-
1
-
-
34247149876
-
The Humoral Immune Response Is Initiated in Lymph Nodes by B Cells that Acquire Soluble Antigen Directly in the Follicles
-
DOI 10.1016/j.immuni.2007.02.011, PII S1074761307001859
-
Pape, K. A., Catron, D. M., Itano, A. A. & Jenkins, M. K. The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles. Immunity 26, 491-502 (2007). (Pubitemid 46602995)
-
(2007)
Immunity
, vol.26
, Issue.4
, pp. 491-502
-
-
Pape, K.A.1
Catron, D.M.2
Itano, A.A.3
Jenkins, M.K.4
-
2
-
-
60149086845
-
Conduits mediate transport of low-molecular-weight antigen to lymph node follicles
-
Roozendaal, R. et al. Conduits mediate transport of low-molecular-weight antigen to lymph node follicles. Immunity 30, 264-276 (2009).
-
(2009)
Immunity
, vol.30
, pp. 264-276
-
-
Roozendaal, R.1
-
3
-
-
33745133006
-
Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells
-
DOI 10.1126/science.1125703
-
Qi, H., Egen, J. G., Huang, A. Y. & Germain, R. N. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 312, 1672-1676 (2006). (Pubitemid 43902670)
-
(2006)
Science
, vol.312
, Issue.5780
, pp. 1672-1676
-
-
Qi, H.1
Egen, J.G.2
Huang, A.Y.C.3
Germain, R.N.4
-
4
-
-
58149097584
-
The who, how and where of antigen presentation to B cells
-
Batista, F. D. & Harwood, N. E. The who, how and where of antigen presentation to B cells. Nature Rev. Immunol. 9, 15-27 (2009).
-
(2009)
Nature Rev. Immunol.
, vol.9
, pp. 15-27
-
-
Batista, F.D.1
Harwood, N.E.2
-
5
-
-
34447623566
-
B Cells Acquire Particulate Antigen in a Macrophage-Rich Area at the Boundary between the Follicle and the Subcapsular Sinus of the Lymph Node
-
DOI 10.1016/j.immuni.2007.06.007, PII S1074761307003342
-
Carrasco, Y. R. & Batista, F. D. B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity 27, 160-171 (2007). (Pubitemid 47089026)
-
(2007)
Immunity
, vol.27
, Issue.1
, pp. 160-171
-
-
Carrasco, Y.R.1
Batista, F.D.2
-
6
-
-
35948935059
-
Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells
-
DOI 10.1038/nature06287, PII NATURE06287
-
Junt, T. et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 450, 110-114 (2007). (Pubitemid 350070574)
-
(2007)
Nature
, vol.450
, Issue.7166
, pp. 110-114
-
-
Junt, T.1
Moseman, E.A.2
Iannacone, M.3
Massberg, S.4
Lang, P.A.5
Boes, M.6
Fink, K.7
Henrickson, S.E.8
Shayakhmetov, D.M.9
Di Paolo, N.C.10
Van Rooijen, N.11
Mempel, T.R.12
Whelan, S.P.13
Von Andrian, U.H.14
-
7
-
-
67649221652
-
Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation
-
Phan, T. G., Green, J. A., Gray, E. E., Xu, Y. & Cyster, J. G. Immune complex relay by subcapsular sinus macrophages and noncognate B cells drives antibody affinity maturation. Nature Immunol. 10, 786-793 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 786-793
-
-
Phan, T.G.1
Green, J.A.2
Gray, E.E.3
Xu, Y.4
Cyster, J.G.5
-
8
-
-
77953920853
-
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus
-
Iannacone, M. et al. Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus. Nature 465, 1079-1083 (2010).
-
(2010)
Nature
, vol.465
, pp. 1079-1083
-
-
Iannacone, M.1
-
9
-
-
33646454106
-
B cell ligand discrimination through a spreading and contraction response
-
Fleire, S. J. et al. B cell ligand discrimination through a spreading and contraction response. Science 312, 738-741 (2006).
-
(2006)
Science
, vol.312
, pp. 738-741
-
-
Fleire, S.J.1
-
10
-
-
78650649691
-
The essential role of DOCK8 in humoral immunity
-
Randall, K. L., Lambe, T., Goodnow, C. C. & Cornall, R. J. The essential role of DOCK8 in humoral immunity. Dis. Markers 29, 141-150 (2010).
