-
1
-
-
3242669145
-
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
-
F. Arai, A. Hirao, M. Ohmura, H. Sato, S. Matsuoka, K. Takubo, K. Ito, G.Y. Koh, and T. Suda Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche Cell 118 2004 149 161
-
(2004)
Cell
, vol.118
, pp. 149-161
-
-
Arai, F.1
Hirao, A.2
Ohmura, M.3
Sato, H.4
Matsuoka, S.5
Takubo, K.6
Ito, K.7
Koh, G.Y.8
Suda, T.9
-
2
-
-
77953462161
-
Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection
-
M.T. Baldridge, K.Y. King, N.C. Boles, D.C. Weksberg, and M.A. Goodell Quiescent haematopoietic stem cells are activated by IFN-gamma in response to chronic infection Nature 465 2010 793 797
-
(2010)
Nature
, vol.465
, pp. 793-797
-
-
Baldridge, M.T.1
King, K.Y.2
Boles, N.C.3
Weksberg, D.C.4
Goodell, M.A.5
-
3
-
-
34447517654
-
Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2
-
C. Berthet, M.C. Rodriguez-Galan, D.L. Hodge, J. Gooya, V. Pascal, H.A. Young, J. Keller, R. Bosselut, and P. Kaldis Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2 Mol. Cell. Biol. 27 2007 5079 5089
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 5079-5089
-
-
Berthet, C.1
Rodriguez-Galan, M.C.2
Hodge, D.L.3
Gooya, J.4
Pascal, V.5
Young, H.A.6
Keller, J.7
Bosselut, R.8
Kaldis, P.9
-
4
-
-
79960121483
-
CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation
-
N.C. Boles, K.K. Lin, G.L. Lukov, T.V. Bowman, M.T. Baldridge, and M.A. Goodell CD48 on hematopoietic progenitors regulates stem cells and suppresses tumor formation Blood 118 2011 80 87
-
(2011)
Blood
, vol.118
, pp. 80-87
-
-
Boles, N.C.1
Lin, K.K.2
Lukov, G.L.3
Bowman, T.V.4
Baldridge, M.T.5
Goodell, M.A.6
-
5
-
-
23844542698
-
Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization
-
J.A. Cancelas, A.W. Lee, R. Prabhakar, K.F. Stringer, Y. Zheng, and D.A. Williams Rac GTPases differentially integrate signals regulating hematopoietic stem cell localization Nat. Med. 11 2005 886 891
-
(2005)
Nat. Med.
, vol.11
, pp. 886-891
-
-
Cancelas, J.A.1
Lee, A.W.2
Prabhakar, R.3
Stringer, K.F.4
Zheng, Y.5
Williams, D.A.6
-
6
-
-
33745079016
-
The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation
-
C. Capron, Y. Lécluse, A.L. Kaushik, A. Foudi, C. Lacout, D. Sekkai, I. Godin, O. Albagli, I. Poullion, and F. Svinartchouk The SCL relative LYL-1 is required for fetal and adult hematopoietic stem cell function and B-cell differentiation Blood 107 2006 4678 4686
-
(2006)
Blood
, vol.107
, pp. 4678-4686
-
-
Capron, C.1
Lécluse, Y.2
Kaushik, A.L.3
Foudi, A.4
Lacout, C.5
Sekkai, D.6
Godin, I.7
Albagli, O.8
Poullion, I.9
Svinartchouk, F.10
-
7
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
G.A. Challen, D. Sun, M. Jeong, M. Luo, J. Jelinek, J.S. Berg, C. Bock, A. Vasanthakumar, H. Gu, and Y. Xi Dnmt3a is essential for hematopoietic stem cell differentiation Nat. Genet. 44 2012 23 31
-
(2012)
Nat. Genet.
, vol.44
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
Luo, M.4
Jelinek, J.5
Berg, J.S.6
Bock, C.7
Vasanthakumar, A.8
Gu, H.9
Xi, Y.10
-
8
-
-
0037180509
-
Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells
-
C.Z. Chen, M. Li, D. de Graaf, S. Monti, B. Göttgens, M.J. Sanchez, E.S. Lander, T.R. Golub, A.R. Green, and H.F. Lodish Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells Proc. Natl. Acad. Sci. USA 99 2002 15468 15473
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 15468-15473
-
-
Chen, C.Z.1
Li, M.2
De Graaf, D.3
Monti, S.4
Göttgens, B.5
Sanchez, M.J.6
Lander, E.S.7
Golub, T.R.8
Green, A.R.9
Lodish, H.F.10
-
9
-
-
0036965726
-
Hematopoietic stem cell functional failure in interleukin-2-deficient mice
-
J. Chen, C.M. Astle, and D.E. Harrison Hematopoietic stem cell functional failure in interleukin-2-deficient mice J. Hematother. Stem Cell Res. 11 2002 905 912
-
(2002)
J. Hematother. Stem Cell Res.
, vol.11
, pp. 905-912
-
-
Chen, J.1
Astle, C.M.2
Harrison, D.E.3
-
10
-
-
0033694302
-
Stem cell repopulation efficiency but not pool size is governed by p27(kip1)
-
T. Cheng, N. Rodrigues, D. Dombkowski, S. Stier, and D.T. Scadden Stem cell repopulation efficiency but not pool size is governed by p27(kip1) Nat. Med. 6 2000 1235 1240
-
(2000)
Nat. Med.
, vol.6
, pp. 1235-1240
-
-
Cheng, T.1
Rodrigues, N.2
Dombkowski, D.3
Stier, S.4
Scadden, D.T.5
-
11
-
-
0034629129
-
Hematopoietic stem cell quiescence maintained by p21cip1/waf1
-
T. Cheng, N. Rodrigues, H. Shen, Y. Yang, D. Dombkowski, M. Sykes, and D.T. Scadden Hematopoietic stem cell quiescence maintained by p21cip1/waf1 Science 287 2000 1804 1808
-
(2000)
Science
, vol.287
, pp. 1804-1808
-
-
Cheng, T.1
Rodrigues, N.2
Shen, H.3
Yang, Y.4
Dombkowski, D.5
Sykes, M.6
Scadden, D.T.7
-
12
-
-
65549165761
-
Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization
-
M.J. Christopher, F. Liu, M.J. Hilton, F. Long, and D.C. Link Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization Blood 114 2009 1331 1339
-
(2009)
Blood
, vol.114
, pp. 1331-1339
-
-
Christopher, M.J.1
Liu, F.2
Hilton, M.J.3
Long, F.4
Link, D.C.5
-
13
-
-
1642499734
-
Beta-catenin is dispensable for hematopoiesis and lymphopoiesis
-
M. Cobas, A. Wilson, B. Ernst, S.J. Mancini, H.R. MacDonald, R. Kemler, and F. Radtke Beta-catenin is dispensable for hematopoiesis and lymphopoiesis J. Exp. Med. 199 2004 221 229
-
(2004)
J. Exp. Med.
, vol.199
, pp. 221-229
-
-
Cobas, M.1
Wilson, A.2
Ernst, B.3
Mancini, S.J.4
MacDonald, H.R.5
Kemler, R.6
Radtke, F.7
-
14
-
-
9444242683
-
Shared role of the pRB-related p130 and p107 proteins in limb development
-
D. Cobrinik, M.H. Lee, G. Hannon, G. Mulligan, R.T. Bronson, N. Dyson, E. Harlow, D. Beach, R.A. Weinberg, and T. Jacks Shared role of the pRB-related p130 and p107 proteins in limb development Genes Dev. 10 1996 1633 1644
-
(1996)
Genes Dev.
