MicroRNA 125b inhibition of B cell differentiation in germinal centers

International Immunology

Volumn 22, Issue 7, 2010, Pages 583-592

  Gururajan, Murali ^a,b   Haga, Christopher L ^a,b   Das, Sabyasachi ^a,b   Leu, Chuen Miin ^c   Hodson, Daniel ^d   Josson, Sajni ^e   Turner, Martin ^d   Cooper, Max D ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

^d BABRAHAM INSTITUTE   (United Kingdom)

^e CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

BLIMP 1; Centroblasts; Gene regulation; IRF 4; MicroRNA; Plasma cell differentiation

Indexed keywords

B LYMPHOCYTE INDUCED MATURATION PROTEIN 1; IMMUNOGLOBULIN M; INTERFERON REGULATORY FACTOR 4; LIPOPOLYSACCHARIDE; MESSENGER RNA; MICRORNA; MICRORNA 125A; MICRORNA 125B; MICRORNA 99B; MICRORNA LET 7C; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CHROMOSOME 19; CONTROLLED STUDY; GENE CLUSTER; GENE CONTROL; GENE EXPRESSION PROFILING; GENE LOCATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GERMINAL CENTER; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; UNTRANSLATED REGION;

ANIMALS; B-LYMPHOCYTES; BASE SEQUENCE; CELL DIFFERENTIATION; CELL LINE; CLUSTER ANALYSIS; CONSERVED SEQUENCE; GERMINAL CENTER; HUMANS; INTERFERON REGULATORY FACTORS; MICE; MICRORNAS; MODELS, ANIMAL; REPRESSOR PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC;

EID: 77954263256     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxq042     Document Type: Article

References (47)