-
(2010)
Dis. Markers
, vol.29
, pp. 141-150
-
-
Randall, K.L.1
Lambe, T.2
Goodnow, C.C.3
Cornall, R.J.4
-
11
-
-
32244431975
-
The calcineurin phosphatase complex modulates immunogenic B cell responses
-
DOI 10.1016/j.immuni.2005.12.013, PII S1074761306000057
-
Winslow, M. M., Gallo, E. M., Neilson, J. R. & Crabtree, G. R. The calcineurin phosphatase complex modulates immunogenic B cell responses. Immunity 24, 141-152 (2006). (Pubitemid 43214584)
-
(2006)
Immunity
, vol.24
, Issue.2
, pp. 141-152
-
-
Winslow, M.M.1
Gallo, E.M.2
Neilson, J.R.3
Crabtree, G.R.4
-
12
-
-
55949107108
-
A p38 MAPK-MEF2C pathway regulates B-cell proliferation
-
Khiem, D., Cyster, J. G., Schwarz, J. J. & Black, B. L. A p38 MAPK-MEF2C pathway regulates B-cell proliferation. Proc. Natl Acad. Sci. USA 105, 17067-17072 (2008).
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 17067-17072
-
-
Khiem, D.1
Cyster, J.G.2
Schwarz, J.J.3
Black, B.L.4
-
13
-
-
44049105823
-
Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation
-
DOI 10.1038/ni.1609, PII NI.1609
-
Wilker, P. R. et al. Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation. Nature Immunol. 9, 603-612 (2008). (Pubitemid 351712631)
-
(2008)
Nature Immunology
, vol.9
, Issue.6
, pp. 603-612
-
-
Wilker, P.R.1
Kohyama, M.2
Sandau, M.M.3
Albring, J.C.4
Nakagawa, O.5
Schwarz, J.J.6
Murphy, K.M.7
-
14
-
-
79956303933
-
The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production
-
Matsumoto, M. et al. The calcium sensors STIM1 and STIM2 control B cell regulatory function through interleukin-10 production. Immunity 34, 703-714 (2011).
-
(2011)
Immunity
, vol.34
, pp. 703-714
-
-
Matsumoto, M.1
-
15
-
-
76949092900
-
HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species
-
Capasso, M. et al. HVCN1 modulates BCR signal strength via regulation of BCR-dependent generation of reactive oxygen species. Nature Immunol. 11, 265-272 (2010).
-
(2010)
Nature Immunol
, vol.11
, pp. 265-272
-
-
Capasso, M.1
-
16
-
-
77950022062
-
Single round of antigen receptor signaling programs naive B cells to receive T cell help
-
Damdinsuren, B. et al. Single round of antigen receptor signaling programs naive B cells to receive T cell help. Immunity 32, 355-366 (2010).
-
(2010)
Immunity
, vol.32
, pp. 355-366
-
-
Damdinsuren, B.1
-
17
-
-
62849128302
-
CD98hc facilitates B cell proliferation and adaptive humoral immunity
-
Cantor, J. et al. CD98hc facilitates B cell proliferation and adaptive humoral immunity. Nature Immunol. 10, 412-419 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 412-419
-
-
Cantor, J.1
-
18
-
-
79955014406
-
ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation
-
Yasuda, T. et al. ERKs induce expression of the transcriptional repressor Blimp-1 and subsequent plasma cell differentiation. Sci. Signal. 4, ra25 (2011).
-
(2011)
Sci. Signal.
, vol.4
-
-
Yasuda, T.1
-
19
-
-
79952675131
-
Follicular helper CD4 T cells (TFH)
-
Crotty, S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 29, 621-663 (2011).
-
(2011)
Annu. Rev. Immunol.
, vol.29
, pp. 621-663
-
-
Crotty, S.1
-
20
-
-
61949131896
-
Follicular helper T cells: Lineage and location
-
Fazilleau, N., Mark, L., McHeyzer-Williams, L. J. & McHeyzer-Williams, M. G. Follicular helper T cells: lineage and location. Immunity 30, 324-335 (2009).
-
(2009)
Immunity
, vol.30
, pp. 324-335
-
-
Fazilleau, N.1
Mark, L.2
McHeyzer-Williams, L.J.3
McHeyzer-Williams, M.G.4
-
21
-
-
62849126473
-
The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
-
Fazilleau, N., McHeyzer-Williams, L. J., Rosen, H. & McHeyzer-Williams, M. G. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nature Immunol. 10, 375-384 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 375-384
-
-
Fazilleau, N.1
McHeyzer-Williams, L.J.2
Rosen, H.3
McHeyzer-Williams, M.G.4
-
22
-
-
69249109601
-
Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
-
Johnston, R. J. et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 325, 1006-1010 (2009).
-
(2009)
Science
, vol.325
, pp. 1006-1010
-
-
Johnston, R.J.1
-
23
-
-
69249101229
-
Bcl6 mediates the development of T follicular helper cells
-
Nurieva, R. I. et al. Bcl6 mediates the development of T follicular helper cells. Science 325, 1001-1005 (2009).
-
(2009)
Science
, vol.325
, pp. 1001-1005
-
-
Nurieva, R.I.1
-
24
-
-
70049101558
-
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
-
Yu, D. et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 31, 457-468 (2009).
