Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 21, 2010, Pages 9783-9788

  Dickstein, Jerome ^a   Senyuk, Vitalyi ^b   Premanand, Kavitha ^b   Laricchia Robbio, Leopoldo ^b   Xu, Peng ^b   Cattaneo, Francesca ^b   Fazzina, Raffaella ^c   Nucifora, Giuseppina ^b  

^a UNIVERSITY OF CHICAGO   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; PROTEIN EVI1; STRUCTURAL PROTEIN; TRANSCRIPTION FACTOR GATA 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CELL DIVISION; CELL RENEWAL; DNA METHYLATION; DNA REPLICATION; ERYTHROPOIESIS; GENE SILENCING; HEMATOPOIETIC STEM CELL; MEGAKARYOPOIESIS; MOUSE; MYELODYSPLASTIC SYNDROME; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL;

ANIMALS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; CPG ISLANDS; DNA REPLICATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; METHYLATION; MICE; MICRORNAS; MOLECULAR SEQUENCE DATA; MUTATION; MYELODYSPLASTIC SYNDROMES; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENES; RNA INTERFERENCE; TRANSCRIPTION FACTORS;

MURINAE; MUS;

EID: 77953087435     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004297107     Document Type: Article

References (22)

1. Nimer SD (2008) Myelodysplastic syndromes. Blood 111:4841-4851.
2. Buonamici S, et al. (2004) EVI1 induces myelodysplastic syndrome in mice. J Clin Invest 114:713-719.
3. Cantor AB, Orkin SH (2002) Transcriptional regulation of erythropoiesis: An affair involving multiple partners. Oncogene 21:3368-3376.
4. Laricchia-Robbio L, et al. (2006) Point mutations in two EVI1 Zn fingers abolish EVI1-GATA1 interaction and allow erythroid differentiation of murine bone marrow cells. Mol Cell Biol 26:7658-7666.
5. Heaney ML, Golde DW (1999) Myelodysplasia. N Engl J Med 340:1649-1660.
6. Kilbey A, Stephens V, Bartholomew C (1999) Loss of cell cycle control by deregulation of cyclin-dependent kinase 2 kinase activity in Evi-1 transformed fibroblasts. Cell Growth Differ 10:601-610. (Pubitemid 29455724)
7. Lessard J, Sauvageau G (2003) Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells. Nature 423:255-260.
8. Tsai FY, et al. (1994) An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature 371:221-226.
9. Abramovich C, Pineault N, Ohta H, Humphries RK (2005) Hox genes: From leukemia to hematopoietic stem cell expansion. Ann NY Acad Sci 1044:109-116.
10. Zeng H, Yücel R, Kosan C, Klein-Hitpass L, Möröy T (2004) Transcription factor Gfi1 regulates self-renewal and engraftment of hematopoietic stem cells. EMBO J 23:4116-4125.
11. Dirks P (2007) Bmi1 and cell of origin determinants of brain tumor phenotype. Cancer Cell 12:295-297.
12. Sangiorgi E, Capecchi MR (2008) Bmi1 is expressed in vivo in intestinal stem cells. Nat Genet 40:915-920.
13. Dovey JS, Zacharek SJ, Kim CF, Lees JA (2008) Bmi1 is critical for lung tumorigenesis and bronchioalveolar stem cell expansion. Proc Natl Acad Sci USA 105:11857-11862.
14. Silber J, et al. (2008) miR-124 and miR-137 inhibit proliferation of glioblastoma multiformecells and induce differentiation of brain tumor stemcells. BMC Med 6:14-18.
15. Furuta M, et al. (October 20, 2009) miR-124 and miR-203 are epigenetically silenced tumor-suppressive microRNAs in hepatocellular carcinoma. Carcinogenesis, 10.1093/carcin/bgp250.
16. Morishita K, Parganas E, Matsugi T, Ihle JN (1992) Expression of the Evi-1 zinc finger gene in 32Dc13 myeloid cells blocks granulocytic differentiation in response to granulocyte colony-stimulating factor. Mol Cell Biol 12:183-189.
17. Laricchia-Robbio L, Nucifora G (2008) Significant increase of self-renewal in hematopoietic cells after forced expression of EVI1. Blood Cells Mol Dis 40:141-147.
18. Hoyt PR, et al. (1997) The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Mech Dev 65:55-70.
19. Kustikova O, et al. (2005) Clonal dominance of hematopoietic stem cells triggered by retroviral gene marking. Science 308:1171-1174.
20. Calmels B, et al. (2005) Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. Blood 106:2530-2533.
21. Ott MG, et al. (2006) Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS1-EVI1, PRDM16 or SETBP1. Nat Med 12:401-409.
22. Stein S, et al. (2010) Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med 16:198-204.