-
1
-
-
84894197205
-
Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes
-
COI: 1:CAS:528:DC%2BC2cXis1Crur0%3D, PID: 24412516
-
Abbondante S, Baglietto-Vargas D, Rodriguez-Ortiz CJ, Estrada-Hernandez T, Medeiros R, Laferla FM (2014) Genetic ablation of tau mitigates cognitive impairment induced by type 1 diabetes. Am J Pathol 184(3):819–826
-
(2014)
Am J Pathol
, vol.184
, Issue.3
, pp. 819-826
-
-
Abbondante, S.1
Baglietto-Vargas, D.2
Rodriguez-Ortiz, C.J.3
Estrada-Hernandez, T.4
Medeiros, R.5
Laferla, F.M.6
-
2
-
-
0033197996
-
The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses
-
COI: 1:CAS:528:DyaK1MXlslWnu78%3D, PID: 10460236
-
Abbott MA, Wells DG, Fallon JR (1999) The insulin receptor tyrosine kinase substrate p58/53 and the insulin receptor are components of CNS synapses. J Neurosci 19(17):7300–7308
-
(1999)
J Neurosci
, vol.19
, Issue.17
, pp. 7300-7308
-
-
Abbott, M.A.1
Wells, D.G.2
Fallon, J.R.3
-
3
-
-
0030978351
-
beta-catenin is a target for the ubiquitin-proteasome pathway
-
COI: 1:CAS:528:DyaK2sXkslShsbk%3D, PID: 9233789
-
Aberle H, Bauer A, Stappert J, Kispert A, Kemler R (1997) beta-catenin is a target for the ubiquitin-proteasome pathway. EMBO J 16(13):3797–3804
-
(1997)
EMBO J
, vol.16
, Issue.13
, pp. 3797-3804
-
-
Aberle, H.1
Bauer, A.2
Stappert, J.3
Kispert, A.4
Kemler, R.5
-
4
-
-
77954036677
-
Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells
-
PID: 20041157
-
Abiola M, Favier M, Christodoulou-Vafeiadou E, Pichard AL, Martelly I, Guillet-Deniau I (2009) Activation of Wnt/beta-catenin signaling increases insulin sensitivity through a reciprocal regulation of Wnt10b and SREBP-1c in skeletal muscle cells. PLoS One 4(12):e8509
-
(2009)
PLoS One
, vol.4
, Issue.12
, pp. 8509
-
-
Abiola, M.1
Favier, M.2
Christodoulou-Vafeiadou, E.3
Pichard, A.L.4
Martelly, I.5
Guillet-Deniau, I.6
-
5
-
-
84863011177
-
Postsynaptic complexin controls AMPA receptor exocytosis during LTP
-
COI: 1:CAS:528:DC%2BC38XhsFSisb0%3D, PID: 22284181
-
Ahmad M, Polepalli JS, Goswami D, Yang X, Kaeser-Woo YJ, Sudhof TC, Malenka RC (2012) Postsynaptic complexin controls AMPA receptor exocytosis during LTP. Neuron 73(2):260–267
-
(2012)
Neuron
, vol.73
, Issue.2
, pp. 260-267
-
-
Ahmad, M.1
Polepalli, J.S.2
Goswami, D.3
Yang, X.4
Kaeser-Woo, Y.J.5
Sudhof, T.C.6
Malenka, R.C.7
-
6
-
-
33750987305
-
Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study
-
PID: 17101823
-
Akomolafe A, Beiser A, Meigs JB, Au R, Green RC, Farrer LA, Wolf PA, Seshadri S (2006) Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham Study. Arch Neurol 63(11):1551–1555
-
(2006)
Arch Neurol
, vol.63
, Issue.11
, pp. 1551-1555
-
-
Akomolafe, A.1
Beiser, A.2
Meigs, J.B.3
Au, R.4
Green, R.C.5
Farrer, L.A.6
Wolf, P.A.7
Seshadri, S.8
-
7
-
-
58849131048
-
Beta-amyloid deposition in brains of subjects with diabetes
-
COI: 1:STN:280:DC%2BD1M7ht1WqsA%3D%3D, PID: 18346114
-
Alafuzoff I, Aho L, Helisalmi S, Mannermaa A, Soininen H (2009) Beta-amyloid deposition in brains of subjects with diabetes. Neuropathol Appl Neurobiol 35(1):60–68
-
(2009)
Neuropathol Appl Neurobiol
, vol.35
, Issue.1
, pp. 60-68
-
-
Alafuzoff, I.1
Aho, L.2
Helisalmi, S.3
Mannermaa, A.4
Soininen, H.5
-
8
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
COI: 1:CAS:528:DyaK2sXht1Oqs7o%3D, PID: 8978681
-
Alessi DR, Andjelkovic M, Caudwell B, Cron P, Morrice N, Cohen P, Hemmings BA (1996) Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J 15(23):6541–6551
-
(1996)
EMBO J
, vol.15
, Issue.23
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
9
-
-
27444445782
-
Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta
-
COI: 1:CAS:528:DC%2BD2MXhtFWmtbjK
-
Al-Khouri AM, Ma Y, Togo SH, Williams S, Mustelin T (2005) Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3beta. J Bio Chem 280(42):35195–35202
-
(2005)
J Bio Chem
, vol.280
, Issue.42
, pp. 35195-35202
-
-
Al-Khouri, A.M.1
Ma, Y.2
Togo, S.H.3
Williams, S.4
Mustelin, T.5
-
10
-
-
84875224517
-
GDNF, NGF and BDNF as therapeutic options for neurodegeneration
-
COI: 1:CAS:528:DC%2BC3sXitlaiurc%3D, PID: 23348013
-
Allen SJ, Watson JJ, Shoemark DK, Barua NU, Patel NK (2013) GDNF, NGF and BDNF as therapeutic options for neurodegeneration. Pharmacol Ther 138(2):155–175
-
(2013)
Pharmacol Ther
, vol.138
, Issue.2
, pp. 155-175
-
-
Allen, S.J.1
Watson, J.J.2
Shoemark, D.K.3
Barua, N.U.4
Patel, N.K.5
-
11
-
-
0030035749
-
In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta
-
COI: 1:CAS:528:DyaK28XksFCjt7o%3D, PID: 8764598
-
Aplin AE, Gibb GM, Jacobsen JS, Gallo JM, Anderton BH (1996) In vitro phosphorylation of the cytoplasmic domain of the amyloid precursor protein by glycogen synthase kinase-3beta. J Neurochem 67(2):699–707
-
(1996)
J Neurochem
, vol.67
, Issue.2
, pp. 699-707
-
-
Aplin, A.E.1
Gibb, G.M.2
Jacobsen, J.S.3
Gallo, J.M.4
Anderton, B.H.5
-
12
-
-
0028032895
-
Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
-
COI: 1:CAS:528:DyaK2cXmvFehu7Y%3D, PID: 7526222
-
Araki E, Lipes MA, Patti ME, Bruning JC, Haag B 3rd, Johnson RS, Kahn CR (1994) Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. Nature 372(6502):186–190
-
(1994)
Nature
, vol.372
, Issue.6502
, pp. 186-190
-
-
Araki, E.1
Lipes, M.A.2
Patti, M.E.3
Bruning, J.C.4
Haag, B.5
Johnson, R.S.6
Kahn, C.R.7
-
13
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease
-
COI: 1:STN:280:DyaK387psFCktw%3D%3D, PID: 1549228
-
Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 42(3 Pt 1):631–639
-
(1992)
Neurology
, vol.42
, Issue.3
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
Hyman, B.T.4
-
14
-
-
2442424380
-
Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function
-
PID: 15148141
-
Arvanitakis Z, Wilson RS, Bienias JL, Evans DA, Bennett DA (2004) Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function. Arch Neurol 61(5):661–666
-
(2004)
Arch Neurol
, vol.61
, Issue.5
, pp. 661-666
-
-
Arvanitakis, Z.1
Wilson, R.S.2
Bienias, J.L.3
Evans, D.A.4
Bennett, D.A.5
-
15
-
-
84865575373
-
Insulin in the brain: there and back again
-
COI: 1:CAS:528:DC%2BC38XhtFGku73F, PID: 22820012
-
Banks WA, Owen JB, Erickson MA (2012) Insulin in the brain: there and back again. Pharmacol Ther 136(1):82–93
-
(2012)
Pharmacol Ther
, vol.136
, Issue.1
, pp. 82-93
-
-
Banks, W.A.1
Owen, J.B.2
Erickson, M.A.3
-
16
-
-
0000197284
-
Pancreatic Extracts in the Treatment of Diabetes Mellitus
-
COI: 1:CAS:528:DyaB38Xpt1Gm, PID: 20314060
-
Banting FG, Best CH, Collip JB, Campbell WR, Fletcher AA (1922) Pancreatic Extracts in the Treatment of Diabetes Mellitus. Can Med Assoc J 12(3):141–146
-
(1922)
Can Med Assoc J
, vol.12
, Issue.3
, pp. 141-146
-
-
Banting, F.G.1
Best, C.H.2
Collip, J.B.3
Campbell, W.R.4
Fletcher, A.A.5
-
17
-
-
19944433628
-
Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors
-
COI: 1:CAS:528:DC%2BD2MXhvVCntw%3D%3D, PID: 15456405
-
Barnett SF, Defeo-Jones D, Fu S, Hancock PJ, Haskell KM, Jones RE, Kahana JA, Kral AM, Leander K, Lee LL, Malinowski J, McAvoy EM, Nahas DD, Robinson RG, Huber HE (2005) Identification and characterization of pleckstrin-homology-domain-dependent and isoenzyme-specific Akt inhibitors. Biochem J 385(Pt 2):399–408
-
(2005)
Biochem J
, vol.385
, pp. 399-408
-
-
Barnett, S.F.1
Defeo-Jones, D.2
Fu, S.3
Hancock, P.J.4
Haskell, K.M.5
Jones, R.E.6
Kahana, J.A.7
Kral, A.M.8
Leander, K.9
Lee, L.L.10
Malinowski, J.11
McAvoy, E.M.12
Nahas, D.D.13
Robinson, R.G.14
Huber, H.E.15
-
18
-
-
0027757042
-
Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5
-
COI: 1:CAS:528:DyaK2cXhtlWgsb8%3D, PID: 8282104
-
Baumann K, Mandelkow EM, Biernat J, Piwnica-Worms H, Mandelkow E (1993) Abnormal Alzheimer-like phosphorylation of tau-protein by cyclin-dependent kinases cdk2 and cdk5. FEBS Lett 336(3):417–424
-
(1993)
FEBS Lett
, vol.336
, Issue.3
, pp. 417-424
-
-
Baumann, K.1
Mandelkow, E.M.2
Biernat, J.3
Piwnica-Worms, H.4
Mandelkow, E.5
-
19
-
-
70849120946
-
Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
-
COI: 1:CAS:528:DC%2BD1MXhsVyhsrbK, PID: 19752219
-
Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R (2009) Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev 30(6):586–623
-
(2009)
Endocr Rev
, vol.30
, Issue.6
, pp. 586-623
-
-
Belfiore, A.1
Frasca, F.2
Pandini, G.3
Sciacca, L.4
Vigneri, R.5
-
20
-
-
0026095665
-
A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
-
COI: 1:CAS:528:DyaK3sXpsFantA%3D%3D, PID: 1833819
-
Bellacosa A, Testa JR, Staal SP, Tsichlis PN (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254(5029):274–277
-
(1991)
Science
, vol.254
, Issue.5029
, pp. 274-277
-
-
Bellacosa, A.1
Testa, J.R.2
Staal, S.P.3
Tsichlis, P.N.4
-
21
-
-
79960809092
-
Neuronal activity regulates the regional vulnerability to amyloid-beta deposition
-
COI: 1:CAS:528:DC%2BC3MXlsVGltro%3D, PID: 21532579
-
Bero AW, Yan P, Roh JH, Cirrito JR, Stewart FR, Raichle ME, Lee JM, Holtzman DM (2011) Neuronal activity regulates the regional vulnerability to amyloid-beta deposition. Nat Neurosci 14(6):750–756