, vol.10
, pp. 1633-1644
-
-
Cobrinik, D.1
Lee, M.H.2
Hannon, G.3
Mulligan, G.4
Bronson, R.T.5
Dyson, N.6
Harlow, E.7
Beach, D.8
Weinberg, R.A.9
Jacks, T.10
-
15
-
-
41349095902
-
The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress
-
D. Daria, M.D. Filippi, E.S. Knudsen, R. Faccio, Z. Li, T. Kalfa, and H. Geiger The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress Blood 111 2008 1894 1902
-
(2008)
Blood
, vol.111
, pp. 1894-1902
-
-
Daria, D.1
Filippi, M.D.2
Knudsen, E.S.3
Faccio, R.4
Li, Z.5
Kalfa, T.6
Geiger, H.7
-
16
-
-
78650734181
-
Regulation of hematopoietic stem cells by their mature progeny
-
C.A. de Graaf, M. Kauppi, T. Baldwin, C.D. Hyland, D. Metcalf, T.A. Willson, M.R. Carpinelli, G.K. Smyth, W.S. Alexander, and D.J. Hilton Regulation of hematopoietic stem cells by their mature progeny Proc. Natl. Acad. Sci. USA 107 2010 21689 21694
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 21689-21694
-
-
De Graaf, C.A.1
Kauppi, M.2
Baldwin, T.3
Hyland, C.D.4
Metcalf, D.5
Willson, T.A.6
Carpinelli, M.R.7
Smyth, G.K.8
Alexander, W.S.9
Hilton, D.J.10
-
17
-
-
0035437164
-
The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver
-
J.F. DiMartino, L. Selleri, D. Traver, M.T. Firpo, J. Rhee, R. Warnke, S. O'Gorman, I.L. Weissman, and M.L. Cleary The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver Blood 98 2001 618 626
-
(2001)
Blood
, vol.98
, pp. 618-626
-
-
Dimartino, J.F.1
Selleri, L.2
Traver, D.3
Firpo, M.T.4
Rhee, J.5
Warnke, R.6
O'Gorman, S.7
Weissman, I.L.8
Cleary, M.L.9
-
18
-
-
66149115277
-
IFNalpha activates dormant haematopoietic stem cells in vivo
-
M.A. Essers, S. Offner, W.E. Blanco-Bose, Z. Waibler, U. Kalinke, M.A. Duchosal, and A. Trumpp IFNalpha activates dormant haematopoietic stem cells in vivo Nature 458 2009 904 908
-
(2009)
Nature
, vol.458
, pp. 904-908
-
-
Essers, M.A.1
Offner, S.2
Blanco-Bose, W.E.3
Waibler, Z.4
Kalinke, U.5
Duchosal, M.A.6
Trumpp, A.7
-
19
-
-
37549048915
-
The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation
-
C.G. Feng, D.C. Weksberg, G.A. Taylor, A. Sher, and M.A. Goodell The p47 GTPase Lrg-47 (Irgm1) links host defense and hematopoietic stem cell proliferation Cell Stem Cell 2 2008 83 89
-
(2008)
Cell Stem Cell
, vol.2
, pp. 83-89
-
-
Feng, C.G.1
Weksberg, D.C.2
Taylor, G.A.3
Sher, A.4
Goodell, M.A.5
-
20
-
-
42649142267
-
Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence
-
F. Ficara, M.J. Murphy, M. Lin, and M.L. Cleary Pbx1 regulates self-renewal of long-term hematopoietic stem cells by maintaining their quiescence Cell Stem Cell 2 2008 484 496
-
(2008)
Cell Stem Cell
, vol.2
, pp. 484-496
-
-
Ficara, F.1
Murphy, M.J.2
Lin, M.3
Cleary, M.L.4
-
21
-
-
39749178390
-
Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo
-
H.E. Fleming, V. Janzen, C. Lo Celso, J. Guo, K.M. Leahy, H.M. Kronenberg, and D.T. Scadden Wnt signaling in the niche enforces hematopoietic stem cell quiescence and is necessary to preserve self-renewal in vivo Cell Stem Cell 2 2008 274 283
-
(2008)
Cell Stem Cell
, vol.2
, pp. 274-283
-
-
Fleming, H.E.1
Janzen, V.2
Lo Celso, C.3
Guo, J.4
Leahy, K.M.5
Kronenberg, H.M.6
Scadden, D.T.7
-
22
-
-
78649874959
-
Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
-
B. Gan, J. Hu, S. Jiang, Y. Liu, E. Sahin, L. Zhuang, E. Fletcher-Sananikone, S. Colla, Y.A. Wang, L. Chin, and R.A. Depinho Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells Nature 468 2010 701 704
-
(2010)
Nature
, vol.468
, pp. 701-704
-
-
Gan, B.1
Hu, J.2
Jiang, S.3
Liu, Y.4
Sahin, E.5
Zhuang, L.6
Fletcher-Sananikone, E.7
Colla, S.8
Wang, Y.A.9
Chin, L.10
Depinho, R.A.11
-
24
-
-
64049107119
-
Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells
-
G. Ghiaur, M.J. Ferkowicz, M.D. Milsom, J. Bailey, D. Witte, J.A. Cancelas, M.C. Yoder, and D.A. Williams Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells Blood 111 2008 3313 3321
-
(2008)
Blood
, vol.111
, pp. 3313-3321
-
-
Ghiaur, G.1
Ferkowicz, M.J.2
Milsom, M.D.3
Bailey, J.4
Witte, D.5
Cancelas, J.A.6
Yoder, M.C.7
Williams, D.A.8
-
25
-
-
44349088690
-
Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation
-
W. Guo, J.L. Lasky, C.J. Chang, S. Mosessian, X. Lewis, Y. Xiao, J.E. Yeh, J.Y. Chen, M.L. Iruela-Arispe, M. Varella-Garcia, and H. Wu Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation Nature 453 2008 529 533
-
(2008)
Nature
, vol.453
, pp. 529-533
-
-
Guo, W.1
Lasky, J.L.2
Chang, C.J.3
Mosessian, S.4
Lewis, X.5
Xiao, Y.6
Yeh, J.E.7
Chen, J.Y.8
Iruela-Arispe, M.L.9
Varella-Garcia, M.10
Wu, H.11
-
26
-
-
78649851511
-
The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
-
S. Gurumurthy, S.Z. Xie, B. Alagesan, J. Kim, R.Z. Yusuf, B. Saez, A. Tzatsos, F. Ozsolak, P. Milos, and F. Ferrari The Lkb1 metabolic sensor maintains haematopoietic stem cell survival Nature 468 2010 659 663
-
(2010)
Nature
, vol.468
, pp. 659-663
-
-
Gurumurthy, S.1
Xie, S.Z.2
Alagesan, B.3
Kim, J.4
Yusuf, R.Z.5
Saez, B.6
Tzatsos, A.7
Ozsolak, F.8
Milos, P.9
Ferrari, F.10
-
27
-
-
0037417892
-
The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12
-
M.A. Hall, D.J. Curtis, D. Metcalf, A.G. Elefanty, K. Sourris, L. Robb, J.R. Gothert, S.M. Jane, and C.G. Begley The critical regulator of embryonic hematopoiesis, SCL, is vital in the adult for megakaryopoiesis, erythropoiesis, and lineage choice in CFU-S12 Proc. Natl. Acad. Sci. USA 100 2003 992 997
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 992-997
-
-
Hall, M.A.1
Curtis, D.J.2
Metcalf, D.3
Elefanty, A.G.4
Sourris, K.5
Robb, L.6
Gothert, J.R.7
Jane, S.M.8
Begley, C.G.9
-
28
-
-
57849136005
-
ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling
-
J.C. Hartner, C.R. Walkley, J. Lu, and S.H. Orkin ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling Nat. Immunol. 10 2009 109 115
-
(2009)
Nat. Immunol.
