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Volumn 16, Issue 5, 2016, Pages 279-294

MicroRNAs as regulatory elements in immune system logic

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 223;

EID: 84964754401     PISSN: 14741733     EISSN: 14741741     Source Type: Journal    
DOI: 10.1038/nri.2016.40     Document Type: Review
Times cited : (555)

References (255)
  • 1
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo, M., Weissman, I. L., & Akashi, K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell 91, 661-672 (1997).
    • (1997) Cell , vol.91 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 2
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi, K., Traver, D., Miyamoto, T., & Weissman, I. L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404, 193-197 (2000).
    • (2000) Nature , vol.404 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 3
    • 39349096526 scopus 로고    scopus 로고
    • Hematopoiesis: An evolving paradigm for stem cell biology
    • Orkin, S. H., & Zon, L. I. Hematopoiesis: an evolving paradigm for stem cell biology. Cell 132, 631-644 (2008).
    • (2008) Cell , vol.132 , pp. 631-644
    • Orkin, S.H.1    Zon, L.I.2
  • 4
    • 28544436371 scopus 로고    scopus 로고
    • Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates
    • Passegue, E., Wagers, A. J., Giuriato, S., Anderson, W. C., & Weissman, I. L. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J. Exp. Med. 202, 1599-1611 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 1599-1611
    • Passegue, E.1    Wagers, A.J.2    Giuriato, S.3    Anderson, W.C.4    Weissman, I.L.5
  • 5
    • 78651486442 scopus 로고    scopus 로고
    • Densely interconnected transcriptional circuits control cell states in human hematopoiesis
    • Novershtern, N. et al. Densely interconnected transcriptional circuits control cell states in human hematopoiesis. Cell 144, 296-309 (2011).
    • (2011) Cell , vol.144 , pp. 296-309
    • Novershtern, N.1
  • 6
    • 84866129506 scopus 로고    scopus 로고
    • Less is more: Unveiling the functional core of hematopoietic stem cells through knockout mice
    • Rossi, L. et al. Less is more: unveiling the functional core of hematopoietic stem cells through knockout mice. Cell Stem Cell 11, 302-317 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 302-317
    • Rossi, L.1
  • 7
    • 84879421185 scopus 로고    scopus 로고
    • The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment
    • Laurenti, E. et al. The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nat. Immunol. 14, 756-763 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 756-763
    • Laurenti, E.1
  • 8
    • 84922541996 scopus 로고    scopus 로고
    • Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA Methylome analysis
    • Cabezas-Wallscheid, N. et al. Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA Methylome analysis. Cell Stem Cell 15, 507-522 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 507-522
    • Cabezas-Wallscheid, N.1
  • 9
    • 0042383366 scopus 로고    scopus 로고
    • Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential
    • Martin, C. H. et al. Efficient thymic immigration of B220+ lymphoid-restricted bone marrow cells with T precursor potential. Nat. Immunol. 4, 866-873 (2003).
    • (2003) Nat. Immunol. , vol.4 , pp. 866-873
    • Martin, C.H.1
  • 10
    • 33644641356 scopus 로고    scopus 로고
    • Determinants of lymphoid-myeloid lineage diversification
    • Laiosa, C. V., Stadtfeld, M., & Graf, T. Determinants of lymphoid-myeloid lineage diversification. Annu. Rev. Immunol. 24, 705-738 (2006).
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 705-738
    • Laiosa, C.V.1    Stadtfeld, M.2    Graf, T.3
  • 11
    • 0034699390 scopus 로고    scopus 로고
    • Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines
    • Kondo, M. et al. Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines. Nature 407, 383-386 (2000).
    • (2000) Nature , vol.407 , pp. 383-386
    • Kondo, M.1
  • 12
    • 20244387299 scopus 로고    scopus 로고
    • Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment
    • Adolfsson, J. et al. Identification of Flt3+ lympho-myeloid stem cells lacking erythro-megakaryocytic potential a revised road map for adult blood lineage commitment. Cell 121, 295-306 (2005).
    • (2005) Cell , vol.121 , pp. 295-306
    • Adolfsson, J.1
  • 13
    • 84883428326 scopus 로고    scopus 로고
    • Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells
    • Yamamoto, R. et al. Clonal analysis unveils self-renewing lineage-restricted progenitors generated directly from hematopoietic stem cells. Cell 154, 1112-1126 (2013).
    • (2013) Cell , vol.154 , pp. 1112-1126
    • Yamamoto, R.1
  • 14
    • 77449093887 scopus 로고    scopus 로고
    • Hematopoietic stem cell heterogeneity: Subtypes, not unpredictable behavior
    • Schroeder, T. Hematopoietic stem cell heterogeneity: subtypes, not unpredictable behavior. Cell Stem Cell 6, 203-207 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 203-207
    • Schroeder, T.1
  • 15
    • 34848896359 scopus 로고    scopus 로고
    • Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy
    • Pronk, C. J. et al. Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy. Cell Stem Cell 1, 428-442 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 428-442
    • Pronk, C.J.1
  • 16
    • 34948831114 scopus 로고    scopus 로고
    • Defining the pathways of early adult hematopoiesis
    • Murre, C. Defining the pathways of early adult hematopoiesis. Cell Stem Cell 1, 357-358 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 357-358
    • Murre, C.1
  • 17
    • 34848883146 scopus 로고    scopus 로고
    • Reciprocal activation of GATA 1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages
    • Arinobu, Y. et al. Reciprocal activation of GATA 1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages. Cell Stem Cell 1, 416-427 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 416-427
    • Arinobu, Y.1
  • 18
    • 84876297531 scopus 로고    scopus 로고
    • Diverse and heritable lineage imprinting of early haematopoietic progenitors
    • Naik, S. H. et al. Diverse and heritable lineage imprinting of early haematopoietic progenitors. Nature 496, 229-232 (2013).
    • (2013) Nature , vol.496 , pp. 229-232
    • Naik, S.H.1
  • 19
    • 71849114718 scopus 로고    scopus 로고
    • Balancing dormant and self-renewing hematopoietic stem cells
    • Wilson, A., Laurenti, E., & Trumpp, A. Balancing dormant and self-renewing hematopoietic stem cells. Curr. Opin. Genet. Dev. 19, 461-468 (2009).
    • (2009) Curr. Opin. Genet. Dev. , vol.19 , pp. 461-468
    • Wilson, A.1    Laurenti, E.2    Trumpp, A.3
  • 20
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    • Wilson, A. et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135, 1118-1129 (2008).
    • (2008) Cell , vol.135 , pp. 1118-1129
    • Wilson, A.1
  • 21
    • 0028534860 scopus 로고
    • The long-Term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype
    • Morrison, S. J., & Weissman, I. L. The long-Term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype. Immunity 1, 661-673 (1994).
    • (1994) Immunity , vol.1 , pp. 661-673
    • Morrison, S.J.1    Weissman, I.L.2
  • 22
    • 84937023176 scopus 로고    scopus 로고
    • Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions
    • Pietras, E. M. et al. Functionally distinct subsets of lineage-biased multipotent progenitors control blood production in normal and regenerative conditions. Cell Stem Cell 17, 35-46 (2015).
    • (2015) Cell Stem Cell , vol.17 , pp. 35-46
    • Pietras, E.M.1
  • 23
    • 34247092922 scopus 로고    scopus 로고
    • Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
    • Mansson, R. et al. Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors. Immunity 26, 407-419 (2007).
    • (2007) Immunity , vol.26 , pp. 407-419
    • Mansson, R.1
  • 24
    • 36749098400 scopus 로고    scopus 로고
    • Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood
    • Majeti, R., Park, C. Y., & Weissman, I. L. Identification of a hierarchy of multipotent hematopoietic progenitors in human cord blood. Cell Stem Cell 1, 635-645 (2007).
    • (2007) Cell Stem Cell , vol.1 , pp. 635-645
    • Majeti, R.1    Park, C.Y.2    Weissman, I.L.3
  • 25
    • 21244463426 scopus 로고    scopus 로고
    • SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells
    • Kiel, M. J. et al. SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell 121, 1109-1121 (2005).
    • (2005) Cell , vol.121 , pp. 1109-1121
    • Kiel, M.J.1
  • 26
    • 80053133049 scopus 로고    scopus 로고
    • Inflammatory modulation of HSCs: Viewing the HSC as a foundation for the immune response
    • King, K. Y., & Goodell, M. A. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nature reviews. Immunology 11, 685-692 (2011).
    • (2011) Nature Reviews. Immunology , vol.11 , pp. 685-692
    • King, K.Y.1    Goodell, M.A.2
  • 27
    • 79751536458 scopus 로고    scopus 로고
    • Inflammatory signals regulate hematopoietic stem cells
    • Baldridge, M. T., King, K. Y., & Goodell, M. A. Inflammatory signals regulate hematopoietic stem cells. Trends Immunol. 32, 57-65 (2011).
    • (2011) Trends Immunol. , vol.32 , pp. 57-65
    • Baldridge, M.T.1    King, K.Y.2    Goodell, M.A.3
  • 28
    • 77951926024 scopus 로고    scopus 로고
    • Cutting edge: Bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling
    • Scumpia, P. O. et al. Cutting edge: bacterial infection induces hematopoietic stem and progenitor cell expansion in the absence of TLR signaling. J. Immunol. 184, 2247-2251 (2010).
    • (2010) J. Immunol. , vol.184 , pp. 2247-2251
    • Scumpia, P.O.1
  • 29
    • 84902436102 scopus 로고    scopus 로고
    • Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling
    • Burberry, A. et al. Infection mobilizes hematopoietic stem cells through cooperative NOD-like receptor and Toll-like receptor signaling. Cell Host Microbe 15, 779-791 (2014).
    • (2014) Cell Host Microbe , vol.15 , pp. 779-791
    • Burberry, A.1
  • 30
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova, Z. et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 128, 325-339 (2007).
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1
  • 31
    • 79955530513 scopus 로고    scopus 로고
    • Chronic exposure to a TLR ligand injures hematopoietic stem cells
    • Esplin, B. L. et al. Chronic exposure to a TLR ligand injures hematopoietic stem cells. J. Immunol. 186, 5367-5375 (2011).
    • (2011) J. Immunol. , vol.186 , pp. 5367-5375
    • Esplin, B.L.1
  • 32
    • 77953462161 scopus 로고    scopus 로고
    • Quiescent haematopoietic stem cells are activated by IFN-? in response to chronic infection
    • Baldridge, M. T., King, K. Y., Boles, N. C., Weksberg, D. C., & Goodell, M. A. Quiescent haematopoietic stem cells are activated by IFN-? in response to chronic infection. Nature 465, 793-797 (2010).
    • (2010) Nature , vol.465 , pp. 793-797
    • Baldridge, M.T.1    King, K.Y.2    Boles, N.C.3    Weksberg, D.C.4    Goodell, M.A.5
  • 33
    • 84906254220 scopus 로고    scopus 로고
    • Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
    • Flach, J. et al. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature 512, 198-202 (2014).
    • (2014) Nature , vol.512 , pp. 198-202
    • Flach, J.1
  • 34
    • 33847304124 scopus 로고    scopus 로고
    • CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control
    • Georgantas, R. W., 3rd et al. CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc. Natl Acad. Sci. USA 104, 2750-2755 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 2750-2755
    • Georgantas, R.W.1
  • 35
    • 77956270732 scopus 로고    scopus 로고
    • MicroRNA miR 125a controls hematopoietic stem cell number
    • Guo, S. et al. MicroRNA miR 125a controls hematopoietic stem cell number. Proc. Natl Acad. Sci. USA 107, 14229-14234 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 14229-14234
    • Guo, S.1
  • 36
    • 84937597623 scopus 로고    scopus 로고
    • The microRNA 132 and microRNA 212 cluster regulates hematopoietic stem cell maintenance and survival with age by buffering FOXO3 expression
    • Mehta, A. et al. The microRNA 132 and microRNA 212 cluster regulates hematopoietic stem cell maintenance and survival with age by buffering FOXO3 expression. Immunity 42, 1021-1032 (2015).