-
(2011)
Nat Neurosci
, vol.14
, Issue.6
, pp. 750-756
-
-
Bero, A.W.1
Yan, P.2
Roh, J.H.3
Cirrito, J.R.4
Stewart, F.R.5
Raichle, M.E.6
Lee, J.M.7
Holtzman, D.M.8
-
22
-
-
84944714835
-
Hippocampal insulin resistance and cognitive dysfunction
-
COI: 1:CAS:528:DC%2BC2MXhs1eksr7P, PID: 26462756
-
Biessels GJ, Reagan LP (2015) Hippocampal insulin resistance and cognitive dysfunction. Nat Rev Neurosci 16(11):660–671
-
(2015)
Nat Rev Neurosci
, vol.16
, Issue.11
, pp. 660-671
-
-
Biessels, G.J.1
Reagan, L.P.2
-
23
-
-
0027476024
-
A synaptic model of memory: long-term potentiation in the hippocampus
-
COI: 1:CAS:528:DyaK3sXntlOntw%3D%3D, PID: 8421494
-
Bliss TV, Collingridge GL (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361(6407):31–39
-
(1993)
Nature
, vol.361
, Issue.6407
, pp. 31-39
-
-
Bliss, T.V.1
Collingridge, G.L.2
-
24
-
-
0032543578
-
The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
-
COI: 1:CAS:528:DyaK1cXktVKqtb0%3D, PID: 9651683
-
Blume-Jensen P, Janknecht R, Hunter T (1998) The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136. Curr Biol 8(13):779–782
-
(1998)
Curr Biol
, vol.8
, Issue.13
, pp. 779-782
-
-
Blume-Jensen, P.1
Janknecht, R.2
Hunter, T.3
-
25
-
-
84859726053
-
An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease- associated Abeta oligomers
-
COI: 1:CAS:528:DC%2BC38Xlt1egtbc%3D, PID: 22476196
-
Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG (2012) An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer’s disease- associated Abeta oligomers. J Clin Invest 122(4):1339–1353
-
(2012)
J Clin Invest
, vol.122
, Issue.4
, pp. 1339-1353
-
-
Bomfim, T.R.1
Forny-Germano, L.2
Sathler, L.B.3
Brito-Moreira, J.4
Houzel, J.C.5
Decker, H.6
Silverman, M.A.7
Kazi, H.8
Melo, H.M.9
McClean, P.L.10
Holscher, C.11
Arnold, S.E.12
Talbot, K.13
Klein, W.L.14
Munoz, D.P.15
Ferreira, S.T.16
De Felice, F.G.17
-
26
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
COI: 1:STN:280:DyaK387gtFOiug%3D%3D
-
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol (Berl) 82(4):239–259
-
(1991)
Acta Neuropathol (Berl)
, vol.82
, Issue.4
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
27
-
-
84863063951
-
A pivotal role of GSK-3 in synaptic plasticity
-
COI: 1:CAS:528:DC%2BC38Xjt1Kks7k%3D, PID: 22363262
-
Bradley CA, Peineau S, Taghibiglou C, Nicolas CS, Whitcomb DJ, Bortolotto ZA, Kaang BK, Cho K, Wang YT, Collingridge GL (2012) A pivotal role of GSK-3 in synaptic plasticity. Front Mol Neurosci 5:13
-
(2012)
Front Mol Neurosci
, vol.5
, pp. 13
-
-
Bradley, C.A.1
Peineau, S.2
Taghibiglou, C.3
Nicolas, C.S.4
Whitcomb, D.J.5
Bortolotto, Z.A.6
Kaang, B.K.7
Cho, K.8
Wang, Y.T.9
Collingridge, G.L.10
-
28
-
-
0033515625
-
A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain
-
COI: 1:CAS:528:DyaK1MXisVWlsL0%3D
-
Brodbeck D, Cron P, Hemmings BA (1999) A human protein kinase Bgamma with regulatory phosphorylation sites in the activation loop and in the C-terminal hydrophobic domain. J Biolumin Chemilumin 274(14):9133–9136
-
(1999)
J Biolumin Chemilumin
, vol.274
, Issue.14
, pp. 9133-9136
-
-
Brodbeck, D.1
Cron, P.2
Hemmings, B.A.3
-
29
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
COI: 1:CAS:528:DyaK1MXitFGgsr0%3D, PID: 10102273
-
Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96(6):857–868
-
(1999)
Cell
, vol.96
, Issue.6
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
30
-
-
0034703229
-
Role of brain insulin receptor in control of body weight and reproduction
-
COI: 1:CAS:528:DC%2BD3cXmvVClsLY%3D, PID: 11000114
-
Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR (2000) Role of brain insulin receptor in control of body weight and reproduction. Science 289(5487):2122–2125
-
(2000)
Science
, vol.289
, Issue.5487
, pp. 2122-2125
-
-
Bruning, J.C.1
Gautam, D.2
Burks, D.J.3
Gillette, J.4
Schubert, M.5
Orban, P.C.6
Klein, R.7
Krone, W.8
Muller-Wieland, D.9
Kahn, C.R.10
-
31
-
-
0035911803
-
Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake
-
COI: 1:STN:280:DC%2BD3M3jsVyjtg%3D%3D, PID: 11223811
-
Buijs RM, Chun SJ, Niijima A, Romijn HJ, Nagai K (2001) Parasympathetic and sympathetic control of the pancreas: a role for the suprachiasmatic nucleus and other hypothalamic centers that are involved in the regulation of food intake. J Comp Neurol 431(4):405–423
-
(2001)
J Comp Neurol
, vol.431
, Issue.4
, pp. 405-423
-
-
Buijs, R.M.1
Chun, S.J.2
Niijima, A.3
Romijn, H.J.4
Nagai, K.5
-
32
-
-
0032515027
-
Regulation of cell death protease caspase-9 by phosphorylation
-
COI: 1:CAS:528:DyaK1cXnsFentLY%3D, PID: 9812896
-
Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282(5392):1318–1321
-
(1998)
Science
, vol.282
, Issue.5392
, pp. 1318-1321
-
-
Cardone, M.H.1
Roy, N.2
Stennicke, H.R.3
Salvesen, G.S.4
Franke, T.F.5
Stanbridge, E.6
Frisch, S.7
Reed, J.C.8
-
33
-
-
77951060396
-
PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila
-
COI: 1:CAS:528:DC%2BC3cXltFSjtL0%3D, PID: 20351282
-
Chiang HC, Wang L, Xie Z, Yau A, Zhong Y (2010) PI3 kinase signaling is involved in Abeta-induced memory loss in Drosophila. Proc Natl Acad Sci U S A 107(15):7060–7065
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.15
, pp. 7060-7065
-
-
Chiang, H.C.1
Wang, L.2
Xie, Z.3
Yau, A.4
Zhong, Y.5
-
34
-
-
44649198605
-
Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo
-
COI: 1:CAS:528:DC%2BD1cXnvVSqtr4%3D, PID: 18549783
-
Chiu SL, Chen CM, Cline HT (2008) Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 58(5):708–719
-
(2008)
Neuron
, vol.58
, Issue.5
, pp. 708-719
-
-
Chiu, S.L.1
Chen, C.M.2
Cline, H.T.3
-
35
-
-
84909645342
-
Early detection of Alzheimer’s disease using PiB and FDG PET
-
COI: 1:CAS:528:DC%2BC2cXhtVWrsL%2FO, PID: 24825318
-
Cohen AD, Klunk WE (2014) Early detection of Alzheimer’s disease using PiB and FDG PET. Neurobiol Dis 72(Pt A):117–122
-
(2014)
Neurobiol Dis
, vol.72
, pp. 117-122
-
-
Cohen, A.D.1
Klunk, W.E.2
-
36
-
-
33745188027
-
Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo
-
COI: 1:CAS:528:DC%2BD28XlsV2ltro%3D
-
Cole AR, Causeret F, Yadirgi G, Hastie CJ, McLauchlan H, McManus EJ, Hernandez F, Eickholt BJ, Nikolic M, Sutherland C (2006) Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biolumin Chemilumin 281(24):16591–16598
-
(2006)
J Biolumin Chemilumin
, vol.281
, Issue.24
, pp. 16591-16598
-
-
Cole, A.R.1
Causeret, F.2
Yadirgi, G.3
Hastie, C.J.4
McLauchlan, H.5
McManus, E.J.6
Hernandez, F.7
Eickholt, B.J.8
Nikolic, M.9
Sutherland, C.10
-
37
-
-
49649119782
-
Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation
-
COI: 1:CAS:528:DC%2BD1cXnsVCns7s%3D
-
Cole AR, Soutar MP, Rembutsu M, van Aalten L, Hastie CJ, McLauchlan H, Peggie M, Balastik M, Lu KP, Sutherland C (2008) Relative resistance of Cdk5-phosphorylated CRMP2 to dephosphorylation. J Biolumin Chemilumin 283(26):18227–18237
-
(2008)
J Biolumin Chemilumin
, vol.283
, Issue.26
, pp. 18227-18237
-
-
Cole, A.R.1
Soutar, M.P.2
Rembutsu, M.3
van Aalten, L.4
Hastie, C.J.5
McLauchlan, H.6
Peggie, M.7
Balastik, M.8
Lu, K.P.9
Sutherland, C.10
-
38
-
-
77953785351
-
Long-term depression in the CNS
-
COI: 1:CAS:528:DC%2BC3cXns1Gju78%3D, PID: 20559335
-
Collingridge GL, Peineau S, Howland JG, Wang YT (2010) Long-term depression in the CNS. Nat Rev Neurosci 11(7):459–473
-
(2010)
Nat Rev Neurosci
, vol.11
, Issue.7
, pp. 459-473
-
-
Collingridge, G.L.1
Peineau, S.2
Howland, J.G.3
Wang, Y.T.4
-
39
-
-
69849091630
-
NGF is essential for hippocampal plasticity and learning
-
COI: 1:CAS:528:DC%2BD1MXhtFehsLrN, PID: 19726646
-
Conner JM, Franks KM, Titterness AK, Russell K, Merrill DA, Christie BR, Sejnowski TJ, Tuszynski MH (2009) NGF is essential for hippocampal plasticity and learning. J Neurosci 29(35):10883–10889
-
(2009)
J Neurosci
, vol.29
, Issue.35
, pp. 10883-10889
-
-
Conner, J.M.1
Franks, K.M.2
Titterness, A.K.3
Russell, K.4
Merrill, D.A.5
Christie, B.R.6
Sejnowski, T.J.7
Tuszynski, M.H.8
-
40
-
-
0030658839
-
Brain-derived neurotrophic factor is reduced in Alzheimer’s disease
-
COI: 1:CAS:528:DyaK2sXlsleqtLc%3D, PID: 9387865
-
Connor B, Young D, Yan Q, Faull RL, Synek B, Dragunow M (1997) Brain-derived neurotrophic factor is reduced in Alzheimer’s disease. Brain Res Mol Brain Res 49(1–2):71–81
-
(1997)
Brain Res Mol Brain Res
, vol.49
, Issue.1-2
, pp. 71-81
-
-
Connor, B.1
Young, D.2
Yan, Q.3
Faull, R.L.4
Synek, B.5
Dragunow, M.6
-
41
-
-
84866122780
-
Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2
-
COI: 1:STN:280:DC%2BC38fmtVSrsg%3D%3D, PID: 22869320
-
Copps KD, White MF (2012) Regulation of insulin sensitivity by serine/threonine phosphorylation of insulin receptor substrate proteins IRS1 and IRS2. Diabetologia 55(10):2565–2582
-
(2012)
Diabetologia
, vol.55
, Issue.10
, pp. 2565-2582
-
-
Copps, K.D.1
White, M.F.2
-
42
-
-
79952449386
-
Insulin-resistant brain state: the culprit in sporadic Alzheimer’s disease?
