic function in diet-induced obesity
-
Velloso, L. A. & Schwartz, M. W. Altered hypothalamic function in diet-induced obesity. Int. J. Obes (Lond.) 35, 1455-1465 (2011).
-
(2011)
Int. J. Obes (Lond.)
, vol.35
, pp. 1455-1465
-
-
Velloso, L.A.1
Schwartz, M.W.2
-
45
-
-
84861918690
-
Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver
-
Milanski, M. et al. Inhibition of hypothalamic inflammation reverses diet-induced insulin resistance in the liver. Diabetes 61, 1455-1462 (2012).
-
(2012)
Diabetes
, vol.61
, pp. 1455-1462
-
-
Milanski, M.1
-
46
-
-
79953889813
-
Inflammation of the hypothalamus leads to defective pancreatic islet function
-
Calegari, V. C. et al. Inflammation of the hypothalamus leads to defective pancreatic islet function. J. Biol. Chem. 286, 12870-12880 (2011).
-
(2011)
J. Biol. Chem
, vol.286
, pp. 12870-12880
-
-
Calegari, V.C.1
-
47
-
-
79960117277
-
Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB
-
Purkayastha, S., Zhang, G. & Cai, D. Uncoupling the mechanisms of obesity and hypertension by targeting hypothalamic IKK-β and NF-κB. Nat. Med. 17, 883-887 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 883-887
-
-
Purkayastha, S.1
Zhang, G.2
Cai, D.3
-
48
-
-
84875136149
-
Turning off the inflammatory, but not the metabolic, flames
-
Calay, E. S. & Hotamisligil, G. S. Turning off the inflammatory, but not the metabolic, flames. Nat. Med. 19, 265-267 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 265-267
-
-
Calay, E.S.1
Hotamisligil, G.S.2
-
49
-
-
84867911343
-
Biomarkers and immune-modulating therapies for type 2 diabetes
-
Brooks-Worrell, B., Narla, R. & Palmer, J. P. Biomarkers and immune-modulating therapies for type 2 diabetes. Trends Immunol. 33, 546-553 (2012).
-
(2012)
Trends Immunol.
, vol.33
, pp. 546-553
-
-
Brooks-Worrell, B.1
Narla, R.2
Palmer, J.P.3
-
50
-
-
84868122221
-
Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation
-
Barbarroja, N. et al. Progression from high insulin resistance to type 2 diabetes does not entail additional visceral adipose tissue inflammation. PLoS ONE 7, e48155 (2012).
-
(2012)
PLoS ONE
, vol.7
-
-
Barbarroja, N.1
-
51
-
-
34548431826
-
Increased number of islet-associated macrophages in type 2 diabetes
-
DOI 10.2337/db06-1650
-
Ehses, J. A. et al. Increased number of islet-associated macrophages in type 2 diabetes. Diabetes 56, 2356-2370 (2007). (Pubitemid 47358243)
-
(2007)
Diabetes
, vol.56
, Issue.9
, pp. 2356-2370
-
-
Ehses, J.A.1
Perren, A.2
Eppler, E.3
Ribaux, P.4
Pospisilik, J.A.5
Maor-Cahn, R.6
Gueripel, X.7
Ellingsgaard, H.8
Schneider, M.K.J.9
Biollaz, G.10
Fontana, A.11
Reinecke, M.12
Homo-Delarche, F.13
Donath, M.Y.14
-
52
-
-
67650685521
-
Islet-associated macrophages in type 2 diabetes
-
Richardson, S. J., Willcox, A., Bone, A. J., Foulis, A. K. & Morgan, N. G. Islet-associated macrophages in type 2 diabetes. Diabetologia 52, 1686-1688 (2009).
-
(2009)
Diabetologia
, vol.52
, pp. 1686-1688
-
-
Richardson, S.J.1
Willcox, A.2
Bone, A.J.3
Foulis, A.K.4
Morgan, N.G.5
-
53
-
-
77956958947
-
Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
-
Masters, S. L. et al. Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat. Immunol. 11, 897-904 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
-
54
-
-
77955658618
-
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by β cells in type 2 diabetes
-
Igoillo-Esteve, M. et al. Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by β cells in type 2 diabetes. Diabetologia 53, 1395-1405 (2010).
-
(2010)
Diabetologia
, vol.53
, pp. 1395-1405
-
-
Igoillo-Esteve, M.1
-
55
-
-
84871426151
-
Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes
-
Mahdi, T. et al. Secreted frizzled-related protein 4 reduces insulin secretion and is overexpressed in type 2 diabetes. Cell Metab. 16, 625-633 (2012).
-
(2012)
Cell Metab.
, vol.16
, pp. 625-633
-
-
Mahdi, T.1
-
56
-
-
0027500697
-
Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease
-
Tuomi, T. et al. Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 42, 359-362 (1993). (Pubitemid 23045043)
-
(1993)
Diabetes
, vol.42
, Issue.2
, pp. 359-362
-
-
Tuomi, T.1
Groop, L.C.2
Zimmet, P.Z.3
Rowley, M.J.4
Knowles, W.5
Mackay, I.R.6
-
57
-
-
82655171679
-
Immunology in the Clinic Review Series; Focus on metabolic diseases: Development of islet autoimmune disease in type 2 diabetes patients: Potential sequelae of chronic inflammation
-
Brooks-Worrell, B. & Palmer, J. P. Immunology in the Clinic Review Series; focus on metabolic diseases: development of islet autoimmune disease in type 2 diabetes patients: potential sequelae of chronic inflammation. Clin. Exp. Immunol. 167, 40-46 (2012).