-
(2009)
Immunity
, vol.31
, pp. 457-468
-
-
Yu, D.1
-
25
-
-
77149122105
-
IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
-
Linterman, M. A. et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J. Exp. Med. 207, 353-363 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 353-363
-
-
Linterman, M.A.1
-
26
-
-
77149142640
-
IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
-
Zotos, D. et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J. Exp. Med. 207, 365-378 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 365-378
-
-
Zotos, D.1
-
27
-
-
77952304784
-
Batf coordinates multiple aspects of B and T cell function required for normal antibody responses
-
Betz, B. C. et al. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J. Exp. Med. 207, 933-942 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 933-942
-
-
Betz, B.C.1
-
28
-
-
79956081339
-
The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells
-
Ise, W. et al. The transcription factor BATF controls the global regulators of class-switch recombination in both B cells and T cells. Nature Immunol. 12, 536-543 (2011).
-
(2011)
Nature Immunol
, vol.12
, pp. 536-543
-
-
Ise, W.1
-
29
-
-
79959328032
-
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
-
Choi, Y. S. et al. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 34, 932-946 (2011).
-
(2011)
Immunity
, vol.34
, pp. 932-946
-
-
Choi, Y.S.1
-
30
-
-
79952745936
-
Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response
-
Hou, B. et al. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the antiviral germinal center response. Immunity 34, 375-384 (2011).
-
(2011)
Immunity
, vol.34
, pp. 375-384
-
-
Hou, B.1
-
31
-
-
79959343565
-
Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
-
Kitano, M. et al. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 34, 961-972 (2011).
-
(2011)
Immunity
, vol.34
, pp. 961-972
-
-
Kitano, M.1
-
32
-
-
53649107278
-
SAP-controlled T-B cell interactions underlie germinal centre formation
-
Qi, H., Cannons, J. L., Klauschen, F., Schwartzberg, P. L. & Germain, R. N. SAP-controlled T-B cell interactions underlie germinal centre formation. Nature 455, 764-769 (2008).
-
(2008)
Nature
, vol.455
, pp. 764-769
-
-
Qi, H.1
Cannons, J.L.2
Klauschen, F.3
Schwartzberg, P.L.4
Germain, R.N.5
-
33
-
-
79959342619
-
Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone
-
Kerfoot, S. M. et al. Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone. Immunity 34, 947-960 (2011).
-
(2011)
Immunity
, vol.34
, pp. 947-960
-
-
Kerfoot, S.M.1
-
34
-
-
42649123314
-
Mechanism and regulation of class switch recombination
-
DOI 10.1146/annurev.immunol.26.021607.090248
-
Stavnezer, J., Guikema, J. E. & Schrader, C. E. Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 26, 261-292 (2008). (Pubitemid 351600377)
-
(2008)
Annual Review of Immunology
, vol.26
, pp. 261-292
-
-
Stavnezer, J.1
Guikema, J.E.J.2
Schrader, C.E.3
-
35
-
-
75649096381
-
B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
-
Tran, T. H. et al. B cell-specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers. Nature Immunol. 11, 148-154 (2010).
-
(2010)
Nature Immunol
, vol.11
, pp. 148-154
-
-
Tran, T.H.1
-
36
-
-
67349090990
-
HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation
-
Park, S. R. et al. HoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutation. Nature Immunol. 10, 540-550 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 540-550
-
-
Park, S.R.1
-
37
-
-
56349127778
-
Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation
-
Dengler, H. S. et al. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nature Immunol. 9, 1388-1398 (2008).
-
(2008)
Nature Immunol
, vol.9
, pp. 1388-1398
-
-
Dengler, H.S.1
-
38
-
-
77956345401
-
14-3-3 adaptor proteins recruit AID to 5-AGCT-3-rich switch regions for class switch recombination
-
Xu, Z. et al. 14-3-3 adaptor proteins recruit AID to 5?-AGCT-3?-rich switch regions for class switch recombination. Nature Struct. Mol. Biol. 17, 1124-1135 (2010).
-
(2010)
Nature Struct. Mol. Biol.
, vol.17
, pp. 1124-1135
-
-
Xu, Z.1
-
39
-
-
63049129975
-
Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability
-
Schenten, D. et al. Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability. J. Exp. Med. 206, 477-490 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 477-490
-
-
Schenten, D.1
-
40
-
-
67650457059
-
Mechanisms promoting translocations in editing and switching peripheral B cells
-
Wang, J. H. et al. Mechanisms promoting translocations in editing and switching peripheral B cells. Nature 460, 231-236 (2009).
-
(2009)
Nature
, vol.460
, pp. 231-236
-
-
Wang, J.H.1
-
41
-
-
0025726702
-
In situ studies of the primary immune response to (4-hydroxy-3- nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations
-
Jacob, J., Kassir, R. & Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J. Exp. Med. 173, 1165-1175 (1991).
