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Volumn 29, Issue 3, 2015, Pages 535-547

NF-κB/STAT5/miR-155 network targets PU.1 in FLT3-ITD-driven acute myeloid leukemia

Author keywords

[No Author keywords available]

Indexed keywords

FLT3 LIGAND; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICRORNA; MICRORNA 155; STAT5 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR PU 1; CD135 ANTIGEN; FLT3 PROTEIN, HUMAN; MIRN155 MICRORNA, HUMAN; ONCOPROTEIN; PROTO-ONCOGENE PROTEIN SPI-1; SMALL INTERFERING RNA; TRANSACTIVATOR PROTEIN; TRANSCRIPTION FACTOR RELA;

EID: 84924551273     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2014.231     Document Type: Article
Times cited : (117)

References (61)
  • 1
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood 2002; 100: 1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 2
    • 32144437947 scopus 로고    scopus 로고
    • Mutant FLT3 signaling contributes to a block in myeloid differentiation
    • Zheng R, Small D. Mutant FLT3 signaling contributes to a block in myeloid differentiation. Leuk Lymphoma 2005; 46: 1679-1687.
    • (2005) Leuk Lymphoma , vol.46 , pp. 1679-1687
    • Zheng, R.1    Small, D.2
  • 4
    • 22044448746 scopus 로고    scopus 로고
    • AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations
    • Choudhary C, Schwable J, Brandts C, Tickenbrock L, Sargin B, Kindler T et al. AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations. Blood 2005; 106: 265-273.
    • (2005) Blood , vol.106 , pp. 265-273
    • Choudhary, C.1    Schwable, J.2    Brandts, C.3    Tickenbrock, L.4    Sargin, B.5    Kindler, T.6
  • 6
    • 0037838661 scopus 로고    scopus 로고
    • Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells
    • Spiekermann K, Bagrintseva K, Schwab R, Schmieja K, Hiddemann W. Overexpression and constitutive activation of FLT3 induces STAT5 activation in primary acute myeloid leukemia blast cells. Clin Cancer Res 2003; 9: 2140-2150.
    • (2003) Clin Cancer Res , vol.9 , pp. 2140-2150
    • Spiekermann, K.1    Bagrintseva, K.2    Schwab, R.3    Schmieja, K.4    Hiddemann, W.5
  • 7
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, Tanimoto M, Kitamura T, Saito H et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene 2000; 19: 624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3    Tanimoto, M.4    Kitamura, T.5    Saito, H.6
  • 8
    • 0033820091 scopus 로고    scopus 로고
    • Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation
    • Tse KF, Mukherjee G, Small D. Constitutive activation of FLT3 stimulates multiple intracellular signal transducers and results in transformation. Leukemia 2000; 14: 1766-1776.
    • (2000) Leukemia , vol.14 , pp. 1766-1776
    • Tse, K.F.1    Mukherjee, G.2    Small, D.3
  • 9
    • 22544482989 scopus 로고    scopus 로고
    • Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies
    • Chalandon Y, Schwaller J. Targeting mutated protein tyrosine kinases and their signaling pathways in hematologic malignancies. Haematologica 2005; 90: 949-968.
    • (2005) Haematologica , vol.90 , pp. 949-968
    • Chalandon, Y.1    Schwaller, J.2
  • 10
    • 0037944120 scopus 로고    scopus 로고
    • Suppression of myeloid transcription factors and induction of STAT response genes by AML-speci fic Flt3 mutations
    • Mizuki M, Schwable J, Steur C, Choudhary C, Agrawal S, Sargin B et al. Suppression of myeloid transcription factors and induction of STAT response genes by AML-speci fic Flt3 mutations. Blood 2003; 101: 3164-3173.