    • (2015) Immunity , vol.42 , pp. 1021-1032
    • Mehta, A.1
  • 37
    • 77956288810 scopus 로고    scopus 로고
    • MicroRNAs enriched in hematopoietic stem cells differentially regulate long-Term hematopoietic output
    • Oconnell, R. M. et al. MicroRNAs enriched in hematopoietic stem cells differentially regulate long-Term hematopoietic output. Proc. Natl Acad. Sci. USA 107, 14235-14240 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 14235-14240
    • Oconnell, R.M.1
  • 38
    • 3242669145 scopus 로고    scopus 로고
    • Tie2/angiopoietin 1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    • Arai, F. et al. Tie2/angiopoietin 1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell 118, 149-161 (2004).
    • (2004) Cell , vol.118 , pp. 149-161
    • Arai, F.1
  • 39
    • 84874192375 scopus 로고    scopus 로고
    • FOXO3A directs a protective autophagy program in haematopoietic stem cells
    • Warr, M. R. et al. FOXO3A directs a protective autophagy program in haematopoietic stem cells. Nature 494, 323-327 (2013).
    • (2013) Nature , vol.494 , pp. 323-327
    • Warr, M.R.1
  • 40
    • 33744978765 scopus 로고    scopus 로고
    • Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment
    • Nagai, Y. et al. Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment. Immunity 24, 801-812 (2006).
    • (2006) Immunity , vol.24 , pp. 801-812
    • Nagai, Y.1
  • 41
    • 84898012347 scopus 로고    scopus 로고
    • Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis
    • Zhao, J. L. et al. Conversion of danger signals into cytokine signals by hematopoietic stem and progenitor cells for regulation of stress-induced hematopoiesis. Cell Stem Cell 14, 445-459 (2014).
    • (2014) Cell Stem Cell , vol.14 , pp. 445-459
    • Zhao, J.L.1
  • 42
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis, function and decay
    • Krol, J., Loedige, I., & Filipowicz, W. The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597-610 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 43
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116, 281-297 (2004).
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 44
    • 60949102130 scopus 로고    scopus 로고
    • Dicer is regulated by cellular stresses and interferons
    • Wiesen, J. L., & Tomasi, T. B. Dicer is regulated by cellular stresses and interferons. Mol. Immunol. 46, 1222-1228 (2009).
    • (2009) Mol. Immunol. , vol.46 , pp. 1222-1228
    • Wiesen, J.L.1    Tomasi, T.B.2
  • 45
    • 67749143728 scopus 로고    scopus 로고
    • Modulation of microRNA processing by p53
    • Suzuki, H. I. et al. Modulation of microRNA processing by p53. Nature 460, 529-533 (2009).
    • (2009) Nature , vol.460 , pp. 529-533
    • Suzuki, H.I.1
  • 46
    • 33845295461 scopus 로고    scopus 로고
    • Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules
    • Leung, A. K., Calabrese, J. M., & Sharp, P. A. Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proc. Natl Acad. Sci. USA 103, 18125-18130 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 18125-18130
    • Leung, A.K.1    Calabrese, J.M.2    Sharp, P.A.3
  • 47
    • 84875778506 scopus 로고    scopus 로고
    • Regulation of miRNA biogenesis and turnover in the immune system
    • Bronevetsky, Y., & Ansel, K. M. Regulation of miRNA biogenesis and turnover in the immune system. Immunol. Rev. 253, 304-316 (2013).
    • (2013) Immunol. Rev. , vol.253 , pp. 304-316
    • Bronevetsky, Y.1    Ansel, K.M.2
  • 48
    • 84858379476 scopus 로고    scopus 로고
    • MicroRNAs in stress signaling and human disease
    • Mendell, J. T., & Olson, E. N. MicroRNAs in stress signaling and human disease. Cell 148, 1172-1187 (2012).
    • (2012) Cell , vol.148 , pp. 1172-1187
    • Mendell, J.T.1    Olson, E.N.2
  • 49
    • 78649378267 scopus 로고    scopus 로고
    • MicroRNA functions in stress responses
    • Leung, A. K., & Sharp, P. A. MicroRNA functions in stress responses. Mol. Cell 40, 205-215 (2010).
    • (2010) Mol. Cell , vol.40 , pp. 205-215
    • Leung, A.K.1    Sharp, P.A.2
  • 50
    • 67349273027 scopus 로고    scopus 로고
    • MicroRNA in autoimmunity and autoimmune diseases
    • Pauley, K. M., Cha, S., & Chan, E. K. MicroRNA in autoimmunity and autoimmune diseases. J. Autoimmun. 32, 189-194 (2009).
    • (2009) J. Autoimmun. , vol.32 , pp. 189-194
    • Pauley, K.M.1    Cha, S.2    Chan, E.K.3
  • 51
    • 77956339881 scopus 로고    scopus 로고
    • OncomiR addiction in an in vivo model of microRNA 21 induced pre B cell lymphoma
    • Medina, P. P., Nolde, M., & Slack, F. J. OncomiR addiction in an in vivo model of microRNA 21 induced pre B cell lymphoma. Nature 467, 86-90 (2010).
    • (2010) Nature , vol.467 , pp. 86-90
    • Medina, P.P.1    Nolde, M.2    Slack, F.J.3
  • 52
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs-microRNAs with a role in cancer
    • Esquela-Kerscher, A., & Slack, F. J. Oncomirs-microRNAs with a role in cancer. Nat. Rev. Cancer 6, 259-269 (2006).
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 53
    • 77953763449 scopus 로고    scopus 로고
    • A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate
    • Lin, Y. C. et al. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat. Immunol. 11, 635-643 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 635-643
    • Lin, Y.C.1
  • 54
    • 84871390259 scopus 로고    scopus 로고
    • Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B cell fate
    • Mansson, R. et al. Positive intergenic feedback circuitry, involving EBF1 and FOXO1, orchestrates B cell fate. Proc. Natl Acad. Sci. USA 109, 21028-21033 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 21028-21033
    • Mansson, R.1
  • 55
    • 84866361701 scopus 로고    scopus 로고
    • Circuitry and dynamics of human transcription factor regulatory networks
    • Neph, S. et al. Circuitry and dynamics of human transcription factor regulatory networks. Cell 150, 1274-1286 (2012).
    • (2012) Cell , vol.150 , pp. 1274-1286
    • Neph, S.1
  • 56
    • 84860324470 scopus 로고    scopus 로고
    • Roles for microRNAs in conferring robustness to biological processes
    • Ebert, M. S., & Sharp, P. A. Roles for microRNAs in conferring robustness to biological processes. Cell 149, 515-524 (2012).
    • (2012) Cell , vol.149 , pp. 515-524
    • Ebert, M.S.1    Sharp, P.A.2
  • 57
    • 77957664647 scopus 로고    scopus 로고
    • MicroRNAs as regulators of differentiation and cell fate decisions
    • Ivey, K. N., & Srivastava, D. MicroRNAs as regulators of differentiation and cell fate decisions. Cell Stem Cell 7, 36-41 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 36-41
    • Ivey, K.N.1    Srivastava, D.2
  • 58
    • 84937706626 scopus 로고    scopus 로고
    • A Single miRNA-mRNA interaction affects the immune response in a context-And cell-Type-specific manner
    • Lu, L. F. et al. A Single miRNA-mRNA interaction affects the immune response in a context-And cell-Type-specific manner. Immunity 43, 52-64 (2015).
    • (2015) Immunity , vol.43 , pp. 52-64
    • Lu, L.F.1
  • 59
    • 84900873500 scopus 로고    scopus 로고
    • MicroRNA-based single-gene circuits buffer protein synthesis rates against perturbations
    • Strovas, T. J., Rosenberg, A. B., Kuypers, B. E., Muscat, R. A., & Seelig, G. MicroRNA-based single-gene circuits buffer protein synthesis rates against perturbations. ACS Synthet. Biol. 3, 324-331 (2014).
    • (2014) ACS Synthet. Biol. , vol.3 , pp. 324-331
    • Strovas, T.J.1    Rosenberg, A.B.2    Kuypers, B.E.3    Muscat, R.A.4    Seelig, G.5
  • 61
    • 84924420342 scopus 로고    scopus 로고
    • MicroRNAs regulate cell to cell variability of endogenous target gene expression in developing mouse thymocytes
    • Blevins, R. et al. microRNAs regulate cell to cell variability of endogenous target gene expression in developing mouse thymocytes. PLoS Genet. 11, e1005020 (2015).
    • (2015) PLoS Genet. , vol.11 , pp. e1005020
    • Blevins, R.1
  • 62
    • 84887120736 scopus 로고    scopus 로고
    • Dampening of expression oscillations by synchronous regulation of a microRNA and its target
    • Kim, D., Grun, D., & van Oudenaarden, A. Dampening of expression oscillations by synchronous regulation of a microRNA and its target. Nat. Genet. 45, 1337-1344 (2013).
    • (2013) Nat. Genet. , vol.45 , pp. 1337-1344
    • Kim, D.1    Grun, D.2    Van Oudenaarden, A.3
  • 63
    • 80052266532 scopus 로고    scopus 로고
    • MicroRNAs can generate thresholds in target gene expression
    • Mukherji, S. et al. MicroRNAs can generate thresholds in target gene expression. Nat. Genet. 43, 854-859 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 854-859
    • Mukherji, S.1
  • 64
    • 84907678240 scopus 로고    scopus 로고
    • Understanding cooperativity of microRNAs via microRNA association networks
    • Na, Y. J., & Kim, J. H. Understanding cooperativity of microRNAs via microRNA association networks. BMC genomics 14 (Suppl. 5), S17 (2013).
    • (2013) BMC Genomics 14 (Suppl. 5) , vol.17
    • Na, Y.J.1    Kim, J.H.2
  • 65
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon, U. Network motifs: theory and experimental approaches. Nat. Rev. Genet. 8, 450-461 (2007).
    • (2007) Nat. Rev. Genet. , vol.8 , pp. 450-461
    • Alon, U.1
  • 66
    • 77954517267 scopus 로고    scopus 로고
    • MicroRNAs and gene regulatory networks: Managing the impact of noise in biological systems
    • Herranz, H., & Cohen, S. M. MicroRNAs and gene regulatory networks: managing the impact of noise in biological systems. Genes Dev. 24, 1339-1344 (2010).
    • (2010) Genes Dev. , vol.24 , pp. 1339-1344
    • Herranz, H.1    Cohen, S.M.2
  • 67
    • 84892610064 scopus 로고    scopus 로고
    • The bone marrow niche for haematopoietic stem cells
    • Morrison, S. J., & Scadden, D. T. The bone marrow niche for haematopoietic stem cells. Nature 505, 327-334 (2014).
    • (2014) Nature , vol.505 , pp. 327-334
    • Morrison, S.J.1    Scadden, D.T.2
  • 68
    • 84943154962 scopus 로고    scopus 로고
    • Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal
    • Acar, M. et al. Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal. Nature 526, 126-130 (2015).
    • (2015) Nature , vol.526 , pp. 126-130
    • Acar, M.1
  • 69
    • 43949134440 scopus 로고    scopus 로고
    • MicroRNAs play a role in the development of human hematopoietic stem cells
    • Liao, R. et al. MicroRNAs play a role in the development of human hematopoietic stem cells. J. Cell. Biochem. 104, 805-817 (2008).
