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Volumn 125, Issue 14, 2015, Pages 2206-2216

MiR-29a maintains mouse hematopoietic stem cell self-renewal by regulating Dnmt3a

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3A; MICRORNA 29A; MICRORNA 29B; MICRORNA 29B1; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; DNA (CYTOSINE 5) METHYLTRANSFERASE; MESSENGER RNA; MICRORNA; MIRN29 MICRORNA, MOUSE;

EID: 84926674795     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-06-585273     Document Type: Article
Times cited : (67)

References (46)
  • 1
    • 33746617272 scopus 로고    scopus 로고
    • Hematopoietic stem cells: The paradigmatic tissue-specific stem cell
    • Bryder D, Rossi DJ, Weissman IL. Hematopoietic stem cells: the paradigmatic tissue-specific stem cell. Am J Pathol. 2006;169(2):338-346.
    • (2006) Am J Pathol. , vol.169 , Issue.2 , pp. 338-346
    • Bryder, D.1    Rossi, D.J.2    Weissman, I.L.3
  • 2
    • 84862532139 scopus 로고    scopus 로고
    • Hematopoietic stem cell heterogeneity takes center stage
    • Copley MR, Beer PA, Eaves CJ. Hematopoietic stem cell heterogeneity takes center stage. Cell Stem Cell. 2012;10(6):690-697.
    • (2012) Cell Stem Cell. , vol.10 , Issue.6 , pp. 690-697
    • Copley, M.R.1    Beer, P.A.2    Eaves, C.J.3
  • 3
    • 84868374023 scopus 로고    scopus 로고
    • The transcriptional landscape of hematopoietic stem cell ontogeny
    • McKinney-Freeman S, Cahan P, Li H, et al. The transcriptional landscape of hematopoietic stem cell ontogeny. Cell Stem Cell. 2012;11(5): 701-714.
    • (2012) Cell Stem Cell. , vol.11 , Issue.5 , pp. 701-714
    • McKinney-Freeman, S.1    Cahan, P.2    Li, H.3
  • 4
    • 20044363097 scopus 로고    scopus 로고
    • Gene expression profile of murine long-term reconstituting vs. Short-term reconstituting hematopoietic stem cells
    • Zhong JF, Zhao Y, Sutton S, et al. Gene expression profile of murine long-term reconstituting vs. short-term reconstituting hematopoietic stem cells. Proc Natl Acad Sci USA. 2005;102(7):2448-2453.
    • (2005) Proc Natl Acad Sci USA. , vol.102 , Issue.7 , pp. 2448-2453
    • Zhong, J.F.1    Zhao, Y.2    Sutton, S.3
  • 5
    • 61849137222 scopus 로고    scopus 로고
    • Many roads to maturity: MicroRNA biogenesis pathways and their regulation
    • Winter J, Jung S, Keller S, Gregory RI, Diederichs S. Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol. 2009; 11(3):228-234.
    • (2009) Nat Cell Biol. , vol.11 , Issue.3 , pp. 228-234
    • Winter, J.1    Jung, S.2    Keller, S.3    Gregory, R.I.4    Diederichs, S.5
  • 6
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell. 2009;136(2):215-233.
    • (2009) Cell. , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 7
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • Friedman RC, Farh KK-H, Burge CB, Bartel DP. Most mammalian mRNAs are conserved targets of microRNAs. Genome Res. 2009;19(1):92-105.
    • (2009) Genome Res. , vol.19 , Issue.1 , pp. 92-105
    • Friedman, R.C.1    Kk-H, F.2    Burge, C.B.3    Bartel, D.P.4
  • 8
    • 79955570371 scopus 로고    scopus 로고
    • MicroRNA programs in normal and aberrant stem and progenitor cells
    • Arnold CP, Tan R, Zhou B, et al. MicroRNA programs in normal and aberrant stem and progenitor cells. Genome Res. 2011;21(5): 798-810.
    • (2011) Genome Res. , vol.21 , Issue.5 , pp. 798-810
    • Arnold, C.P.1    Tan, R.2    Zhou, B.3
  • 9
    • 77949518018 scopus 로고    scopus 로고
    • MicroRNA- 29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia
    • Han Y-C, Park CY, Bhagat G, et al. microRNA- 29a induces aberrant self-renewal capacity in hematopoietic progenitors, biased myeloid development, and acute myeloid leukemia. J Exp Med. 2010;207(3):475-489.
    • (2010) J Exp Med. , vol.207 , Issue.3 , pp. 475-489
    • Han, Y.-C.1    Park, C.Y.2    Bhagat, G.3
  • 10
    • 77957252821 scopus 로고    scopus 로고
    • Comprehensive microRNA expression profiling of the hematopoietic hierarchy
    • Petriv OI, Kuchenbauer F, Delaney AD, et al. Comprehensive microRNA expression profiling of the hematopoietic hierarchy. Proc Natl Acad Sci USA. 2010;107(35):15443-15448.