    • (2003) Blood , vol.101 , pp. 3164-3173
    • Mizuki, M.1    Schwable, J.2    Steur, C.3    Choudhary, C.4    Agrawal, S.5    Sargin, B.6
  • 11
    • 33344455424 scopus 로고    scopus 로고
    • Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations
    • Radomska HS, Basseres DS, Zheng R, Zhang P, Dayaram T, Yamamoto Y et al. Block of C/EBP alpha function by phosphorylation in acute myeloid leukemia with FLT3 activating mutations. J Exp Med 2006; 203: 371-381.
    • (2006) J Exp Med , vol.203 , pp. 371-381
    • Radomska, H.S.1    Basseres, D.S.2    Zheng, R.3    Zhang, P.4    Dayaram, T.5    Yamamoto, Y.6
  • 12
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways
    • Mizuki M, Fenski R, Halfter H, Matsumura I, Schmidt R, Muller C et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. Blood 2000; 96: 3907-3914.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3    Matsumura, I.4    Schmidt, R.5    Muller, C.6
  • 13
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • 23
    • Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004 23; 116: 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 14
    • 4644309196 scopus 로고    scopus 로고
    • The functions of animal microRNAs
    • Ambros V. The functions of animal microRNAs. Nature 2004; 431: 350-355.
    • (2004) Nature , vol.431 , pp. 350-355
    • Ambros, V.1
  • 15
    • 77950354353 scopus 로고    scopus 로고
    • Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia
    • Pulikkan JA, Dengler V, Peramangalam PS, Peer Zada AA, Muller-Tidow C, Bohlander SK et al. Cell-cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia. Blood 2010; 115: 1768-1778.
    • (2010) Blood , vol.115 , pp. 1768-1778
    • Pulikkan, J.A.1    Dengler, V.2    Peramangalam, P.S.3    Peer Zada, A.A.4    Muller-Tidow, C.5    Bohlander, S.K.6
  • 16
    • 84887776468 scopus 로고    scopus 로고
    • Transcription factor C/EBPalpha-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia
    • Katzerke C, Madan V, Gerloff D, Brauer-Hartmann D, Hartmann JU, Wurm AA et al. Transcription factor C/EBPalpha-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia. Blood 2013; 122: 2433-2442.
    • (2013) Blood , vol.122 , pp. 2433-2442
    • Katzerke, C.1    Madan, V.2    Gerloff, D.3    Brauer-Hartmann, D.4    Hartmann, J.U.5    Wurm, A.A.6
  • 17
    • 78650459322 scopus 로고    scopus 로고
    • C/EBPalpha regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations
    • Pulikkan JA, Peramangalam PS, Dengler V, Ho PA, Preudhomme C, Meshinchi S et al. C/EBPalpha regulated microRNA-34a targets E2F3 during granulopoiesis and is down-regulated in AML with CEBPA mutations. Blood 2010; 116: 5638-5649.
    • (2010) Blood , vol.116 , pp. 5638-5649
    • Pulikkan, J.A.1    Peramangalam, P.S.2    Dengler, V.3    Ho, P.A.4    Preudhomme, C.5    Meshinchi, S.6
  • 18
    • 84856758666 scopus 로고    scopus 로고
    • MicroRNAs in acute leukemia: From biological players to clinical contributors
    • Schotte D, Pieters R, Den Boer ML. MicroRNAs in acute leukemia: from biological players to clinical contributors. Leukemia 2012; 26: 1-12.
    • (2012) Leukemia , vol.26 , pp. 1-12
    • Schotte, D.1    Pieters, R.2    Den Boer, M.L.3
  • 20
    • 42449141513 scopus 로고    scopus 로고
    • MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia
    • Garzon R, Volinia S, Liu CG, Fernandez-Cymering C, Palumbo T, Pichiorri F et al. MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood 2008; 111: 3183-3189.
    • (2008) Blood , vol.111 , pp. 3183-3189
    • Garzon, R.1    Volinia, S.2    Liu, C.G.3    Fernandez-Cymering, C.4    Palumbo, T.5    Pichiorri, F.6
  • 21
    • 46749108531 scopus 로고    scopus 로고
    • MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia
    • Jongen-Lavrencic M, Sun SM, Dijkstra MK, Valk PJ, Lowenberg B. MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood 2008; 111: 5078-5085.