    • (2008) J. Cell. Biochem. , vol.104 , pp. 805-817
    • Liao, R.1
  • 70
    • 79955425509 scopus 로고    scopus 로고
    • Combined characterization of microRNA and mRNA profiles delineates early differentiation pathways of CD133+ and CD34+ hematopoietic stem and progenitor cells
    • Bissels, U. et al. Combined characterization of microRNA and mRNA profiles delineates early differentiation pathways of CD133+ and CD34+ hematopoietic stem and progenitor cells. Stem Cells 29, 847-857 (2011).
    • (2011) Stem Cells , vol.29 , pp. 847-857
    • Bissels, U.1
  • 71
    • 67650590937 scopus 로고    scopus 로고
    • Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation
    • Gruber, J. J. et al. Ars2 links the nuclear cap-binding complex to RNA interference and cell proliferation. Cell 138, 328-339 (2009).
    • (2009) Cell , vol.138 , pp. 328-339
    • Gruber, J.J.1
  • 72
    • 84855824354 scopus 로고    scopus 로고
    • Genetic screen identifies microRNA cluster 99b/let 7e/125a as a regulator of primitive hematopoietic cells
    • Gerrits, A. et al. Genetic screen identifies microRNA cluster 99b/let 7e/125a as a regulator of primitive hematopoietic cells. Blood 119, 377-387 (2012).
    • (2012) Blood , vol.119 , pp. 377-387
    • Gerrits, A.1
  • 73
    • 84858257170 scopus 로고    scopus 로고
    • Oncomir miR 125b regulates hematopoiesis by targeting the gene Lin28A
    • Chaudhuri, A. A. et al. Oncomir miR 125b regulates hematopoiesis by targeting the gene Lin28A. Proc. Natl Acad. Sci. USA 109, 4233-4238 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. 4233-4238
    • Chaudhuri, A.A.1
  • 74
    • 84961218873 scopus 로고    scopus 로고
    • The microRNA 212/132 cluster regulates B cell development by targeting Sox4
    • Mehta, A. et al. The microRNA 212/132 cluster regulates B cell development by targeting Sox4. J. Exp. Med. 212, 1679-1692 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 1679-1692
    • Mehta, A.1
  • 75
    • 84880703930 scopus 로고    scopus 로고
    • Regulation of miR 17 92a cluster processing by the microRNA binding protein SND1
    • Heinrich, E. M. et al. Regulation of miR 17 92a cluster processing by the microRNA binding protein SND1. FEBS Lett. 587, 2405-2411 (2013).
    • (2013) FEBS Lett. , vol.587 , pp. 2405-2411
    • Heinrich, E.M.1
  • 76
    • 78650722292 scopus 로고    scopus 로고
    • MicroRNA 125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets
    • Ooi, A. G. et al. MicroRNA 125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc. Natl Acad. Sci. USA 107, 21505-21510 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 21505-21510
    • Ooi, A.G.1
  • 77
    • 84907330294 scopus 로고    scopus 로고
    • Dual mechanisms by which miR 125b represses IRF4 to induce myeloid and B cell leukemias
    • So, A. Y. et al. Dual mechanisms by which miR 125b represses IRF4 to induce myeloid and B cell leukemias. Blood 124, 1502-1512 (2014).
    • (2014) Blood , vol.124 , pp. 1502-1512
    • So, A.Y.1
  • 78
    • 84898887673 scopus 로고    scopus 로고
    • MiR 99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling
    • Emmrich, S. et al. miR 99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFβ and Wnt signaling. Genes Dev. 28, 858-874 (2014).
    • (2014) Genes Dev. , vol.28 , pp. 858-874
    • Emmrich, S.1
  • 79
    • 77449145533 scopus 로고    scopus 로고
    • Distinct hematopoietic stem cell subtypes are differentially regulated by TGF β1
    • Challen, G. A., Boles, N. C., Chambers, S. M., & Goodell, M. A. Distinct hematopoietic stem cell subtypes are differentially regulated by TGF β1. Cell Stem Cell 6, 265-278 (2010).
    • (2010) Cell Stem Cell , vol.6 , pp. 265-278
    • Challen, G.A.1    Boles, N.C.2    Chambers, S.M.3    Goodell, M.A.4
  • 80
    • 80053907201 scopus 로고    scopus 로고
    • Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion
    • Luis, T. C. et al. Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion. Cell Stem Cell 9, 345-356 (2011).
    • (2011) Cell Stem Cell , vol.9 , pp. 345-356
    • Luis, T.C.1
  • 81
    • 77949518018 scopus 로고    scopus 로고
    • MicroRNA 29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia
    • Han, Y. C. et al. microRNA 29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J. Exp. Med. 207, 475-489 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 475-489
    • Han, Y.C.1
  • 82
    • 84926674795 scopus 로고    scopus 로고
    • MiR 29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a
    • Hu, W. et al. miR 29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a. Blood 125, 2206-2216 (2015).
    • (2015) Blood , vol.125 , pp. 2206-2216
    • Hu, W.1
  • 83
    • 84880571480 scopus 로고    scopus 로고
    • The oncogenic microRNA miR 22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation
    • Song, S. J. et al. The oncogenic microRNA miR 22 targets the TET2 tumor suppressor to promote hematopoietic stem cell self-renewal and transformation. Cell Stem Cell 13, 87-101 (2013).
    • (2013) Cell Stem Cell , vol.13 , pp. 87-101
    • Song, S.J.1
  • 84
    • 77953087435 scopus 로고    scopus 로고
    • Methylation and silencing of miRNA 124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome
    • Dickstein, J. et al. Methylation and silencing of miRNA 124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome. Proc. Natl Acad. Sci. USA 107, 9783-9788 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 9783-9788
    • Dickstein, J.1
  • 85
    • 78449270317 scopus 로고    scopus 로고
    • Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy
    • 58ra84
    • Gentner, B. et al. Identification of hematopoietic stem cell-specific miRNAs enables gene therapy of globoid cell leukodystrophy. Sci. Transl Med. 2, 58ra84 (2010).
    • (2010) Sci. Transl Med. , vol.2
    • Gentner, B.1
  • 86
    • 84870894496 scopus 로고    scopus 로고
    • Attenuation of miR 126 activity expands HSC in vivo without exhaustion
    • Lechman, E. R. et al. Attenuation of miR 126 activity expands HSC in vivo without exhaustion. Cell Stem Cell 11, 799-811 (2012).
    • (2012) Cell Stem Cell , vol.11 , pp. 799-811
    • Lechman, E.R.1
  • 87
    • 84958635003 scopus 로고    scopus 로고
    • MiR 126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells
    • Lechman, E. R. et al. miR 126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells. Cancer Cell 29, 214-228 (2016).
    • (2016) Cancer Cell , vol.29 , pp. 214-228
    • Lechman, E.R.1
  • 89
    • 84881460310 scopus 로고    scopus 로고
    • The Lin28b let 7 Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells
    • Copley, M. R. et al. The Lin28b let 7 Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells. Nature Cell Biol. 15, 916-925 (2013).
    • (2013) Nature Cell Biol. , vol.15 , pp. 916-925
    • Copley, M.R.1
  • 90
    • 84862776981 scopus 로고    scopus 로고
    • Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis
    • Yuan, J., Nguyen, C. K., Liu, X., Kanellopoulou, C., & Muljo, S. A. Lin28b reprograms adult bone marrow hematopoietic progenitors to mediate fetal-like lymphopoiesis. Science 335, 1195-1200 (2012).
    • (2012) Science , vol.335 , pp. 1195-1200
    • Yuan, J.1    Nguyen, C.K.2    Liu, X.3    Kanellopoulou, C.4    Muljo, S.A.5
  • 92
    • 79952186298 scopus 로고    scopus 로고
    • MicroRNAs: The fine-Tuners of toll-like receptor signalling
    • Oneill, L. A., Sheedy, F. J., & McCoy, C. E. MicroRNAs: the fine-Tuners of Toll-like receptor signalling. Nat. Rev. Immunol. 11, 163-175 (2011).
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 163-175
    • Oneill, L.A.1    Sheedy, F.J.2    McCoy, C.E.3
  • 93
    • 33747608638 scopus 로고    scopus 로고
    • NF κb-dependent induction of microRNA miR 146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov, K. D., Boldin, M. P., Chang, K. J., & Baltimore, D. NF κB-dependent induction of microRNA miR 146, an inhibitor targeted to signaling proteins of innate immune responses. Proc. Natl Acad. Sci. USA 103, 12481-12486 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 94
    • 79959362128 scopus 로고    scopus 로고
    • NF κb dysregulation in microRNA 146a deficient mice drives the development of myeloid malignancies
    • Zhao, J. L. et al. NF κB dysregulation in microRNA 146a deficient mice drives the development of myeloid malignancies. Proc. Natl Acad. Sci. USA 108, 9184-9189 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 9184-9189
    • Zhao, J.L.1
  • 95
    • 84879060116 scopus 로고    scopus 로고
    • MicroRNA 146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice
    • Zhao, J. L., Rao, D. S., Oconnell, R. M., Garcia-Flores, Y., & Baltimore, D. MicroRNA 146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. eLife 2, e00537 (2013).
    • (2013) ELife , vol.2 , pp. e00537
    • Zhao, J.L.1    Rao, D.S.2    Oconnell, R.M.3    Garcia-Flores, Y.4    Baltimore, D.5
  • 96
    • 77955736174 scopus 로고    scopus 로고
    • MiR 33 mediated downregulation of p53 controls hematopoietic stem cell self-renewal
    • Herrera-Merchan, A. et al. miR 33 mediated downregulation of p53 controls hematopoietic stem cell self-renewal. Cell Cycle) 9, 3277-3285 (2010).
    • (2010) Cell Cycle) , vol.9 , pp. 3277-3285
    • Herrera-Merchan, A.1
  • 97
    • 84948700160 scopus 로고    scopus 로고
    • STAT5 regulated microRNA 193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling
    • Haetscher, N. et al. STAT5 regulated microRNA 193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling. Nature Commun. 6, 8928 (2015).
    • (2015) Nature Commun. , vol.6 , pp. 8928
    • Haetscher, N.1
  • 98
    • 29144440077 scopus 로고    scopus 로고
    • MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation
    • Felli, N. et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc. Natl Acad. Sci. USA 102, 18081-18086 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 18081-18086
    • Felli, N.1
  • 99
  • 100
    • 80052936529 scopus 로고    scopus 로고
    • MicroRNA function in myeloid biology
    • Oconnell, R. M., Zhao, J. L., & Rao, D. S. MicroRNA function in myeloid biology. Blood 118, 2960-2969 (2011).
    • (2011) Blood , vol.118 , pp. 2960-2969
    • Oconnell, R.M.1    Zhao, J.L.2    Rao, D.S.3
  • 101
    • 84931275600 scopus 로고    scopus 로고
    • Circadian control of innate immunity in macrophages by mir 155 targeting bmal1
    • Curtis, A. M.et al. Circadian control of innate immunity in macrophages by miR 155 targeting Bmal1. Proc. Natl Acad. Sci. USA 112, 7231-7236 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 7231-7236
    • Curtis, A.M.1
  • 104
    • 84903993535 scopus 로고    scopus 로고
    • Notch-dependent repression of miR 155 in the bone marrow niche regulates hematopoiesis in an NF κb-dependent manner
    • Wang, L. et al. Notch-dependent repression of miR 155 in the bone marrow niche regulates hematopoiesis in an NF κB-dependent manner. Cell Stem Cell 15, 51-65 (2014).