-
COI: 1:CAS:528:DC%2BC3MXjtFWjtbw%3D, PID: 21262392
-
Correia SC, Santos RX, Perry G, Zhu X, Moreira PI, Smith MA (2011) Insulin-resistant brain state: the culprit in sporadic Alzheimer’s disease? Ageing Res Rev 10(2):264–273
-
(2011)
Ageing Res Rev
, vol.10
, Issue.2
, pp. 264-273
-
-
Correia, S.C.1
Santos, R.X.2
Perry, G.3
Zhu, X.4
Moreira, P.I.5
Smith, M.A.6
-
43
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
COI: 1:CAS:528:DyaK28XltFWj, PID: 8524413
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA (1995) Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378(6559):785–789
-
(1995)
Nature
, vol.378
, Issue.6559
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
44
-
-
84901188020
-
Insights into the physiological function of the beta-amyloid precursor protein: beyond Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC2cXotFentbY%3D, PID: 24517464
-
Dawkins E, Small DH (2014) Insights into the physiological function of the beta-amyloid precursor protein: beyond Alzheimer’s disease. J Neurochem 129(5):756–769
-
(2014)
J Neurochem
, vol.129
, Issue.5
, pp. 756-769
-
-
Dawkins, E.1
Small, D.H.2
-
45
-
-
60549084867
-
Protection of synapses against Alzheimer’s-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers
-
PID: 19188609
-
De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL (2009) Protection of synapses against Alzheimer’s-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proc Natl Acad Sci U S A 106(6):1971–1976
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, Issue.6
, pp. 1971-1976
-
-
De Felice, F.G.1
Vieira, M.N.2
Bomfim, T.R.3
Decker, H.4
Velasco, P.T.5
Lambert, M.P.6
Viola, K.L.7
Zhao, W.Q.8
Ferreira, S.T.9
Klein, W.L.10
-
46
-
-
84855602576
-
Interplay between microtubule dynamics and intracellular organization
-
PID: 22108200
-
de Forges H, Bouissou A, Perez F (2012) Interplay between microtubule dynamics and intracellular organization. Int J Biochem Cell Biol 44(2):266–274
-
(2012)
Int J Biochem Cell Biol
, vol.44
, Issue.2
, pp. 266-274
-
-
de Forges, H.1
Bouissou, A.2
Perez, F.3
-
47
-
-
33748755428
-
Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease
-
de la Monte SM, Tong M, Lester-Coll N, Plater M Jr, Wands JR (2006) Therapeutic rescue of neurodegeneration in experimental type 3 diabetes: relevance to Alzheimer’s disease. J Alzheimers Dis 10(1):89–109
-
(2006)
J Alzheimers Dis
, vol.10
, Issue.1
, pp. 89-109
-
-
de la Monte, S.M.1
Tong, M.2
Lester-Coll, N.3
Plater, M.4
Wands, J.R.5
-
48
-
-
77954466407
-
Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons
-
COI: 1:CAS:528:DC%2BC3cXpt1yisb0%3D, PID: 20610750
-
Decker H, Lo KY, Unger SM, Ferreira ST, Silverman MA (2010) Amyloid-beta peptide oligomers disrupt axonal transport through an NMDA receptor-dependent mechanism that is mediated by glycogen synthase kinase 3beta in primary cultured hippocampal neurons. J Neurosci 30(27):9166–9171
-
(2010)
J Neurosci
, vol.30
, Issue.27
, pp. 9166-9171
-
-
Decker, H.1
Lo, K.Y.2
Unger, S.M.3
Ferreira, S.T.4
Silverman, M.A.5
-
49
-
-
73649112749
-
Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3cXhslSjtb0%3D, PID: 19815707
-
Deng Y, Li B, Liu Y, Iqbal K, Grundke-Iqbal I, Gong CX (2009) Dysregulation of insulin signaling, glucose transporters, O-GlcNAcylation, and phosphorylation of tau and neurofilaments in the brain: Implication for Alzheimer’s disease. Am J Pathol 175(5):2089–2098
-
(2009)
Am J Pathol
, vol.175
, Issue.5
, pp. 2089-2098
-
-
Deng, Y.1
Li, B.2
Liu, Y.3
Iqbal, K.4
Grundke-Iqbal, I.5
Gong, C.X.6
-
50
-
-
34249311572
-
Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines
-
COI: 1:CAS:528:DC%2BD2sXmsFentrg%3D, PID: 17543867
-
Doble BW, Patel S, Wood GA, Kockeritz LK, Woodgett JR (2007) Functional redundancy of GSK-3alpha and GSK-3beta in Wnt/beta-catenin signaling shown by using an allelic series of embryonic stem cell lines. Dev Cell 12(6):957–971
-
(2007)
Dev Cell
, vol.12
, Issue.6
, pp. 957-971
-
-
Doble, B.W.1
Patel, S.2
Wood, G.A.3
Kockeritz, L.K.4
Woodgett, J.R.5
-
51
-
-
0027753055
-
Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2 A
-
COI: 1:CAS:528:DyaK2cXhtlWgsbw%3D, PID: 8282105
-
Drewes G, Mandelkow EM, Baumann K, Goris J, Merlevede W, Mandelkow E (1993) Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2 A. FEBS Lett 336(3):425–432
-
(1993)
FEBS Lett
, vol.336
, Issue.3
, pp. 425-432
-
-
Drewes, G.1
Mandelkow, E.M.2
Baumann, K.3
Goris, J.4
Merlevede, W.5
Mandelkow, E.6
-
52
-
-
77954904485
-
A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors
-
COI: 1:CAS:528:DC%2BC3cXot1eksL0%3D, PID: 20534517
-
Du J, Wei Y, Liu L, Wang Y, Khairova R, Blumenthal R, Tragon T, Hunsberger JG, Machado-Vieira R, Drevets W, Wang YT, Manji HK (2010) A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. Proc Natl Acad Sci U S A 107(25):11573–11578
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, Issue.25
, pp. 11573-11578
-
-
Du, J.1
Wei, Y.2
Liu, L.3
Wang, Y.4
Khairova, R.5
Blumenthal, R.6
Tragon, T.7
Hunsberger, J.G.8
Machado-Vieira, R.9
Drevets, W.10
Wang, Y.T.11
Manji, H.K.12
-
53
-
-
34247116441
-
Physiological roles of PKB/Akt isoforms in development and disease
-
COI: 1:CAS:528:DC%2BD2sXjt1WrsLg%3D, PID: 17371246
-
Dummler B, Hemmings BA (2007) Physiological roles of PKB/Akt isoforms in development and disease. Biochem Soc Trans 35(Pt 2):231–235
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 231-235
-
-
Dummler, B.1
Hemmings, B.A.2
-
54
-
-
20044382806
-
Role for Akt3/protein kinase Bgamma in attainment of normal brain size
-
COI: 1:CAS:528:DC%2BD2MXhvFGqt7Y%3D, PID: 15713641
-
Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ (2005) Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Mol Cell Biol 25(5):1869–1878
-
(2005)
Mol Cell Biol
, vol.25
, Issue.5
, pp. 1869-1878
-
-
Easton, R.M.1
Cho, H.2
Roovers, K.3
Shineman, D.W.4
Mizrahi, M.5
Forman, M.S.6
Lee, V.M.7
Szabolcs, M.8
de Jong, R.9
Oltersdorf, T.10
Ludwig, T.11
Efstratiadis, A.12
Birnbaum, M.J.13
-
55
-
-
0030931560
-
Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action
-
COI: 1:CAS:528:DyaK2sXlvVWjsLY%3D, PID: 9275179
-
Eldar-Finkelman H, Krebs EG (1997) Phosphorylation of insulin receptor substrate 1 by glycogen synthase kinase 3 impairs insulin action. Proc Natl Acad Sci U S A 94(18):9660–9664
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, Issue.18
, pp. 9660-9664
-
-
Eldar-Finkelman, H.1
Krebs, E.G.2
-
56
-
-
0029973286
-
Cerebral amyloid angiopathy in the brains of patients with Alzheimer’s disease: the CERAD experience, Part XV
-
COI: 1:STN:280:DyaK283kvV2ksQ%3D%3D, PID: 8649554
-
Ellis RJ, Olichney JM, Thal LJ, Mirra SS, Morris JC, Beekly D, Heyman A (1996) Cerebral amyloid angiopathy in the brains of patients with Alzheimer’s disease: the CERAD experience, Part XV. Neurology 46(6):1592–1596
-
(1996)
Neurology
, vol.46
, Issue.6
, pp. 1592-1596
-
-
Ellis, R.J.1
Olichney, J.M.2
Thal, L.J.3
Mirra, S.S.4
Morris, J.C.5
Beekly, D.6
Heyman, A.7
-
57
-
-
0019026208
-
Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase
-
COI: 1:CAS:528:DyaL3cXkvFSrt7Y%3D, PID: 6249596
-
Embi N, Rylatt DB, Cohen P (1980) Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 107(2):519–527
-
(1980)
Eur J Biochem
, vol.107
, Issue.2
, pp. 519-527
-
-
Embi, N.1
Rylatt, D.B.2
Cohen, P.3
-
58
-
-
0034988819
-
Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells
-
COI: 1:CAS:528:DC%2BD3MXkslelsL4%3D, PID: 11416002
-
Esposito DL, Li Y, Cama A, Quon MJ (2001) Tyr(612) and Tyr(632) in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology 142(7):2833–2840
-
(2001)
Endocrinology
, vol.142
, Issue.7
, pp. 2833-2840
-
-
Esposito, D.L.1
Li, Y.2
Cama, A.3
Quon, M.J.4
-
59
-
-
30544453564
-
Protein kinase B/Akt at a glance
-
COI: 1:CAS:528:DC%2BD28XosFemsw%3D%3D, PID: 16339964
-
Fayard E, Tintignac LA, Baudry A, Hemmings BA (2005) Protein kinase B/Akt at a glance. J Cell Sci 118(Pt 24):5675–5678
-
(2005)
J Cell Sci
, vol.118
