Switching from repression to activation: MicroRNAs can up-regulate translation

Science

Volumn 318, Issue 5858, 2007, Pages 1931-1934

  Vasudevan, Shobha ^a   Tong, Yingchun ^a   Steitz, Joan A ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGONAUTE PROTEIN; FRAGILE X MENTAL RETARDATION PROTEIN; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; MESSENGER RNA; MICRORNA; RIBONUCLEOPROTEIN; TUMOR NECROSIS FACTOR ALPHA;

CYTOGENETICS; GENE EXPRESSION; INHIBITION; PROTEIN; RNA;

ANIMAL CELL; ARTICLE; CELL CYCLE ARREST; CONTROLLED STUDY; GENE ACTIVATION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE REPRESSION; GENE SWITCHING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; UPREGULATION;

3' UNTRANSLATED REGIONS; BASE PAIRING; CELL CYCLE; CELL LINE; CELL PROLIFERATION; COMPUTATIONAL BIOLOGY; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION; HELA CELLS; HMGA2 PROTEIN; HUMANS; INTERPHASE; MICRORNAS; PROTEIN BIOSYNTHESIS; RIBONUCLEOPROTEINS; RNA, MESSENGER; RNA-BINDING PROTEINS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 36749026906     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1149460     Document Type: Article

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15. This work was supported by NIH grants to J.A.S. and by a Cancer Research Institute postdoctoral fellowship to S.V. J.A.S is an investigator of HHMI. We are grateful to G. Dreyfuss and G. Hannon for sharing reagents. We thank E. Ullu, D. Black, A. Alexandrov, N. Kolev, A. Nag, and K. Tycowski for critical commentary and A. Miccinello for editorial assistance.