MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors

Developmental Cell

Volumn 14, Issue 6, 2008, Pages 843-853

  Lu, Jun ^a,b   Guo, Shangqin ^b,d   Ebert, Benjamin L ^a,b,f   Zhang, Hao ^a   Peng, Xiao ^a   Bosco, Jocelyn ^a   Pretz, Jennifer ^a   Schlanger, Rita ^b,d   Wang, Judy Y ^a   Mak, Raymond H ^a   Dombkowski, David M ^c   Preffer, Frederic I ^c   Scadden, David T ^b,d   Golub, Todd R ^a,b,e  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HARVARD STEM CELL INSTITUTE   (United States)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^f BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

DEVBIO; RNA

Indexed keywords

CD123 ANTIGEN; CD3 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD45 ANTIGEN; CD45RA ANTIGEN; CD61 ANTIGEN; CD71 ANTIGEN; FIBRINOGEN RECEPTOR; MICRORNA; PROTEIN MYB;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FATE; CELL LINEAGE; CONTROLLED STUDY; DEVELOPMENTAL BIOLOGY; ERYTHROCYTE; ERYTHROID CELL; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; HEMATOPOIESIS; HUMAN; HUMAN CELL; HYPOTHESIS; IN VITRO STUDY; IN VIVO STUDY; MAMMAL; MEGAKARYOCYTE; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; REGENERATIVE ABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEM CELL;

ANIMALS; ANTIGENS, CD34; BONE MARROW CELLS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; ERYTHROID CELLS; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; GENES, REPORTER; HEMATOPOIETIC STEM CELLS; HUMANS; INTEGRIN BETA3; K562 CELLS; MEGAKARYOCYTES; MICE; MICE, INBRED C57BL; MICRORNAS; MODELS, BIOLOGICAL; PLATELET MEMBRANE GLYCOPROTEIN IIB; PROTO-ONCOGENE PROTEINS C-MYB; THROMBOPOIETIN;

MAMMALIA;

EID: 44449108570     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2008.03.012     Document Type: Article

References (38)