, pp. 5675-5678
-
-
Fayard, E.1
Tintignac, L.A.2
Baudry, A.3
Hemmings, B.A.4
-
60
-
-
0036942843
-
Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer’s disease, Pick’s disease, progressive supranuclear palsy and corticobasal degeneration
-
COI: 1:CAS:528:DC%2BD38Xot1Ojur8%3D, PID: 12410379
-
Ferrer I, Barrachina M, Puig B (2002) Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer’s disease, Pick’s disease, progressive supranuclear palsy and corticobasal degeneration. Acta Neuropathol 104(6):583–591
-
(2002)
Acta Neuropathol
, vol.104
, Issue.6
, pp. 583-591
-
-
Ferrer, I.1
Barrachina, M.2
Puig, B.3
-
61
-
-
0031039024
-
Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate
-
COI: 1:CAS:528:DyaK2sXptV2mtQ%3D%3D, PID: 9005852
-
Franke TF, Kaplan DR, Cantley LC, Toker A (1997) Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275(5300):665–668
-
(1997)
Science
, vol.275
, Issue.5300
, pp. 665-668
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
Toker, A.4
-
62
-
-
84880555817
-
Intranasal insulin as a treatment for Alzheimer’s disease: a review of basic research and clinical evidence
-
COI: 1:CAS:528:DC%2BC3sXhvVWmsrbL, PID: 23719722
-
Freiherr J, Hallschmid M, Frey WH 2nd, Brunner YF, Chapman CD, Holscher C, Craft S, De Felice FG, Benedict C (2013) Intranasal insulin as a treatment for Alzheimer’s disease: a review of basic research and clinical evidence. CNS Drugs 27(7):505–514
-
(2013)
CNS Drugs
, vol.27
, Issue.7
, pp. 505-514
-
-
Freiherr, J.1
Hallschmid, M.2
Frey, W.H.3
Brunner, Y.F.4
Chapman, C.D.5
Holscher, C.6
Craft, S.7
De Felice, F.G.8
Benedict, C.9
-
63
-
-
33644698732
-
Peripheral hyperinsulinemia promotes tau phosphorylation in vivo
-
COI: 1:CAS:528:DC%2BD2MXht12gs7bK, PID: 16306348
-
Freude S, Plum L, Schnitker J, Leeser U, Udelhoven M, Krone W, Bruning JC, Schubert M (2005) Peripheral hyperinsulinemia promotes tau phosphorylation in vivo. Diabetes 54(12):3343–3348
-
(2005)
Diabetes
, vol.54
, Issue.12
, pp. 3343-3348
-
-
Freude, S.1
Plum, L.2
Schnitker, J.3
Leeser, U.4
Udelhoven, M.5
Krone, W.6
Bruning, J.C.7
Schubert, M.8
-
64
-
-
67149139990
-
The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer’s disease: from model organisms to human disease
-
COI: 1:CAS:528:DC%2BD1MXnsFWktb8%3D, PID: 19519303
-
Freude S, Schilbach K, Schubert M (2009) The role of IGF-1 receptor and insulin receptor signaling for the pathogenesis of Alzheimer’s disease: from model organisms to human disease. Curr Alzheimer Res 6(3):213–223
-
(2009)
Curr Alzheimer Res
, vol.6
, Issue.3
, pp. 213-223
-
-
Freude, S.1
Schilbach, K.2
Schubert, M.3
-
65
-
-
84883483789
-
Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin
-
COI: 1:CAS:528:DC%2BC3sXhsVSht7bM, PID: 24011077
-
Fujikawa T, Berglund ED, Patel VR, Ramadori G, Vianna CR, Vong L, Thorel F, Chera S, Herrera PL, Lowell BB, Elmquist JK, Baldi P, Coppari R (2013) Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin. Cell Metab 18(3):431–444
-
(2013)
Cell Metab
, vol.18
, Issue.3
, pp. 431-444
-
-
Fujikawa, T.1
Berglund, E.D.2
Patel, V.R.3
Ramadori, G.4
Vianna, C.R.5
Vong, L.6
Thorel, F.7
Chera, S.8
Herrera, P.L.9
Lowell, B.B.10
Elmquist, J.K.11
Baldi, P.12
Coppari, R.13
-
66
-
-
79953216041
-
Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate
-
COI: 1:CAS:528:DC%2BC3MXjslKhu74%3D
-
Gan X, Wang J, Su B, Wu D (2011) Evidence for direct activation of mTORC2 kinase activity by phosphatidylinositol 3,4,5-trisphosphate. J Biolumin Chemilumin 286(13):10998–11002
-
(2011)
J Biolumin Chemilumin
, vol.286
, Issue.13
, pp. 10998-11002
-
-
Gan, X.1
Wang, J.2
Su, B.3
Wu, D.4
-
67
-
-
2442681877
-
Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils
-
COI: 1:CAS:528:DC%2BD2cXjvV2nt7w%3D
-
Gardai SJ, Hildeman DA, Frankel SK, Whitlock BB, Frasch SC, Borregaard N, Marrack P, Bratton DL, Henson PM (2004) Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. J Biolumin Chemilumin 279(20):21085–21095
-
(2004)
J Biolumin Chemilumin
, vol.279
, Issue.20
, pp. 21085-21095
-
-
Gardai, S.J.1
Hildeman, D.A.2
Frankel, S.K.3
Whitlock, B.B.4
Frasch, S.C.5
Borregaard, N.6
Marrack, P.7
Bratton, D.L.8
Henson, P.M.9
-
68
-
-
0035871641
-
Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling
-
COI: 1:CAS:528:DC%2BD3MXjtVWkurs%3D, PID: 11306609
-
Gasparini L, Gouras GK, Wang R, Gross RS, Beal MF, Greengard P, Xu H (2001) Stimulation of beta-amyloid precursor protein trafficking by insulin reduces intraneuronal beta-amyloid and requires mitogen-activated protein kinase signaling. J Neurosci 21(8):2561–2570
-
(2001)
J Neurosci
, vol.21
, Issue.8
, pp. 2561-2570
-
-
Gasparini, L.1
Gouras, G.K.2
Wang, R.3
Gross, R.S.4
Beal, M.F.5
Greengard, P.6
Xu, H.7
-
69
-
-
0020696197
-
Modulation of substrate transport to the brain
-
COI: 1:CAS:528:DyaL3sXhsFyhsbw%3D, PID: 6301198
-
Gjedde A (1983) Modulation of substrate transport to the brain. Acta Neurol Scand 67(1):3–25
-
(1983)
Acta Neurol Scand
, vol.67
, Issue.1
, pp. 3-25
-
-
Gjedde, A.1
-
70
-
-
0021207461
-
Alzheimer’s disease and Down’s syndrome: sharing of a unique cerebrovascular amyloid fibril protein
-
COI: 1:CAS:528:DyaL2cXlt1ygtL4%3D, PID: 6236805
-
Glenner GG, Wong CW (1984) Alzheimer’s disease and Down’s syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem Biophys Res Commun 122(3):1131–1135
-
(1984)
Biochem Biophys Res Commun
, vol.122
, Issue.3
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
71
-
-
0026088977
-
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease
-
COI: 1:CAS:528:DyaK3MXhsFyhu7k%3D, PID: 1671712
-
Goate A, Chartier-Harlin MC, Mullan M, Brown J, Crawford F, Fidani L, Giuffra L, Haynes A, Irving N, James L, et al. (1991) Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer’s disease. Nature 349(6311):704–706
-
(1991)
Nature
, vol.349
, Issue.6311
, pp. 704-706
-
-
Goate, A.1
Chartier-Harlin, M.C.2
Mullan, M.3
Brown, J.4
Crawford, F.5
Fidani, L.6
Giuffra, L.7
Haynes, A.8
Irving, N.9
James, L.10
-
72
-
-
78751692575
-
Anti-abeta therapeutics in Alzheimer’s disease: the need for a paradigm shift
-
COI: 1:CAS:528:DC%2BC3MXhtVWmsLg%3D, PID: 21262461
-
Golde TE, Schneider LS, Koo EH (2011) Anti-abeta therapeutics in Alzheimer’s disease: the need for a paradigm shift. Neuron 69(2):203–213
-
(2011)
Neuron
, vol.69
, Issue.2
, pp. 203-213
-
-
Golde, T.E.1
Schneider, L.S.2
Koo, E.H.3
-
73
-
-
0029979798
-
Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease
-
Gomez-Isla T, Price JL, McKeel DW Jr, Morris JC, Growdon JH, Hyman BT (1996) Profound loss of layer II entorhinal cortex neurons occurs in very mild Alzheimer’s disease. J Neurosci 16(14):4491–4500
-
(1996)
J Neurosci
, vol.16
, Issue.14
, pp. 4491-4500
-
-
Gomez-Isla, T.1
Price, J.L.2
McKeel, D.W.3
Morris, J.C.4
Growdon, J.H.5
Hyman, B.T.6
-
74
-
-
0028350740
-
Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease
-
COI: 1:CAS:528:DyaK2cXis1Ogtbo%3D, PID: 8137929
-
Gong CX, Grundke-Iqbal I, Damuni Z, Iqbal K (1994) Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease. FEBS Lett 341(1):94–98
-
(1994)
FEBS Lett
, vol.341
, Issue.1
, pp. 94-98
-
-
Gong, C.X.1
Grundke-Iqbal, I.2
Damuni, Z.3
Iqbal, K.4
-
75
-
-
80052400687
-
Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association
-
PID: 21778438
-
Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Iadecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S, American Heart Association Stroke Council CoE, Prevention CoCNCoCR, Intervention, Council on Cardiovascular S and Anesthesia (2011) Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke 42(9):2672–2713
-
(2011)
Stroke
, vol.42
, Issue.9
, pp. 2672-2713
-
-
Gorelick, P.B.1
Scuteri, A.2
Black, S.E.3
Decarli, C.4
Greenberg, S.M.5
Iadecola, C.6
Launer, L.J.7
Laurent, S.8
Lopez, O.L.9
Nyenhuis, D.10
Petersen, R.C.11
Schneider, J.A.12
Tzourio, C.13
Arnett, D.K.14
Bennett, D.A.15
Chui, H.C.16
Higashida, R.T.17
Lindquist, R.18
Nilsson, P.M.19
Roman, G.C.20
Sellke, F.W.21
Seshadri, S.22
more..