, vol.10
, pp. 109-115
-
-
Hartner, J.C.1
Walkley, C.R.2
Lu, J.3
Orkin, S.H.4
-
29
-
-
0037090881
-
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: A tool for temporally regulated gene activation/inactivation in the mouse
-
S. Hayashi, and A.P. McMahon Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse Dev. Biol. 244 2002 305 318
-
(2002)
Dev. Biol.
, vol.244
, pp. 305-318
-
-
Hayashi, S.1
McMahon, A.P.2
-
30
-
-
7244231429
-
Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells
-
H. Hock, M.J. Hamblen, H.M. Rooke, J.W. Schindler, S. Saleque, Y. Fujiwara, and S.H. Orkin Gfi-1 restricts proliferation and preserves functional integrity of haematopoietic stem cells Nature 431 2004 1002 1007
-
(2004)
Nature
, vol.431
, pp. 1002-1007
-
-
Hock, H.1
Hamblen, M.J.2
Rooke, H.M.3
Schindler, J.W.4
Saleque, S.5
Fujiwara, Y.6
Orkin, S.H.7
-
31
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
K. Ito, A. Hirao, F. Arai, S. Matsuoka, K. Takubo, I. Hamaguchi, K. Nomiyama, K. Hosokawa, K. Sakurada, and N. Nakagata Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells Nature 431 2004 997 1002
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
Matsuoka, S.4
Takubo, K.5
Hamaguchi, I.6
Nomiyama, K.7
Hosokawa, K.8
Sakurada, K.9
Nakagata, N.10
-
32
-
-
23944446085
-
Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation
-
H. Iwasaki, C. Somoza, H. Shigematsu, E.A. Duprez, J. Iwasaki-Arai, S. Mizuno, Y. Arinobu, K. Geary, P. Zhang, and T. Dayaram Distinctive and indispensable roles of PU.1 in maintenance of hematopoietic stem cells and their differentiation Blood 106 2005 1590 1600
-
(2005)
Blood
, vol.106
, pp. 1590-1600
-
-
Iwasaki, H.1
Somoza, C.2
Shigematsu, H.3
Duprez, E.A.4
Iwasaki-Arai, J.5
Mizuno, S.6
Arinobu, Y.7
Geary, K.8
Zhang, P.9
Dayaram, T.10
-
33
-
-
15544385625
-
Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure
-
M. Jansen, F.C. Yang, J.A. Cancelas, J.R. Bailey, and D.A. Williams Rac2-deficient hematopoietic stem cells show defective interaction with the hematopoietic microenvironment and long-term engraftment failure Stem Cells 23 2005 335 346
-
(2005)
Stem Cells
, vol.23
, pp. 335-346
-
-
Jansen, M.1
Yang, F.C.2
Cancelas, J.A.3
Bailey, J.R.4
Williams, D.A.5
-
34
-
-
77953283847
-
AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species
-
M.M. Juntilla, V.D. Patil, M. Calamito, R.P. Joshi, M.J. Birnbaum, and G.A. Koretzky AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species Blood 115 2010 4030 4038
-
(2010)
Blood
, vol.115
, pp. 4030-4038
-
-
Juntilla, M.M.1
Patil, V.D.2
Calamito, M.3
Joshi, R.P.4
Birnbaum, M.J.5
Koretzky, G.A.6
-
35
-
-
34547201175
-
A novel function of interleukin-10 promoting self-renewal of hematopoietic stem cells
-
Y.J. Kang, S.J. Yang, G. Park, B. Cho, C.K. Min, T.Y. Kim, J.S. Lee, and I.H. Oh A novel function of interleukin-10 promoting self-renewal of hematopoietic stem cells Stem Cells 25 2007 1814 1822
-
(2007)
Stem Cells
, vol.25
, pp. 1814-1822
-
-
Kang, Y.J.1
Yang, S.J.2
Park, G.3
Cho, B.4
Min, C.K.5
Kim, T.Y.6
Lee, J.S.7
Oh, I.H.8
-
36
-
-
33947419709
-
Smad4 is critical for self-renewal of hematopoietic stem cells
-
G. Karlsson, U. Blank, J.L. Moody, M. Ehinger, S. Singbrant, C.X. Deng, and S. Karlsson Smad4 is critical for self-renewal of hematopoietic stem cells J. Exp. Med. 204 2007 467 474
-
(2007)