    • (2008) Blood , vol.111 , pp. 5078-5085
    • Jongen-Lavrencic, M.1    Sun, S.M.2    Dijkstra, M.K.3    Valk, P.J.4    Lowenberg, B.5
  • 22
    • 77951540421 scopus 로고    scopus 로고
    • Differential expression of specific microRNA and their targets in acute myeloid leukemia
    • Cammarata G, Augugliaro L, Salemi D, Agueli C, La Rosa M, Dagnino L et al. Differential expression of specific microRNA and their targets in acute myeloid leukemia. Am J Hematol 2010; 85: 331-339.
    • (2010) Am J Hematol , vol.85 , pp. 331-339
    • Cammarata, G.1    Augugliaro, L.2    Salemi, D.3    Agueli, C.4    La Rosa, M.5    Dagnino, L.6
  • 23
    • 56649123539 scopus 로고    scopus 로고
    • Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway
    • Gatto G, Rossi A, Rossi D, Kroening S, Bonatti S, Mallardo M. Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathway. Nucleic Acids Res 2008; 36: 6608-6619.
    • (2008) Nucleic Acids Res , vol.36 , pp. 6608-6619
    • Gatto, G.1    Rossi, A.2    Rossi, D.3    Kroening, S.4    Bonatti, S.5    Mallardo, M.6
  • 24
    • 55249124589 scopus 로고    scopus 로고
    • Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence
    • Lu F, Weidmer A, Liu CG, Volinia S, Croce CM, Lieberman PM. Epstein-Barr virus-induced miR-155 attenuates NF-kappaB signaling and stabilizes latent virus persistence. J Virol 2008; 82: 10436-10443.
    • (2008) J Virol , vol.82 , pp. 10436-10443
    • Lu, F.1    Weidmer, A.2    Liu, C.G.3    Volinia, S.4    Croce, C.M.5    Lieberman, P.M.6
  • 27
    • 26044481464 scopus 로고    scopus 로고
    • BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas
    • Kluiver J, Poppema S, de Jong D, Blokzijl T, Harms G, Jacobs S et al. BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomas. J Pathol 2005; 207: 243-249.
    • (2005) J Pathol , vol.207 , pp. 243-249
    • Kluiver, J.1    Poppema, S.2    De Jong, D.3    Blokzijl, T.4    Harms, G.5    Jacobs, S.6
  • 28
    • 49749107841 scopus 로고    scopus 로고
    • Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth
    • Wang X, Tang S, Le SY, Lu R, Rader JS, Meyers C et al. Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 2008; 3: e2557.
    • (2008) PLoS One , vol.3 , pp. e2557
    • Wang, X.1    Tang, S.2    Le, S.Y.3    Lu, R.4    Rader, J.S.5    Meyers, C.6
  • 32
    • 41149130219 scopus 로고    scopus 로고
    • Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder
    • O'Connell RM, Rao DS, Chaudhuri AA, Boldin MP, Taganov KD, Nicoll J et al. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J Exp Med 2008; 205: 585-594.
    • (2008) J Exp Med , vol.205 , pp. 585-594
    • O'Connell, R.M.1    Rao, D.S.2    Chaudhuri, A.A.3    Boldin, M.P.4    Taganov, K.D.5    Nicoll, J.6
  • 33
    • 84885424565 scopus 로고    scopus 로고
    • Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: MiR-155 upregulation independently identifies high-risk patients
    • Marcucci G, Maharry KS, Metzeler KH, Volinia S, Wu YZ, Mrozek K et al. Clinical role of microRNAs in cytogenetically normal acute myeloid leukemia: miR-155 upregulation independently identifies high-risk patients. J Clin Oncol 2013; 31: 2086-2093.
