Altered lymphopoiesis and immunodeficiency in miR-142 null mice

Blood

Volumn 125, Issue 24, 2015, Pages 3720-3730

  Kramer, Nicholas J ^a   Wang, Wei Le ^a   Reyes, Estefany Y ^a   Kumar, Bijender ^a   Chen, Ching Cheng ^a   Ramakrishna, Chandran ^a   Cantin, Edouard M ^a   Vonderfecht, Steven L ^a   Taganov, Konstantin D ^b   Chau, Nelson ^b   Boldin, Mark P ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b REGULUS THERAPEUTICS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; B CELL ACTIVATING FACTOR RECEPTOR; MICRORNA; MICRORNA 142; UNCLASSIFIED DRUG; MIRN142 MICRORNA, MOUSE; TNFRSF13C PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; GENE DOSAGE; GENE EXPRESSION PROFILING; GENE FUNCTION; GENE TARGETING; HEMATOPOIESIS; HOMEOSTASIS; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IMMUNOGLOBULIN DEFICIENCY; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; LYMPHOPOIESIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS; WILD TYPE MOUSE; ANIMAL; C57BL MOUSE; CELLULAR IMMUNITY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE INACTIVATION; GENETICS; HUMORAL IMMUNITY; IMMUNOLOGY; LYMPHOPROLIFERATIVE DISEASE; METABOLISM; PATHOLOGY;

ANIMALS; B-CELL ACTIVATION FACTOR RECEPTOR; B-LYMPHOCYTES; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE KNOCKOUT TECHNIQUES; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; IMMUNOLOGIC DEFICIENCY SYNDROMES; IMMUNOPROLIFERATIVE DISORDERS; LYMPHOPOIESIS; MALE; MICE; MICE, INBRED C57BL; MICRORNAS;

EID: 84931281751     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-10-603951     Document Type: Article

References (38)