J. Exp. Med.
, vol.204
, pp. 467-474
-
-
Karlsson, G.1
Blank, U.2
Moody, J.L.3
Ehinger, M.4
Singbrant, S.5
Deng, C.X.6
Karlsson, S.7
-
37
-
-
34547668398
-
Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells
-
I. Kim, T.L. Saunders, and S.J. Morrison Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells Cell 130 2007 470 483
-
(2007)
Cell
, vol.130
, pp. 470-483
-
-
Kim, I.1
Saunders, T.L.2
Morrison, S.J.3
-
38
-
-
0032477741
-
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin
-
S. Kimura, A.W. Roberts, D. Metcalf, and W.S. Alexander Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin Proc. Natl. Acad. Sci. USA 95 1998 1195 1200
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1195-1200
-
-
Kimura, S.1
Roberts, A.W.2
Metcalf, D.3
Alexander, W.S.4
-
39
-
-
80053133049
-
Inflammatory modulation of HSCs: Viewing the HSC as a foundation for the immune response
-
K.Y. King, and M.A. Goodell Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response Nat. Rev. Immunol. 11 2011 685 692
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 685-692
-
-
King, K.Y.1
Goodell, M.A.2
-
40
-
-
79960810509
-
Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling
-
K.Y. King, M.T. Baldridge, D.C. Weksberg, S.M. Chambers, G.L. Lukov, S. Wu, N.C. Boles, S.Y. Jung, J. Qin, and D. Liu Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling Blood 118 2011 1525 1533
-
(2011)
Blood
, vol.118
, pp. 1525-1533
-
-
King, K.Y.1
Baldridge, M.T.2
Weksberg, D.C.3
Chambers, S.M.4
Lukov, G.L.5
Wu, S.6
Boles, N.C.7
Jung, S.Y.8
Qin, J.9
Liu, D.10
-
41
-
-
33748850636
-
Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block
-
P. Kirstetter, K. Anderson, B.T. Porse, S.E. Jacobsen, and C. Nerlov Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block Nat. Immunol. 7 2006 1048 1056
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1048-1056
-
-
Kirstetter, P.1
Anderson, K.2
Porse, B.T.3
Jacobsen, S.E.4
Nerlov, C.5
-
42
-
-
80052284526
-
Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice
-
M. Ko, H.S. Bandukwala, J. An, E.D. Lamperti, E.C. Thompson, R. Hastie, A. Tsangaratou, K. Rajewsky, S.B. Koralov, and A. Rao Ten-Eleven-Translocation 2 (TET2) negatively regulates homeostasis and differentiation of hematopoietic stem cells in mice Proc. Natl. Acad. Sci. USA 108 2011 14566 14571
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 14566-14571
-
-
Ko, M.1
Bandukwala, H.S.2
An, J.3
Lamperti, E.D.4
Thompson, E.C.5
Hastie, R.6
Tsangaratou, A.7
Rajewsky, K.8
Koralov, S.B.9
Rao, A.10
-
43
-
-
4444307411
-
Mouse development and cell proliferation in the absence of D-cyclins
-
K. Kozar, M.A. Ciemerych, V.I. Rebel, H. Shigematsu, A. Zagozdzon, E. Sicinska, Y. Geng, Q. Yu, S. Bhattacharya, and R.T. Bronson Mouse development and cell proliferation in the absence of D-cyclins Cell 118 2004 477 491
-
(2004)
Cell
, vol.118
, pp. 477-491
-
-
Kozar, K.1
Ciemerych, M.A.2
Rebel, V.I.3
Shigematsu, H.4
Zagozdzon, A.5
Sicinska, E.6
Geng, Y.7
Yu, Q.8
Bhattacharya, S.9
Bronson, R.T.10
-
44
-
-
73349092431
-
Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration
-
Y. Kubota, M. Osawa, L.M. Jakt, K. Yoshikawa, and S. Nishikawa Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration Blood 114 2009 4383 4392
-
(2009)
Blood
, vol.114
, pp. 4383-4392
-
-
Kubota, Y.1
Osawa, M.2
Jakt, L.M.3
Yoshikawa, K.4
Nishikawa, S.5
-
46
-
-
0346024089
-
Quantitative trait analysis reveals transforming growth factor-beta2 as a positive regulator of early hematopoietic progenitor and stem cell function
-
J.C. Langer, E. Henckaerts, J. Orenstein, and H.W. Snoeck Quantitative trait analysis reveals transforming growth factor-beta2 as a positive regulator of early hematopoietic progenitor and stem cell function J. Exp. Med. 199 2004 5 14
-
(2004)
J. Exp. Med.
, vol.199
, pp. 5-14
-
-
Langer, J.C.1
Henckaerts, E.2
Orenstein, J.3
Snoeck, H.W.4
-
47
-
-
17744397294
-
Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type i receptor-deficient mice
-
J. Larsson, M.J. Goumans, L.J. Sjöstrand, M.A. van Rooijen, D. Ward, P. Levéen, X. Xu, P. ten Dijke, C.L. Mummery, and S. Karlsson Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice EMBO J. 20 2001 1663 1673
-
(2001)
EMBO J.
, vol.20
, pp. 1663-1673
-
-
Larsson, J.1
Goumans, M.J.2
Sjöstrand, L.J.3
Van Rooijen, M.A.4
Ward, D.5
Levéen, P.6
Xu, X.7
Ten Dijke, P.8
Mummery, C.L.9
Karlsson, S.10
-
48
-
-
0142245613
-
TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro
-
J. Larsson, U. Blank, H. Helgadottir, J.M. Björnsson, M. Ehinger, M.J. Goumans, X. Fan, P. Levéen, and S. Karlsson TGF-beta signaling-deficient hematopoietic stem cells have normal self-renewal and regenerative ability in vivo despite increased proliferative capacity in vitro Blood 102 2003 3129 3135
-
(2003)
Blood
, vol.102
, pp. 3129-3135
-
-
Larsson, J.1
Blank, U.2
Helgadottir, H.3
Björnsson, J.M.4
Ehinger, M.5
Goumans, M.J.6
Fan, X.7
Levéen, P.8
Karlsson, S.9
-
49
-
-
28444455240
-
Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells
-
H.J. Lawrence, J. Christensen, S. Fong, Y.L. Hu, I. Weissman, G. Sauvageau, R.K. Humphries, and C. Largman Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells Blood 106 2005 3988 3994
-
(2005)
Blood
, vol.106
, pp. 3988-3994
-
-
Lawrence, H.J.1
Christensen, J.2
Fong, S.3
Hu, Y.L.4
Weissman, I.5
Sauvageau, G.6
Humphries, R.K.7
Largman, C.8
-
50
-
-
0032433267
-
Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene
-
J.E. LeCouter, B. Kablar, P.F. Whyte, C. Ying, and M.A. Rudnicki Strain-dependent embryonic lethality in mice lacking the retinoblastoma-related p130 gene Development 125 1998 4669 4679
-
(1998)
Development
, vol.125
, pp. 4669-4679
-
-
Lecouter, J.E.1
Kablar, B.2
Whyte, P.F.3
Ying, C.4
Rudnicki, M.A.5
-
51
-
-
80053296176
-
CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway
-
K.K. Lin, L. Rossi, N.C. Boles, B.E. Hall, T.C. George, and M.A. Goodell CD81 is essential for the re-entry of hematopoietic stem cells to quiescence following stress-induced proliferation via deactivation of the Akt pathway PLoS Biol. 9 2011 e1001148
-
(2011)
PLoS Biol.