    • (2013) J Clin Oncol , vol.31 , pp. 2086-2093
    • Marcucci, G.1    Maharry, K.S.2    Metzeler, K.H.3    Volinia, S.4    Wu, Y.Z.5    Mrozek, K.6
  • 34
    • 0035478329 scopus 로고    scopus 로고
    • STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65
    • Kawashima T, Murata K, Akira S, Tonozuka Y, Minoshima Y, Feng S et al. STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappaB p65. J Immunol 2001; 167: 3652-3660.
    • (2001) J Immunol , vol.167 , pp. 3652-3660
    • Kawashima, T.1    Murata, K.2    Akira, S.3    Tonozuka, Y.4    Minoshima, Y.5    Feng, S.6
  • 35
    • 4444268818 scopus 로고    scopus 로고
    • Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation
    • Cui Y, Riedlinger G, Miyoshi K, Tang W, Li C, Deng CX et al. Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation. Mol Cell Biol 2004; 24: 8037-8047.
    • (2004) Mol Cell Biol , vol.24 , pp. 8037-8047
    • Cui, Y.1    Riedlinger, G.2    Miyoshi, K.3    Tang, W.4    Li, C.5    Deng, C.X.6
  • 36
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, Manley P, Fabbro D, Meyer T et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell 2002; 1: 433-443.
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3    Manley, P.4    Fabbro, D.5    Meyer, T.6
  • 37
    • 0037108298 scopus 로고    scopus 로고
    • SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
    • Yee KW, O'Farrell AM, Smolich BD, Cherrington JM, McMahon G, Wait CL et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood 2002; 100: 2941-2949.
    • (2002) Blood , vol.100 , pp. 2941-2949
    • Yee, K.W.1    O'Farrell, A.M.2    Smolich, B.D.3    Cherrington, J.M.4    McMahon, G.5    Wait, C.L.6
  • 38
    • 0037441745 scopus 로고    scopus 로고
    • The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3
    • Spiekermann K, Dirschinger RJ, Schwab R, Bagrintseva K, Faber F, Buske C et al. The protein tyrosine kinase inhibitor SU5614 inhibits FLT3 and induces growth arrest and apoptosis in AML-derived cell lines expressing a constitutively activated FLT3. Blood 2003; 101: 1494-1504.
    • (2003) Blood , vol.101 , pp. 1494-1504
    • Spiekermann, K.1    Dirschinger, R.J.2    Schwab, R.3    Bagrintseva, K.4    Faber, F.5    Buske, C.6
  • 39
    • 0036624916 scopus 로고    scopus 로고
    • A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
    • Levis M, Allebach J, Tse KF, Zheng R, Baldwin BR, Smith BD et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood 2002; 99: 3885-3891.
    • (2002) Blood , vol.99 , pp. 3885-3891
    • Levis, M.1    Allebach, J.2    Tse, K.F.3    Zheng, R.4    Baldwin, B.R.5    Smith, B.D.6
  • 40
    • 20444402664 scopus 로고    scopus 로고
    • FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model
    • Grundler R, Miething C, Thiede C, Peschel C, Duyster J. FLT3-ITD and tyrosine kinase domain mutants induce 2 distinct phenotypes in a murine bone marrow transplantation model. Blood 2005; 105: 4792-4799.
    • (2005) Blood , vol.105 , pp. 4792-4799
    • Grundler, R.1    Miething, C.2    Thiede, C.3    Peschel, C.4    Duyster, J.5
  • 41
    • 78751533109 scopus 로고    scopus 로고
    • NF-kappaB downregulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway
    • Thompson RC, Herscovitch M, Zhao I, Ford TJ, Gilmore TD. NF-kappaB downregulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway. J Biol Chem 2011; 286: 1675-1682.
    • (2011) J Biol Chem , vol.286 , pp. 1675-1682
    • Thompson, R.C.1    Herscovitch, M.2    Zhao, I.3    Ford, T.J.4    Gilmore, T.D.5
  • 42
    • 20544467182 scopus 로고    scopus 로고
    • Overexpression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6
    • Takahashi S, Harigae H, Ishii KK, Inomata M, Fujiwara T, Yokoyama H et al. Overexpression of Flt3 induces NF-kappaB pathway and increases the expression of IL-6. Leuk Res 2005; 29: 893-899.
