Targeting Human MicroRNA Genes Using Engineered Tal-Effector Nucleases (TALENs)

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Hu, Ruozhen ^a   Wallace, Jared ^a   Dahlem, Timothy J ^a   Grunwald, David Jonah ^a   O'Connell, Ryan M ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEINS AND BINDING PROTEINS; MICRORNA; MICRORNA 125B; MICRORNA 146A; MICRORNA 155; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; CONTROLLED STUDY; EX VIVO STUDY; GENE DELETION; GENE MUTATION; GENE TARGETING; PROTEIN ENGINEERING; RNA GENE; RNA SEQUENCE; RNA STRUCTURE; SEQUENCE ANALYSIS;

ALLELES; ANIMALS; BASE SEQUENCE; ENDONUCLEASES; GENETIC ENGINEERING; GENETIC LOCI; GENOME, HUMAN; HEK293 CELLS; HUMANS; MICE; MICRORNAS; MOLECULAR SEQUENCE DATA; MUTATION RATE; NUCLEIC ACID CONFORMATION; SEQUENCE DELETION; TRANSFECTION;

EID: 84877105430     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0063074     Document Type: Article

References (17)

1. O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D, (2010) Physiological and pathological roles for microRNAs in the immune system. Nature reviews Immunology 10: 111-122.
2. Ono K, Kuwabara Y, Han J, (2011) MicroRNAs and cardiovascular diseases. The FEBS journal 278: 1619-1633.
3. Meza-Sosa KF, Valle-Garcia D, Pedraza-Alva G, Perez-Martinez L, (2012) Role of microRNAs in central nervous system development and pathology. Journal of neuroscience research 90: 1-12.
4. Hu R, O'Connell RM, (2013) MicroRNA control in the development of systemic autoimmunity. Arthritis research & therapy 15: 202.
5. Mallanna SK, Rizzino A, (2010) Emerging roles of microRNAs in the control of embryonic stem cells and the generation of induced pluripotent stem cells. Developmental biology 344: 16-25.
6. Filipowicz W, Grosshans H, (2011) The liver-specific microRNA miR-122: biology and therapeutic potential. Progress in drug research Fortschritte der Arzneimittelforschung Progres des recherches pharmaceutiques 67: 221-238.
7. Filipowicz W, Bhattacharyya SN, Sonenberg N, (2008) Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature reviews Genetics 9: 102-114.
8. Bogdanove AJ, Voytas DF, (2011) TAL effectors: customizable proteins for DNA targeting. Science 333: 1843-1846.
9. Cermak T, Doyle EL, Christian M, Wang L, Zhang Y, et al. (2011) Efficient design and assembly of custom TALEN and other TAL effector-based constructs for DNA targeting. Nucleic acids research 39: e82.
10. Miller JC, Tan S, Qiao G, Barlow KA, Wang J, et al. (2011) A TALE nuclease architecture for efficient genome editing. Nature biotechnology 29: 143-148.
11. Dahlem TJ, Hoshijima K, Jurynec MJ, Gunther D, Starker CG, et al. (2012) Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome. PLoS genetics 8: e1002861.
12. Bedell VM, Wang Y, Campbell JM, Poshusta TL, Starker CG, et al. (2012) In vivo genome editing using a high-efficiency TALEN system. Nature 491: 114-118.
13. Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, et al. (2008) Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proceedings of the National Academy of Sciences of the United States of America 105: 7269-7274.
14. Paraboschi EM, Solda G, Gemmati D, Orioli E, Zeri G, et al. (2011) Genetic association and altered gene expression of mir-155 in multiple sclerosis patients. International journal of molecular sciences 12: 8695-8712.
15. Holkers M, Maggio I, Liu J, Janssen JM, Miselli F, et al. (2012) Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic acids research.
16. Szczepek M, Brondani V, Buchel J, Serrano L, Segal DJ, et al. (2007) Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases. Nature biotechnology 25: 786-793.
17. Doyon Y, Vo TD, Mendel MC, Greenberg SG, Wang J, et al. (2011) Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures. Nature methods 8: 74-79.