-
(1991)
J. Exp. Med.
, vol.173
, pp. 1165-1175
-
-
Jacob, J.1
Kassir, R.2
Kelsoe, G.3
-
42
-
-
65549114338
-
IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells
-
King, I. L. & Mohrs, M. IL-4-producing CD4+ T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J. Exp. Med. 206, 1001-1007 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1001-1007
-
-
King, I.L.1
Mohrs, M.2
-
43
-
-
62849090439
-
Cytokine-secreting follicular T cells shape the antibody repertoire
-
Reinhardt, R. L., Liang, H. E. & Locksley, R. M. Cytokine-secreting follicular T cells shape the antibody repertoire. Nature Immunol. 10, 385-393 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 385-393
-
-
Reinhardt, R.L.1
Liang, H.E.2
Locksley, R.M.3
-
44
-
-
65549134481
-
T follicular helper cells differentiate from Th2 cells in response to helminth antigens
-
Zaretsky, A. G. et al. T follicular helper cells differentiate from Th2 cells in response to helminth antigens. J. Exp. Med. 206, 991-999 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 991-999
-
-
Zaretsky, A.G.1
-
45
-
-
0023197097
-
Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production
-
Snapper, C. M. & Paul, W. E. Interferon-γ and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 236, 944-947 (1987). (Pubitemid 17107942)
-
(1987)
Science
, vol.236
, Issue.4804
, pp. 944-947
-
-
Snapper, C.M.1
Paul, W.E.2
-
46
-
-
0033697670
-
TGF-β receptor controls B cell responsiveness and induction of IgA in vivo
-
Cazac, B. B. & Roes, J. TGF-β receptor controls B cell responsiveness and induction of IgA in vivo. Immunity 13, 443-451 (2000).
-
(2000)
Immunity
, vol.13
, pp. 443-451
-
-
Cazac, B.B.1
Roes, J.2
-
47
-
-
78049248431
-
IFN-γ produced by CD8 T cells induces T-bet-dependent and-independent class switching in B cells in responses to alum-precipitated protein vaccine
-
Mohr, E. et al. IFN-γ produced by CD8 T cells induces T-bet-dependent and-independent class switching in B cells in responses to alum-precipitated protein vaccine. Proc. Natl Acad. Sci. USA 107, 17292-17297 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 17292-17297
-
-
Mohr, E.1
-
48
-
-
0037117557
-
T-bet regulates IgG class switching and pathogenic autoantibody production
-
DOI 10.1073/pnas.082114899
-
Peng, S. L., Szabo, S. J. & Glimcher, L. H. T-bet regulates IgG class switching and pathogenic autoantibody production. Proc. Natl Acad. Sci. USA 99, 5545-5550 (2002). (Pubitemid 34411585)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.8
, pp. 5545-5550
-
-
Peng, S.L.1
Szabo, S.J.2
Glimcher, L.H.3
-
49
-
-
77951909462
-
Requirement for Runx proteins in IgA class switching acting downstream of TGF-β1 and retinoic acid signaling
-
Watanabe, K. et al. Requirement for Runx proteins in IgA class switching acting downstream of TGF-β1 and retinoic acid signaling. J. Immunol. 184, 2785-2792 (2010).
-
(2010)
J. Immunol.
, vol.184
, pp. 2785-2792
-
-
Watanabe, K.1
-
50
-
-
66049120992
-
Ikaros controls isotype selection during immunoglobulin class switch recombination
-
Sellars, M., Reina-San-Martin, B., Kastner, P. & Chan, S. Ikaros controls isotype selection during immunoglobulin class switch recombination. J. Exp. Med. 206, 1073-1087 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 1073-1087
-
-
Sellars, M.1
Reina-San-Martin, B.2
Kastner, P.3
Chan, S.4
-
52
-
-
0036754646
-
Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells
-
DOI 10.1016/S1074-7613(02)00387-4
-
Toyama, H. et al. Memory B cells without somatic hypermutation are generated from Bcl6-deficient B cells. Immunity 17, 329-339 (2002). (Pubitemid 35279553)
-
(2002)
Immunity
, vol.17
, Issue.3
, pp. 329-339
-
-
Toyama, H.1
Okada, S.2
Hatano, M.3
Takahashi, Y.4
Takeda, N.5
Ichii, H.6
Takemori, T.7
Kuroda, Y.8
Tokuhisa, T.9
-
53
-
-
67349176043
-
XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells
-
Hu, C. C., Dougan, S. K., McGehee, A. M., Love, J. C. & Ploegh, H. L. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 28, 1624-1636 (2009).
-
(2009)
EMBO J.