    • (2005) Leuk Res , vol.29 , pp. 893-899
    • Takahashi, S.1    Harigae, H.2    Ishii, K.K.3    Inomata, M.4    Fujiwara, T.5    Yokoyama, H.6
  • 43
    • 0035886024 scopus 로고    scopus 로고
    • Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells
    • Guzman ML, Neering SJ, Upchurch D, Grimes B, Howard DS, Rizzieri DA et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood 2001; 98: 2301-2307.
    • (2001) Blood , vol.98 , pp. 2301-2307
    • Guzman, M.L.1    Neering, S.J.2    Upchurch, D.3    Grimes, B.4    Howard, D.S.5    Rizzieri, D.A.6
  • 44
    • 10744224210 scopus 로고    scopus 로고
    • Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia
    • Bueso-Ramos CE, Rocha FC, Shishodia S, Medeiros LJ, Kantarjian HM, Vadhan-Raj S et al. Expression of constitutively active nuclear-kappa B RelA transcription factor in blasts of acute myeloid leukemia. Hum Pathol 2004; 35: 246-253.
    • (2004) Hum Pathol , vol.35 , pp. 246-253
    • Bueso-Ramos, C.E.1    Rocha, F.C.2    Shishodia, S.3    Medeiros, L.J.4    Kantarjian, H.M.5    Vadhan-Raj, S.6
  • 45
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways
    • Grandage VL, Gale RE, Linch DC, Khwaja A. PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia 2005; 19: 586-594.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 46
    • 27544450742 scopus 로고    scopus 로고
    • Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation
    • Brandts CH, Sargin B, Rode M, Biermann C, Lindtner B, Schwable J et al. Constitutive activation of Akt by Flt3 internal tandem duplications is necessary for increased survival, proliferation, and myeloid transformation. Cancer Res 2005; 65: 9643-9650.
    • (2005) Cancer Res , vol.65 , pp. 9643-9650
    • Brandts, C.H.1    Sargin, B.2    Rode, M.3    Biermann, C.4    Lindtner, B.5    Schwable, J.6
  • 47
    • 49349094497 scopus 로고    scopus 로고
    • Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia
    • Grosjean-Raillard J, Ades L, Boehrer S, Tailler M, Fabre C, Braun T et al. Flt3 receptor inhibition reduces constitutive NFkappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Apoptosis 2008; 13: 1148-1161.
    • (2008) Apoptosis , vol.13 , pp. 1148-1161
    • Grosjean-Raillard, J.1    Ades, L.2    Boehrer, S.3    Tailler, M.4    Fabre, C.5    Braun, T.6
  • 48
    • 33847304124 scopus 로고    scopus 로고
    • CD34+ hematopoietic stem-progenitor cell microRNA expression and function: A circuit diagram of differentiation control
    • Georgantas III RW, Hildreth R, Morisot S, Alder J, Liu CG, Heimfeld S et al. CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control. Proc Natl Acad Sci USA 2007; 104: 2750-2755.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2750-2755
    • Georgantas, R.W.1    Hildreth, R.2    Morisot, S.3    Alder, J.4    Liu, C.G.5    Heimfeld, S.6
  • 49
    • 0031907329 scopus 로고    scopus 로고
    • Role of PU.1 in hematopoiesis
    • Fisher RC, Scott EW. Role of PU.1 in hematopoiesis. Stem Cells 1998; 16: 25-37.
    • (1998) Stem Cells , vol.16 , pp. 25-37
    • Fisher, R.C.1    Scott, E.W.2
  • 50
    • 0036771841 scopus 로고    scopus 로고
    • Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts
    • Baumgartner B, Weber M, Quirling M, Fischer C, Page S, Adam M et al. Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts. Leukemia 2002; 16: 2062-2071.