1. Maatouk, D. and Harfe, B. 2006. MicroRNAs in development. Scientific World Journal 6:1828.
2. Humphreys, D. T., Westman, B. J., Martin, D. I. and Preiss, T. 2005. MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function. Proc. Natl Acad. Sci. USA 102:16961.
3. Tabara, H., Yigit, E., Siomi, H. and Mello, C. C. 2002. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExHbox helicase to direct RNAi in C. elegans. Cell 109:861.
4. Lee, R. C., Feinbaum, R. L. and Ambros, V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843.
5. Mendell, J. T. 2008. miRiad roles for the miR-17-92 cluster in development and disease. Cell 133:217.
6. O'Connell, R. M., Rao, D. S., Chaudhuri, A. A. et al. 2008. Sustained expression of microRNA-155 in hematopoietic stem cells causes a myeloproliferative disorder. J. Exp. Med. 205:585.
7. Kumar, M. S., Erkeland, S. J., Pester, R. E. et al. 2008. Suppression of non-small cell lung tumor development by the let-7 microRNA family. Proc. Natl Acad. Sci. USA 105:3903.
8. Koralov, S. B., Muljo, S. A., Galler, G. R. et al. 2008. Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. Cell 132:860.
9. Ventura, A., Young, A. G., Winslow, M. M. et al. 2008. Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clusters. Cell 132:875.
10. Dorsett, Y., McBride, K. M., Jankovic, M. et al. 2008. MicroRNA- 155 suppresses activation-induced cytidine deaminase-mediated Myc-Igh translocation. Immunity 28:630.
11. Teng, G., Hakimpour, P., Landgraf, P. et al. 2008. MicroRNA-155 is a negative regulator of activation-induced cytidine deaminase. Immunity 28:621.
12. Thai, T. H., Calado, D. P., Casola, S. et al. 2007. Regulation of the germinal center response by microRNA-155. Science 316:604.
13. Vigorito, E., Perks, K. L., Abreu-Goodger, C. et al. 2007. microRNA-155 regulates the generation of immunoglobulin class-switched plasma cells. Immunity 27:847.
14. Rodriguez, A., Vigorito, E., Clare, S. et al. 2007. Requirement of bic/microRNA-155 for normal immune function. Science 316:608.
15. Costinean, S., Zanesi, N., Pekarsky, Y. et al. 2006. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc. Natl Acad. Sci. USA 103:7024
16. Ehrhardt, G. R., Hijikata, A., Kitamura, H., Ohara, O., Wang, J. Y. and Cooper, M. D. 2008. Discriminating gene expression profiles of memory B cell subpopulations. J. Exp. Med. 205:1807.
17. Lao, K., Xu, N. L., Sun, Y. A., Livak, K. J. and Straus, N. A. 2007. Real time PCR profiling of 330 human micro-RNAs. Biotechnol. J. 2:33.
18. Mestdagh, P., Feys, T., Bernard, N. et al. 2008. High-throughput stem-loop RT-qPCR miRNA expression profiling using minute amounts of input RNA. Nucleic Acids Res. 36:e143.
19. Josson, S., Sung, S. Y., Lao, K., Chung, L. W. and Johnstone, P. A. 2008. Radiation modulation of microRNA in prostate cancer cell lines. Prostate 68:1599.
20. Shapiro-Shelef, M., Lin, K. I., McHeyzer-Williams, L. J., Liao, J., McHeyzer-Williams, M. G. and Calame, K. 2003. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. Immunity 19:607.
21. Griffiths-Jones, S., Saini, H. K., van Dongen, S. and Enright, A. J. 2008. miRBase: tools for microRNA genomics. Nucleic Acids Res. 36:D154.
22. Lewis, B. P., Burge, C. B. and Bartel, D. P. 2005. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120:15.
23. Kruger, J. and Rehmsmeier, M. 2006. RNAhybrid: microRNA target prediction easy, fast and flexible. Nucleic Acids Res. 34:W451.
24. Calame, K. L., Lin, K. I. and Tunyaplin, C. 2003. Regulatory mechanisms that determine the development and function of plasma cells. Annu. Rev. Immunol. 21:205.
25. Jiang, D., Yin, C., Yu, A. et al. 2006. Duplication and expression analysis of multicopy miRNA gene family members in Arabidopsis and rice. Cell Res. 16:507.
26. Das, S. 2009. Evolutionary origin and genomic organization of micro-RNA genes in immunoglobulin lambda variable region gene family. Mol. Biol. Evol. 26:1179.
27. Bartel, D. P. 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116:281.
28. Kim, V. N. and Nam, J. W. 2006. Genomics of microRNA. Trends Genet. 22:165.
29. He, X., He, L. and Hannon, G. J. 2007. The guardian's little helper: microRNAs in the p53 tumor suppressor network. Cancer Res. 67:11099.
30. Chang, T. C., Yu, D., Lee, Y. S. et al. 2008. Widespread microRNA repression by Myc contributes to tumorigenesis. Nat. Genet. 40:43.
31. Malumbres, R., Sarosiek, K. A., Cubedo, E. et al. 2009. Differentiation stage-specific expression of microRNAs in B lymphocytes and diffuse large B-cell lymphomas. Blood 113:3754.
32. Klein, U., Tu, Y., Stolovitzky, G. A. et al. 2003. Transcriptional analysis of the B cell germinal center reaction. Proc. Natl Acad. Sci. USA 100:2639
33. Ci, W., Polo, J. M., Cerchietti, L. et al. 2009. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood 113:5536.
34. van Laar, J. M., Melchers, M., Teng, Y. K. et al. 2007. Sustained secretion of immunoglobulin by long-lived human tonsil plasma cells. Am. J. Pathol. 171:917.
35. Klein, U. and Dalla-Favera, R. 2008. Germinal centres: role in B-cell physiology and malignancy. Nat. Rev. Immunol. 8:22.
36. Kuppers, R., Klein, U., Hansmann, M.-L. and Rajewsky, K. 1999. Cellular origin of human B-cell lymphomas. N. Engl. J. Med. 341:1520.
37. Kuppers, R. 2005. Mechanisms of B-cell lymphoma pathogenesis. Nat. Rev. Cancer 5:251.
38. Basso, K., Sumazin, P., Morozov, P. et al. 2009. Identification of the human mature B cell miRNome. Immunity 30:744.
39. Kuo, T. C., Shaffer, A. L., Haddad, J. Jr. Choi, Y. S., Staudt, L. M. and Calame, K. 2007. Repression of BCL-6 is required for the formation of human memory B cells in vitro. J. Exp. Med. 204:819.
40. Tunyaplin, C., Shaffer, A. L., Angelin-Duclos, C. D., Yu, X., Staudt, L. M. and Calame, K. L. 2004. Direct repression of prdm1 by Bcl-6 inhibits plasmacytic differentiation. J. Immunol. 173:1158.
41. Sciammas, R., Shaffer, A. L., Schatz, J. H., Zhao, H., Staudt, L. M. and Singh, H. 2006. Graded expression of interferon regulatory factor-4 coordinates isotype switching with plasma cell differentiation. Immunity 25:225.
42. Chen, C., Ridzon, D. A., Broomer, A. J. et al. 2005. Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res. 33:e179.
43. Grimson, A., Farh, K. K., Johnston, W. K., Garrett-Engele, P., Lim, L. P. and Bartel, D. P. 2007. MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol. Cell 27:91.
44. Zhang, J., Jima, D. D., Jacobs, C. et al. 2009. Patterns of microRNA expression characterize stages of human B-cell differentiation. Blood 113:4586.
45. Angelin-Duclos, C., Cattoretti, G., Lin, K.-I. and Calame, K. 2000. Commitment of B lymphocytes to a plasma cell fate is associated with blimp-1 expression in vivo. J. Immunol. 165: 5462.
46. Shaffer, A. L., Emre, N. C., Lamy, L. et al. 2008. IRF4 addiction in multiple myeloma. Nature 454:226.
47. Lin, F. R., Kuo, H. K., Ying, H. Y., Yang, F. H. and Lin, K. I. 2007. Induction of apoptosis in plasma cells by B lymphocyte-induced maturation protein-1 knockdown. Cancer Res. 67:11914.