Integrated genetic approaches identify the molecular mechanisms of Sox4 in early B-cell development: Intricate roles for RAG1/2 and CK1ε

Blood

Volumn 123, Issue 26, 2014, Pages 4064-4076

  Mallampati, Saradhi ^a   Sun, Baohua ^a   Lu, Yue ^a   Ma, Haiqing ^a   Gong, Yun ^a   Wang, Donghai ^b   Lee, Ju Seog ^a   Lin, Kevin ^a   Sun, Xiaoping ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; CASEIN KINASE IEPSILON; GA BINDING PROTEIN; GA BINDING PROTEIN ALPHA; IMMUNOGLOBULIN HEAVY CHAIN; RAG1 PROTEIN; RAG2 PROTEIN; TRANSCRIPTION FACTOR SOX4; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL RENEWAL; CONTROLLED STUDY; DOWN REGULATION; GENE CONTROL; GENE FUNCTION; GENE LOCUS; GENE REARRANGEMENT; GENE REGULATORY NETWORK; GENETIC ASSOCIATION; GENETIC RECOMBINATION; IMMUNOGLOBULIN HEAVY CHAIN GENE; IN VITRO STUDY; LYMPHOPOIESIS; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; UPREGULATION; WNT SIGNALING PATHWAY;

ANIMALS; B-LYMPHOCYTES; CASEIN KINASE IEPSILON; CELL DIFFERENTIATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HOMEODOMAIN PROTEINS; MICE; MICE, KNOCKOUT; SOXC TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; WNT SIGNALING PATHWAY;

EID: 84903639223     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-12-543801     Document Type: Article

References (47)