    • (2014) Cell Stem Cell , vol.15 , pp. 51-65
    • Wang, L.1
  • 105
    • 80054739828 scopus 로고    scopus 로고
    • MicroRNAs regulate dendritic cell differentiation and function
    • Turner, M. L., Schnorfeil, F. M., & Brocker, T. MicroRNAs regulate dendritic cell differentiation and function. J. Immunol. 187, 3911-3917 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 3911-3917
    • Turner, M.L.1    Schnorfeil, F.M.2    Brocker, T.3
  • 106
    • 77957664009 scopus 로고    scopus 로고
    • MiRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate
    • Mann, M. Barad, O., Agami, R., Geiger, B., & Hornstein, E. miRNA-based mechanism for the commitment of multipotent progenitors to a single cellular fate. Proc. Natl Acad. Sci. USA 107, 15804-15809 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 15804-15809
    • Mann Barad M, O.1    Agami, R.2    Geiger, B.3    Hornstein, E.4
  • 107
    • 68649091506 scopus 로고    scopus 로고
    • The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs
    • Androulidaki, A. et al. The kinase Akt1 controls macrophage response to lipopolysaccharide by regulating microRNAs. Immunity 31, 220-231 (2009).
    • (2009) Immunity , vol.31 , pp. 220-231
    • Androulidaki, A.1
  • 108
    • 77954223697 scopus 로고    scopus 로고
    • IL 10 inhibits miR 155 induction by toll-like receptors
    • McCoy, C. E. et al. IL 10 inhibits miR 155 induction by toll-like receptors. J. Biol. Chem. 285, 20492-20498 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 20492-20498
    • McCoy, C.E.1
  • 109
    • 41149130219 scopus 로고    scopus 로고
    • Sustained expression of microRNA 155 in hematopoietic stem cells causes a myeloproliferative disorder
    • Oconnell, R. M. et al. Sustained expression of microRNA 155 in hematopoietic stem cells causes a myeloproliferative disorder. J. Exp. Med. 205, 585-594 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 585-594
    • Oconnell, R.M.1
  • 110
    • 28344438648 scopus 로고    scopus 로고
    • A minicircuitry comprised of microRNA 223 and transcription factors NFI A and C/EBPα regulates human granulopoiesis
    • Fazi, F. et al. A minicircuitry comprised of microRNA 223 and transcription factors NFI A and C/EBPα regulates human granulopoiesis. Cell 123, 819-831 (2005).
    • (2005) Cell , vol.123 , pp. 819-831
    • Fazi, F.1
  • 111
    • 77950354353 scopus 로고    scopus 로고
    • Cell-cycle regulator E2F1 and microRNA 223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia
    • Pulikkan, J. A. et al. Cell-cycle regulator E2F1 and microRNA 223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood 115, 1768-1778 (2010).
    • (2010) Blood , vol.115 , pp. 1768-1778
    • Pulikkan, J.A.1
  • 112
    • 39849096995 scopus 로고    scopus 로고
    • Regulation of progenitor cell proliferation and granulocyte function by microRNA 223
    • Johnnidis, J. B. et al. Regulation of progenitor cell proliferation and granulocyte function by microRNA 223. Nature 451, 1125-1129 (2008).
    • (2008) Nature , vol.451 , pp. 1125-1129
    • Johnnidis, J.B.1
  • 113
    • 34247483919 scopus 로고    scopus 로고
    • An evolutionarily conserved mechanism for microRNA 223 expression revealed by microRNA gene profiling
    • Fukao, T. et al. An evolutionarily conserved mechanism for microRNA 223 expression revealed by microRNA gene profiling. Cell 129, 617-631 (2007).
    • (2007) Cell , vol.129 , pp. 617-631
    • Fukao, T.1
  • 114
    • 84892442548 scopus 로고    scopus 로고
    • Transcriptional fine-Tuning of microRNA 223 levels directs lineage choice of human hematopoietic progenitors
    • Vian, L. et al. Transcriptional fine-Tuning of microRNA 223 levels directs lineage choice of human hematopoietic progenitors. Cell Death Differ. 21, 290-301 (2014).
    • (2014) Cell Death Differ. , vol.21 , pp. 290-301
    • Vian, L.1
  • 115
    • 0037244284 scopus 로고    scopus 로고
    • Intrinsic requirement for zinc finger transcription factor Gfi 1 in neutrophil differentiation
    • Hock, H. et al. Intrinsic requirement for zinc finger transcription factor Gfi 1 in neutrophil differentiation. Immunity 18, 109-120 (2003).
    • (2003) Immunity , vol.18 , pp. 109-120
    • Hock, H.1
  • 116
    • 66549105485 scopus 로고    scopus 로고
    • Gfi1 regulates miR 21 and miR 196b to control myelopoiesis
    • Velu, C. S., Baktula, A. M., & Grimes, H. L. Gfi1 regulates miR 21 and miR 196b to control myelopoiesis. Blood 113, 4720-4728 (2009).
    • (2009) Blood , vol.113 , pp. 4720-4728
    • Velu, C.S.1    Baktula, A.M.2    Grimes, H.L.3
  • 117
    • 84055218897 scopus 로고    scopus 로고
    • MicroRNA 130a mediated down-regulation of Smad4 contributes to reduced sensitivity to TGF β1 stimulation in granulocytic precursors
    • Hager, M. et al. MicroRNA 130a mediated down-regulation of Smad4 contributes to reduced sensitivity to TGF β1 stimulation in granulocytic precursors. Blood 118, 6649-6659 (2011).
    • (2011) Blood , vol.118 , pp. 6649-6659
    • Hager, M.1
  • 118
    • 84928588556 scopus 로고    scopus 로고
    • Let 7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function
    • Pobezinsky, L. A. et al. Let 7 microRNAs target the lineage-specific transcription factor PLZF to regulate terminal NKT cell differentiation and effector function. Blood 16, 517-524 (2015).
    • (2015) Blood , vol.16 , pp. 517-524
    • Pobezinsky, L.A.1
  • 119
    • 83755173483 scopus 로고    scopus 로고
    • Cutting edge: MicroRNA 181 promotes human NK cell development by regulating Notch signaling
    • Cichocki, F. et al. Cutting edge: microRNA 181 promotes human NK cell development by regulating Notch signaling. J. Immunol. 187, 6171-6175 (2011).
    • (2011) J. Immunol. , vol.187 , pp. 6171-6175
    • Cichocki, F.1
  • 120
    • 84855501133 scopus 로고    scopus 로고
    • L miR 150 regulates the development of NK and iNKT cells
    • Bezman, N. A., Chakraborty, T., Bender, T., & Lanier, L. L. miR 150 regulates the development of NK and iNKT cells. J. Exp. Med. 208, 2717-2731 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 2717-2731
    • Bezman, N.A.1    Chakraborty, T.2    Bender, T.3    Lanier, L.4
  • 121
    • 84875792300 scopus 로고    scopus 로고
    • MicroRNA function in NK cell biology
    • Beaulieu, A. M. et al. MicroRNA function in NK cell biology. Immunol. Rev. 253, 40-52 (2013).
    • (2013) Immunol. Rev. , vol.253 , pp. 40-52
    • Beaulieu, A.M.1
  • 122
    • 84868582519 scopus 로고    scopus 로고
    • Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms
    • Xu, X. et al. Systematic analysis of microRNA fingerprints in thrombocythemic platelets using integrated platforms. Blood 120, 3575-3585 (2012).
    • (2012) Blood , vol.120 , pp. 3575-3585
    • Xu, X.1
  • 123
    • 44449108570 scopus 로고    scopus 로고
    • MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors
    • Lu, J. et al. MicroRNA-mediated control of cell fate in megakaryocyte-erythrocyte progenitors. Dev. Cell 14, 843-853 (2008).
    • (2008) Dev. Cell , vol.14 , pp. 843-853
    • Lu, J.1
  • 124
    • 33645525964 scopus 로고    scopus 로고
    • MicroRNA fingerprints during human megakaryocytopoiesis
    • Garzon, R. et al. MicroRNA fingerprints during human megakaryocytopoiesis. Proc. Natl Acad. Sci. USA 103, 5078-5083 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , pp. 5078-5083
    • Garzon, R.1
  • 125
    • 77954408884 scopus 로고    scopus 로고
    • The miR 144/451 locus is required for erythroid homeostasis
    • Rasmussen, K. D. et al. The miR 144/451 locus is required for erythroid homeostasis. J. Exp. Med. 207, 1351-1358 (2010).
    • (2010) J. Exp. Med. , vol.207 , pp. 1351-1358
    • Rasmussen, K.D.1
  • 126
    • 84873564061 scopus 로고    scopus 로고
    • MiR 223 deficiency increases eosinophil progenitor proliferation
    • Lu, T. X. et al. MiR 223 deficiency increases eosinophil progenitor proliferation. J. Immunol. 190, 1576-1582 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 1576-1582
    • Lu, T.X.1
  • 127
    • 59849122726 scopus 로고    scopus 로고
    • MicroRNA 221 222 regulate the cell cycle in mast cells
    • Mayoral, R. J. et al. MicroRNA 221 222 regulate the cell cycle in mast cells. J. Immunol. 182, 433-445 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 433-445
    • Mayoral, R.J.1
  • 128
    • 84921334044 scopus 로고    scopus 로고
    • MicroRNAs in B cells: From normal differentiation to treatment of malignancies
    • Marques, S. C. et al. MicroRNAs in B cells: from normal differentiation to treatment of malignancies. Oncotarget 6, 7-25 (2015).
    • (2015) Oncotarget , vol.6 , pp. 7-25
    • Marques, S.C.1
  • 129
    • 84884175591 scopus 로고    scopus 로고
    • MicroRNA regulation of T lymphocyte immunity: Modulation of molecular networks responsible for T cell activation, differentiation, and development
    • Podshivalova, K., & Salomon, D. R. MicroRNA regulation of T lymphocyte immunity: modulation of molecular networks responsible for T cell activation, differentiation, and development. Crit. Rev. Immunol. 33, 435-476 (2013).
    • (2013) Crit. Rev. Immunol. , vol.33 , pp. 435-476
    • Podshivalova, K.1    Salomon, D.R.2
  • 130
    • 84875769973 scopus 로고    scopus 로고
    • MicroRNA regulation of T cell development
    • Dooley, J., Linterman, M. A., & Liston, A. MicroRNA regulation of T cell development. Immunol. Rev. 253, 53-64 (2013).
    • (2013) Immunol. Rev. , vol.253 , pp. 53-64
    • Dooley, J.1    Linterman, M.A.2    Liston, A.3
  • 131
  • 132
    • 84874605454 scopus 로고    scopus 로고
    • The role of microRNAs in B cell development and function
    • Li, J., Wan, Y., Ji, Q., Fang, Y., & Wu, Y. The role of microRNAs in B cell development and function. Cell. Mol. Immunol. 10, 107-112 (2013).
    • (2013) Cell. Mol. Immunol. , vol.10 , pp. 107-112
    • Li, J.1    Wan, Y.2    Ji, Q.3    Fang, Y.4    Wu, Y.5
  • 133
    • 84875777840 scopus 로고    scopus 로고
    • MicroRNA regulation of T cell differentiation and function
    • Jeker, L. T., & Bluestone, J. A. MicroRNA regulation of T cell differentiation and function. Immunol. Rev. 253, 65-81 (2013).