    • (2010) Proc Natl Acad Sci USA. , vol.107 , Issue.35 , pp. 15443-15448
    • Petriv, O.I.1    Kuchenbauer, F.2    Delaney, A.D.3
  • 11
    • 78751557893 scopus 로고    scopus 로고
    • Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations
    • Starczynowski DT, Morin R, McPherson A, et al. Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations. Blood. 2011;117(2):595-607.
    • (2011) Blood. , vol.117 , Issue.2 , pp. 595-607
    • Starczynowski, D.T.1    Morin, R.2    McPherson, A.3
  • 12
    • 77956270732 scopus 로고    scopus 로고
    • MicroRNA miR- 125a controls hematopoietic stem cell number
    • Guo S, Lu J, Schlanger R, et al. MicroRNA miR- 125a controls hematopoietic stem cell number. Proc Natl Acad Sci USA. 2010;107(32): 14229-14234.
    • (2010) Proc Natl Acad Sci USA. , vol.107 , Issue.32 , pp. 14229-14234
    • Guo, S.1    Lu, J.2    Schlanger, R.3
  • 13
    • 84898887673 scopus 로고    scopus 로고
    • MiR- 99a/100;125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFb and Wnt signaling
    • Emmrich S, Rasche M, Schöning J, et al. miR- 99a/100;125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGFb and Wnt signaling. Genes Dev. 2014;28(8):858-874.
    • (2014) Genes Dev. , vol.28 , Issue.8 , pp. 858-874
    • Emmrich, S.1    Rasche, M.2    Schöning, J.3
  • 14
    • 78650722292 scopus 로고    scopus 로고
    • MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets
    • Ooi AGL, Sahoo D, Adorno M, Wang Y, Weissman IL, Park CY. MicroRNA-125b expands hematopoietic stem cells and enriches for the lymphoid-balanced and lymphoid-biased subsets. Proc Natl Acad Sci USA. 2010;107(50): 21505-21510.
    • (2010) Proc Natl Acad Sci USA. , vol.107 , Issue.50 , pp. 21505-21510
    • Ooi, A.G.L.1    Sahoo, D.2    Adorno, M.3    Wang, Y.4    Weissman, I.L.5    Park, C.Y.6
  • 15
    • 84870894496 scopus 로고    scopus 로고
    • Attenuation of miR-126 activity expands HSC in vivo without exhaustion
    • Lechman ER, Gentner B, van Galen P, et al. Attenuation of miR-126 activity expands HSC in vivo without exhaustion. Cell Stem Cell. 2012; 11(6):799-811.
    • (2012) Cell Stem Cell. , vol.11 , Issue.6 , pp. 799-811
    • Lechman, E.R.1    Gentner, B.2    Van Galen, P.3
  • 16
    • 84879060116 scopus 로고    scopus 로고
    • MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice
    • Zhao JL, Rao DS, O'Connell RM, Garcia-Flores Y, Baltimore D. MicroRNA-146a acts as a guardian of the quality and longevity of hematopoietic stem cells in mice. eLife. 2013;2: e00537.
    • (2013) ELife. , vol.2 , pp. e00537
    • Zhao, J.L.1    Rao, D.S.2    O'Connell, R.M.3    Garcia-Flores, Y.4    Baltimore, D.5
  • 17
  • 18
    • 80052033649 scopus 로고    scopus 로고
    • The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-g
    • Ma F, Xu S, Liu X, et al. The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-g. Nat Immunol. 2011;12(9):861-869.
    • (2011) Nat Immunol. , vol.12 , Issue.9 , pp. 861-869
    • Ma, F.1    Xu, S.2    Liu, X.3
  • 19
    • 84855931651 scopus 로고    scopus 로고
    • The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-A receptor
    • Papadopoulou AS, Dooley J, Linterman MA, et al. The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-a receptor. Nat Immunol. 2012;13(2): 181-187.
    • (2012) Nat Immunol. , vol.13 , Issue.2 , pp. 181-187
    • Papadopoulou, A.S.1    Dooley, J.2    Linterman, M.A.3
  • 20
    • 84872038076 scopus 로고    scopus 로고
    • MicroRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming
    • Guo X, Liu Q, Wang G, et al. microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming. Cell Res. 2013; 23(1):142-156.