1. Xiao C, Rajewsky K. MicroRNA control in the immune system: basic principles. Cell. 2009; 136(1):26-36.
2. Baltimore D, Boldin MP, O'Connell RM, Rao DS, Taganov KD. MicroRNAs: new regulators of immune cell development and function. Nat Immunol. 2008;9(8):839-845.
3. Belver L, de Yébenes VG, Ramiro AR. MicroRNAs prevent the generation of autoreactive antibodies. Immunity. 2010;33(5):713-722.
4. Xu S, Guo K, Zeng Q, Huo J, Lam KP. The RNase III enzyme Dicer is essential for germinal center B-cell formation. Blood. 2012;119(3):767-776.
5. Muljo SA, Ansel KM, Kanellopoulou C, Livingston DM, Rao A, Rajewsky K. Aberrant T cell differentiation in the absence of Dicer. J Exp Med. 2005;202(2):261-269.
6. Monticelli S, Ansel KM, Xiao C, et al. MicroRNA profiling of the murine hematopoietic system. Genome Biol. 2005;6(8):R71.
7. Chen CZ, Li L, Lodish HF, Bartel DP. MicroRNAs modulate hematopoietic lineage differentiation. Science. 2004;303(5654):83-86.
8. Landgraf P, Rusu M, Sheridan R, et al. A mammalian microRNA expression atlas based on small RNA library sequencing. Cell. 2007;129(7):1401-1414.
9. Fan HB, Liu YJ, Wang L, et al. miR-142-3p acts as an essential modulator of neutrophil development in zebrafish. Blood. 2014;124(8):1320-1330.
10. Lu X, Li X, He Q, et al. miR-142-3p regulates the formation and differentiation of hematopoietic stem cells in vertebrates. Cell Res. 2013;23(12): 1356-1368.
11. Nishiyama T, Kaneda R, Ono T, et al. miR-142-3p is essential for hematopoiesis and affects cardiac cell fate in zebrafish. Biochem Biophys Res Commun. 2012;425(4):755-761.
12. Chapnik E, Rivkin N, Mildner A, et al. miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis. Elife. 2014;3:e01964.
13. Mildner A, Chapnik E, Manor O, et al. Mononuclear phagocyte miRNome analysis identifies miR-142 as critical regulator of murine dendritic cell homeostasis. Blood. 2013;121(6):1016-1027.
14. Yamada Y, Kosaka K, Miyazawa T, Kurata-Miura K, Yoshida T. miR-142-3p enhances FcεRI-mediated degranulation in mast cells. Biochem Biophys Res Commun. 2014;443(3):980-986.
15. Allman D, Pillai S. Peripheral B cell subsets. Curr Opin Immunol. 2008;20(2):149-157.
16. Xiao C, Calado DP, Galler G, et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell. 2007;131(1):146-159.
17. Leadbetter EA, Brigl M, Illarionov P, et al. NK T cells provide lipid antigen-specific cognate help for B cells. Proc Natl Acad Sci USA. 2008;105(24):8339-8344.
18. Fairfax KA, Kallies A, Nutt SL, Tarlinton DM. Plasma cell development: from B-cell subsets to long-term survival niches. Semin Immunol. 2008;20(1):49-58.
19. Liu T, Khanna KM, Chen X, Fink DJ, Hendricks RL. CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. J Exp Med. 2000;191(9):1459-1466.
20. Banerjee K, Biswas PS, Kumaraguru U, Schoenberger SP, Rouse BT. Protective and pathological roles of virus-specific and bystander CD8+ T cells in herpetic stromal keratitis. J Immunol. 2004;173(12):7575-7583.
21. Lang A, Nikolich-Zugich J. Development and migration of protective CD8+ T cells into the nervous system following ocular herpes simplex virus-1 infection. J Immunol. 2005;174(5):2919-2925.
22. Ghiasi H, Cai S, Perng GC, Nesburn AB, Wechsler SL. Both CD4+ and CD8+ T cells are involved in protection against HSV-1 induced corneal scarring. Br J Ophthalmol. 2000;84(4):408-412.
23. Bartonicek N, Enright AJ. SylArray: a web server for automated detection of miRNA effects from expression data. Bioinformatics. 2010;26(22):2900-2901.
24. Inui M, Martello G, Piccolo S. MicroRNA control of signal transduction. Nat Rev Mol Cell Biol. 2010;11(4):252-263.
25. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15-20.
26. Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, Bartel DP. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell. 2007;27(1):91-105.
27. Schneider P. The role of APRIL and BAFF in lymphocyte activation. Curr Opin Immunol. 2005;17(3):282-289.
28. Mackay F, Schneider P. Cracking the BAFF code. Nat Rev Immunol. 2009;9(7):491-502.
29. Rickert RC, Jellusova J, Miletic AV. Signaling by the tumor necrosis factor receptor superfamily in B-cell biology and disease. Immunol Rev. 2011;244(1):115-133.
30. Schweighoffer E, Vanes L, Nys J, et al. The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway. Immunity. 2013;38(3):475-488.
31. Thompson JS, Bixler SA, Qian F, et al. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science. 2001;293(5537):2108-2111.
32. Mayne CG, Amanna IJ, Nashold FE, Hayes CE. Systemic autoimmunity in BAFF-R-mutant A/WySnJ strain mice. Eur J Immunol. 2008;38(2):587-598.
33. Boldin MP, Baltimore D. MicroRNAs, new effectors and regulators of NF-κB. Immunol Rev. 2012;246(1):205-220.
34. Ghiasi H, Perng G, Nesburn AB, Wechsler SL. Either a CD4(+)or CD8(+)T cell function is sufficient for clearance of infectious virus from trigeminal ganglia and establishment of herpes simplex virus type 1 latency in mice. Microb Pathog. 1999;27(6):387-394.
35. Chiang HR, Schoenfeld LW, Ruby JG, et al. Mammalian microRNAs: experimental evaluation of novel and previously annotated genes. Genes Dev. 2010;24(10):992-1009.
36. Mackay F, Woodcock SA, Lawton P, et al. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med. 1999;190(11):1697-1710.
37. Fischer A. Human primary immunodeficiency diseases. Immunity. 2007;27(6):835-845.
38. Kwanhian W, Lenze D, Alles J, et al. MicroRNA-142 is mutated in about 20% of diffuse large B-cell lymphoma. Cancer Med. 2012;1(2):141-155.