The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia

Journal of Experimental Medicine

Volumn 210, Issue 8, 2013, Pages 1545-1557

  Mansour, Marc R ^a,b   Sanda, Takaomi ^a,c   Lawton, Lee N ^d   Li, Xiaoyu ^a   Kreslavsky, Taras ^a   Novina, Carl D ^a,e   Brand, Marjorie ^f,g   Gutierrez, Alejandro ^a,h   Kelliher, Michelle A ⁱ   Jamieson, Catriona H M ^j   von Boehmer, Harald ^a   Young, Richard A ^d,e   Look, A Thomas ^a,h  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^g UNIVERSITY OF OTTAWA   (Canada)

^h BOSTON CHILDREN S HOSPITAL   (United States)

ⁱ UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^j UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN E; MICRORNA 223; MYC PROTEIN; NOTCH1 RECEPTOR; PROTEIN FBXW7; PROTEIN MYB; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR RUNX1; TRANSCRIPTION FACTOR TAL1; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CELL GROWTH; CELL MATURATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DNA SEQUENCE; DOWN REGULATION; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; STABLE EXPRESSION; T CELL ACUTE LYMPHOBLASTIC LEUKEMIA; THYMOCYTE; UPREGULATION;

3' UNTRANSLATED REGIONS; ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL CYCLE PROTEINS; F-BOX PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, LEUKEMIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICE; MICRORNAS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTO-ONCOGENE PROTEINS; THYMUS GLAND; TRANSCRIPTIONAL ACTIVATION; UBIQUITIN-PROTEIN LIGASES;

EID: 84884263191     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20122516     Document Type: Article

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