, vol.28
, pp. 1624-1636
-
-
Hu, C.C.1
Dougan, S.K.2
McGehee, A.M.3
Love, J.C.4
Ploegh, H.L.5
-
54
-
-
70350452319
-
XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development
-
Todd, D. J. et al. XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development. J. Exp. Med. 206, 2151-2159 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 2151-2159
-
-
Todd, D.J.1
-
55
-
-
68649108084
-
Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses
-
Gatto, D., Paus, D., Basten, A., Mackay, C. R. & Brink, R. Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses. Immunity 31, 259-269 (2009).
-
(2009)
Immunity
, vol.31
, pp. 259-269
-
-
Gatto, D.1
Paus, D.2
Basten, A.3
MacKay, C.R.4
Brink, R.5
-
56
-
-
69349087555
-
EBI2 mediates B cell segregation between the outer and centre follicle
-
Pereira, J. P., Kelly, L. M., Xu, Y. & Cyster, J. G. EBI2 mediates B cell segregation between the outer and centre follicle. Nature 460, 1122-1126 (2009).
-
(2009)
Nature
, vol.460
, pp. 1122-1126
-
-
Pereira, J.P.1
Kelly, L.M.2
Xu, Y.3
Cyster, J.G.4
-
57
-
-
64049084826
-
Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles
-
Coffey, F., Alabyev, B. & Manser, T. Initial clonal expansion of germinal center B cells takes place at the perimeter of follicles. Immunity 30, 599-609 (2009).
-
(2009)
Immunity
, vol.30
, pp. 599-609
-
-
Coffey, F.1
Alabyev, B.2
Manser, T.3
-
58
-
-
0037029607
-
Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced
-
DOI 10.1084/jem.20011550
-
Dal Porto, J. M., Haberman, A. M., Kelsoe, G. & Shlomchik, M. J. Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced. J. Exp. Med. 195, 1215-1221 (2002). (Pubitemid 34517148)
-
(2002)
Journal of Experimental Medicine
, vol.195
, Issue.9
, pp. 1215-1221
-
-
Dal Porto, J.M.1
Haberman, A.M.2
Kelsoe, G.3
Shlomchik, M.J.4
-
59
-
-
0036073140
-
Role of BCR affinity in T cell-dependent antibody responses in vivo
-
DOI 10.1038/ni803
-
Shih, T. A., Meffre, E., Roederer, M. & Nussenzweig, M. C. Role of BCR affinity in T cell dependent antibody responses in vivo. Nature Immunol. 3, 570-575 (2002). (Pubitemid 34662310)
-
(2002)
Nature Immunology
, vol.3
, Issue.6
, pp. 570-575
-
-
Shih, T.-A.Y.1
Meffre, E.2
Roederer, M.3
Nussenzweig, M.C.4
-
60
-
-
33645856486
-
Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation
-
Paus, D. et al. Antigen recognition strength regulates the choice between extrafollicular plasma cell and germinal center B cell differentiation. J. Exp. Med. 203, 1081-1091 (2006).
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1081-1091
-
-
Paus, D.1
-
61
-
-
79958255209
-
A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center
-
Schwickert, T. A. et al. A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center. J. Exp. Med. 208, 1243-1252 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 1243-1252
-
-
Schwickert, T.A.1
-
62
-
-
34548036949
-
Germinal-center organization and cellular dynamics
-
DOI 10.1016/j.immuni.2007.07.009, PII S1074761307003706
-
Allen, C. D., Okada, T. & Cyster, J. G. Germinal-center organization and cellular dynamics. Immunity 27, 190-202 (2007). (Pubitemid 47284923)
-
(2007)
Immunity
, vol.27
, Issue.2
, pp. 190-202
-
-
Allen, C.D.C.1
Okada, T.2
Cyster, J.G.3
-
64
-
-
34249790004
-
Molecular mechanisms of antibody somatic hypermutation
-
Di Noia, J. M. & Neuberger, M. S. Molecular mechanisms of antibody somatic hypermutation. Annu. Rev. Biochem. 76, 1-22 (2007).
-
(2007)
Annu. Rev. Biochem.
, vol.76
, pp. 1-22
-
-
Di Noia, J.M.1
Neuberger, M.S.2
-
65
-
-
39149099085
-
Two levels of protection for the B cell genome during somatic hypermutation
-
DOI 10.1038/nature06547, PII NATURE06547
-
Liu, M. et al. Two levels of protection for the B cell genome during somatic hypermutation. Nature 451, 841-845 (2008). (Pubitemid 351253166)
-
(2008)
Nature
, vol.451
, Issue.7180
, pp. 841-845
-
-
Liu, M.1
Duke, J.L.2
Richter, D.J.3
Vinuesa, C.G.4
Goodnow, C.C.5
Kleinstein, S.H.6
Schatz, D.G.7
-
66
-
-
76149119416
-
Altering the spectrum of immunoglobulin v gene somatic hypermutation by modifying the active site of AID
-
Wang, M., Rada, C. & Neuberger, M. S. Altering the spectrum of immunoglobulin V gene somatic hypermutation by modifying the active site of AID. J. Exp. Med. 207, 141-153 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 141-153
-
-
Wang, M.1
Rada, C.2
Neuberger, M.S.3
-
67
-
-
67650330317
-
AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity
-
Wang, M., Yang, Z., Rada, C. & Neuberger, M. S. AID upmutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity. Nature Struct. Mol. Biol. 16, 769-776 (2009).