-
76
-
-
0027092647
-
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
-
COI: 1:CAS:528:DyaK3sXnvVGksA%3D%3D, PID: 1361685
-
Grant SG, O’Dell TJ, Karl KA, Stein PL, Soriano P, Kandel ER (1992) Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. Science 258(5090):1903–1910
-
(1992)
Science
, vol.258
, Issue.5090
, pp. 1903-1910
-
-
Grant, S.G.1
O’Dell, T.J.2
Karl, K.A.3
Stein, P.L.4
Soriano, P.5
Kandel, E.R.6
-
77
-
-
0028179001
-
Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation
-
COI: 1:CAS:528:DyaK2cXltVGqsbw%3D, PID: 8041753
-
Greenberg SM, Koo EH, Selkoe DJ, Qiu WQ, Kosik KS (1994) Secreted beta-amyloid precursor protein stimulates mitogen-activated protein kinase and enhances tau phosphorylation. Proc Natl Acad Sci U S A 91(15):7104–7108
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, Issue.15
, pp. 7104-7108
-
-
Greenberg, S.M.1
Koo, E.H.2
Selkoe, D.J.3
Qiu, W.Q.4
Kosik, K.S.5
-
78
-
-
16244391770
-
Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer’s disease pathology
-
COI: 1:CAS:528:DC%2BD2MXjtFCgt7s%3D, PID: 15773910
-
Griffin RJ, Moloney A, Kelliher M, Johnston JA, Ravid R, Dockery P, O’Connor R, O’Neill C (2005) Activation of Akt/PKB, increased phosphorylation of Akt substrates and loss and altered distribution of Akt and PTEN are features of Alzheimer’s disease pathology. J Neurochem 93(1):105–117
-
(2005)
J Neurochem
, vol.93
, Issue.1
, pp. 105-117
-
-
Griffin, R.J.1
Moloney, A.2
Kelliher, M.3
Johnston, J.A.4
Ravid, R.5
Dockery, P.6
O’Connor, R.7
O’Neill, C.8
-
79
-
-
33750596002
-
Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes
-
COI: 1:CAS:528:DC%2BD28Xis1Sitr4%3D, PID: 16929378
-
Groop PH, Forsblom C, Thomas MC (2005) Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes. Nat Clin Pract Endocrinol Metab 1(2):100–110
-
(2005)
Nat Clin Pract Endocrinol Metab
, vol.1
, Issue.2
, pp. 100-110
-
-
Groop, P.H.1
Forsblom, C.2
Thomas, M.C.3
-
80
-
-
34247324303
-
Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein
-
PID: 17448147
-
Grunblatt E, Salkovic-Petrisic M, Osmanovic J, Riederer P, Hoyer S (2007) Brain insulin system dysfunction in streptozotocin intracerebroventricularly treated rats generates hyperphosphorylated tau protein. J Neurochem 101(3):757–770
-
(2007)
J Neurochem
, vol.101
, Issue.3
, pp. 757-770
-
-
Grunblatt, E.1
Salkovic-Petrisic, M.2
Osmanovic, J.3
Riederer, P.4
Hoyer, S.5
-
81
-
-
84888402101
-
Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies
-
PID: 24843720
-
Gudala K, Bansal D, Schifano F, Bhansali A (2013) Diabetes mellitus and risk of dementia: A meta-analysis of prospective observational studies. J Diabetes Investig 4(6):640–650
-
(2013)
J Diabetes Investig
, vol.4
, Issue.6
, pp. 640-650
-
-
Gudala, K.1
Bansal, D.2
Schifano, F.3
Bhansali, A.4
-
82
-
-
84867178512
-
PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance
-
COI: 1:CAS:528:DC%2BC38XhsFSmt7nE, PID: 22875989
-
Gupta A, Dey CS (2012) PTEN, a widely known negative regulator of insulin/PI3K signaling, positively regulates neuronal insulin resistance. Mol Biol Cell 23(19):3882–3898
-
(2012)
Mol Biol Cell
, vol.23
, Issue.19
, pp. 3882-3898
-
-
Gupta, A.1
Dey, C.S.2
-
83
-
-
0026487365
-
Glycogen synthase kinase-3 induces Alzheimer’s disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase
-
COI: 1:CAS:528:DyaK3sXpvFGksg%3D%3D, PID: 1336152
-
Hanger DP, Hughes K, Woodgett JR, Brion JP, Anderton BH (1992) Glycogen synthase kinase-3 induces Alzheimer’s disease-like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci Lett 147(1):58–62
-
(1992)
Neurosci Lett
, vol.147
, Issue.1
, pp. 58-62
-
-
Hanger, D.P.1
Hughes, K.2
Woodgett, J.R.3
Brion, J.P.4
Anderton, B.H.5
-
84
-
-
0026597063
-
Alzheimer’s disease: the amyloid cascade hypothesis
-
COI: 1:CAS:528:DyaK38Xitlarurg%3D, PID: 1566067
-
Hardy JA, Higgins GA (1992) Alzheimer’s disease: the amyloid cascade hypothesis. Science 256(5054):184–185
-
(1992)
Science
, vol.256
, Issue.5054
, pp. 184-185
-
-
Hardy, J.A.1
Higgins, G.A.2
-
85
-
-
0037135111
-
The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics
-
COI: 1:CAS:528:DC%2BD38Xls1Cju7s%3D, PID: 12130773
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297(5580):353–356
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
86
-
-
0032883250
-
No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans
-
COI: 1:CAS:528:DyaK1MXmsVCjsr8%3D, PID: 10512354
-
Hasselbalch SG, Knudsen GM, Videbaek C, Pinborg LH, Schmidt JF, Holm S, Paulson OB (1999) No effect of insulin on glucose blood-brain barrier transport and cerebral metabolism in humans. Diabetes 48(10):1915–1921
-
(1999)
Diabetes
, vol.48
, Issue.10
, pp. 1915-1921
-
-
Hasselbalch, S.G.1
Knudsen, G.M.2
Videbaek, C.3
Pinborg, L.H.4
Schmidt, J.F.5
Holm, S.6
Paulson, O.B.7
-
87
-
-
0018090354
-
Insulin receptors are widely distributed in the central nervous system of the rat
-
COI: 1:CAS:528:DyaE1cXkvVCqt7g%3D, PID: 205798
-
Havrankova J, Roth J, Brownstein M (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272(5656):827–829
-
(1978)
Nature
, vol.272
, Issue.5656
, pp. 827-829
-
-
Havrankova, J.1
Roth, J.2
Brownstein, M.3
-
88
-
-
0018773152
-
Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents
-
COI: 1:CAS:528:DyaE1MXlt1Wlurg%3D, PID: 156737
-
Havrankova J, Roth J, Brownstein MJ (1979) Concentrations of insulin and insulin receptors in the brain are independent of peripheral insulin levels. Studies of obese and streptozotocin-treated rodents. J Clin Invest 64(2):636–642
-
(1979)
J Clin Invest
, vol.64
, Issue.2
, pp. 636-642
-
-
Havrankova, J.1
Roth, J.2
Brownstein, M.J.3
-
89
-
-
84866518216
-
An anatomically comprehensive atlas of the adult human brain transcriptome
-
COI: 1:CAS:528:DC%2BC38Xhtlymu77N, PID: 22996553
-
Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, van de Lagemaat LN, Smith KA, Ebbert A, Riley ZL, Abajian C, Beckmann CF, Bernard A, Bertagnolli D, Boe AF, Cartagena PM, Chakravarty MM, Chapin M, Chong J, Dalley RA, Daly BD, Dang C, Datta S, Dee N, Dolbeare TA, Faber V, Feng D, Fowler DR, Goldy J, Gregor BW, Haradon Z, Haynor DR, Hohmann JG, Horvath S, Howard RE, Jeromin A, Jochim JM, Kinnunen M, Lau C, Lazarz ET, Lee C, Lemon TA, Li L, Li Y, Morris JA, Overly CC, Parker PD, Parry SE, Reding M, Royall JJ, Schulkin J, Sequeira PA, Slaughterbeck CR, Smith SC, Sodt AJ, Sunkin SM, Swanson BE, Vawter MP, Williams D, Wohnoutka P, Zielke HR, Geschwind DH, Hof PR, Smith SM, Koch C, Grant SG, Jones AR (2012) An anatomically comprehensive atlas of the adult human brain transcriptome. Nature 489(7416):391–399
-
(2012)
Nature
, vol.489
, Issue.7416
, pp. 391-399
-
-
Hawrylycz, M.J.1
Lein, E.S.2
Guillozet-Bongaarts, A.L.3
Shen, E.H.4
Ng, L.5
Miller, J.A.6
van de Lagemaat, L.N.7
Smith, K.A.8
Ebbert, A.9
Riley, Z.L.10
Abajian, C.11
Beckmann, C.F.12
Bernard, A.13
Bertagnolli, D.14
Boe, A.F.15
Cartagena, P.M.16
Chakravarty, M.M.17
Chapin, M.18
Chong, J.19
Dalley, R.A.20
Daly, B.D.21
Dang, C.22
Datta, S.23
Dee, N.24
Dolbeare, T.A.25
Faber, V.26
Feng, D.27
Fowler, D.R.28
Goldy, J.29
Gregor, B.W.30
Haradon, Z.31
Haynor, D.R.32
Hohmann, J.G.33
Horvath, S.34
Howard, R.E.35
Jeromin, A.36
Jochim, J.M.37
Kinnunen, M.38
Lau, C.39
Lazarz, E.T.40
Lee, C.41
Lemon, T.A.42
Li, L.43
Li, Y.44
Morris, J.A.45
Overly, C.C.46
Parker, P.D.47
Parry, S.E.48
Reding, M.49
Royall, J.J.50
Schulkin, J.51
Sequeira, P.A.52
Slaughterbeck, C.R.53
Smith, S.C.54
Sodt, A.J.55
Sunkin, S.M.56
Swanson, B.E.57
Vawter, M.P.58
Williams, D.59
Wohnoutka, P.60
Zielke, H.R.61
Geschwind, D.H.62
Hof, P.R.63
Smith, S.M.64
Koch, C.65
Grant, S.G.66
Jones, A.R.67
more..