, vol.9
, pp. 1001148
-
-
Lin, K.K.1
Rossi, L.2
Boles, N.C.3
Hall, B.E.4
George, T.C.5
Goodell, M.A.6
-
52
-
-
0030292823
-
Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice
-
F. Liu, H.Y. Wu, R. Wesselschmidt, T. Kornaga, and D.C. Link Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice Immunity 5 1996 491 501
-
(1996)
Immunity
, vol.5
, pp. 491-501
-
-
Liu, F.1
Wu, H.Y.2
Wesselschmidt, R.3
Kornaga, T.4
Link, D.C.5
-
53
-
-
70349897697
-
The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior
-
Y. Liu, S.E. Elf, T. Asai, Y. Miyata, Y. Liu, G. Sashida, G. Huang, S. Di Giandomenico, A. Koff, and S.D. Nimer The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior Cell Cycle 8 2009 3120 3124
-
(2009)
Cell Cycle
, vol.8
, pp. 3120-3124
-
-
Liu, Y.1
Elf, S.E.2
Asai, T.3
Miyata, Y.4
Liu, Y.5
Sashida, G.6
Huang, G.7
Di Giandomenico, S.8
Koff, A.9
Nimer, S.D.10
-
54
-
-
58049216794
-
P53 regulates hematopoietic stem cell quiescence
-
Y. Liu, S.E. Elf, Y. Miyata, G. Sashida, Y. Liu, G. Huang, S. Di Giandomenico, J.M. Lee, A. Deblasio, and S. Menendez p53 regulates hematopoietic stem cell quiescence Cell Stem Cell 4 2009 37 48
-
(2009)
Cell Stem Cell
, vol.4
, pp. 37-48
-
-
Liu, Y.1
Elf, S.E.2
Miyata, Y.3
Sashida, G.4
Liu, Y.5
Huang, G.6
Di Giandomenico, S.7
Lee, J.M.8
Deblasio, A.9
Menendez, S.10
-
55
-
-
60249101799
-
Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation
-
T.C. Luis, F. Weerkamp, B.A. Naber, M.R. Baert, E.F. de Haas, T. Nikolic, S. Heuvelmans, R.R. De Krijger, J.J. van Dongen, and F.J. Staal Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation Blood 113 2009 546 554
-
(2009)
Blood
, vol.113
, pp. 546-554
-
-
Luis, T.C.1
Weerkamp, F.2
Naber, B.A.3
Baert, M.R.4
De Haas, E.F.5
Nikolic, T.6
Heuvelmans, S.7
De Krijger, R.R.8
Van Dongen, J.J.9
Staal, F.J.10
-
56
-
-
80053907201
-
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion
-
T.C. Luis, B.A. Naber, P.P. Roozen, M.H. Brugman, E.F. de Haas, M. Ghazvini, W.E. Fibbe, J.J. van Dongen, R. Fodde, and F.J. Staal Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion Cell Stem Cell 9 2011 345 356
-
(2011)
Cell Stem Cell
, vol.9
, pp. 345-356
-
-
Luis, T.C.1
Naber, B.A.2
Roozen, P.P.3
Brugman, M.H.4
De Haas, E.F.5
Ghazvini, M.6
Fibbe, W.E.7
Van Dongen, J.J.8
Fodde, R.9
Staal, F.J.10
-
57
-
-
4444247138
-
Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
-
M. Malumbres, R. Sotillo, D. Santamaría, J. Galán, A. Cerezo, S. Ortega, P. Dubus, and M. Barbacid Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6 Cell 118 2004 493 504
-
(2004)
Cell
, vol.118
, pp. 493-504
-
-
Malumbres, M.1
Sotillo, R.2
Santamaría, D.3
Galán, J.4
Cerezo, A.5
Ortega, S.6
Dubus, P.7
Barbacid, M.8
-
58
-
-
80052289298
-
P57 is required for quiescence and maintenance of adult hematopoietic stem cells
-
A. Matsumoto, S. Takeishi, T. Kanie, E. Susaki, I. Onoyama, Y. Tateishi, K. Nakayama, and K.I. Nakayama p57 is required for quiescence and maintenance of adult hematopoietic stem cells Cell Stem Cell 9 2011 262 271
-
(2011)
Cell Stem Cell
, vol.9
, pp. 262-271
-
-
Matsumoto, A.1
Takeishi, S.2
Kanie, T.3
Susaki, E.4
Onoyama, I.5
Tateishi, Y.6
Nakayama, K.7
Nakayama, K.I.8
-
60
-
-
84555189736
-
The bone marrow at the crossroads of blood and immunity
-
F.E. Mercier, C. Ragu, and D.T. Scadden The bone marrow at the crossroads of blood and immunity Nat. Rev. Immunol. 12 2012 49 60
-
(2012)
Nat. Rev. Immunol.
, vol.12
, pp. 49-60
-
-
Mercier, F.E.1
Ragu, C.2
Scadden, D.T.3
-
61
-
-
0037472895
-
Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene
-
H.K. Mikkola, J. Klintman, H. Yang, H. Hock, T.M. Schlaeger, Y. Fujiwara, and S.H. Orkin Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene Nature 421 2003 547 551
-
(2003)
Nature
, vol.421
, pp. 547-551
-
-
Mikkola, H.K.1
Klintman, J.2
Yang, H.3
Hock, H.4
Schlaeger, T.M.5
Fujiwara, Y.6
Orkin, S.H.7
-
62
-
-
41449118699
-
The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells
-
I.M. Min, G. Pietramaggiori, F.S. Kim, E. Passegué, K.E. Stevenson, and A.J. Wagers The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells Cell Stem Cell 2 2008 380 391
-
(2008)
Cell Stem Cell
, vol.2
, pp. 380-391
-
-
Min, I.M.1
Pietramaggiori, G.2
Kim, F.S.3
Passegué, E.4
Stevenson, K.E.5
Wagers, A.J.6
-
63
-
-
34249882777
-
Foxo3a is essential for maintenance of the hematopoietic stem cell pool
-
K. Miyamoto, K.Y. Araki, K. Naka, F. Arai, K. Takubo, S. Yamazaki, S. Matsuoka, T. Miyamoto, K. Ito, and M. Ohmura Foxo3a is essential for maintenance of the hematopoietic stem cell pool Cell Stem Cell 1 2007 101 112
-
(2007)
Cell Stem Cell
, vol.1
, pp. 101-112
-
-
Miyamoto, K.1
Araki, K.Y.2
Naka, K.3
Arai, F.4
Takubo, K.5
Yamazaki, S.6
Matsuoka, S.7
Miyamoto, T.8
Ito, K.9
Ohmura, M.10
-
64
-
-
79960064353
-
Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation
-
K. Moran-Crusio, L. Reavie, A. Shih, O. Abdel-Wahab, D. Ndiaye-Lobry, C. Lobry, M.E. Figueroa, A. Vasanthakumar, J. Patel, and X. Zhao Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation Cancer Cell 20 2011 11 24
-
(2011)
Cancer Cell
, vol.20
, pp. 11-24
-
-
Moran-Crusio, K.1
Reavie, L.2
Shih, A.3
Abdel-Wahab, O.4
Ndiaye-Lobry, D.5
Lobry, C.6
Figueroa, M.E.7
Vasanthakumar, A.8
Patel, J.9
Zhao, X.10
-
65
-
-
78649811793
-
Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
-
D. Nakada, T.L. Saunders, and S.J. Morrison Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells Nature 468 2010 653 658
-
(2010)
Nature
, vol.468
, pp. 653-658
-
-
Nakada, D.1
Saunders, T.L.2
Morrison, S.J.3
-
66
-
-
77958001789
-
Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells
-
M. Naramura, N. Nandwani, H. Gu, V. Band, and H. Band Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells Proc. Natl. Acad. Sci. USA 107 2010 16274 16279
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 16274-16279
-
-
Naramura, M.1
Nandwani, N.2
Gu, H.3
Band, V.4
Band, H.5
-
67
-
-
33749065765
-
Tcf3 governs stem cell features and represses cell fate determination in skin
-
H. Nguyen, M. Rendl, and E. Fuchs Tcf3 governs stem cell features and represses cell fate determination in skin Cell 127 2006 171 183
-
(2006)
Cell
, vol.127
, pp. 171-183
-
-
Nguyen, H.1
Rendl, M.2
Fuchs, E.3
-
68
-
-
42249103574
-
CXCR4 is required for the quiescence of primitive hematopoietic cells
-
Y. Nie, Y.C. Han, and Y.R. Zou CXCR4 is required for the quiescence of primitive hematopoietic cells J. Exp. Med. 205 2008 777 783
-
(2008)