-
(2009)
Nature Struct. Mol. Biol.
, vol.16
, pp. 769-776
-
-
Wang, M.1
Yang, Z.2
Rada, C.3
Neuberger, M.S.4
-
68
-
-
78649404299
-
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90
-
Orthwein, A. et al. Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. J. Exp. Med. 207, 2751-2765 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 2751-2765
-
-
Orthwein, A.1
-
69
-
-
33846635838
-
Imaging of germinal center selection events during affinity maturation
-
DOI 10.1126/science.1136736
-
Allen, C. D., Okada, T., Tang, H. L. & Cyster, J. G. Imaging of germinal center selection events during affinity maturation. Science 315, 528-531 (2007). (Pubitemid 46175759)
-
(2007)
Science
, vol.315
, Issue.5811
, pp. 528-531
-
-
Allen, C.D.C.1
Okada, T.2
Tang, H.L.3
Cyster, J.G.4
-
70
-
-
34248585765
-
Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns
-
DOI 10.1016/j.immuni.2007.04.008, PII S107476130700252X
-
Hauser, A. E. et al. Definition of germinal-center B cell migration in vivo reveals predominant intrazonal circulation patterns. Immunity 26, 655-667 (2007). (Pubitemid 46756352)
-
(2007)
Immunity
, vol.26
, Issue.5
, pp. 655-667
-
-
Hauser, A.E.1
Junt, T.2
Mempel, T.R.3
Sneddon, M.W.4
Kleinstein, S.H.5
Henrickson, S.E.6
Von Andrian, U.H.7
Shlomchik, M.J.8
Haberman, A.M.9
-
71
-
-
33847206141
-
In vivo imaging of germinal centres reveals a dynamic open structure
-
DOI 10.1038/nature05573, PII NATURE05573
-
Schwickert, T. A. et al. In vivo imaging of germinal centres reveals a dynamic open structure. Nature 446, 83-87 (2007). (Pubitemid 46348044)
-
(2007)
Nature
, vol.446
, Issue.7131
, pp. 83-87
-
-
Schwickert, T.A.1
Lindquist, R.L.2
Shakhar, G.3
Livshits, G.4
Skokos, D.5
Kosco-Vilbois, M.H.6
Dustin, M.L.7
Nussenzweig, M.C.8
-
72
-
-
79957671415
-
B cells within germinal centers migrate preferentially from dark to light zone
-
Beltman, J. B., Allen, C. D., Cyster, J. G. & de Boer, R. J. B cells within germinal centers migrate preferentially from dark to light zone. Proc. Natl Acad. Sci. USA 108, 8755-8760 (2011).
-
(2011)
Proc. Natl Acad. Sci. USA
, vol.108
, pp. 8755-8760
-
-
Beltman, J.B.1
Allen, C.D.2
Cyster, J.G.3
De Boer, R.J.4
-
73
-
-
78149477766
-
Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter
-
Victora, G. D. et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell 143, 592-605 (2010).
-
(2010)
Cell
, vol.143
, pp. 592-605
-
-
Victora, G.D.1
-
74
-
-
78449282121
-
Mcl-1 is essential for germinal center formation and B cell memory
-
Vikstrom, I. et al. Mcl-1 is essential for germinal center formation and B cell memory. Science 330, 1095-1099 (2010).
-
(2010)
Science
, vol.330
, pp. 1095-1099
-
-
Vikstrom, I.1
-
75
-
-
46749115446
-
A fundamental role for interleukin-21 in the generation of T follicular helper cells
-
Vogelzang, A. et al. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 29, 127-137 (2008).
-
(2008)
Immunity
, vol.29
, pp. 127-137
-
-
Vogelzang, A.1
-
76
-
-
79959377393
-
The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement
-
Green, J. A. et al. The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement. Nature Immunol. 12, 672-680 (2011).
-
(2011)
Nature Immunol
, vol.12
, pp. 672-680
-
-
Green, J.A.1
-
77
-
-
38049144850
-
Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
-
Haynes, N. M. et al. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J. Immunol. 179, 5099-5108 (2007).
-
(2007)
J. Immunol.
, vol.179
, pp. 5099-5108
-
-
Haynes, N.M.1
-
78
-
-
77952557954
-
PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells
-
Good-Jacobson, K. L. et al. PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Nature Immunol. 11, 535-542 (2010).