-
(2012)
Clin. Exp. Immunol.
, vol.167
, pp. 40-46
-
-
Brooks-Worrell, B.1
Palmer, J.P.2
-
58
-
-
33644749322
-
Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: Many differences, few similarities
-
DOI 10.2337/diabetes.54.suppl-2.S97
-
Cnop, M. et al. Mechanisms of pancreatic β-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 (Suppl. 2), S97-S107 (2005). (Pubitemid 43343337)
-
(2005)
Diabetes
, vol.54
, Issue.SUPPL. 2
-
-
Cnop, M.1
Welsh, N.2
Jonas, J.-C.3
Jorns, A.4
Lenzen, S.5
Eizirik, D.L.6
-
59
-
-
84875179301
-
An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice
-
Reilly, S. M. et al. An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice. Nat. Med. 19, 313-321 (2013).
-
(2013)
Nat. Med.
, vol.19
, pp. 313-321
-
-
Reilly, S.M.1
-
60
-
-
36648999877
-
Modulation of T-cell signalling by non-esterified fatty acids
-
DOI 10.1016/j.plefa.2007.10.025, PII S0952327807001457, Proceedings of the 8th Fatty Acid and Cell Signaling (FACS Workshop held in Quebec City on June 26-28, 2007 Polyunsaturates, Inflammation and Brain Function
-
Brassard, P. et al. Modulation of T-cell signalling by non-esterified fatty acids. Prostaglandins Leukot. Essent. Fatty Acids 77, 337-343 (2007). (Pubitemid 350198860)
-
(2007)
Prostaglandins Leukotrienes and Essential Fatty Acids
, vol.77
, Issue.5-6
, pp. 337-343
-
-
Brassard, P.1
Larbi, A.2
Grenier, A.3
Frisch, F.4
Fortin, C.5
Carpentier, A.C.6
Fulop, T.7
-
61
-
-
0028588920
-
Recognition of a lipid antigen by CD1-restricted αβ+ T cells
-
Beckman, E. M. et al. Recognition of a lipid antigen by CD1-restricted αβ+ T cells. Nature 372, 691-694 (1994).
-
(1994)
Nature
, vol.372
, pp. 691-694
-
-
Beckman, E.M.1
-
62
-
-
66149179356
-
Antigen presentation by CD1 lipids, T cells, and NKT cells in microbial immunity
-
Cohen, N. R., Garg, S. & Brenner, M. B. Antigen presentation by CD1 lipids, T cells, and NKT cells in microbial immunity. Adv. Immunol. 102, 1-94 (2009).
-
(2009)
Adv. Immunol.
, vol.102
, pp. 1-94
-
-
Cohen, N.R.1
Garg, S.2
Brenner, M.B.3
-
63
-
-
34347399563
-
Metabolic endotoxemia initiates obesity and insulin resistance
-
DOI 10.2337/db06-1491
-
Cani, P. D. et al. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56, 1761-1772 (2007). (Pubitemid 47025442)
-
(2007)
Diabetes
, vol.56
, Issue.7
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
Bastelica, D.6
Neyrinck, A.M.7
Fava, F.8
Tuohy, K.M.9
Chabo, C.10
Waget, A.11
Delmee, E.12
Cousin, B.13
Sulpice, T.14
Chamontin, B.15
Ferrieres, J.16
Tanti, J.-F.17
Gibson, G.R.18
Casteilla, L.19
Delzenne, N.M.20
Alessi, M.C.21
Burcelin, R.22
more..
-
64
-
-
33845874101
-
An obesity-associated gut microbiome with increased capacity for energy harvest
-
DOI 10.1038/nature05414, PII NATURE05414
-
Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006). (Pubitemid 46018515)
-
(2006)
Nature
, vol.444
, Issue.7122
, pp. 1027-1031
-
-
Turnbaugh, P.J.1
Ley, R.E.2
Mahowald, M.A.3
Magrini, V.4
Mardis, E.R.5
Gordon, J.I.6
-
65
-
-
84855174006
-
Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice
-
Caricilli, A. M. et al. Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice. PLoS Biol. 9, e1001212 (2011).
-
(2011)
PLoS Biol.
, vol.9
-
-
Caricilli, A.M.1
-
66
-
-
79960131814
-
Identification of an innate T helper type 17 response to intestinal bacterial pathogens
-
Geddes, K. et al. Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nat. Med. 17, 837-844 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 837-844
-
-
Geddes, K.1
-
67
-
-
82955249159
-
Microbiota in autoimmunity and tolerance
-
Atarashi, K. & Honda, K. Microbiota in autoimmunity and tolerance. Curr. Opin. Immunol. 23, 761-768 (2011).
-
(2011)
Curr. Opin. Immunol.
, vol.23
, pp. 761-768
-
-
Atarashi, K.1
Honda, K.2
|