1. Akashi K., Traver D., Miyamoto T., and Weissman I.L. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 404 (2000) 193-197
2. Ambros V. The functions of animal microRNAs. Nature 431 (2004) 350-355
3. Bartel D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116 (2004) 281-297
4. Cantor A.B., and Orkin S.H. Transcriptional regulation of erythropoiesis: an affair involving multiple partners. Oncogene 21 (2002) 3368-3376
5. Chang T.C., Yu D., Lee Y.S., Wentzel E.A., Arking D.E., West K.M., Dang C.V., Thomas-Tikhonenko A., and Mendell J.T. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat. Genet. 40 (2008) 43-50
6. Chen C.Z., Li L., Lodish H.F., and Bartel D.P. MicroRNAs modulate hematopoietic lineage differentiation. Science 303 (2004) 83-86
7. Ebert B.L., Lee M.M., Pretz J.L., Subramanian A., Mak R., Golub T.R., and Sieff C.A. An RNA interference model of RPS19 deficiency in Diamond-Blackfan anemia recapitulates defective hematopoiesis and rescue by dexamethasone: identification of dexamethasone-responsive genes by microarray. Blood 105 (2005) 4620-4626
8. Emambokus N., Vegiopoulos A., Harman B., Jenkinson E., Anderson G., and Frampton J. Progression through key stages of haemopoiesis is dependent on distinct threshold levels of c-Myb. EMBO J. 22 (2003) 4478-4488
9. Fazi F., Rosa A., Fatica A., Gelmetti V., De Marchis M.L., Nervi C., and Bozzoni I. A minicircuitry comprised of microRNA-223 and transcription factors NFI-A and C/EBPα regulates human granulopoiesis. Cell 123 (2005) 819-831
10. Felli N., Fontana L., Pelosi E., Botta R., Bonci D., Facchiano F., Liuzzi F., Lulli V., Morsilli O., Santoro S., et al. MicroRNAs 221 and 222 inhibit normal erythropoiesis and erythroleukemic cell growth via kit receptor down-modulation. Proc. Natl. Acad. Sci. USA 102 (2005) 18081-18086
11. Fontana L., Pelosi E., Greco P., Racanicchi S., Testa U., Liuzzi F., Croce C.M., Brunetti E., Grignani F., and Peschle C. MicroRNAs 17-5p-20a-106a control monocytopoiesis through AML1 targeting and M-CSF receptor upregulation. Nat. Cell Biol. 9 (2007) 775-787
12. Friedman A.D. Transcriptional regulation of granulocyte and monocyte development. Oncogene 21 (2002) 3377-3390
13. Fukao T., Fukuda Y., Kiga K., Sharif J., Hino K., Enomoto Y., Kawamura A., Nakamura K., Takeuchi T., and Tanabe M. An evolutionarily conserved mechanism for microRNA-223 expression revealed by microRNA gene profiling. Cell 129 (2007) 617-631
14. Griffiths-Jones S., Grocock R.J., van Dongen S., Bateman A., and Enright A.J. miRBase: microRNA sequences, targets and gene nomenclature. Nucleic Acids Res. 34 (2006) D140-D144
15. Kasper L.H., Boussouar F., Ney P.A., Jackson C.W., Rehg J., van Deursen J.M., and Brindle P.K. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419 (2002) 738-743
16. Krek A., Grun D., Poy M.N., Wolf R., Rosenberg L., Epstein E.J., MacMenamin P., da Piedade I., Gunsalus K.C., Stoffel M., et al. Combinatorial microRNA target predictions. Nat. Genet. 37 (2005) 495-500
17. Krutzfeldt J., Rajewsky N., Braich R., Rajeev K.G., Tuschl T., Manoharan M., and Stoffel M. Silencing of microRNAs in vivo with 'antagomirs'. Nature 438 (2005) 685-689
18. Leverson J.D., Koskinen P.J., Orrico F.C., Rainio E.M., Jalkanen K.J., Dash A.B., Eisenman R.N., and Ness S.A. Pim-1 kinase and p100 cooperate to enhance c-Myb activity. Mol. Cell 2 (1998) 417-425
19. Lewis B.P., Burge C.B., and Bartel D.P. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120 (2005) 15-20
20. Li Y., Wang F., Lee J.A., and Gao F.B. MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev. 20 (2006) 2793-2805
21. Lu J., Pazin M.J., and Ravid K. Properties of ets-1 binding to chromatin and its effect on platelet factor 4 gene expression. Mol. Cell. Biol. 24 (2004) 428-441
22. Lu J., Getz G., Miska E.A., Alvarez-Saavedra E., Lamb J., Peck D., Sweet-Cordero A., Ebert B.L., Mak R.H., Ferrando A.A., et al. MicroRNA expression profiles classify human cancers. Nature 435 (2005) 834-838
23. Mucenski M.L., McLain K., Kier A.B., Swerdlow S.H., Schreiner C.M., Miller T.A., Pietryga D.W., Scott Jr. W.J., and Potter S.S. A functional c-myb gene is required for normal murine fetal hepatic hematopoiesis. Cell 65 (1991) 677-689
24. Mukai H.Y., Motohashi H., Ohneda O., Suzuki N., Nagano M., and Yamamoto M. Transgene insertion in proximity to the c-myb gene disrupts erythroid-megakaryocytic lineage bifurcation. Mol. Cell. Biol. 26 (2006) 7953-7965
25. Ramsay R.G., Barton A.L., and Gonda T.J. Targeting c-Myb expression in human disease. Expert Opin. Ther. Targets 7 (2003) 235-248
26. Ravid K., Beeler D.L., Rabin M.S., Ruley H.E., and Rosenberg R.D. Selective targeting of gene products with the megakaryocyte platelet factor 4 promoter. Proc. Natl. Acad. Sci. USA 88 (1991) 1521-1525
27. Reich M., Liefeld T., Gould J., Lerner J., Tamayo P., and Mesirov J.P. GenePattern 2.0. Nat. Genet. 38 (2006) 500-501
28. Sandberg M.L., Sutton S.E., Pletcher M.T., Wiltshire T., Tarantino L.M., Hogenesch J.B., and Cooke M.P. c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation. Dev. Cell 8 (2005) 153-166
29. Socolovsky M., Nam H., Fleming M.D., Haase V.H., Brugnara C., and Lodish H.F. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood 98 (2001) 3261-3273
30. Stier S., Cheng T., Dombkowski D., Carlesso N., and Scadden D.T. Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome. Blood 99 (2002) 2369-2378
31. Thomson J.M., Newman M., Parker J.S., Morin-Kensicki E.M., Wright T., and Hammond S.M. Extensive post-transcriptional regulation of microRNAs and its implications for cancer. Genes Dev. 20 (2006) 2202-2207
32. Xiao C., Calado D.P., Galler G., Thai T.H., Patterson H.C., Wang J., Rajewsky N., Bender T.P., and Rajewsky K. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131 (2007) 146-159
33. Xie X., Lu J., Kulbokas E.J., Golub T.R., Mootha V., Lindblad-Toh K., Lander E.S., and Kellis M. Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals. Nature 434 (2005) 338-345
34. Ye M., and Graf T. Early decisions in lymphoid development. Curr. Opin. Immunol. 19 (2007) 123-128
35. Zhan M., Miller C.P., Papayannopoulou T., Stamatoyannopoulos G., and Song C.Z. MicroRNA expression dynamics during murine and human erythroid differentiation. Exp. Hematol. 35 (2007) 1015-1025
36. Zheng W., and Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997) 587-596
37. Zhou B., Wang S., Mayr C., Bartel D.P., and Lodish H.F. miR-150, a microRNA expressed in mature B and T cells, blocks early B cell development when expressed prematurely. Proc. Natl. Acad. Sci. USA. 104 (2007) 7080-7085
38. Zhu J., and Emerson S.G. Hematopoietic cytokines, transcription factors and lineage commitment. Oncogene 21 (2002) 3295-3313