J. Exp. Med.
, vol.205
, pp. 777-783
-
-
Nie, Y.1
Han, Y.C.2
Zou, Y.R.3
-
69
-
-
0038349957
-
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells
-
I.K. Park, D. Qian, M. Kiel, M.W. Becker, M. Pihalja, I.L. Weissman, S.J. Morrison, and M.F. Clarke Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells Nature 423 2003 302 305
-
(2003)
Nature
, vol.423
, pp. 302-305
-
-
Park, I.K.1
Qian, D.2
Kiel, M.3
Becker, M.W.4
Pihalja, M.5
Weissman, I.L.6
Morrison, S.J.7
Clarke, M.F.8
-
70
-
-
0242331643
-
Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis
-
M.C. Puri, and A. Bernstein Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesis Proc. Natl. Acad. Sci. USA 100 2003 12753 12758
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 12753-12758
-
-
Puri, M.C.1
Bernstein, A.2
-
71
-
-
34548417118
-
Limiting factors in murine hematopoietic stem cell assays
-
L.E. Purton, and D.T. Scadden Limiting factors in murine hematopoietic stem cell assays Cell Stem Cell 1 2007 263 270
-
(2007)
Cell Stem Cell
, vol.1
, pp. 263-270
-
-
Purton, L.E.1
Scadden, D.T.2
-
72
-
-
36749001043
-
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
-
H. Qian, N. Buza-Vidas, C.D. Hyland, C.T. Jensen, J. Antonchuk, R. Månsson, L.A. Thoren, M. Ekblom, W.S. Alexander, and S.E. Jacobsen Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells Cell Stem Cell 1 2007 671 684
-
(2007)
Cell Stem Cell
, vol.1
, pp. 671-684
-
-
Qian, H.1
Buza-Vidas, N.2
Hyland, C.D.3
Jensen, C.T.4
Antonchuk, J.5
Månsson, R.6
Thoren, L.A.7
Ekblom, M.8
Alexander, W.S.9
Jacobsen, S.E.10
-
73
-
-
51049108335
-
A critical role for Apc in hematopoietic stem and progenitor cell survival
-
Z. Qian, L. Chen, A.A. Fernald, B.O. Williams, and M.M. Le Beau A critical role for Apc in hematopoietic stem and progenitor cell survival J. Exp. Med. 205 2008 2163 2175
-
(2008)
J. Exp. Med.
, vol.205
, pp. 2163-2175
-
-
Qian, Z.1
Chen, L.2
Fernald, A.A.3
Williams, B.O.4
Le Beau, M.M.5
-
74
-
-
79960062301
-
TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis
-
C. Quivoron, L. Couronné, V. Della Valle, C.K. Lopez, I. Plo, O. Wagner-Ballon, M. Do Cruzeiro, F. Delhommeau, B. Arnulf, and M.H. Stern TET2 inactivation results in pleiotropic hematopoietic abnormalities in mouse and is a recurrent event during human lymphomagenesis Cancer Cell 20 2011 25 38
-
(2011)
Cancer Cell
, vol.20
, pp. 25-38
-
-
Quivoron, C.1
Couronné, L.2
Della Valle, V.3
Lopez, C.K.4
Plo, I.5
Wagner-Ballon, O.6
Do Cruzeiro, M.7
Delhommeau, F.8
Arnulf, B.9
Stern, M.H.10
-
75
-
-
77950862042
-
Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
-
M.H. Raaijmakers, S. Mukherjee, S. Guo, S. Zhang, T. Kobayashi, J.A. Schoonmaker, B.L. Ebert, F. Al-Shahrour, R.P. Hasserjian, and E.O. Scadden Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia Nature 464 2010 852 857
-
(2010)
Nature
, vol.464
, pp. 852-857
-
-
Raaijmakers, M.H.1
Mukherjee, S.2
Guo, S.3
Zhang, S.4
Kobayashi, T.5
Schoonmaker, J.A.6
Ebert, B.L.7
Al-Shahrour, F.8
Hasserjian, R.P.9
Scadden, E.O.10
-
76
-
-
42149188212
-
The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells
-
C. Rathinam, C.B. Thien, W.Y. Langdon, H. Gu, and R.A. Flavell The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells Genes Dev. 22 2008 992 997
-
(2008)
Genes Dev.
, vol.22
, pp. 992-997
-
-
Rathinam, C.1
Thien, C.B.2
Langdon, W.Y.3
Gu, H.4
Flavell, R.A.5
-
77
-
-
79955028943
-
The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells
-
C. Rathinam, L.E. Matesic, and R.A. Flavell The E3 ligase Itch is a negative regulator of the homeostasis and function of hematopoietic stem cells Nat. Immunol. 12 2011 399 407
-
(2011)
Nat. Immunol.
, vol.12
, pp. 399-407
-
-
Rathinam, C.1
Matesic, L.E.2
Flavell, R.A.3
-
78
-
-
0033571183
-
Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level
-
V.I. Rebel, S. Hartnett, G.R. Hill, S.B. Lazo-Kallanian, J.L. Ferrara, and C.A. Sieff Essential role for the p55 tumor necrosis factor receptor in regulating hematopoiesis at a stem cell level J. Exp. Med. 190 1999 1493 1504
-
(1999)
J. Exp. Med.
, vol.190
, pp. 1493-1504
-
-
Rebel, V.I.1
Hartnett, S.2
Hill, G.R.3
Lazo-Kallanian, S.B.4
Ferrara, J.L.5
Sieff, C.A.6
-
79
-
-
0037069424
-
Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal
-
V.I. Rebel, A.L. Kung, E.A. Tanner, H. Yang, R.T. Bronson, and D.M. Livingston Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal Proc. Natl. Acad. Sci. USA 99 2002 14789 14794
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 14789-14794
-
-
Rebel, V.I.1
Kung, A.L.2
Tanner, E.A.3
Yang, H.4
Bronson, R.T.5
Livingston, D.M.6
-
80
-
-
67849122659
-
Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells
-
J. Renström, R. Istvanffy, K. Gauthier, A. Shimono, J. Mages, A. Jardon-Alvarez, M. Kröger, M. Schiemann, D.H. Busch, and I. Esposito Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells Cell Stem Cell 5 2009 157 167
-
(2009)
Cell Stem Cell
, vol.5
, pp. 157-167
-
-
Renström, J.1
Istvanffy, R.2
Gauthier, K.3
Shimono, A.4
Mages, J.5
Jardon-Alvarez, A.6
Kröger, M.7
Schiemann, M.8
Busch, D.H.9
Esposito, I.10
-
81
-
-
13344294981
-
C-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation
-
M.L. Sandberg, S.E. Sutton, M.T. Pletcher, T. Wiltshire, L.M. Tarantino, J.B. Hogenesch, and M.P. Cooke c-Myb and p300 regulate hematopoietic stem cell proliferation and differentiation Dev. Cell 8 2005 153 166
-
(2005)
Dev. Cell
, vol.8
, pp. 153-166
-
-
Sandberg, M.L.1
Sutton, S.E.2
Pletcher, M.T.3
Wiltshire, T.4
Tarantino, L.M.5
Hogenesch, J.B.6
Cooke, M.P.7
-
82
-
-
33845624247
-
Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling
-
J.F. Santibanez, A. Letamendia, F. Perez-Barriocanal, C. Silvestri, M. Saura, C.P. Vary, J.M. Lopez-Novoa, L. Attisano, and C. Bernabeu Endoglin increases eNOS expression by modulating Smad2 protein levels and Smad2-dependent TGF-beta signaling J. Cell. Physiol. 210 2007 456 468
-
(2007)
J. Cell. Physiol.
, vol.210
, pp. 456-468
-
-
Santibanez, J.F.1
Letamendia, A.2
Perez-Barriocanal, F.3
Silvestri, C.4
Saura, M.5
Vary, C.P.6
Lopez-Novoa, J.M.7
Attisano, L.8
Bernabeu, C.9
-
83
-
-
67149091317
-
Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type i interferon-dependent exhaustion
-
T. Sato, N. Onai, H. Yoshihara, F. Arai, T. Suda, and T. Ohteki Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion Nat. Med. 15 2009 696 700
-
(2009)
Nat. Med.