    • (2013) Cell Res. , vol.23 , Issue.1 , pp. 142-156
    • Guo, X.1    Liu, Q.2    Wang, G.3
  • 21
    • 77954647669 scopus 로고    scopus 로고
    • The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML
    • Eyholzer M, Schmid S, Wilkens L, Mueller BU, Pabst T. The tumour-suppressive miR-29a/b1 cluster is regulated by CEBPA and blocked in human AML. Br J Cancer. 2010;103(2):275-284.
    • (2010) Br J Cancer. , vol.103 , Issue.2 , pp. 275-284
    • Eyholzer, M.1    Schmid, S.2    Wilkens, L.3    Mueller, B.U.4    Pabst, T.5
  • 22
    • 63349102720 scopus 로고    scopus 로고
    • In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood
    • Park CY, Majeti R, Weissman IL. In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood. Nat Protoc. 2008;3(12):1932-1940.
    • (2008) Nat Protoc. , vol.3 , Issue.12 , pp. 1932-1940
    • Park, C.Y.1    Majeti, R.2    Weissman, I.L.3
  • 23
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell. 2005;120(1):15-20.
    • (2005) Cell. , vol.120 , Issue.1 , pp. 15-20
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 25
    • 0034624828 scopus 로고    scopus 로고
    • A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
    • Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000; 404(6774):193-197.
    • (2000) Nature. , vol.404 , Issue.6774 , pp. 193-197
    • Akashi, K.1    Traver, D.2    Miyamoto, T.3    Weissman, I.L.4
  • 26
    • 77950418688 scopus 로고    scopus 로고
    • Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion
    • Beerman I, Bhattacharya D, Zandi S, et al. Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion. Proc Natl Acad Sci USA. 2010;107(12):5465-5470.
    • (2010) Proc Natl Acad Sci USA. , vol.107 , Issue.12 , pp. 5465-5470
    • Beerman, I.1    Bhattacharya, D.2    Zandi, S.3
  • 27
    • 84857873445 scopus 로고    scopus 로고
    • Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs
    • Benz C, Copley MR, Kent DG, et al. Hematopoietic stem cell subtypes expand differentially during development and display distinct lymphopoietic programs. Cell Stem Cell. 2012;10(3):273-283.
    • (2012) Cell Stem Cell. , vol.10 , Issue.3 , pp. 273-283
    • Benz, C.1    Copley, M.R.2    Kent, D.G.3
  • 28
    • 0030831130 scopus 로고    scopus 로고
    • Identification of clonogenic common lymphoid progenitors in mouse bone marrow
    • Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91(5):661-672.
    • (1997) Cell. , vol.91 , Issue.5 , pp. 661-672
    • Kondo, M.1    Weissman, I.L.2    Akashi, K.3
  • 29
    • 38349132624 scopus 로고    scopus 로고
    • Deconstructing stem cell self-renewal: Genetic insights into cell-cycle regulation
    • Orford KW, Scadden DT. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat Rev Genet. 2008;9(2):115-128.
    • (2008) Nat Rev Genet. , vol.9 , Issue.2 , pp. 115-128
    • Orford, K.W.1    Scadden, D.T.2
  • 32
    • 67650588646 scopus 로고    scopus 로고
    • MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
    • Garzon R, Liu S, Fabbri M, et al. MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood. 2009;113(25): 6411-6418.
    • (2009) Blood. , vol.113 , Issue.25 , pp. 6411-6418
    • Garzon, R.1    Liu, S.2    Fabbri, M.3
  • 33
    • 35649020283 scopus 로고    scopus 로고
    • MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B
    • Fabbri M, Garzon R, Cimmino A, et al. MicroRNA-29 family reverts aberrant methylation in lung cancer by targeting DNA methyltransferases 3A and 3B. Proc Natl Acad Sci USA. 2007;104(40): 15805-15810.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , Issue.40 , pp. 15805-15810
    • Fabbri, M.1    Garzon, R.2    Cimmino, A.3
  • 34
    • 84555207349 scopus 로고    scopus 로고
    • Dnmt3a is essential for hematopoietic stem cell differentiation
    • Challen GA, Sun D, Jeong M, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nat Genet. 2012;44(1):23-31.
    • (2012) Nat Genet. , vol.44 , Issue.1 , pp. 23-31
    • Challen, G.A.1    Sun, D.2    Jeong, M.3
  • 35
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • Ley TJ, Ding L, Walter MJ, et al. DNMT3A mutations in acute myeloid leukemia. N Engl J Med. 2010;363(25):2424-2433.
    • (2010) N Engl J Med. , vol.363 , Issue.25 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 36
    • 79953176952 scopus 로고    scopus 로고
    • Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia
    • Yan X-J, Xu J, Gu Z-H, et al. Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia. Nat Genet. 2011;43(4): 309-315.