-
(2010)
Nature Immunol
, vol.11
, pp. 535-542
-
-
Good-Jacobson, K.L.1
-
79
-
-
79955731369
-
NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network
-
Bhattacharyya, S. et al. NFATc1 affects mouse splenic B cell function by controlling the calcineurin-NFAT signaling network. J. Exp. Med. 208, 823-839 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 823-839
-
-
Bhattacharyya, S.1
-
80
-
-
79952282195
-
Different B cell populations mediate early and late memory during an endogenous immune response
-
Pape, K. A., Taylor, J. J., Maul, R. W., Gearhart, P. J. & Jenkins, M. K. Different B cell populations mediate early and late memory during an endogenous immune response. Science 331, 1203-1207 (2011).
-
(2011)
Science
, vol.331
, pp. 1203-1207
-
-
Pape, K.A.1
Taylor, J.J.2
Maul, R.W.3
Gearhart, P.J.4
Jenkins, M.K.5
-
81
-
-
70449722777
-
Multiple layers of B cell memory with different effector functions
-
Dogan, I. et al. Multiple layers of B cell memory with different effector functions. Nature Immunol. 10, 1292-1299 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 1292-1299
-
-
Dogan, I.1
-
82
-
-
79952173864
-
Programming the magnitude and persistence of antibody responses with innate immunity
-
Kasturi, S. P. et al. Programming the magnitude and persistence of antibody responses with innate immunity. Nature 470, 543-547 (2011).
-
(2011)
Nature
, vol.470
, pp. 543-547
-
-
Kasturi, S.P.1
-
83
-
-
33750502877
-
High affinity germinal center B cells are actively selected into the plasma cell compartment
-
DOI 10.1084/jem.20061254
-
Phan, T. G. et al. High affinity germinal center B cells are actively selected into the plasma cell compartment. J. Exp. Med. 203, 2419-2424 (2006). (Pubitemid 44664611)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.11
, pp. 2419-2424
-
-
Phan, T.G.1
Paus, D.2
Chan, T.D.3
Turner, M.L.4
Nutt, S.L.5
Basten, A.6
Brink, R.7
-
84
-
-
61449162967
-
Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature
-
Mohr, E. et al. Dendritic cells and monocyte/macrophages that create the IL-6/APRIL-rich lymph node microenvironments where plasmablasts mature. J. Immunol. 182, 2113-2123 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 2113-2123
-
-
Mohr, E.1
-
85
-
-
77954895311
-
Development and migration of plasma cells in the mouse lymph node
-
Fooksman, D. R. et al. Development and migration of plasma cells in the mouse lymph node. Immunity 33, 118-127 (2010).
-
(2010)
Immunity
, vol.33
, pp. 118-127
-
-
Fooksman, D.R.1
-
86
-
-
62649159900
-
CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche
-
Chevrier, S. et al. CD93 is required for maintenance of antibody secretion and persistence of plasma cells in the bone marrow niche. Proc. Natl Acad. Sci. USA 106, 3895-3900 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 3895-3900
-
-
Chevrier, S.1
-
87
-
-
0037073930
-
Maintenance of serological memory by polyclonal activation of human memory B cells
-
DOI 10.1126/science.1076071
-
Bernasconi, N. L., Traggiai, E. & Lanzavecchia, A. Maintenance of serological memory by polyclonal activation of human memory B cells. Science 298, 2199-2202 (2002). (Pubitemid 35471246)
-
(2002)
Science
, vol.298
, Issue.5601
, pp. 2199-2202
-
-
Bernasconi, N.L.1
Traggiai, E.2
Lanzavecchia, A.3
-
88
-
-
78449273613
-
Plasma cells negatively regulate the follicular helper T cell program
-
Pelletier, N. et al. Plasma cells negatively regulate the follicular helper T cell program. Nature Immunol. 11, 1110-1118 (2010).
-
(2010)
Nature Immunol
, vol.11
, pp. 1110-1118
-
-
Pelletier, N.1
-
89
-
-
0034609775
-
Memory B-cell persistence is independent of persisting immunizing antigen
-
Maruyama, M., Lam, K. P. & Rajewsky, K. Memory B-cell persistence is independent of persisting immunizing antigen. Nature 407, 636-642 (2000).
-
(2000)
Nature
, vol.407
, pp. 636-642
-
-
Maruyama, M.1
Lam, K.P.2
Rajewsky, K.3
-
90
-
-
70350304558
-
PI3 kinase signals BCR-dependent mature B cell survival
-
Srinivasan, L. et al. PI3 kinase signals BCR-dependent mature B cell survival. Cell 139, 573-586 (2009).
-
(2009)
Cell
, vol.139
, pp. 573-586
-
-
Srinivasan, L.1
-
91
-
-
63449105305
-
PLC-γ2 is essential for formation and maintenance of memory B cells
-
Hikida, M. et al. PLC-γ2 is essential for formation and maintenance of memory B cells. J. Exp. Med. 206, 681-689 (2009).