    • (2013) Immunol. Rev. , vol.253 , pp. 65-81
    • Jeker, L.T.1    Bluestone, J.A.2
  • 134
    • 84883162180 scopus 로고    scopus 로고
    • MicroRNA-mediated regulation of T helper cell differentiation and plasticity
    • Baumjohann, D., & Ansel, K. M. MicroRNA-mediated regulation of T helper cell differentiation and plasticity. Nat. Rev. Immunology 13, 666-678 (2013).
    • (2013) Nat. Rev. Immunology , vol.13 , pp. 666-678
    • Baumjohann, D.1    Ansel, K.M.2
  • 135
    • 34250212629 scopus 로고    scopus 로고
    • The transcriptional regulation of B cell lineage commitment
    • Nutt, S. L., & Kee, B. L. The transcriptional regulation of B cell lineage commitment. Immunity 26, 715-725 (2007).
    • (2007) Immunity , vol.26 , pp. 715-725
    • Nutt, S.L.1    Kee, B.L.2
  • 136
    • 20644461729 scopus 로고    scopus 로고
    • Transcriptional networks in developing and mature B cells
    • Matthias, P., & Rolink, A. G. Transcriptional networks in developing and mature B cells. Nat. Rev. Immunol. 5, 497-508 (2005).
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 497-508
    • Matthias, P.1    Rolink, A.G.2
  • 137
    • 0036669273 scopus 로고    scopus 로고
    • Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow
    • Igarashi, H., Gregory, S. C., Yokota, T., Sakaguchi, N., & Kincade, P. W. Transcription from the RAG1 locus marks the earliest lymphocyte progenitors in bone marrow. Immunity 17, 117-130 (2002).
    • (2002) Immunity , vol.17 , pp. 117-130
    • Igarashi, H.1    Gregory, S.C.2    Yokota, T.3    Sakaguchi, N.4    Kincade, P.W.5
  • 138
    • 0033166301 scopus 로고    scopus 로고
    • Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A
    • O?Riordan, M., & Grosschedl, R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity 11, 21-31 (1999).
    • (1999) Immunity , vol.11 , pp. 21-31
    • Oriordan, M.1    Grosschedl, R.2
  • 140
    • 0036906546 scopus 로고    scopus 로고
    • Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1
    • Souabni, A., Cobaleda, C., Schebesta, M., & Busslinger, M. Pax5 promotes B lymphopoiesis and blocks T cell development by repressing Notch1. Immunity 17, 781-793 (2002).
    • (2002) Immunity , vol.17 , pp. 781-793
    • Souabni, A.1    Cobaleda, C.2    Schebesta, M.3    Busslinger, M.4
  • 141
    • 84874283550 scopus 로고    scopus 로고
    • Sox4 is required for the survival of pro B cells
    • Sun, B. et al. Sox4 is required for the survival of pro B cells. J. Immunol. 190, 2080-2089 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 2080-2089
    • Sun, B.1
  • 142
    • 84903639223 scopus 로고    scopus 로고
    • Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B cell development: Intricate roles for RAG1/2 and CK1?
    • Mallampati, S. et al. Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B cell development: intricate roles for RAG1/2 and CK1?. Blood 123, 4064-4076 (2014).
    • (2014) Blood , vol.123 , pp. 4064-4076
    • Mallampati, S.1
  • 143
    • 0346727524 scopus 로고    scopus 로고
    • MicroRNAs modulate hematopoietic lineage differentiation
    • Chen, C. Z., Li, L., Lodish, H. F., & Bartel, D. P. MicroRNAs modulate hematopoietic lineage differentiation. Science 303, 83-86 (2004).
    • (2004) Science , vol.303 , pp. 83-86
    • Chen, C.Z.1    Li, L.2    Lodish, H.F.3    Bartel, D.P.4
  • 144
    • 65549101556 scopus 로고    scopus 로고
    • Identification of the human mature B cell miRNome
    • Basso, K. et al. Identification of the human mature B cell miRNome. Immunity 30, 744-752 (2009).
    • (2009) Immunity , vol.30 , pp. 744-752
    • Basso, K.1
  • 145
    • 66549119328 scopus 로고    scopus 로고
    • MiRNA profiling of B cell subsets: Specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes
    • Tan, L. P. et al. miRNA profiling of B cell subsets: specific miRNA profile for germinal center B cells with variation between centroblasts and centrocytes. Lab. Invest. 89, 708-716 (2009).
    • (2009) Lab. Invest. , vol.89 , pp. 708-716
    • Tan, L.P.1
  • 146
    • 66549101276 scopus 로고    scopus 로고
    • Patterns of microRNA expression characterize stages of human B cell differentiation
    • Zhang, J. et al. Patterns of microRNA expression characterize stages of human B cell differentiation. Blood 113, 4586-4594 (2009).
    • (2009) Blood , vol.113 , pp. 4586-4594
    • Zhang, J.1
  • 147
    • 39749101294 scopus 로고    scopus 로고
    • Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage
    • Koralov, S. B. et al. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell 132, 860-874 (2008).
    • (2008) Cell , vol.132 , pp. 860-874
    • Koralov, S.B.1
  • 148
    • 34249851499 scopus 로고    scopus 로고
    • F miR 150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely
    • Zhou, B., Wang, S., Mayr, C., Bartel, D. P., & Lodish, H. F. miR 150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc. Natl Acad. Sci. USA 104, 7080-7085 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 7080-7085
    • Zhou, B.1    Wang, S.2    Mayr, C.3    Bartel, D.P.4    Lodish, H.5
  • 149
    • 34547941361 scopus 로고    scopus 로고
    • MiR 150 controls B cell differentiation by targeting the transcription factor c Myb
    • Xiao, C. et al. MiR 150 controls B cell differentiation by targeting the transcription factor c Myb. Cell 131, 146-159 (2007).
    • (2007) Cell , vol.131 , pp. 146-159
    • Xiao, C.1
  • 150
    • 0022618283 scopus 로고
    • Expression of the c myb proto-oncogene during cellular proliferation
    • Thompson, C. B., Challoner, P. B., Neiman, P. E., & Groudine, M. Expression of the c myb proto-oncogene during cellular proliferation. Nature 319, 374-380 (1986).
    • (1986) Nature , vol.319 , pp. 374-380
    • Thompson, C.B.1    Challoner, P.B.2    Neiman, P.E.3    Groudine, M.4
  • 151
    • 34247641748 scopus 로고    scopus 로고
    • Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia
    • Lahortiga, I. et al. Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia. Nat. Genet. 39, 593-595 (2007).
    • (2007) Nat. Genet. , vol.39 , pp. 593-595
    • Lahortiga, I.1
  • 152
    • 77954958215 scopus 로고    scopus 로고
    • MicroRNA 34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1
    • Rao, D. S. et al. MicroRNA 34a perturbs B lymphocyte development by repressing the forkhead box transcription factor Foxp1. Immunity 33, 48-59 (2010).
    • (2010) Immunity , vol.33 , pp. 48-59
    • Rao, D.S.1
  • 153
    • 39749143354 scopus 로고    scopus 로고
    • Targeted deletion reveals essential and overlapping functions of the miR 17 through 92 family of miRNA clusters
    • Ventura, A. et al. Targeted deletion reveals essential and overlapping functions of the miR 17 through 92 family of miRNA clusters. Cell 132, 875-886 (2008).
    • (2008) Cell , vol.132 , pp. 875-886
    • Ventura, A.1
  • 155
    • 84873536866 scopus 로고    scopus 로고
    • IL 21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp 1 in human B cells
    • Ding, B. B., Bi, E., Chen, H., Yu, J. J., & Ye, B. H. IL 21 and CD40L synergistically promote plasma cell differentiation through upregulation of Blimp 1 in human B cells. J. Immunol. 190, 1827-1836 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 1827-1836
    • Ding, B.B.1    Bi, E.2    Chen, H.3    Yu, J.J.4    Ye, B.H.5
  • 157
    • 84862889421 scopus 로고    scopus 로고
    • BLIMP 1 and STAT3 counterregulate microRNA 21 during plasma cell differentiation
    • Barnes, N. A., Stephenson, S., Cocco, M., Tooze, R. M., & Doody, G. M. BLIMP 1 and STAT3 counterregulate microRNA 21 during plasma cell differentiation. J. Immunol. 189, 253-260 (2012).
    • (2012) J. Immunol. , vol.189 , pp. 253-260
    • Barnes, N.A.1    Stephenson, S.2    Cocco, M.3    Tooze, R.M.4    Doody, G.M.5
  • 158
    • 84908252748 scopus 로고    scopus 로고
    • The miR 155 PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation
    • Lu, D. et al. The miR 155 PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation. J. Exp. Med. 211, 2183-2198 (2014).
    • (2014) J. Exp. Med. , vol.211 , pp. 2183-2198
    • Lu, D.1
  • 159
    • 84927041623 scopus 로고    scopus 로고
    • MiR 148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2
    • Porstner, M. et al. miR 148a promotes plasma cell differentiation and targets the germinal center transcription factors Mitf and Bach2. Eur. J. Immunol. 45, 1206-1215 (2015).
    • (2015) Eur. J. Immunol. , vol.45 , pp. 1206-1215
    • Porstner, M.1
  • 160
    • 41449093809 scopus 로고    scopus 로고
    • B cell receptor activation induces BIC/miR 155 expression through a conserved AP 1 element
    • Yin, Q., Wang, X., McBride, J., Fewell, C., & Flemington, E. B cell receptor activation induces BIC/miR 155 expression through a conserved AP 1 element. J. Biol. Chem. 283, 2654-2662 (2008).
    • (2008) J. Biol. Chem. , vol.283 , pp. 2654-2662
    • Yin, Q.1    Wang, X.2    McBride, J.3    Fewell, C.4    Flemington, E.5
  • 161
    • 84924551273 scopus 로고    scopus 로고
    • NF κb/STAT5/miR 155 network targets PU.1 in FLT3 ITD-driven acute myeloid leukemia
    • Gerloff, D. et al. NF κB/STAT5/miR 155 network targets PU.1 in FLT3 ITD-driven acute myeloid leukemia. Leukemia 29, 535-547 (2015).
    • (2015) Leukemia , vol.29 , pp. 535-547
    • Gerloff, D.1
  • 162
    • 84959076294 scopus 로고    scopus 로고
    • The microRNA miR 148a functions as a critical regulator of B cell tolerance and autoimmunity
    • Gonzalez-Martin, A. et al. The microRNA miR 148a functions as a critical regulator of B cell tolerance and autoimmunity. Nat. Immunol. http://dx.doi.org/ 10.1038/ni.3385 (2016).
    • (2016) Nat. Immunol.
    • Gonzalez-Martin, A.1
  • 163
    • 77954263256 scopus 로고    scopus 로고
    • MicroRNA 125b inhibition of B cell differentiation in germinal centers
    • Gururajan, M. et al. MicroRNA 125b inhibition of B cell differentiation in germinal centers. Int. Immunol. 22, 583-592 (2010).
    • (2010) Int. Immunol. , vol.22 , pp. 583-592
    • Gururajan, M.1
  • 164
    • 84856254706 scopus 로고    scopus 로고
    • B-1 B cell development in the fetus and adult
    • Montecino-Rodriguez, E., & Dorshkind, K. B-1 B cell development in the fetus and adult. Immunity 36, 13-21 (2012).
    • (2012) Immunity , vol.36 , pp. 13-21
    • Montecino-Rodriguez, E.1    Dorshkind, K.2
  • 165
    • 84928239791 scopus 로고    scopus 로고
    • Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a
    • Zhou, Y. et al. Lin28b promotes fetal B lymphopoiesis through the transcription factor Arid3a. J. Exp. Med. 212, 569-580 (2015).