    • (2002) Leukemia , vol.16 , pp. 2062-2071
    • Baumgartner, B.1    Weber, M.2    Quirling, M.3    Fischer, C.4    Page, S.5    Adam, M.6
  • 52
    • 0037155133 scopus 로고    scopus 로고
    • Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappa B activation in murine proB cell line Ba/F3 cells
    • Nakamura T, Ouchida R, Kodama T, Kawashima T, Makino Y, Yoshikawa N et al. Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappa B activation in murine proB cell line Ba/F3 cells. J Biol Chem 2002; 277: 6254-6265.
    • (2002) J Biol Chem , vol.277 , pp. 6254-6265
    • Nakamura, T.1    Ouchida, R.2    Kodama, T.3    Kawashima, T.4    Makino, Y.5    Yoshikawa, N.6
  • 53
    • 70350087559 scopus 로고    scopus 로고
    • STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells
    • Nagy ZS, LeBaron MJ, Ross JA, Mitra A, Rui H, Kirken RA. STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells. Mol Cancer 2009; 8: 67.
    • (2009) Mol Cancer , vol.8 , pp. 67
    • Nagy, Z.S.1    LeBaron, M.J.2    Ross, J.A.3    Mitra, A.4    Rui, H.5    Kirken, R.A.6
  • 54
    • 67650227725 scopus 로고    scopus 로고
    • MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by downregulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN)
    • Martinez-Nunez RT, Louafi F, Friedmann PS, Sanchez-Elsner T. MicroRNA-155 modulates the pathogen binding ability of dendritic cells (DCs) by downregulation of DC-specific intercellular adhesion molecule-3 grabbing non-integrin (DC-SIGN). J Biol Chem 2009; 284: 16334-16342.
    • (2009) J Biol Chem , vol.284 , pp. 16334-16342
    • Martinez-Nunez, R.T.1    Louafi, F.2    Friedmann, P.S.3    Sanchez-Elsner, T.4
  • 55
    • 37049002638 scopus 로고    scopus 로고
    • microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells
    • Vigorito E, Perks KL, Abreu-Goodger C, Bunting S, Xiang Z, Kohlhaas S et al. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity 2007; 27: 847-859.
    • (2007) Immunity , vol.27 , pp. 847-859
    • Vigorito, E.1    Perks, K.L.2    Abreu-Goodger, C.3    Bunting, S.4    Xiang, Z.5    Kohlhaas, S.6
  • 56
    • 31944450531 scopus 로고    scopus 로고
    • Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia
    • Metcalf D, Dakic A, Mifsud S, Di Rago L, Wu L, Nutt S. Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia. Proc Natl Acad Sci USA 2006; 103: 1486-1491.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1486-1491
    • Metcalf, D.1    Dakic, A.2    Mifsud, S.3    Di Rago, L.4    Wu, L.5    Nutt, S.6
  • 57
    • 2642519463 scopus 로고    scopus 로고
    • Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1
    • Rosenbauer F, Wagner K, Kutok JL, Iwasaki H, Le Beau MM, Okuno Y et al. Acute myeloid leukemia induced by graded reduction of a lineage-specific transcription factor, PU.1. Nat Genet 2004; 36: 624-630.
    • (2004) Nat Genet , vol.36 , pp. 624-630
    • Rosenbauer, F.1    Wagner, K.2    Kutok, J.L.3    Iwasaki, H.4    Le Beau, M.M.5    Okuno, Y.6
  • 59
  • 60
    • 70450267416 scopus 로고    scopus 로고
    • PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL
    • Ueno S, Tatetsu H, Hata H, Iino T, Niiro H, Akashi K et al. PU.1 induces apoptosis in myeloma cells through direct transactivation of TRAIL. Oncogene 2009; 28: 4116-4125.
    • (2009) Oncogene , vol.28 , pp. 4116-4125
    • Ueno, S.1    Tatetsu, H.2    Hata, H.3    Iino, T.4    Niiro, H.5    Akashi, K.6
  • 61


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