MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

Nature Immunology

Volumn 10, Issue 12, 2009, Pages 1252-1259

  Du, Changsheng ^a   Liu, Chang ^a   Kang, Jiuhong ^a,b   Zhao, Guixian ^c   Ye, Zhiqiang ^d   Huang, Shichao ^a   Li, Zhenxin ^c   Wu, Zhiying ^c   Pei, Gang ^a  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b TONGJI UNIVERSITY   (China)

^c FUDAN UNIVERSITY   (China)

^d Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; INTERLEUKIN 17; MICRORNA; MICRORNA 326; TRANSCRIPTION FACTOR ETS 1; UNCLASSIFIED DRUG;

ADULT; ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; EMBRYO; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOPATHOGENESIS; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; TH17 CELL;

ADULT; ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; HUMANS; INTERLEUKIN-17; MALE; MICE; MICRORNAS; MULTIPLE SCLEROSIS; PROTO-ONCOGENE PROTEIN C-ETS-1; T-LYMPHOCYTES, HELPER-INDUCER; UP-REGULATION;

EID: 70449716915     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1798     Document Type: Article

References (41)

1. Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V.K. IL-17 and Th17 cells. Annu. Rev. Immunol. 27, 485-517 (2009).
2. H17 cells in development: An updated view of their molecular identity and genetic programming. Nat. Rev. Immunol. 8, 337-348 (2008).
3. Zhou, L. & Littman, D.R. Transcriptional regulatory networks in Th17 cell differentiation. Curr. Opin. Immunol. 21, 146-152 (2009).
4. H17-cell-mediated autoimmunity to environmental toxins. Nature 453, 106-109 (2008).
5. H-17 cells requires interferonregulatory factor 4. Nat. Immunol. 8, 958-966 (2007).
6. H17 cell differentiation by antagonizing RORγt function. Nature 453, 236-240 (2008).
7. Moisan, J., Grenningloh, R., Bettelli, E., Oukka, M. & Ho, I.C. Ets-1 is a negative regulator of Th17 differentiation. J. Exp. Med. 204 2825-2835 (2007).
8. Compston, A. & Coles, A. Multiple sclerosis. Lancet 359, 1221-1231 (2002).
9. Frohman, E.M., Racke, M.K. & Raine, C.S. Multiple sclerosis-the plaque and its pathogenesis. N. Engl. J. Med. 354, 942-955 (2006).
10. Kantarci, O.H. Genetics and natural history of multiple sclerosis. Semin. Neurol. 28, 7-16 (2008).
11. Polman, C.H. et al. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria". Ann. Neurol. 58 840-846 (2005).
12. Sospedra, M. & Martin, R. Immunology of multiple sclerosis. Annu. Rev. Immunol. 23, 683-747 (2005).
13. - T lymphocytes. J. Immunol. 127, 1420-1423 (1981).
14. Langrish, C.L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240 (2005).
15. + T helper cells. Cell 126, 1121-1133 (2006).
16. Tzartos, J.S. et al. Interleukin-17 production in central nervous system-infiltrating T cells and glial cells is associated with active disease in multiple sclerosis. Am. J. Pathol. 172, 146-155 (2008).
17. Bartel, D.P. MicroRNAs: Target recognition and regulatory functions. Cell 136, 215-233 (2009).
18. Ma, L., Teruya-Feldstein, J. & Weinberg, R.A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 449, 682-688 (2007).
19. Thum, T. et al. MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature 456 980-984 (2008).
20. Lu, J. et al. MicroRNA expression profiles classify human cancers. Nature 435, 834-838 (2005).
21. Slack, F.J. & Weidhaas, J.B. MicroRNA in cancer prognosis. N. Engl. J. Med. 359, 2720-2722 (2008).
22. Zhou, X. et al. Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity. J. Exp. Med. 205, 1983-1991 (2008).
23. Chong, M.M., Rasmussen, J.P., Rudensky, A.Y. & Littman, D.R. The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease. J. Exp. Med. 205, 2005-2017 (2008).
24. Wingerchuk, D.M., Lennon, V.A., Lucchinetti, C.F., Pittock, S.J. & Weinshenker, B.G. The spectrum of neuromyelitis optica. Lancet Neurol. 6, 805-815 (2007).
25. Acosta-Rodriguez, E.V. et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8, 639-646 (2007).
26. Ebert, M.S., Neilson, J.R. & Sharp, P.A. MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells. Nat. Methods 4, 721-726 (2007).
27. Pan, D. et al. Biodistribution and toxicity studies of VSVG-pseudotyped lentiviral vector after intravenous administration in mice with the observation of in vivo transduction of bone marrow. Mol. Ther. 6, 19-29 (2002).
28. Lewis, B.P., Shih, I.H., Jones-Rhoades, M.W., Bartel, D.P. & Burge, C.B. Prediction of mammalian microRNA targets. Cell 115, 787-798 (2003).
29. John, B., Sander, C. & Marks, D.S. Prediction of human microRNA targets. Methods Mol. Biol. 342, 101-113 (2006).
30. Tesmer, L.A., Lundy, S.K., Sarkar, S. & Fox, D.A. Th17 cells in human disease. Immunol. Rev. 223, 87-113 (2008).
31. Miossec, P., Korn, T. & Kuchroo, V.K. Interleukin-17 and type 17 helper T cells. N. Engl. J. Med. 361, 888-898 (2009).
32. Lennon, V.A. et al. A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis. Lancet 364, 2106-2112 (2004).
33. Xiao, C. & Rajewsky, K. MicroRNA control in the immune system: Basic principles. Cell 136, 26-36 (2009).
34. Hoefig, K.P. & Heissmeyer, V. MicroRNAs grow up in the immune system. Curr. Opin. Immunol. 20, 281-287 (2008).
35. Li, Q.J. et al. miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell 129, 147-161 (2007).
36. Lin, Y.C. et al. c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development. Mol. Biol. Evol. 25, 2189-2198 (2008).
37. Xiao, C. et al. MiR-150 controls B cell differentiation by targeting the transcription factor c-Myb. Cell 131, 146-159 (2007).
38. Schrempf, W. & Ziemssen, T. Glatiramer acetate: Mechanisms of action in multiple sclerosis. Autoimmun. Rev. 6, 469-475 (2007).
39. Brusaferri, F. & Candelise, L. Steroids for multiple sclerosis and optic neuritis: A meta-analysis of randomized controlled clinical trials. J. Neurol. 247, 435-442 (2000).
40. Stromnes, I.M. & Goverman, J.M. Active induction of experimental allergic encephalomyelitis. Nat. Protoc. 1, 1810-1819 (2006).
41. Chen, J.F. et al. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat. Genet. 38, 228-233 (2006).