-
90
-
-
0030680107
-
Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study
-
COI: 1:STN:280:DyaK1c%2FjvFWrsA%3D%3D, PID: 9371913
-
Heitner J, Dickson D (1997) Diabetics do not have increased Alzheimer-type pathology compared with age-matched control subjects. A retrospective postmortem immunocytochemical and histofluorescent study. Neurology 49(5):1306–1311
-
(1997)
Neurology
, vol.49
, Issue.5
, pp. 1306-1311
-
-
Heitner, J.1
Dickson, D.2
-
91
-
-
84866725201
-
Amyloid-beta protein modulates insulin signaling in presynaptic terminals
-
COI: 1:CAS:528:DC%2BC38Xns1Wlt7k%3D, PID: 22638775
-
Heras-Sandoval D, Ferrera P, Arias C (2012) Amyloid-beta protein modulates insulin signaling in presynaptic terminals. Neurochem Res 37(9):1879–1885
-
(2012)
Neurochem Res
, vol.37
, Issue.9
, pp. 1879-1885
-
-
Heras-Sandoval, D.1
Ferrera, P.2
Arias, C.3
-
92
-
-
4644286910
-
Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD2cXjvVCltr8%3D, PID: 15033922
-
Ho L, Qin W, Pompl PN, Xiang Z, Wang J, Zhao Z, Peng Y, Cambareri G, Rocher A, Mobbs CV, Hof PR, Pasinetti GM (2004) Diet-induced insulin resistance promotes amyloidosis in a transgenic mouse model of Alzheimer’s disease. FASEB J 18(7):902–904
-
(2004)
FASEB J
, vol.18
, Issue.7
, pp. 902-904
-
-
Ho, L.1
Qin, W.2
Pompl, P.N.3
Xiang, Z.4
Wang, J.5
Zhao, Z.6
Peng, Y.7
Cambareri, G.8
Rocher, A.9
Mobbs, C.V.10
Hof, P.R.11
Pasinetti, G.M.12
-
93
-
-
0030748390
-
Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
-
COI: 1:CAS:528:DyaK2sXltFSgtro%3D
-
Hong M, Lee VM (1997) Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biolumin Chemilumin 272(31):19547–19553
-
(1997)
J Biolumin Chemilumin
, vol.272
, Issue.31
, pp. 19547-19553
-
-
Hong, M.1
Lee, V.M.2
-
94
-
-
84880566446
-
A growing role for mTOR in promoting anabolic metabolism
-
COI: 1:CAS:528:DC%2BC3sXhtF2msr3K, PID: 23863154
-
Howell JJ, Ricoult SJ, Ben-Sahra I, Manning BD (2013) A growing role for mTOR in promoting anabolic metabolism. Biochem Soc Trans 41(4):906–912
-
(2013)
Biochem Soc Trans
, vol.41
, Issue.4
, pp. 906-912
-
-
Howell, J.J.1
Ricoult, S.J.2
Ben-Sahra, I.3
Manning, B.D.4
-
95
-
-
0033380660
-
Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats
-
COI: 1:CAS:528:DC%2BD3cXms1GlsQ%3D%3D, PID: 10672254
-
Hoyer S, Lannert H (1999) Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats. Ann N Y Acad Sci 893:301–303
-
(1999)
Ann N Y Acad Sci
, vol.893
, pp. 301-303
-
-
Hoyer, S.1
Lannert, H.2
-
96
-
-
0028170864
-
Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism
-
COI: 1:CAS:528:DyaK2MXksVOrtb8%3D, PID: 7897397
-
Hoyer S, Muller D, Plaschke K (1994) Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism. J Neural Transm Suppl 44:259–268
-
(1994)
J Neural Transm Suppl
, vol.44
, pp. 259-268
-
-
Hoyer, S.1
Muller, D.2
Plaschke, K.3
-
97
-
-
59749091850
-
A complex interplay between Akt, TSC2 and the two mTOR complexes
-
COI: 1:CAS:528:DC%2BD1MXotVWlsg%3D%3D, PID: 19143635
-
Huang J, Manning BD (2009) A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37(Pt 1):217–222
-
(2009)
Biochem Soc Trans
, vol.37
, pp. 217-222
-
-
Huang, J.1
Manning, B.D.2
-
98
-
-
0027475421
-
Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation
-
COI: 1:CAS:528:DyaK3sXhvVKmurw%3D, PID: 8382613
-
Hughes K, Nikolakaki E, Plyte SE, Totty NF, Woodgett JR (1993) Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation. EMBO J 12(2):803–808
-
(1993)
EMBO J
, vol.12
, Issue.2
, pp. 803-808
-
-
Hughes, K.1
Nikolakaki, E.2
Plyte, S.E.3
Totty, N.F.4
Woodgett, J.R.5
-
99
-
-
44649147170
-
Neuronal hypertrophy in asymptomatic Alzheimer disease
-
PID: 18520776
-
Iacono D, O’Brien R, Resnick SM, Zonderman AB, Pletnikova O, Rudow G, An Y, West MJ, Crain B, Troncoso JC (2008) Neuronal hypertrophy in asymptomatic Alzheimer disease. J Neuropathol Exp Neurol 67(6):578–589
-
(2008)
J Neuropathol Exp Neurol
, vol.67
, Issue.6
, pp. 578-589
-
-
Iacono, D.1
O’Brien, R.2
Resnick, S.M.3
Zonderman, A.B.4
Pletnikova, O.5
Rudow, G.6
An, Y.7
West, M.J.8
Crain, B.9
Troncoso, J.C.10
-
100
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
COI: 1:CAS:528:DC%2BD38Xms1ahtL4%3D, PID: 12172553
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4(9):648–657
-
(2002)
Nat Cell Biol
, vol.4
, Issue.9
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
101
-
-
0027255817
-
Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments
-
COI: 1:CAS:528:DyaK3sXlsFCmtr4%3D, PID: 7686508
-
Ishiguro K, Shiratsuchi A, Sato S, Omori A, Arioka M, Kobayashi S, Uchida T, Imahori K (1993) Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments. FEBS Lett 325(3):167–172
-
(1993)
FEBS Lett
, vol.325
, Issue.3
, pp. 167-172
-
-
Ishiguro, K.1
Shiratsuchi, A.2
Sato, S.3
Omori, A.4
Arioka, M.5
Kobayashi, S.6
Uchida, T.7
Imahori, K.8
-
102
-
-
84856956771
-
Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells
-
COI: 1:CAS:528:DC%2BC38Xht1ejsrY%3D, PID: 22278060
-
Israel MA, Yuan SH, Bardy C, Reyna SM, Mu Y, Herrera C, Hefferan MP, Van Gorp S, Nazor KL, Boscolo FS, Carson CT, Laurent LC, Marsala M, Gage FH, Remes AM, Koo EH, Goldstein LS (2012) Probing sporadic and familial Alzheimer’s disease using induced pluripotent stem cells. Nature 482(7384):216–220
-
(2012)
Nature
, vol.482
, Issue.7384
, pp. 216-220
-
-
Israel, M.A.1
Yuan, S.H.2
Bardy, C.3
Reyna, S.M.4
Mu, Y.5
Herrera, C.6
Hefferan, M.P.7
Van Gorp, S.8
Nazor, K.L.9
Boscolo, F.S.10
Carson, C.T.11
Laurent, L.C.12
Marsala, M.13
Gage, F.H.14
Remes, A.M.15
Koo, E.H.16
Goldstein, L.S.17
-
103
-
-
77955322042
-
Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer’s Disease Mouse Models
-
COI: 1:CAS:528:DC%2BC3cXpvFKrtr4%3D, PID: 20655099
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J, Wolfing H, Chieng BC, Christie MJ, Napier IA, Eckert A, Staufenbiel M, Hardeman E, Gotz J (2010) Dendritic Function of Tau Mediates Amyloid-beta Toxicity in Alzheimer’s Disease Mouse Models. Cell 142(3):387–397
-
(2010)
Cell
, vol.142
, Issue.3
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
van Eersel, J.6
Wolfing, H.7
Chieng, B.C.8
Christie, M.J.9
Napier, I.A.10
Eckert, A.11
Staufenbiel, M.12
Hardeman, E.13
Gotz, J.14
-
104
-
-
0041570229
-
Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats
-
COI: 1:CAS:528:DC%2BD3sXls1yns7w%3D, PID: 12827244
-
Izumi Y, Yamada KA, Matsukawa M, Zorumski CF (2003) Effects of insulin on long-term potentiation in hippocampal slices from diabetic rats. Diabetologia 46(7):1007–1012
-
(2003)
Diabetologia
, vol.46
, Issue.7
, pp. 1007-1012
-
-
Izumi, Y.1
Yamada, K.A.2
Matsukawa, M.3
Zorumski, C.F.4
-
105
-
-
0842309993
-
Increased risk of type 2 diabetes in Alzheimer disease
-
COI: 1:CAS:528:DC%2BD2cXhtlWgsr8%3D, PID: 14747300
-
Janson J, Laedtke T, Parisi JE, O’Brien P, Petersen RC, Butler PC (2004) Increased risk of type 2 diabetes in Alzheimer disease. Diabetes 53(2):474–481
-
(2004)
Diabetes
, vol.53
, Issue.2
, pp. 474-481
-
-
Janson, J.1
Laedtke, T.2
Parisi, J.E.3
O’Brien, P.4
Petersen, R.C.5
Butler, P.C.6
-
106
-
-
83055188883
-
GSK-3alpha/beta kinases and amyloid production in vivo
-
PID: 22158250
-
Jaworski T, Dewachter I, Lechat B, Gees M, Kremer A, Demedts D, Borghgraef P, Devijver H, Kugler S, Patel S, Woodgett JR, Van Leuven F (2011) GSK-3alpha/beta kinases and amyloid production in vivo. Nature 480(7376):E4-5; discussion E6
-
(2011)
Nature
, vol.480
, Issue.7376
-
-
Jaworski, T.1
Dewachter, I.2
Lechat, B.3
Gees, M.4
Kremer, A.5
Demedts, D.6
Borghgraef, P.7
Devijver, H.8
Kugler, S.9
Patel, S.10
Woodgett, J.R.11
Van Leuven, F.12
-
107
-
-
84897365236
-
Pathology and pathogenesis of vascular cognitive impairment-a critical update
-
PID: 23596414
-
Jellinger KA (2013) Pathology and pathogenesis of vascular cognitive impairment-a critical update. Front Aging Neurosci 5:17
-
(2013)
Front Aging Neurosci
, vol.5
, pp. 17
-
-
Jellinger, K.A.1
-
108
-
-
79956320988
-
Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model
-
COI: 1:CAS:528:DC%2BC3MXmtlGlsLc%3D
-
Jimenez S, Torres M, Vizuete M, Sanchez-Varo R, Sanchez-Mejias E, Trujillo-Estrada L, Carmona-Cuenca I, Caballero C, Ruano D, Gutierrez A, Vitorica J (2011) Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model. J Biolumin Chemilumin 286(21):18414–18425
-
(2011)
J Biolumin Chemilumin
, vol.286
, Issue.21
, pp. 18414-18425
-
-
Jimenez, S.1
Torres, M.2
Vizuete, M.3
Sanchez-Varo, R.4
Sanchez-Mejias, E.5
Trujillo-Estrada, L.6
Carmona-Cuenca, I.7
Caballero, C.8
Ruano, D.9
Gutierrez, A.10
Vitorica, J.11
-
109
-
-
84861863684
-
Increased Abeta production prompts the onset of glucose intolerance and insulin resistance
-
COI: 1:CAS:528:DC%2BC38XhtVGlsr%2FN, PID: 22414803
-
Jimenez-Palomares M, Ramos-Rodriguez JJ, Lopez-Acosta JF, Pacheco-Herrero M, Lechuga-Sancho AM, Perdomo G, Garcia-Alloza M, Cozar-Castellano I (2012) Increased Abeta production prompts the onset of glucose intolerance and insulin resistance. Am J Physiol Endocrinol Metab 302(11):E1373–E1380
-
(2012)
Am J Physiol Endocrinol Metab
, vol.302
, Issue.11
, pp. E1373-E1380
-
-
Jimenez-Palomares, M.1
Ramos-Rodriguez, J.J.2
Lopez-Acosta, J.F.3
Pacheco-Herrero, M.4
Lechuga-Sancho, A.M.5
Perdomo, G.6
Garcia-Alloza, M.7
Cozar-Castellano, I.8
-
110
-
-
79955484857
-
Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta
-
COI: 1:CAS:528:DC%2BC3MXjvVOitLs%3D, PID: 21441921
-
Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo SC, Bru-Mercier G, Dickinson B, Scullion S, Sheng M, Collingridge G, Cho K (2011) Abeta(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3beta. Nat Neurosci 14(5):545–547
-
(2011)
Nat Neurosci
, vol.14
, Issue.5
, pp. 545-547
-
-
Jo, J.1
Whitcomb, D.J.2
Olsen, K.M.3
Kerrigan, T.L.4
Lo, S.C.5
Bru-Mercier, G.6
Dickinson, B.7
Scullion, S.8
Sheng, M.9
Collingridge, G.10
Cho, K.11
-
111
-
-
84864471159
-
A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline
-
COI: 1:CAS:528:DC%2BC38XhtFWmt73M, PID: 22801501
-
Jonsson T, Atwal JK, Steinberg S, Snaedal J, Jonsson PV, Bjornsson S, Stefansson H, Sulem P, Gudbjartsson D, Maloney J, Hoyte K, Gustafson A, Liu Y, Lu Y, Bhangale T, Graham RR, Huttenlocher J, Bjornsdottir G, Andreassen OA, Jonsson EG, Palotie A, Behrens TW, Magnusson OT, Kong A, Thorsteinsdottir U, Watts RJ, Stefansson K (2012) A mutation in APP protects against Alzheimer’s disease and age-related cognitive decline. Nature 488(7409):96–99
-
(2012)
Nature
, vol.488
, Issue.7409
, pp. 96-99
-
-
Jonsson, T.1
Atwal, J.K.2
Steinberg, S.3
Snaedal, J.4
Jonsson, P.V.5
Bjornsson, S.6
Stefansson, H.7
Sulem, P.8
Gudbjartsson, D.9
Maloney, J.10
Hoyte, K.11
Gustafson, A.12
Liu, Y.13
Lu, Y.14
Bhangale, T.15
Graham, R.R.16
Huttenlocher, J.17
Bjornsdottir, G.18
Andreassen, O.A.19
Jonsson, E.G.20
Palotie, A.21
Behrens, T.W.22
Magnusson, O.T.23
Kong, A.24
Thorsteinsdottir, U.25
Watts, R.J.26
Stefansson, K.27
more..