    • (2015) J. Exp. Med. , vol.212 , pp. 569-580
    • Zhou, Y.1
  • 166
    • 84931281751 scopus 로고    scopus 로고
    • Altered lymphopoiesis and immunodeficiency in miR 142 null mice
    • Palsson-McDermott, E. M. et al. Altered lymphopoiesis and immunodeficiency in miR 142 null mice. Proc. Natl Acad. Sci. USA 125, 3720-3730 (2015).
    • (2015) Proc. Natl Acad. Sci. USA , vol.125 , pp. 3720-3730
    • Palsson-McDermott, E.M.1
  • 167
    • 79958257077 scopus 로고    scopus 로고
    • MiR 146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice
    • Boldin, M. P. et al. miR 146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J. Exp. Med. 208, 1189-1201 (2011).
    • (2011) J. Exp. Med. , vol.208 , pp. 1189-1201
    • Boldin, M.P.1
  • 168
    • 34247584465 scopus 로고    scopus 로고
    • Requirement of bic/microRNA 155 for normal immune function
    • Rodriguez, A. et al. Requirement of bic/microRNA 155 for normal immune function. Science 316, 608-611 (2007).
    • (2007) Science , vol.316 , pp. 608-611
    • Rodriguez, A.1
  • 169
    • 84875788209 scopus 로고    scopus 로고
    • MiR 155: An ancient regulator of the immune system
    • Vigorito, E. Kohlhaas, S., Lu, D., & Leyland, R. miR 155: an ancient regulator of the immune system. Immunol. Rev. 253, 146-157 (2013).
    • (2013) Immunol. Rev. , vol.253 , pp. 146-157
    • Vigorito Kohlhaas E, S.1    Lu, D.2    Leyland, R.3
  • 170
    • 37049002638 scopus 로고    scopus 로고
    • MicroRNA 155 regulates the generation of immunoglobulin class-switched plasma cells
    • Vigorito, E. et al. microRNA 155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity 27, 847-859 (2007).
    • (2007) Immunity , vol.27 , pp. 847-859
    • Vigorito, E.1
  • 171
    • 84862865669 scopus 로고    scopus 로고
    • Immunoglobulin class-switch DNA recombination: Induction, targeting and beyond
    • Xu, Z., Zan, H., Pone, E. J., Mai, T., & Casali, P. Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat. Rev. Immunol. 12, 517-531 (2012).
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 517-531
    • Xu, Z.1    Zan, H.2    Pone, E.J.3    Mai, T.4    Casali, P.5
  • 172
    • 43049178852 scopus 로고    scopus 로고
    • MicroRNA 155 is a negative regulator of activation-induced cytidine deaminase
    • Teng, G. et al. MicroRNA 155 is a negative regulator of activation-induced cytidine deaminase. Immunity 28, 621-629 (2008).
    • (2008) Immunity , vol.28 , pp. 621-629
    • Teng, G.1
  • 173
    • 0037881911 scopus 로고    scopus 로고
    • Constitutive expression of AID leads to tumorigenesis
    • Okazaki, I. M. et al. Constitutive expression of AID leads to tumorigenesis. J. Exp. Med. 197, 1173-1181 (2003).
    • (2003) J. Exp. Med. , vol.197 , pp. 1173-1181
    • Okazaki, I.M.1
  • 174
    • 53349129731 scopus 로고    scopus 로고
    • MiR 181b negatively regulates activation-induced cytidine deaminase in B cells
    • de Yebenes, V. G. et al. miR 181b negatively regulates activation-induced cytidine deaminase in B cells. J. Exp. Med. 205, 2199-2206 (2008).
    • (2008) J. Exp. Med. , vol.205 , pp. 2199-2206
    • De Yebenes, V.G.1
  • 175
    • 84884262682 scopus 로고    scopus 로고
    • MiR 210 is induced by Oct 2, regulates B cells, and inhibits autoantibody production
    • Mok, Y. et al. MiR 210 is induced by Oct 2, regulates B cells, and inhibits autoantibody production. J. Immunol. 191, 3037-3048 (2013).
    • (2013) J. Immunol. , vol.191 , pp. 3037-3048
    • Mok, Y.1
  • 176
    • 84904114788 scopus 로고    scopus 로고
    • MiR 217 is an oncogene that enhances the germinal center reaction
    • de Yebenes, V. G. et al. miR 217 is an oncogene that enhances the germinal center reaction. Blood 124, 229-239 (2014).
    • (2014) Blood , vol.124 , pp. 229-239
    • De Yebenes, V.G.1
  • 177
    • 0036582215 scopus 로고    scopus 로고
    • T cell development and the CD4 CD8 lineage decision
    • Germain, R. N. T cell development and the CD4 CD8 lineage decision. Nat. Rev. Immunol. 2, 309-322 (2002).
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 309-322
    • Germain, R.N.1
  • 178
    • 84904966072 scopus 로고    scopus 로고
    • Developmental gene networks: A triathlon on the course to T cell identity
    • Yui, M. A., & Rothenberg, E. V. Developmental gene networks: a triathlon on the course to T cell identity. Nat. Rev. Immunol. 14, 529-545 (2014).
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 529-545
    • Yui, M.A.1    Rothenberg, E.V.2
  • 179
    • 24644489402 scopus 로고    scopus 로고
    • MicroRNA profiling of the murine hematopoietic system
    • Monticelli, S. et al. MicroRNA profiling of the murine hematopoietic system. Genome Biol. 6, R71 (2005).
    • (2005) Genome Biol. , vol.6 , pp. R71
    • Monticelli, S.1
  • 180
    • 38349016948 scopus 로고    scopus 로고
    • MiRNA profiling of naive, effector and memory CD8 T cells
    • Wu, H. et al. miRNA profiling of naive, effector and memory CD8 T cells. PLoS ONE 2, e1020 (2007).
    • (2007) PLoS ONE , vol.2 , pp. e1020
    • Wu, H.1
  • 181
    • 20844432885 scopus 로고    scopus 로고
    • T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer
    • Cobb, B. S. et al. T cell lineage choice and differentiation in the absence of the RNase III enzyme Dicer. J. Exp. Med. 201, 1367-1373 (2005).
    • (2005) J. Exp. Med. , vol.201 , pp. 1367-1373
    • Cobb, B.S.1
  • 182
    • 22944433872 scopus 로고    scopus 로고
    • Aberrant T cell differentiation in the absence of Dicer
    • Muljo, S. A. et al. Aberrant T cell differentiation in the absence of Dicer. J. Exp. Med. 202, 261-269 (2005).
    • (2005) J. Exp. Med. , vol.202 , pp. 261-269
    • Muljo, S.A.1
  • 183
    • 79959842615 scopus 로고    scopus 로고
    • Modulation of microRNA expression in human T cell development: Targeting of NOTCH3 by miR 150
    • Ghisi, M. et al. Modulation of microRNA expression in human T cell development: targeting of NOTCH3 by miR 150. Blood 117, 7053-7062 (2011).
    • (2011) Blood , vol.117 , pp. 7053-7062
    • Ghisi, M.1
  • 184
    • 33947721625 scopus 로고    scopus 로고
    • MiR 181a is an intrinsic modulator of T cell sensitivity and selection
    • Li, Q. J. et al. miR 181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129, 147-161 (2007).
    • (2007) Cell , vol.129 , pp. 147-161
    • Li, Q.J.1
  • 185
    • 41549134361 scopus 로고    scopus 로고
    • Th17 cell differentiation: The long and winding road
    • McGeachy, M. J., & Cua, D. J. Th17 cell differentiation: the long and winding road. Immunity 28, 445-453 (2008).
    • (2008) Immunity , vol.28 , pp. 445-453
    • McGeachy, M.J.1    Cua, D.J.2
  • 186
    • 84879123259 scopus 로고    scopus 로고
    • MicroRNA 155 confers encephalogenic potential to Th17 cells by promoting effector gene expression
    • Hu, R. et al. MicroRNA 155 confers encephalogenic potential to Th17 cells by promoting effector gene expression. J. Immunol. 190, 5972-5980 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 5972-5980
    • Hu, R.1
  • 187
    • 84867584246 scopus 로고    scopus 로고
    • MicroRNA 155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1
    • Yao, R. et al. MicroRNA 155 modulates Treg and Th17 cells differentiation and Th17 cell function by targeting SOCS1. PLoS ONE 7, e46082 (2012).
    • (2012) PLoS ONE , vol.7 , pp. e46082
    • Yao, R.1
  • 188
    • 84924028501 scopus 로고    scopus 로고
    • MicroRNA 21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis
    • Murugaiyan, G. et al. MicroRNA 21 promotes Th17 differentiation and mediates experimental autoimmune encephalomyelitis. J. Clin. Invest. 125, 1069-1080 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 1069-1080
    • Murugaiyan, G.1
  • 189
    • 84861207616 scopus 로고    scopus 로고
    • MicroRNA 301a regulation of a T helper 17 immune response controls autoimmune demyelination
    • Mycko, M. P. et al. MicroRNA 301a regulation of a T helper 17 immune response controls autoimmune demyelination. Proc. Natl Acad. Sci. USA 109, E1248-E1257 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , pp. E1248-E1257
    • Mycko, M.P.1
  • 190
    • 70449716915 scopus 로고    scopus 로고
    • MicroRNA miR 326 regulates TH 17 differentiation and is associated with the pathogenesis of multiple sclerosis
    • Du, C. et al. MicroRNA miR 326 regulates TH 17 differentiation and is associated with the pathogenesis of multiple sclerosis. Nat. Immunol. 10, 1252-1259 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 1252-1259
    • Du, C.1
  • 191
    • 84902193953 scopus 로고    scopus 로고
    • MiR 20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting ROR?t and STAT3
    • Zhu, E. et al. miR 20b suppresses Th17 differentiation and the pathogenesis of experimental autoimmune encephalomyelitis by targeting ROR?t and STAT3. J. Immunol. 192, 5599-5609 (2014).
    • (2014) J. Immunol. , vol.192 , pp. 5599-5609
    • Zhu, E.1
  • 192
    • 84880352166 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor-mediated induction of the microRNA 132/212 cluster promotes interleukin 17 producing T helper cell differentiation
    • Nakahama, T. et al. Aryl hydrocarbon receptor-mediated induction of the microRNA 132/212 cluster promotes interleukin 17 producing T helper cell differentiation. Proc. Natl Acad. Sci. USA 110, 11964-11969 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 11964-11969
    • Nakahama, T.1
  • 193
    • 84933277411 scopus 로고    scopus 로고
    • An allelic series of miR 17 approximately 92 mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron
    • Han, Y. C., & Vidigal, J. A. An allelic series of miR 17 approximately 92 mutant mice uncovers functional specialization and cooperation among members of a microRNA polycistron. Nat. Genet. 47, 766-775 (2015).
    • (2015) Nat. Genet. , vol.47 , pp. 766-775
    • Han, Y.C.1    Vidigal, J.A.2
  • 194
    • 81555196345 scopus 로고    scopus 로고
    • Molecular dissection of the miR 17 92 cluster?s critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation
    • Jiang, S. et al. Molecular dissection of the miR 17 92 cluster?s critical dual roles in promoting Th1 responses and preventing inducible Treg differentiation. Blood 118, 5487-5497 (2011).