    • (2011) Nat Genet. , vol.43 , Issue.4 , pp. 309-315
    • Yan, X.-J.1    Xu, J.2    Gu, Z.-H.3
  • 37
    • 84863393263 scopus 로고    scopus 로고
    • Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
    • Patel JP, Gönen M, Figueroa ME, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. N Engl J Med. 2012;366(12):1079-1089.
    • (2012) N Engl J Med. , vol.366 , Issue.12 , pp. 1079-1089
    • Patel, J.P.1    Gönen, M.2    Figueroa, M.E.3
  • 38
    • 33846699083 scopus 로고    scopus 로고
    • A hexanucleotide element directs microRNA nuclear import
    • Hwang H-W, Wentzel EA, Mendell JT. A hexanucleotide element directs microRNA nuclear import. Science. 2007;315(5808):97-100.
    • (2007) Science. , vol.315 , Issue.5808 , pp. 97-100
    • Hwang, H.-W.1    Wentzel, E.A.2    Mendell, J.T.3
  • 39
    • 70349469788 scopus 로고    scopus 로고
    • DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells
    • Trowbridge JJ, Snow JW, Kim J, Orkin SH. DNA methyltransferase 1 is essential for and uniquely regulates hematopoietic stem and progenitor cells. Cell Stem Cell. 2009;5(4):442-449.
    • (2009) Cell Stem Cell. , vol.5 , Issue.4 , pp. 442-449
    • Trowbridge, J.J.1    Snow, J.W.2    Kim, J.3    Orkin, S.H.4
  • 40
    • 77951003346 scopus 로고    scopus 로고
    • MicroRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma
    • Zhao J-J, Lin J, Lwin T, et al. microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma. Blood. 2010;115(13):2630-2639.
    • (2010) Blood. , vol.115 , Issue.13 , pp. 2630-2639
    • Zhao, J.-J.1    Lin, J.2    Lwin, T.3
  • 41
    • 33846190181 scopus 로고    scopus 로고
    • Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181
    • Pekarsky Y, Santanam U, Cimmino A, et al. Tcl1 expression in chronic lymphocytic leukemia is regulated by miR-29 and miR-181. Cancer Res. 2006;66(24):11590-11593.
    • (2006) Cancer Res. , vol.66 , Issue.24 , pp. 11590-11593
    • Pekarsky, Y.1    Santanam, U.2    Cimmino, A.3
  • 42
    • 84855885803 scopus 로고    scopus 로고
    • Cell cycle regulation in hematopoietic stem cells
    • Pietras EM, Warr MR, Passegué E. Cell cycle regulation in hematopoietic stem cells. J Cell Biol. 2011;195(5):709-720.
    • (2011) J Cell Biol. , vol.195 , Issue.5 , pp. 709-720
    • Pietras, E.M.1    Warr, M.R.2    Passegué, E.3
  • 43
    • 73949118737 scopus 로고    scopus 로고
    • MicroRNA 29b functions in acute myeloid leukemia
    • Garzon R, Heaphy CEA, Havelange V, et al. MicroRNA 29b functions in acute myeloid leukemia. Blood. 2009;114(26):5331-5341.
    • (2009) Blood. , vol.114 , Issue.26 , pp. 5331-5341
    • Garzon, R.1    Heaphy, C.E.A.2    Havelange, V.3
  • 44
    • 84894304555 scopus 로고    scopus 로고
    • Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission
    • Corces-Zimmerman MR, Hong WJ, Weissman IL, Medeiros BC, Majeti R. Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission. Proc Natl Acad Sci USA. 2014;111(7):2548-2553.
    • (2014) Proc Natl Acad Sci USA. , vol.111 , Issue.7 , pp. 2548-2553
    • Corces-Zimmerman, M.R.1    Hong, W.J.2    Weissman, I.L.3    Medeiros, B.C.4    Majeti, R.5
  • 45
    • 84865827060 scopus 로고    scopus 로고
    • Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia
    • Jan M, Snyder TM, Corces-Zimmerman MR, et al. Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med. 2012;4(149):149ra118.
    • (2012) Sci Transl Med. , vol.4 , Issue.149 , pp. 149ra118
    • Jan, M.1    Snyder, T.M.2    Corces-Zimmerman, M.R.3
  • 46
    • 84894245627 scopus 로고    scopus 로고
    • Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
    • HALT Pan- Leukemia Gene Panel Consortium
    • Shlush LI, Zandi S, Mitchell A, et al; HALT Pan- Leukemia Gene Panel Consortium. Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature. 2014;506(7488): 328-333.
    • (2014) Nature. , vol.506 , Issue.7488 , pp. 328-333
    • Shlush, L.I.1    Zandi, S.2    Mitchell, A.3


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