1. Lefebvre V, Dumitriu B, Penzo-Méndez A, Han Y, Pallavi B. Control of cell fate and differentiation by Sry-related high-mobility-group box (Sox) transcription factors. Int J Biochem Cell Biol. 2007;39(12):2195-2214. (Pubitemid 47484275)
2. Schilham MW, Oosterwegel MA, Moerer P, et al. Defects in cardiac outflow tract formation and pro- B-lymphocyte expansion in mice lacking Sox-4. Nature. 1996;380(6576):711-714. (Pubitemid 26125470)
3. Sun B, Mallampati S, Gong Y, Wang D, Lefebvre V, Sun X. Sox4 is required for the survival of pro- B cells. J Immunol. 2013;190(5):2080-2089.
4. Hardy RR, Carmack CE, Shinton SA, Kemp JD, Hayakawa K. Resolution and characterization of pro-B and pre-pro-B cell stages in normal mouse bone marrow. J Exp Med. 1991;173(5):1213-1225.
5. Busslinger M. Transcriptional control of early B cell development. Annu Rev Immunol. 2004;22:55-79. (Pubitemid 38680418)
6. Nagasawa T. Microenvironmental niches in the bone marrow required for B-cell development. Nat Rev Immunol. 2006;6(2):107-116. (Pubitemid 43361586)
7. Staal FJ, Clevers HC. WNT signalling and haematopoiesis: a WNT-WNT situation. Nat Rev Immunol. 2005;5(1):21-30. (Pubitemid 40070328)
8. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001;2(2):172-180. (Pubitemid 33707938)
9. Varnum-Finney B, Xu L, Brashem-Stein C, et al. Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling. Nat Med. 2000;6(11):1278-1281.
10. Malin S, McManus S, Cobaleda C, et al. Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro- B cell development. Nat Immunol. 2010;11(2):171-179.
11. Fleming HE, Paige CJ. Pre-B cell receptor signaling mediates selective response to IL-7 at the pro-B to pre-B cell transition via an ERK/MAP kinase-dependent pathway. Immunity. 2001;15(4):521-531. (Pubitemid 33016438)
12. Oettinger MA, Schatz DG, Gorka C, Baltimore D. RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science. 1990;248(4962):1517-1523.
13. Matthews AG, Oettinger MA. RAG: a recombinase diversified. Nat Immunol. 2009;10(8):817-821.
14. Mombaerts P, Iacomini J, Johnson RS, Herrup K, Tonegawa S, Papaioannou VE. RAG-1-deficient mice have no mature B and T lymphocytes. Cell. 1992;68(5):869-877.
15. Shinkai Y, Rathbun G, Lam KP, et al. RAG-2- deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement. Cell. 1992;68(5):855-867.
16. Spanopoulou E, Roman CA, Corcoran LM, et al. Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice. Genes Dev. 1994;8(9):1030-1042.
17. O'Riordan M, Grosschedl R. Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A. Immunity. 1999;11(1):21-31. (Pubitemid 29359954)
18. Hu H, Wang B, Borde M, et al. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 2006;7(8):819-826. (Pubitemid 44084088)
19. Zhang Z, Espinoza CR, Yu Z, et al. Transcription factor Pax5 (BSAP) transactivates the RAGmediated V(H)-to-DJ(H) rearrangement of immunoglobulin genes. Nat Immunol. 2006;7(6):616-624. (Pubitemid 43797343)
20. Amin RH, Schlissel MS. Foxo1 directly regulates the transcription of recombination-activating genes during B cell development. Nat Immunol. 2008;9(6):613-622. (Pubitemid 351712632)
21. Dengler HS, Baracho GV, Omori SA, et al. Distinct functions for the transcription factor Foxo1 at various stages of B cell differentiation. Nat Immunol. 2008;9(12):1388-1398.
22. Reynaud D, Demarco IA, Reddy KL, et al. Regulation of B cell fate commitment and immunoglobulin heavy-chain gene rearrangements by Ikaros. Nat Immunol. 2008;9(8):927-936.
23. Kuo TC, Schlissel MS. Mechanisms controlling expression of the RAG locus during lymphocyte development. Curr Opin Immunol. 2009;21(2):173-178.
24. Ferreirós-Vidal I, Carroll T, Taylor B, et al. Genome-wide identification of Ikaros targets elucidates its contribution to mouse B-cell lineage specification and pre-B-cell differentiation. Blood. 2013;121(10):1769-1782.
25. Reya T, Duncan AW, Ailles L, et al. A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003;423(6938):409-414. (Pubitemid 36626987)
26. Willert K, Brown JD, Danenberg E, et al. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003;423(6938): 448-452. (Pubitemid 36626997)
27. Duncan AW, Rattis FM, DiMascio LN, et al. Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance. Nat Immunol. 2005;6(3):314-322. (Pubitemid 41724769)
28. Kirstetter P, Anderson K, Porse BT, Jacobsen SE, Nerlov C. Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol. 2006;7(10):1048-1056. (Pubitemid 44420649)
29. Scheller M, Huelsken J, Rosenbauer F, et al. Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation. Nat Immunol. 2006;7(10):1037-1047. (Pubitemid 44420648)
30. Cobas M, Wilson A, Ernst B, et al. Beta-catenin is dispensable for hematopoiesis and lymphopoiesis. J Exp Med. 2004;199(2):221-229.
31. Yu Q, Quinn WJ III, Salay T, Crowley JE, Cancro MP, Sen JM. Role of beta-catenin in B cell development and function. J Immunol. 2008;181(6):3777- 3783.
32. Reya T, O'Riordan M, Okamura R, et al. Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism. Immunity. 2000;13(1):15-24.
33. Penzo-Méndez A, Dy P, Pallavi B, Lefebvre V. Generation of mice harboring a Sox4 conditional null allele. Genesis. 2007;45(12):776-780. (Pubitemid 351158380)
34. de Boer J, Williams A, Skavdis G, et al. Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol. 2003; 33(2):314-325. (Pubitemid 36267595)
35. Kim J, Cantor AB, Orkin SH, Wang J. Use of in vivo biotinylation to study protein-protein and protein-DNA interactions in mouse embryonic stem cells. Nat Protoc. 2009;4(4):506-517.
36. Liu H, Schmidt-Supprian M, Shi Y, et al. Yin Yang 1 is a critical regulator of B-cell development. Genes Dev. 2007;21(10):1179-1189. (Pubitemid 46789876)
37. Nakano T, Kodama H, Honjo T. Generation of lymphohematopoietic cells from embryonic stem cells in culture. Science. 1994;265(5175):1098-1101. (Pubitemid 24293078)
38. Silver DP, Livingston DM. Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity. Mol Cell. 2001;8(1):233-243. (Pubitemid 32772921)
39. Sharov AA, Ko MS. Exhaustive search for overrepresented DNA sequence motifs with CisFinder. DNA Res. 2009;16(5):261-273.
40. Sakanaka C, Leong P, Xu L, Harrison SD, Williams LT. Casein kinase iepsilon in the wnt pathway: regulation of beta-catenin function. Proc Natl Acad Sci USA. 1999;96(22):12548-12552. (Pubitemid 29513539)
41. Yanagawa S, Matsuda Y, Lee JS, et al. Casein kinase I phosphorylates the Armadillo protein and induces its degradation in Drosophila. EMBO J. 2002;21(7):1733-1742. (Pubitemid 34614629)
42. Swiatek W, Kang H, Garcia BA, et al. Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation. J Biol Chem. 2006;281(18):12233- 12241. (Pubitemid 43855306)
43. Laurenti E, Doulatov S, Zandi S, et al. The transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment. Nat Immunol. 2013;14(7):756-763.
44. Loonstra A, Vooijs M, Beverloo HB, et al. Growth inhibition and DNA damage induced by Cre recombinase in mammalian cells. Proc Natl Acad Sci USA. 2001;98(16):9209-9214. (Pubitemid 32743895)
45. Nutt SL, Kee BL. The transcriptional regulation of B cell lineage commitment. Immunity. 2007;26(6):715-725. (Pubitemid 46908962)
46. Lin YC, Jhunjhunwala S, Benner C, et al. A global network of transcription factors, involving E2A, EBF1 and Foxo1, that orchestrates B cell fate. Nat Immunol. 2010;11(7):635-643.
47. Xue HH, Bollenbacher-Reilley J, Wu Z, et al. The transcription factor GABP is a critical regulator of B lymphocyte development. Immunity. 2007;26(4):421-431. (Pubitemid 46603002)