    • (2011) Blood , vol.118 , pp. 5487-5497
    • Jiang, S.1
  • 195
    • 77958149675 scopus 로고    scopus 로고
    • The microRNA miR 182 is induced by IL 2 and promotes clonal expansion of activated helper T lymphocytes
    • Stittrich, A. B. et al. The microRNA miR 182 is induced by IL 2 and promotes clonal expansion of activated helper T lymphocytes. Nat. Immunol. 11, 1057-1062 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 1057-1062
    • Stittrich, A.B.1
  • 196
    • 77955508072 scopus 로고    scopus 로고
    • Costimulation-dependent expression of microRNA 214 increases the ability of T cells to proliferate by targeting Pten
    • Jindra, P. T., Bagley, J., Godwin, J. G., & Iacomini, J. Costimulation-dependent expression of microRNA 214 increases the ability of T cells to proliferate by targeting Pten. J. Immunol. 185, 990-997 (2010).
    • (2010) J. Immunol. , vol.185 , pp. 990-997
    • Jindra, P.T.1    Bagley, J.2    Godwin, J.G.3    Iacomini, J.4
  • 197
    • 84960335745 scopus 로고    scopus 로고
    • MiR 23 approximately 27 approximately 24 clusters control effector T cell differentiation and function
    • Cho, S. et al. miR 23 approximately 27 approximately 24 clusters control effector T cell differentiation and function. J. Exp. Med. 213, 235-249 (2016).
    • (2016) J. Exp. Med. , vol.213 , pp. 235-249
    • Cho, S.1
  • 198
    • 84956608529 scopus 로고    scopus 로고
    • MicroRNAs 24 and 27 suppress allergic inflammation and target a network of regulators of T helper 2 cell-Associated cytokine production. Immunity
    • Pua, H. H. et al. MicroRNAs 24 and 27 suppress allergic inflammation and target a network of regulators of T helper 2 cell-Associated cytokine production. Immunity http://dx.doi.org/10.1016/ j.immuni.2016.01.003 (2016).
    • (2016) J.immuni.
    • Pua, H.H.1
  • 199
    • 84908146717 scopus 로고    scopus 로고
    • MiR 155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation
    • Hu, R. et al. miR 155 promotes T follicular helper cell accumulation during chronic, low-grade inflammation. Immunity 41, 605-619 (2014).
    • (2014) Immunity , vol.41 , pp. 605-619
    • Hu, R.1
  • 200
    • 84871694595 scopus 로고    scopus 로고
    • Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity
    • Huffaker, T. B. et al. Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity. Cell Rep. 2, 1697-1709 (2012).
    • (2012) Cell Rep. , vol.2 , pp. 1697-1709
    • Huffaker, T.B.1
  • 201
    • 84866354593 scopus 로고    scopus 로고
    • MiR 146a controls the resolution of T cell responses in mice
    • Yang, L. et al. miR 146a controls the resolution of T cell responses in mice. J. Exp. Med. 209, 1655-1670 (2012).
    • (2012) J. Exp. Med. , vol.209 , pp. 1655-1670
    • Yang, L.1
  • 202
    • 77956632634 scopus 로고    scopus 로고
    • Function of miR 146a in controlling Treg cell-mediated regulation of Th1 responses
    • Lu, L. F. et al. Function of miR 146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 142, 914-929 (2010).
    • (2010) Cell , vol.142 , pp. 914-929
    • Lu, L.F.1
  • 203
    • 84880767787 scopus 로고    scopus 로고
    • MicroRNAs of the miR 17 approximately 92 family are critical regulators of TFH differentiation
    • Kang, S. G. et al. MicroRNAs of the miR 17 approximately 92 family are critical regulators of TFH differentiation. Nat. Immunol. 14, 849-857 (2013).
    • (2013) Nat. Immunol. , vol.14 , pp. 849-857
    • Kang, S.G.1
  • 204
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin, G. A., & Croce, C. M. MicroRNA signatures in human cancers. Nature reviews. Cancer 6, 857-866 (2006).
    • (2006) Nature Reviews. Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 205
    • 4143142117 scopus 로고    scopus 로고
    • MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias
    • Calin, G. A. et al. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc. Natl Acad. Sci. USA 101, 11755-11760 (2004).
    • (2004) Proc. Natl Acad. Sci. USA , vol.101 , pp. 11755-11760
    • Calin, G.A.1
  • 206
    • 84877094834 scopus 로고    scopus 로고
    • MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia
    • de Leeuw, D. C. et al. MicroRNA profiling can classify acute leukemias of ambiguous lineage as either acute myeloid leukemia or acute lymphoid leukemia. Clin. Cancer Res. 19, 2187-2196 (2013).
    • (2013) Clin. Cancer Res. , vol.19 , pp. 2187-2196
    • De Leeuw, D.C.1
  • 207
    • 20444460289 scopus 로고    scopus 로고
    • MicroRNA expression profiles classify human cancers
    • Lu, J. et al. MicroRNA expression profiles classify human cancers. Nature 435, 834-838 (2005).
    • (2005) Nature , vol.435 , pp. 834-838
    • Lu, J.1
  • 208
    • 84856758666 scopus 로고    scopus 로고
    • MicroRNAs in acute leukemia: From biological players to clinical contributors
    • Schotte, D., Pieters, R., & Den Boer, M. L. MicroRNAs in acute leukemia: from biological players to clinical contributors. Leukemia 26, 1-12 (2012).
    • (2012) Leukemia , vol.26 , pp. 1-12
    • Schotte, D.1    Pieters, R.2    Den Boer, M.L.3
  • 209
    • 42449141513 scopus 로고    scopus 로고
    • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    • Garzon, R. et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 111, 3183-3189 (2008).
    • (2008) Blood , vol.111 , pp. 3183-3189
    • Garzon, R.1
  • 210
    • 84930396449 scopus 로고    scopus 로고
    • MicroRNA regulation of lymphocyte tolerance and autoimmunity
    • Simpson, L. J., & Ansel, K. M. MicroRNA regulation of lymphocyte tolerance and autoimmunity. J. Clin. Invest. 125, 2242-2249 (2015).
    • (2015) J. Clin. Invest. , vol.125 , pp. 2242-2249
    • Simpson, L.J.1    Ansel, K.M.2
  • 211
    • 84884702252 scopus 로고    scopus 로고
    • The role of miRNA in inflammation and autoimmunity
    • Singh, R. P. et al. The role of miRNA in inflammation and autoimmunity. Autoimmun. Rev. 12, 1160-1165 (2013).
    • (2013) Autoimmun. Rev. , vol.12 , pp. 1160-1165
    • Singh, R.P.1
  • 213
    • 83555166166 scopus 로고    scopus 로고
    • Emu/miR 125b transgenic mice develop lethal B cell malignancies
    • Enomoto, Y. et al. Emu/miR 125b transgenic mice develop lethal B cell malignancies. Leukemia 25, 1849-1856 (2011).
    • (2011) Leukemia , vol.25 , pp. 1849-1856
    • Enomoto, Y.1
  • 214
    • 84901828594 scopus 로고    scopus 로고
    • MicroRNA 28 controls cell proliferation and is down-regulated in B cell lymphomas
    • Schneider, C. et al. MicroRNA 28 controls cell proliferation and is down-regulated in B cell lymphomas. Proc. Natl Acad. Sci. USA 111, 8185-8190 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 8185-8190
    • Schneider, C.1
  • 215
    • 84887310173 scopus 로고    scopus 로고
    • B cell malignancies in microRNA Emu-miR 17~92 transgenic mice
    • Sandhu, S. K. et al. B cell malignancies in microRNA Emu-miR 17~92 transgenic mice. Proc. Natl Acad. Sci. USA 110, 18208-18213 (2013).
    • (2013) Proc. Natl Acad. Sci. USA , vol.110 , pp. 18208-18213
    • Sandhu, S.K.1
  • 216
    • 77951757309 scopus 로고    scopus 로고
    • The miR 17 92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression
    • Wong, P. et al. The miR 17 92 microRNA polycistron regulates MLL leukemia stem cell potential by modulating p21 expression. Cancer Res. 70, 3833-3842 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 3833-3842
    • Wong, P.1
  • 217
    • 20444467290 scopus 로고    scopus 로고
    • A microRNA polycistron as a potential human oncogene
    • He, L. et al. A microRNA polycistron as a potential human oncogene. Nature 435, 828-833 (2005).
    • (2005) Nature , vol.435 , pp. 828-833
    • He, L.1
  • 218
    • 39749163245 scopus 로고    scopus 로고
    • Lymphoproliferative disease and autoimmunity in mice with increased miR 17 92 expression in lymphocytes
    • Xiao, C. et al. Lymphoproliferative disease and autoimmunity in mice with increased miR 17 92 expression in lymphocytes. Nat. Immunol. 9, 405-414 (2008).
    • (2008) Nat. Immunol. , vol.9 , pp. 405-414
    • Xiao, C.1
  • 219
    • 84884263191 scopus 로고    scopus 로고
    • The TAL1 complex targets the FBXW7 tumor suppressor by activating miR 223 in human T cell acute lymphoblastic leukemia
    • Mansour, M. R. et al. The TAL1 complex targets the FBXW7 tumor suppressor by activating miR 223 in human T cell acute lymphoblastic leukemia. J. Exp. Med. 210, 1545-1557 (2013).
    • (2013) J. Exp. Med. , vol.210 , pp. 1545-1557
    • Mansour, M.R.1
  • 220
    • 70350778443 scopus 로고    scopus 로고
    • An epigenetic switch involving NF κb, Lin28, Let 7 MicroRNA, and IL6 links inflammation to cell transformation
    • Iliopoulos, D., Hirsch, H. A., & Struhl, K. An epigenetic switch involving NF κB, Lin28, Let 7 MicroRNA, and IL6 links inflammation to cell transformation. Cell 139, 693-706 (2009).
    • (2009) Cell , vol.139 , pp. 693-706
    • Iliopoulos, D.1    Hirsch, H.A.2    Struhl, K.3
  • 221
    • 84894495362 scopus 로고    scopus 로고
    • STAT3 induction of miR 146b forms a feedback loop to inhibit the NF κb to IL 6 signaling axis and STAT3 driven cancer phenotypes
    • ra11
    • Xiang, M. et al. STAT3 induction of miR 146b forms a feedback loop to inhibit the NF κB to IL 6 signaling axis and STAT3 driven cancer phenotypes. Sci. Signal. 7, ra11 (2014).
    • (2014) Sci. Signal. , vol.7
    • Xiang, M.1
  • 222
    • 77958495102 scopus 로고    scopus 로고
    • MicroRNA 155 promotes autoimmune inflammation by enhancing inflammatory T cell development
    • Oconnell, R. M. et al. MicroRNA 155 promotes autoimmune inflammation by enhancing inflammatory T cell development. Immunity 33, 607-619 (2010).
    • (2010) Immunity , vol.33 , pp. 607-619
    • Oconnell, R.M.1
  • 223
    • 79960595150 scopus 로고    scopus 로고
    • MicroRNA 155 as a proinflammatory regulator in clinical and experimental arthritis
    • Kurowska-Stolarska, M. et al. MicroRNA 155 as a proinflammatory regulator in clinical and experimental arthritis. Proc. Natl Acad. Sci. USA 108, 11193-11198 (2011).
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 11193-11198
    • Kurowska-Stolarska, M.1
  • 224
    • 84907906605 scopus 로고    scopus 로고
    • Quantitative and stoichiometric analysis of the microRNA content of exosomes
    • Chevillet, J. R. et al. Quantitative and stoichiometric analysis of the microRNA content of exosomes. Proc. Natl Acad. Sci. USA 111, 14888-14893 (2014).
    • (2014) Proc. Natl Acad. Sci. USA , vol.111 , pp. 14888-14893
    • Chevillet, J.R.1
  • 225
    • 84922273505 scopus 로고    scopus 로고
    • In vivo delivery of miRNAs for cancer therapy: Challenges and strategies
    • Chen, Y., Gao, D. Y., & Huang, L. In vivo delivery of miRNAs for cancer therapy: challenges and strategies. Adv. Drug Delivery Rev. 81, 128-141 (2015).