-
(2009)
J. Exp. Med.
, vol.206
, pp. 681-689
-
-
Hikida, M.1
-
92
-
-
34250186360
-
Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response
-
Jelley-Gibbs, D. M. et al. Persistent depots of influenza antigen fail to induce a cytotoxic CD8 T cell response. J. Immunol. 178, 7563-7570 (2007). (Pubitemid 46898025)
-
(2007)
Journal of Immunology
, vol.178
, Issue.12
, pp. 7563-7570
-
-
Jelley-Gibbs, D.M.1
Dibble, J.P.2
Brown, D.M.3
Strutt, T.M.4
McKinstry, K.K.5
Swain, S.L.6
-
93
-
-
34250765587
-
Lymphoid reservoirs of antigen-specific memory T helper cells
-
DOI 10.1038/ni1472, PII NI1472
-
Fazilleau, N. et al. Lymphoid reservoirs of antigen-specific memory T helper cells. Nature Immunol. 8, 753-761 (2007). (Pubitemid 46965351)
-
(2007)
Nature Immunology
, vol.8
, Issue.7
, pp. 753-761
-
-
Fazilleau, N.1
Eisenbraun, M.D.2
Malherbe, L.3
Ebright, J.N.4
Pogue-Caley, R.R.5
McHeyzer-Williams, L.J.6
McHeyzer-Williams, M.G.7
-
94
-
-
77953897004
-
Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling
-
Liu, W., Meckel, T., Tolar, P., Sohn, H. W. & Pierce, S. K. Intrinsic properties of immunoglobulin IgG1 isotype-switched B cell receptors promote microclustering and the initiation of signaling. Immunity 32, 778-789 (2010).
-
(2010)
Immunity
, vol.32
, pp. 778-789
-
-
Liu, W.1
Meckel, T.2
Tolar, P.3
Sohn, H.W.4
Pierce, S.K.5
-
95
-
-
0036171910
-
Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory
-
DOI 10.1038/ni752
-
Martin, S. W. & Goodnow, C. C. Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory. Nature Immunol. 3, 182-188 (2002). (Pubitemid 34141449)
-
(2002)
Nature Immunology
, vol.3
, Issue.2
, pp. 182-188
-
-
Martin, S.W.1
Goodnow, C.C.2
-
96
-
-
69049105207
-
Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells
-
Engels, N. et al. Recruitment of the cytoplasmic adaptor Grb2 to surface IgG and IgE provides antigen receptor-intrinsic costimulation to class-switched B cells. Nature Immunol. 10, 1018-1025 (2009).
-
(2009)
Nature Immunol
, vol.10
, pp. 1018-1025
-
-
Engels, N.1
-
97
-
-
34247340435
-
Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors
-
DOI 10.1084/jem.20061923
-
Horikawa, K. et al. Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors. J. Exp. Med. 204, 759-769 (2007). (Pubitemid 46631606)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.4
, pp. 759-769
-
-
Horikawa, K.1
Martin, S.W.2
Pogue, S.L.3
Silver, K.4
Peng, K.5
Takatsu, K.6
Goodnow, C.C.7
-
98
-
-
34247392757
-
IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β
-
DOI 10.1084/jem.20062024
-
Waisman, A. et al. IgG1 B cell receptor signaling is inhibited by CD22 and promotes the development of B cells whose survival is less dependent on Igα/β. J. Exp. Med. 204, 747-758 (2007). (Pubitemid 46631605)
-
(2007)
Journal of Experimental Medicine
, vol.204
, Issue.4
, pp. 747-758
-
-
Waisman, A.1
Kraus, M.2
Seagal, J.3
Ghosh, S.4
Melamed, D.5
Song, J.6
Sasaki, Y.7
Classen, S.8
Lutz, C.9
Brombacher, F.10
Nitschke, L.11
Rajewsky, K.12
-
99
-
-
0037147182
-
A distinct signaling pathway used by the IgG-containing B cell antigen receptor
-
DOI 10.1126/science.1076963
-
Wakabayashi, C., Adachi, T., Wienands, J. & Tsubata, T. A distinct signaling pathway used by the IgG-containing B cell antigen receptor. Science 298, 2392-2395 (2002). (Pubitemid 36014213)
-
(2002)
Science
, vol.298
, Issue.5602
, pp. 2392-2395
-
-
Wakabayashi, C.1
Adachi, T.2
Wienands, J.3
Tsubata, T.4
-
100
-
-
77955460838
-
Preferential localization of IgG memory B cells adjacent to contracted germinal centers
-
Aiba, Y. et al. Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc. Natl Acad. Sci. USA 107, 12192-12197 (2010).
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 12192-12197
-
-
Aiba, Y.1
|