-
112
-
-
77955850746
-
PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression
-
COI: 1:CAS:528:DC%2BC3cXos1yqtbo%3D, PID: 20628354
-
Jurado S, Benoist M, Lario A, Knafo S, Petrok CN, Esteban JA (2010) PTEN is recruited to the postsynaptic terminal for NMDA receptor-dependent long-term depression. EMBO J 29(16):2827–2840
-
(2010)
EMBO J
, vol.29
, Issue.16
, pp. 2827-2840
-
-
Jurado, S.1
Benoist, M.2
Lario, A.3
Knafo, S.4
Petrok, C.N.5
Esteban, J.A.6
-
113
-
-
0021745904
-
Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats
-
COI: 1:CAS:528:DyaL2cXmtVylsr0%3D
-
Kadowaki T, Kasuga M, Akanuma Y, Ezaki O, Takaku F (1984) Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats. J Biolumin Chemilumin 259(22):14208–14216
-
(1984)
J Biolumin Chemilumin
, vol.259
, Issue.22
, pp. 14208-14216
-
-
Kadowaki, T.1
Kasuga, M.2
Akanuma, Y.3
Ezaki, O.4
Takaku, F.5
-
114
-
-
0344672942
-
APP processing and synaptic function
-
COI: 1:CAS:528:DC%2BD3sXivFWkurY%3D, PID: 12670422
-
Kamenetz F, Tomita T, Hsieh H, Seabrook G, Borchelt D, Iwatsubo T, Sisodia S, Malinow R (2003) APP processing and synaptic function. Neuron 37(6):925–937
-
(2003)
Neuron
, vol.37
, Issue.6
, pp. 925-937
-
-
Kamenetz, F.1
Tomita, T.2
Hsieh, H.3
Seabrook, G.4
Borchelt, D.5
Iwatsubo, T.6
Sisodia, S.7
Malinow, R.8
-
115
-
-
0023105114
-
The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor
-
COI: 1:CAS:528:DyaL2sXktVWkt7s%3D, PID: 2881207
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B (1987) The precursor of Alzheimer’s disease amyloid A4 protein resembles a cell-surface receptor. Nature 325(6106):733–736
-
(1987)
Nature
, vol.325
, Issue.6106
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
116
-
-
33847043933
-
Mitochondria and neuronal activity
-
COI: 1:CAS:528:DC%2BD2sXjt1Gmtb4%3D, PID: 17092996
-
Kann O, Kovacs R (2007) Mitochondria and neuronal activity. Am J Physiol Cell Physiol 292(2):C641–C657
-
(2007)
Am J Physiol Cell Physiol
, vol.292
, Issue.2
, pp. C641-C657
-
-
Kann, O.1
Kovacs, R.2
-
117
-
-
70949084806
-
Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer’s disease
-
PID: 19936237
-
Ke YD, Delerue F, Gladbach A, Gotz J, Ittner LM (2009) Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer’s disease. PLoS One 4(11):e7917
-
(2009)
PLoS One
, vol.4
, Issue.11
-
-
Ke, Y.D.1
Delerue, F.2
Gladbach, A.3
Gotz, J.4
Ittner, L.M.5
-
118
-
-
33646751445
-
PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3
-
COI: 1:CAS:528:DC%2BD28XltVKnu7o%3D, PID: 16684527
-
Kerr F, Rickle A, Nayeem N, Brandner S, Cowburn RF, Lovestone S (2006) PTEN, a negative regulator of PI3 kinase signalling, alters tau phosphorylation in cells by mechanisms independent of GSK-3. FEBS Lett 580(13):3121–3128
-
(2006)
FEBS Lett
, vol.580
, Issue.13
, pp. 3121-3128
-
-
Kerr, F.1
Rickle, A.2
Nayeem, N.3
Brandner, S.4
Cowburn, R.F.5
Lovestone, S.6
-
119
-
-
84871703377
-
mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8
-
COI: 1:CAS:528:DC%2BC38Xhs1Kjs7%2FP, PID: 23142081
-
Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E (2012) mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8. Mol Cell 48(6):875–887
-
(2012)
Mol Cell
, vol.48
, Issue.6
, pp. 875-887
-
-
Kim, S.J.1
DeStefano, M.A.2
Oh, W.J.3
Wu, C.C.4
Vega-Cotto, N.M.5
Finlan, M.6
Liu, D.7
Su, B.8
Jacinto, E.9
-
120
-
-
0035133227
-
Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
-
COI: 1:CAS:528:DC%2BD3MXmtVOrsA%3D%3D, PID: 11154276
-
Kim AH, Khursigara G, Sun X, Franke TF, Chao MV (2001) Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21(3):893–901
-
(2001)
Mol Cell Biol
, vol.21
, Issue.3
, pp. 893-901
-
-
Kim, A.H.1
Khursigara, G.2
Sun, X.3
Franke, T.F.4
Chao, M.V.5
-
121
-
-
84875179717
-
Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites
-
COI: 1:CAS:528:DC%2BC3sXktVKmtLk%3D
-
Kimura T, Tsutsumi K, Taoka M, Saito T, Masuda-Suzukake M, Ishiguro K, Plattner F, Uchida T, Isobe T, Hasegawa M, Hisanaga S (2013) Isomerase Pin1 stimulates dephosphorylation of tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites. J Biolumin Chemilumin 288(11):7968–7977
-
(2013)
J Biolumin Chemilumin
, vol.288
, Issue.11
, pp. 7968-7977
-
-
Kimura, T.1
Tsutsumi, K.2
Taoka, M.3
Saito, T.4
Masuda-Suzukake, M.5
Ishiguro, K.6
Plattner, F.7
Uchida, T.8
Isobe, T.9
Hasegawa, M.10
Hisanaga, S.11
-
122
-
-
84888793501
-
Microtubule-associated protein tau is essential for long-term depression in the hippocampus
-
Kimura T, Whitcomb DJ, Jo J, Regan P, Piers T, Heo S, Brown C, Hashikawa T, Murayama M, Seok H, Sotiropoulos I, Kim E, Collingridge GL, Takashima A, Cho K (2014) Microtubule-associated protein tau is essential for long-term depression in the hippocampus. Philos Trans R Soc Lond Ser B Biol Sci 369(1633):20130144
-
(2014)
Philos Trans R Soc Lond Ser B Biol Sci
, vol.369
, Issue.1633
, pp. 20130144
-
-
Kimura, T.1
Whitcomb, D.J.2
Jo, J.3
Regan, P.4
Piers, T.5
Heo, S.6
Brown, C.7
Hashikawa, T.8
Murayama, M.9
Seok, H.10
Sotiropoulos, I.11
Kim, E.12
Collingridge, G.L.13
Takashima, A.14
Cho, K.15
-
123
-
-
0021907605
-
Receptor-mediated transport of insulin across endothelial cells
-
COI: 1:CAS:528:DyaL2MXhs1Srtb4%3D, PID: 3883490
-
King GL, Johnson SM (1985) Receptor-mediated transport of insulin across endothelial cells. Science 227(4694):1583–1586
-
(1985)
Science
, vol.227
, Issue.4694
, pp. 1583-1586
-
-
King, G.L.1
Johnson, S.M.2
-
124
-
-
0032792508
-
High dose insulin does not increase glucose transfer across the blood-brain barrier in humans: a re-evaluation
-
COI: 1:CAS:528:DyaK1MXlt1ajtLg%3D
-
Knudsen GM, Hasselbalch SG, Hertz MM, Paulson OB (1999) High dose insulin does not increase glucose transfer across the blood-brain barrier in humans: a re-evaluation. Eur J Clin Investig 29(8):687–691
-
(1999)
Eur J Clin Investig
, vol.29
, Issue.8
, pp. 687-691
-
-
Knudsen, G.M.1
Hasselbalch, S.G.2
Hertz, M.M.3
Paulson, O.B.4
-
125
-
-
0009364134
-
Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease
-
COI: 1:CAS:528:DyaL28XksVSnt74%3D, PID: 2424016
-
Kosik KS, Joachim CL, Selkoe DJ (1986) Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease. Proc Natl Acad Sci U S A 83(11):4044–4048
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, Issue.11
, pp. 4044-4048
-
-
Kosik, K.S.1
Joachim, C.L.2
Selkoe, D.J.3
-
126
-
-
84883457258
-
Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series
-
COI: 1:CAS:528:DC%2BC3sXht12it7zL, PID: 23900711
-
Kovacs GG, Milenkovic I, Wohrer A, Hoftberger R, Gelpi E, Haberler C, Honigschnabl S, Reiner-Concin A, Heinzl H, Jungwirth S, Krampla W, Fischer P, Budka H (2013) Non-Alzheimer neurodegenerative pathologies and their combinations are more frequent than commonly believed in the elderly brain: a community-based autopsy series. Acta Neuropathol 126(3):365–384
-
(2013)
Acta Neuropathol
, vol.126
, Issue.3
, pp. 365-384
-
-
Kovacs, G.G.1
Milenkovic, I.2
Wohrer, A.3
Hoftberger, R.4
Gelpi, E.5
Haberler, C.6
Honigschnabl, S.7
Reiner-Concin, A.8
Heinzl, H.9
Jungwirth, S.10
Krampla, W.11
Fischer, P.12
Budka, H.13
-
127
-
-
23244458439
-
Regulation of blood glucose by hypothalamic pyruvate metabolism
-
COI: 1:CAS:528:DC%2BD2MXmvFSksr4%3D, PID: 16081739
-
Lam TK, Gutierrez-Juarez R, Pocai A, Rossetti L (2005a) Regulation of blood glucose by hypothalamic pyruvate metabolism. Science 309(5736):943–947
-
(2005)
Science
, vol.309
, Issue.5736
, pp. 943-947
-
-
Lam, T.K.1
Gutierrez-Juarez, R.2
Pocai, A.3
Rossetti, L.4
-
128
-
-
16244388931
-
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
-
COI: 1:CAS:528:DC%2BD2MXhvVSqsro%3D, PID: 15735652
-
Lam TK, Pocai A, Gutierrez-Juarez R, Obici S, Bryan J, Aguilar-Bryan L, Schwartz GJ, Rossetti L (2005b) Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med 11(3):320–327
-
(2005)
Nat Med
, vol.11
, Issue.3
, pp. 320-327
-
-
Lam, T.K.1
Pocai, A.2
Gutierrez-Juarez, R.3
Obici, S.4
Bryan, J.5
Aguilar-Bryan, L.6
Schwartz, G.J.7
Rossetti, L.8
-
129
-
-
65249113325
-
The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid
-
COI: 1:CAS:528:DC%2BD1MXlsFyisLw%3D, PID: 19144826
-