    • (2015) Adv. Drug Delivery Rev. , vol.81 , pp. 128-141
    • Chen, Y.1    Gao, D.Y.2    Huang, L.3
  • 226
    • 84877258007 scopus 로고    scopus 로고
    • Treatment of HCV infection by targeting microRNA
    • Janssen, H. L. et al. Treatment of HCV infection by targeting microRNA. New Engl. J. Med. 368, 1685-1694 (2013).
    • (2013) New Engl. J. Med. , vol.368 , pp. 1685-1694
    • Janssen, H.L.1
  • 227
    • 84905503012 scopus 로고    scopus 로고
    • Therapeutic targeting of microRNAs: Current status and future challenges
    • Li, Z., & Rana, T. M. Therapeutic targeting of microRNAs: current status and future challenges. Nat. Rev. Drug Discov. 13, 622-638 (2014).
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 622-638
    • Li, Z.1    Rana, T.M.2
  • 228
    • 84887101163 scopus 로고    scopus 로고
    • Micrornas and other non-coding rnas as targets for anticancer drug development
    • Ling, H., Fabbri, M., & Calin, G. A. MicroRNAs and other non-coding RNAs as targets for anticancer drug development. Nat. Rev. Drug Discov. 12, 847-865 (2013).
    • (2013) Nat. Rev. Drug Discov. , vol.12 , pp. 847-865
    • Ling, H.1    Fabbri, M.2    Calin, G.A.3
  • 229
    • 84890212376 scopus 로고    scopus 로고
    • TALEN-based knockout library for human microRNAs
    • Kim, Y. K. et al. TALEN-based knockout library for human microRNAs. Nat. Struct. Mol. Biol. 20, 1458-1464 (2013).
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , pp. 1458-1464
    • Kim, Y.K.1
  • 230
    • 84901418880 scopus 로고    scopus 로고
    • A TALEN-based strategy for efficient bi allelic miRNA ablation in human cells
    • Uhde-Stone, C. et al. A TALEN-based strategy for efficient bi allelic miRNA ablation in human cells. RNA 20, 948-955 (2014).
    • (2014) RNA , vol.20 , pp. 948-955
    • Uhde-Stone, C.1
  • 231
    • 84877105430 scopus 로고    scopus 로고
    • Targeting human microRNA genes using engineered Tal-effector nucleases (TALENs)
    • Hu, R., Wallace, J., Dahlem, T. J., Grunwald, D. J., & Oconnell, R. M. Targeting human microRNA genes using engineered Tal-effector nucleases (TALENs). PLoS ONE 8, e63074 (2013).
    • (2013) PLoS ONE , vol.8 , pp. e63074
    • Hu, R.1    Wallace, J.2    Dahlem, T.J.3    Grunwald, D.J.4    Oconnell, R.M.5
  • 232
    • 84936077333 scopus 로고    scopus 로고
    • Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines
    • Ho, T. T. et al. Targeting non-coding RNAs with the CRISPR/Cas9 system in human cell lines. Nucleic Acids Res. 43, e17 (2015).
    • (2015) Nucleic Acids Res. , vol.43 , pp. e17
    • Ho, T.T.1
  • 233
    • 84893819419 scopus 로고    scopus 로고
    • Sequence-specific inhibition of microRNA via CRISPR/CRISPRi system
    • Zhao, Y. et al. Sequence-specific inhibition of microRNA via CRISPR/CRISPRi system. Scientif. Rep. 4, 3943 (2014).
    • (2014) Scientif. Rep. , vol.4 , pp. 3943
    • Zhao, Y.1
  • 234
    • 67749132423 scopus 로고    scopus 로고
    • Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps
    • Chi, S. W., Zang, J. B., Mele, A., & Darnell, R. B. Argonaute HITS-CLIP decodes microRNA-mRNA interaction maps. Nature 460, 479-486 (2009).
    • (2009) Nature , vol.460 , pp. 479-486
    • Chi, S.W.1    Zang, J.B.2    Mele, A.3    Darnell, R.B.4
  • 235
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman, R. C., Farh, K. K., Burge, C. B., & Bartel, D. P. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 19, 92-105 (2009).
    • (2009) Genome Res. , vol.19 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3    Bartel, D.P.4
  • 236
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466, 835-840 (2010).
    • (2010) Nature , vol.466 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 237
    • 84904985459 scopus 로고    scopus 로고
    • Regulation of microRNA biogenesis
    • Ha, M., & Kim, V. N. Regulation of microRNA biogenesis. Nat. Rev. Mol. Cell Biol. 15, 509-524 (2014).
    • (2014) Nat. Rev. Mol. Cell Biol. , vol.15 , pp. 509-524
    • Ha, M.1    Kim, V.N.2
  • 238
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He, L., & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. Nat. Rev. Genet. 5, 522-531 (2004).
    • (2004) Nat. Rev. Genet. , vol.5 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 239
    • 84940502214 scopus 로고    scopus 로고
    • Predicting effective microRNA target sites in mammalian mRNAs
    • Agarwal, V., Bell, G. W., Nam, J. W., & Bartel, D. P. Predicting effective microRNA target sites in mammalian mRNAs. eLife 4, http://dx.doi.org/ 10.7554/eLife.05005 (2015).
    • (2015) ELife , vol.4
    • Agarwal, V.1    Bell, G.W.2    Nam, J.W.3    Bartel, D.P.4
  • 240
    • 70349439320 scopus 로고    scopus 로고
    • MiR 147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses
    • Liu, G. et al. miR 147, a microRNA that is induced upon Toll-like receptor stimulation, regulates murine macrophage inflammatory responses. Proc. Natl Acad. Sci. USA 106, 15819-15824 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 15819-15824
    • Liu, G.1
  • 241
    • 84872722692 scopus 로고    scopus 로고
    • Regulation of TLR2 mediated tolerance and cross-Tolerance through IRAK4 modulation by miR 132 and miR 212
    • Nahid, M. A. et al. Regulation of TLR2 mediated tolerance and cross-Tolerance through IRAK4 modulation by miR 132 and miR 212. J. Immunol. 190, 1250-1263 (2013).
    • (2013) J. Immunol. , vol.190 , pp. 1250-1263
    • Nahid, M.A.1
  • 242
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis, B. N., Hilyard, A. C., Lagna, G., & Hata, A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 454, 56-61 (2008).
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 243
    • 67649277689 scopus 로고    scopus 로고
    • The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs
    • Trabucchi, M. et al. The RNA-binding protein KSRP promotes the biogenesis of a subset of microRNAs. Nature 459, 1010-1014 (2009).
    • (2009) Nature , vol.459 , pp. 1010-1014
    • Trabucchi, M.1
  • 244
    • 68749102148 scopus 로고    scopus 로고
    • TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation
    • Heo, I. et al. TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation. Cell 138, 696-708 (2009).
    • (2009) Cell , vol.138 , pp. 696-708
    • Heo, I.1
  • 245
    • 34547955952 scopus 로고    scopus 로고
    • A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway
    • O?Carroll, D. et al. A Slicer-independent role for Argonaute 2 in hematopoiesis and the microRNA pathway. Genes Dev. 21, 1999-2004 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 1999-2004
    • Ocarroll, D.1
  • 246
    • 43449090367 scopus 로고    scopus 로고
    • MicroRNA 10a binds the 5?UTR of ribosomal protein mRNAs and enhances their translation
    • Orom, U. A., Nielsen, F. C., & Lund, A. H. MicroRNA 10a binds the 5?UTR of ribosomal protein mRNAs and enhances their translation. Mol. Cell 30, 460-471 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 460-471
    • Orom, U.A.1    Nielsen, F.C.2    Lund, A.H.3
  • 247
    • 40349094597 scopus 로고    scopus 로고
    • MicroRNA 373 induces expression of genes with complementary promoter sequences
    • Place, R. F., Li, L. C., Pookot, D., Noonan, E. J., & Dahiya, R. MicroRNA 373 induces expression of genes with complementary promoter sequences. Proc. Natl Acad. Sci. USA 105, 1608-1613 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 1608-1613
    • Place, R.F.1    Li, L.C.2    Pookot, D.3    Noonan, E.J.4    Dahiya, R.5
  • 248
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: MicroRNAs can up regulate translation
    • Vasudevan, S., Tong, Y., & Steitz, J. A. Switching from repression to activation: microRNAs can up regulate translation. Science 318, 1931-1934 (2007).
    • (2007) Science , vol.318 , pp. 1931-1934
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3
  • 249
    • 84940234906 scopus 로고    scopus 로고
    • MicroRNAs and RNA-binding proteins: A complex network of interactions and reciprocal regulations in cancer
    • Ciafre, S. A., & Galardi, S. microRNAs and RNA-binding proteins: a complex network of interactions and reciprocal regulations in cancer. RNA Biol. 10, 935-942 (2013).
    • (2013) RNA Biol. , vol.10 , pp. 935-942
    • Ciafre, S.A.1    Galardi, S.2
  • 250
    • 84868153864 scopus 로고    scopus 로고
    • Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let 7 microRNAs
    • Heo, I. et al. Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let 7 microRNAs. Cell 151, 521-532 (2012).
    • (2012) Cell , vol.151 , pp. 521-532
    • Heo, I.1
  • 251
    • 81855228621 scopus 로고    scopus 로고
    • Molecular basis for interaction of let 7 microRNAs with Lin28
    • Nam, Y., Chen, C., Gregory, R. I., Chou, J. J., & Sliz, P. Molecular basis for interaction of let 7 microRNAs with Lin28. Cell 147, 1080-1091 (2011).
    • (2011) Cell , vol.147 , pp. 1080-1091
    • Nam, Y.1    Chen, C.2    Gregory, R.I.3    Chou, J.J.4    Sliz, P.5
  • 252
    • 80052041185 scopus 로고    scopus 로고
    • MicroRNA regulation by RNA-binding proteins and its implications for cancer
    • van Kouwenhove, M., Kedde, M., & Agami, R. MicroRNA regulation by RNA-binding proteins and its implications for cancer. Nat. Rev. Cancer 11, 644-656 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , pp. 644-656
    • Van Kouwenhove, M.1    Kedde, M.2    Agami, R.3
  • 253
    • 84858446579 scopus 로고    scopus 로고
    • MicroRNAs and their targets: Recognition, regulation and an emerging reciprocal relationship
    • Pasquinelli, A. E. MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship. Nat. Rev. Genet. 13, 271-282 (2012).
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 271-282
    • Pasquinelli, A.E.1
  • 254
    • 79961170994 scopus 로고    scopus 로고
    • A ceRNA hypo thesis: The Rosetta Stone of a hidden RNA language?
    • Salmena, L., Poliseno, L., Tay, Y., Kats, L., & Pandolfi, P. P. A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language?. Cell 146, 353-358 (2011).
    • (2011) Cell , vol.146 , pp. 353-358
    • Salmena, L.1    Poliseno, L.2    Tay, Y.3    Kats, L.4    Pandolfi, P.P.5
  • 255
    • 84892573723 scopus 로고    scopus 로고
    • The multilayered complexity of ceRNA crosstalk and competition
    • Tay, Y., Rinn, J., & Pandolfi, P. P. The multilayered complexity of ceRNA crosstalk and competition. Nature 505, 344-352 (2014).
    • (2014) Nature , vol.505 , pp. 344-352
    • Tay, Y.1    Rinn, J.2    Pandolfi, P.P.3


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