, vol.15
, pp. 696-700
-
-
Sato, T.1
Onai, N.2
Yoshihara, H.3
Arai, F.4
Suda, T.5
Ohteki, T.6
-
84
-
-
80052392777
-
Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells
-
C. Schaniel, D. Sirabella, J. Qiu, X. Niu, I.R. Lemischka, and K.A. Moore Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells Blood 118 2011 2420 2429
-
(2011)
Blood
, vol.118
, pp. 2420-2429
-
-
Schaniel, C.1
Sirabella, D.2
Qiu, J.3
Niu, X.4
Lemischka, I.R.5
Moore, K.A.6
-
85
-
-
33748859509
-
Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation
-
M. Scheller, J. Huelsken, F. Rosenbauer, M.M. Taketo, W. Birchmeier, D.G. Tenen, and A. Leutz Hematopoietic stem cell and multilineage defects generated by constitutive beta-catenin activation Nat. Immunol. 7 2006 1037 1047
-
(2006)
Nat. Immunol.
, vol.7
, pp. 1037-1047
-
-
Scheller, M.1
Huelsken, J.2
Rosenbauer, F.3
Taketo, M.M.4
Birchmeier, W.5
Tenen, D.G.6
Leutz, A.7
-
86
-
-
0033564697
-
CDK inhibitors: Positive and negative regulators of G1-phase progression
-
C.J. Sherr, and J.M. Roberts CDK inhibitors: positive and negative regulators of G1-phase progression Genes Dev. 13 1999 1501 1512
-
(1999)
Genes Dev.
, vol.13
, pp. 1501-1512
-
-
Sherr, C.J.1
Roberts, J.M.2
-
87
-
-
33845245178
-
Smad5 is dispensable for adult murine hematopoiesis
-
S. Singbrant, J.L. Moody, U. Blank, G. Karlsson, L. Umans, A. Zwijsen, and S. Karlsson Smad5 is dispensable for adult murine hematopoiesis Blood 108 2006 3707 3712
-
(2006)
Blood
, vol.108
, pp. 3707-3712
-
-
Singbrant, S.1
Moody, J.L.2
Blank, U.3
Karlsson, G.4
Umans, L.5
Zwijsen, A.6
Karlsson, S.7
-
88
-
-
78649880379
-
The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells
-
O. Sirin, G.L. Lukov, R. Mao, O.M. Conneely, and M.A. Goodell The orphan nuclear receptor Nurr1 restricts the proliferation of haematopoietic stem cells Nat. Cell Biol. 12 2010 1213 1219
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 1213-1219
-
-
Sirin, O.1
Lukov, G.L.2
Mao, R.3
Conneely, O.M.4
Goodell, M.A.5
-
89
-
-
0030014681
-
The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells
-
E. Sitnicka, N. Lin, G.V. Priestley, N. Fox, V.C. Broudy, N.S. Wolf, and K. Kaushansky The effect of thrombopoietin on the proliferation and differentiation of murine hematopoietic stem cells Blood 87 1996 4998 5005
-
(1996)
Blood
, vol.87
, pp. 4998-5005
-
-
Sitnicka, E.1
Lin, N.2
Priestley, G.V.3
Fox, N.4
Broudy, V.C.5
Wolf, N.S.6
Kaushansky, K.7
-
90
-
-
58949098459
-
Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival
-
G.P. Souroullas, J.M. Salmon, F. Sablitzky, D.J. Curtis, and M.A. Goodell Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival Cell Stem Cell 4 2009 180 186
-
(2009)
Cell Stem Cell
, vol.4
, pp. 180-186
-
-
Souroullas, G.P.1
Salmon, J.M.2
Sablitzky, F.3
Curtis, D.J.4
Goodell, M.A.5
-
91
-
-
0037979081
-
Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos
-
K.L. Stenvers, M.L. Tursky, K.W. Harder, N. Kountouri, S. Amatayakul-Chantler, D. Grail, C. Small, R.A. Weinberg, A.M. Sizeland, and H.J. Zhu Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos Mol. Cell. Biol. 23 2003 4371 4385
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 4371-4385
-
-
Stenvers, K.L.1
Tursky, M.L.2
Harder, K.W.3
Kountouri, N.4
Amatayakul-Chantler, S.5
Grail, D.6
Small, C.7
Weinberg, R.A.8
Sizeland, A.M.9
Zhu, H.J.10
-
92
-
-
23044461852
-
A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress
-
L. Stepanova, and B.P. Sorrentino A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress Blood 106 2005 827 832
-
(2005)
Blood
, vol.106
, pp. 827-832
-
-
Stepanova, L.1
Sorrentino, B.P.2
-
93
-
-
21244472780
-
Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size
-
S. Stier, Y. Ko, R. Forkert, C. Lutz, T. Neuhaus, E. Grünewald, T. Cheng, D. Dombkowski, L.M. Calvi, S.R. Rittling, and D.T. Scadden Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size J. Exp. Med. 201 2005 1781 1791
-
(2005)
J. Exp. Med.
, vol.201
, pp. 1781-1791
-
-
Stier, S.1
Ko, Y.2
Forkert, R.3
Lutz, C.4
Neuhaus, T.5
Grünewald, E.6
Cheng, T.7
Dombkowski, D.8
Calvi, L.M.9
Rittling, S.R.10
Scadden, D.T.11
-
94
-
-
84864194496
-
Noncanonical wnt signaling maintains hematopoietic stem cells in the niche
-
R. Sugimura, X.C. He, A. Venkatraman, F. Arai, A. Box, C. Semerad, J.S. Haug, L. Peng, X.B. Zhong, and T. Suda Noncanonical wnt signaling maintains hematopoietic stem cells in the niche Cell 150 2012 351 365
-
(2012)
Cell
, vol.150
, pp. 351-365
-
-
Sugimura, R.1
He, X.C.2
Venkatraman, A.3
Arai, F.4
Box, A.5
Semerad, C.6
Haug, J.S.7
Peng, L.8
Zhong, X.B.9
Suda, T.10
-
95
-
-
0032213752
-
Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis
-
N. Takakura, X.L. Huang, T. Naruse, I. Hamaguchi, D.J. Dumont, G.D. Yancopoulos, and T. Suda Critical role of the TIE2 endothelial cell receptor in the development of definitive hematopoiesis Immunity 9 1998 677 686
-
(1998)
Immunity
, vol.9
, pp. 677-686
-
-
Takakura, N.1
Huang, X.L.2
Naruse, T.3
Hamaguchi, I.4
Dumont, D.J.5
Yancopoulos, G.D.6
Suda, T.7
-
96
-
-
77956217067
-
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells
-
K. Takubo, N. Goda, W. Yamada, H. Iriuchishima, E. Ikeda, Y. Kubota, H. Shima, R.S. Johnson, A. Hirao, M. Suematsu, and T. Suda Regulation of the HIF-1alpha level is essential for hematopoietic stem cells Cell Stem Cell 7 2010 391 402
-
(2010)
Cell Stem Cell
, vol.7
, pp. 391-402
-
-
Takubo, K.1
Goda, N.2
Yamada, W.3
Iriuchishima, H.4
Ikeda, E.5
Kubota, Y.6
Shima, H.7
Johnson, R.S.8
Hirao, A.9
Suematsu, M.10
Suda, T.11
-
97
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Z. Tothova, R. Kollipara, B.J. Huntly, B.H. Lee, D.H. Castrillon, D.E. Cullen, E.P. McDowell, S. Lazo-Kallanian, I.R. Williams, and C. Sears FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress Cell 128 2007 325 339
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
-
98
-
-
34147168247
-
A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning
-
R. van Os, L.M. Kamminga, A. Ausema, L.V. Bystrykh, D.P. Draijer, K. van Pelt, B. Dontje, and G. de Haan A Limited role for p21Cip1/Waf1 in maintaining normal hematopoietic stem cell functioning Stem Cells 25 2007 836 843
-
(2007)
Stem Cells
, vol.25
, pp. 836-843
-
-
Van Os, R.1
Kamminga, L.M.2
Ausema, A.3
Bystrykh, L.V.4
Draijer, D.P.5
Van Pelt, K.6
Dontje, B.7
De Haan, G.8
-
99
-
-
52949114971
-
Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family
-
P. Viatour, T.C. Somervaille, S. Venkatasubrahmanyam, S. Kogan, M.E. McLaughlin, I.L. Weissman, A.J. Butte, E. Passegué, and J. Sage Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family Cell Stem Cell 3 2008 416 428
-
(2008)
Cell Stem Cell
, vol.3
, pp. 416-428
-
-
Viatour, P.1
Somervaille, T.C.2
Venkatasubrahmanyam, S.3
Kogan, S.4
McLaughlin, M.E.5
Weissman, I.L.6
Butte, A.J.7
Passegué, E.8
Sage, J.9
-
100
-
-
56549128268
-
Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
-
A. Wilson, E. Laurenti, G. Oser, R.C. van der Wath, W. Blanco-Bose, M. Jaworski, S. Offner, C.F. Dunant, L. Eshkind, and E. Bockamp Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair Cell 135 2008 1118 1129
-
(2008)
Cell
, vol.135
, pp. 1118-1129
-
-
Wilson, A.1
Laurenti, E.2
Oser, G.3
Van Der Wath, R.C.4
Blanco-Bose, W.5
Jaworski, M.6
Offner, S.7
Dunant, C.F.8
Eshkind, L.9
Bockamp, E.10
-
101
-
-
0028057726
-
Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta
-
H. Yamashita, H. Ichijo, S. Grimsby, A. Morén, P. ten Dijke, and K. Miyazono Endoglin forms a heteromeric complex with the signaling receptors for transforming growth factor-beta J. Biol. Chem. 269 1994 1995 2001
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 1995-2001
-
-
Yamashita, H.1
Ichijo, H.2
Grimsby, S.3
Morén, A.4
Ten Dijke, P.5
Miyazono, K.6
-
102
-
-
60849093771
-
TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation
-
S. Yamazaki, A. Iwama, S.I. Takayanagi, K. Eto, H. Ema, and H. Nakauchi TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation Blood 113 2009 1250 1256
-
(2009)
Blood
, vol.113
, pp. 1250-1256
-
-
Yamazaki, S.1
Iwama, A.2
Takayanagi, S.I.3
Eto, K.4
Ema, H.5
Nakauchi, H.6
-
103
-
-
81855183667
-
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche
-
S. Yamazaki, H. Ema, G. Karlsson, T. Yamaguchi, H. Miyoshi, S. Shioda, M.M. Taketo, S. Karlsson, A. Iwama, and H. Nakauchi Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche Cell 147 2011 1146 1158
-
(2011)
Cell
, vol.147
, pp. 1146-1158
-
-
Yamazaki, S.1
Ema, H.2
Karlsson, G.3
Yamaguchi, T.4
Miyoshi, H.5
Shioda, S.6
Taketo, M.M.7
Karlsson, S.8
Iwama, A.9
Nakauchi, H.10
-
104
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
O.H. Yilmaz, R. Valdez, B.K. Theisen, W. Guo, D.O. Ferguson, H. Wu, and S.J. Morrison Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells Nature 441 2006 475 482
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
105
-
-
2342601849
-
In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C
-
Y. Yuan, H. Shen, D.S. Franklin, D.T. Scadden, and T. Cheng In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C Nat. Cell Biol. 6 2004 436 442
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 436-442
-
-
Yuan, Y.1
Shen, H.2
Franklin, D.S.3
Scadden, D.T.4
Cheng, T.5
-
106
-
-
33144456321
-
Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal
-
C.C. Zhang, A.D. Steele, S. Lindquist, and H.F. Lodish Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal Proc. Natl. Acad. Sci. USA 103 2006 2184 2189
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2184-2189
-
-
Zhang, C.C.1
Steele, A.D.2
Lindquist, S.3
Lodish, H.F.4
-
107
-
-
33646351002
-
PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
-
J. Zhang, J.C. Grindley, T. Yin, S. Jayasinghe, X.C. He, J.T. Ross, J.S. Haug, D. Rupp, K.S. Porter-Westpfahl, and L.M. Wiedemann PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention Nature 441 2006 518 522
-
(2006)
Nature
, vol.441
, pp. 518-522
-
-
Zhang, J.1
Grindley, J.C.2
Yin, T.3
Jayasinghe, S.4
He, X.C.5
Ross, J.T.6
Haug, J.S.7
Rupp, D.8
Porter-Westpfahl, K.S.9
Wiedemann, L.M.10
-
108
-
-
80053653651
-
PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function
-
Y. Zhang, S. Stehling-Sun, K. Lezon-Geyda, S.C. Juneja, L. Coillard, G. Chatterjee, C.A. Wuertzer, F. Camargo, and A.S. Perkins PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function Blood 118 2011 3853 3861
-
(2011)
Blood
, vol.118
, pp. 3853-3861
-
-
Zhang, Y.1
Stehling-Sun, S.2
Lezon-Geyda, K.3
Juneja, S.C.4
Coillard, L.5
Chatterjee, G.6
Wuertzer, C.A.7
Camargo, F.8
Perkins, A.S.9
-
109
-
-
36649002031
-
Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo
-
C. Zhao, J. Blum, A. Chen, H.Y. Kwon, S.H. Jung, J.M. Cook, A. Lagoo, and T. Reya Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo Cancer Cell 12 2007 528 541
-
(2007)
Cancer Cell
, vol.12
, pp. 528-541
-
-
Zhao, C.1
Blum, J.2
Chen, A.3
Kwon, H.Y.4
Jung, S.H.5
Cook, J.M.6
Lagoo, A.7
Reya, T.8
-
110
-
-
80052281899
-
P57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70
-
P. Zou, H. Yoshihara, K. Hosokawa, I. Tai, K. Shinmyozu, F. Tsukahara, Y. Maru, K. Nakayama, K.I. Nakayama, and T. Suda p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70 Cell Stem Cell 9 2011 247 261
-
(2011)
Cell Stem Cell
, vol.9
, pp. 247-261
-
-
Zou, P.1
Yoshihara, H.2
Hosokawa, K.3
Tai, I.4
Shinmyozu, K.5
Tsukahara, F.6
Maru, Y.7
Nakayama, K.8
Nakayama, K.I.9
Suda, T.10
|