Lee HK, Kumar P, Fu Q, Rosen KM, Querfurth HW (2009b) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol Biol Cell 20(5):1533–1544
-
(2009)
Mol Biol Cell
, vol.20
, Issue.5
, pp. 1533-1544
-
-
Lee, H.K.1
Kumar, P.2
Fu, Q.3
Rosen, K.M.4
Querfurth, H.W.5
-
130
-
-
58549102356
-
Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation
-
COI: 1:CAS:528:DC%2BD1MXhtlGrsLk%3D, PID: 17692997
-
Lee CC, Kuo YM, Huang CC, Hsu KS (2009a) Insulin rescues amyloid beta-induced impairment of hippocampal long-term potentiation. Neurobiol Aging 30(3):377–387
-
(2009)
Neurobiol Aging
, vol.30
, Issue.3
, pp. 377-387
-
-
Lee, C.C.1
Kuo, Y.M.2
Huang, C.C.3
Hsu, K.S.4
-
131
-
-
79960016949
-
Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways
-
COI: 1:CAS:528:DC%2BC3MXosFaqs7c%3D, PID: 21683721
-
Lee CC, Huang CC, Hsu KS (2011) Insulin promotes dendritic spine and synapse formation by the PI3K/Akt/mTOR and Rac1 signaling pathways. Neuropharmacology 61(4):867–879
-
(2011)
Neuropharmacology
, vol.61
, Issue.4
, pp. 867-879
-
-
Lee, C.C.1
Huang, C.C.2
Hsu, K.S.3
-
132
-
-
12144288564
-
Phosphorylation of tau by fyn: implications for Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD2cXitlCrur0%3D, PID: 14999081
-
Lee G, Thangavel R, Sharma VM, Litersky JM, Bhaskar K, Fang SM, Do LH, Andreadis A, Van Hoesen G, Ksiezak-Reding H (2004) Phosphorylation of tau by fyn: implications for Alzheimer’s disease. J Neurosci 24(9):2304–2312
-
(2004)
J Neurosci
, vol.24
, Issue.9
, pp. 2304-2312
-
-
Lee, G.1
Thangavel, R.2
Sharma, V.M.3
Litersky, J.M.4
Bhaskar, K.5
Fang, S.M.6
Do, L.H.7
Andreadis, A.8
Van Hoesen, G.9
Ksiezak-Reding, H.10
-
133
-
-
0036942638
-
The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD38XjsFGhsQ%3D%3D, PID: 11810173
-
Leroy K, Boutajangout A, Authelet M, Woodgett JR, Anderton BH, Brion JP (2002) The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer’s disease. Acta Neuropathol 103(2):91–99
-
(2002)
Acta Neuropathol
, vol.103
, Issue.2
, pp. 91-99
-
-
Leroy, K.1
Boutajangout, A.2
Authelet, M.3
Woodgett, J.R.4
Anderton, B.H.5
Brion, J.P.6
-
134
-
-
33846129434
-
Increased level of active GSK-3beta in Alzheimer’s disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration
-
COI: 1:CAS:528:DC%2BD2sXjtlemuro%3D, PID: 17239007
-
Leroy K, Yilmaz Z, Brion JP (2007) Increased level of active GSK-3beta in Alzheimer’s disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathol Appl Neurobiol 33(1):43–55
-
(2007)
Neuropathol Appl Neurobiol
, vol.33
, Issue.1
, pp. 43-55
-
-
Leroy, K.1
Yilmaz, Z.2
Brion, J.P.3
-
135
-
-
0032955426
-
Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase
-
COI: 1:CAS:528:DyaK1MXmt1ygug%3D%3D, PID: 9930729
-
Lesort M, Jope RS, Johnson GV (1999) Insulin transiently increases tau phosphorylation: involvement of glycogen synthase kinase-3beta and Fyn tyrosine kinase. J Neurochem 72(2):576–584
-
(1999)
J Neurochem
, vol.72
, Issue.2
, pp. 576-584
-
-
Lesort, M.1
Jope, R.S.2
Johnson, G.V.3
-
136
-
-
33645960672
-
Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD28Xjs1Kltb0%3D, PID: 16627931
-
Lester-Coll N, Rivera EJ, Soscia SJ, Doiron K, Wands JR, de la Monte SM (2006) Intracerebral streptozotocin model of type 3 diabetes: relevance to sporadic Alzheimer’s disease. J Alzheimers Dis 9(1):13–33
-
(2006)
J Alzheimers Dis
, vol.9
, Issue.1
, pp. 13-33
-
-
Lester-Coll, N.1
Rivera, E.J.2
Soscia, S.J.3
Doiron, K.4
Wands, J.R.5
de la Monte, S.M.6
-
137
-
-
84861444859
-
Regulation of glucose transport by insulin: traffic control of GLUT4
-
COI: 1:CAS:528:DC%2BC38XntlSgsbk%3D, PID: 22617471
-
Leto D, Saltiel AR (2012) Regulation of glucose transport by insulin: traffic control of GLUT4. Nat Rev Mol Cell Biol 13(6):383–396
-
(2012)
Nat Rev Mol Cell Biol
, vol.13
, Issue.6
, pp. 383-396
-
-
Leto, D.1
Saltiel, A.R.2
-
138
-
-
67249087641
-
Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake
-
COI: 1:CAS:528:DC%2BD1MXpsFOnsro%3D, PID: 19555648
-
Li S, Hong S, Shepardson NE, Walsh DM, Shankar GM, Selkoe D (2009) Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake. Neuron 62(6):788–801
-
(2009)
Neuron
, vol.62
, Issue.6
, pp. 788-801
-
-
Li, S.1
Hong, S.2
Shepardson, N.E.3
Walsh, D.M.4
Shankar, G.M.5
Selkoe, D.6
-
139
-
-
77953271477
-
Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization
-
COI: 1:CAS:528:DC%2BC3cXnsFKmsLg%3D, PID: 20510932
-
Li Z, Jo J, Jia JM, Lo SC, Whitcomb DJ, Jiao S, Cho K, Sheng M (2010) Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization. Cell 141(5):859–871
-
(2010)
Cell
, vol.141
, Issue.5
, pp. 859-871
-
-
Li, Z.1
Jo, J.2
Jia, J.M.3
Lo, S.C.4
Whitcomb, D.J.5
Jiao, S.6
Cho, K.7
Sheng, M.8
-
140
-
-
7744227096
-
Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis
-
COI: 1:CAS:528:DC%2BD2cXhtVWht7%2FK, PID: 15525785
-
Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, Laessig TA, Bouchard RJ, Florez-McClure ML, Heidenreich KA (2004) Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J Neurosci 24(44):9993–10002
-
(2004)
J Neurosci
, vol.24
, Issue.44
, pp. 9993-10002
-
-
Linseman, D.A.1
Butts, B.D.2
Precht, T.A.3
Phelps, R.A.4
Le, S.S.5
Laessig, T.A.6
Bouchard, R.J.7
Florez-McClure, M.L.8
Heidenreich, K.A.9
-
141
-
-
79960896430
-
Deficient brain insulin signalling pathway in Alzheimer’s disease and diabetes
-
COI: 1:CAS:528:DC%2BC3MXpt1Cns78%3D, PID: 21598254
-
Liu Y, Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2011) Deficient brain insulin signalling pathway in Alzheimer’s disease and diabetes. J Pathol 225(1):54–62
-
(2011)
J Pathol
, vol.225
, Issue.1
, pp. 54-62
-
-
Liu, Y.1
Liu, F.2
Grundke-Iqbal, I.3
Iqbal, K.4
Gong, C.X.5
-
142
-
-
84860330689
-
Neurological phenotypes for Down syndrome across the life span
-
COI: 1:CAS:528:DC%2BC38Xht1Shur3O, PID: 22541290
-
Lott IT (2012) Neurological phenotypes for Down syndrome across the life span. Prog Brain Res 197:101–121
-
(2012)
Prog Brain Res
, vol.197
, pp. 101-121
-
-
Lott, I.T.1
-
143
-
-
0035132869
-
Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons
-
COI: 1:CAS:528:DC%2BD3MXisleisbo%3D, PID: 11182095
-
Lu W, Man H, Ju W, Trimble WS, MacDonald JF, Wang YT (2001) Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons. Neuron 29(1):243–254
-
(2001)
Neuron
, vol.29
, Issue.1
, pp. 243-254
-
-
Lu, W.1
Man, H.2
Ju, W.3
Trimble, W.S.4
MacDonald, J.F.5
Wang, Y.T.6
-
144
-
-
84873802341
-
Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes
-
COI: 1:CAS:528:DC%2BC3sXnsFGntw%3D%3D, PID: 23202730
-
Ly PT, Wu Y, Zou H, Wang R, Zhou W, Kinoshita A, Zhang M, Yang Y, Cai F, Woodgett J, Song W (2013) Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest 123(1):224–235
-
(2013)
J Clin Invest
, vol.123
, Issue.1
, pp. 224-235
-
-
Ly, P.T.1
Wu, Y.2
Zou, H.3
Wang, R.4
Zhou, W.5
Kinoshita, A.6
Zhang, M.7
Yang, Y.8
Cai, F.9
Woodgett, J.10
Song, W.11
-
145
-
-
84896808522
-
GSK3 in Alzheimer’s disease: mind the isoforms
-
COI: 1:CAS:528:DC%2BC2cXisVagsLo%3D, PID: 24254703
-
Ma T (2014) GSK3 in Alzheimer’s disease: mind the isoforms. J Alzheimers Dis 39(4):707–710
-
(2014)
J Alzheimers Dis
, vol.39
, Issue.4
, pp. 707-710
-
-
Ma, T.1
-
146
-
-
84862014676
-
Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling
-
COI: 1:CAS:528:DC%2BC38XhtVGltrnK, PID: 22443192
-
Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Akiyama H, Takahashi R, Kihara T, Shimohama S, Kinoshita A (2012) Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling. J Neurochem 121(6):964–973
-
(2012)
J Neurochem
, vol.121
, Issue.6
, pp. 964-973
-
-
Maesako, M.1
Uemura, K.2
Kuzuya, A.3
Sasaki, K.4
Asada, M.5
Watanabe, K.6
Ando, K.7
Kubota, M.8
Akiyama, H.9
Takahashi, R.10
Kihara, T.11
Shimohama, S.12
Kinoshita, A.13
-
147
-
-
79960119114
-
Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism
-
COI: 1:CAS:528:DC%2BC3MXosFGmtb0%3D
-
Maesako M, Uemura K, Kuzuya A, Sasaki K, Asada M, Watanabe K, Ando K, Kubota M, Kihara T, Kinoshita A (2011) Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism. J Biolumin Chemilumin 286(28):25309–25316
-
(2011)
J Biolumin Chemilumin
, vol.286
, Issue.28
, pp. 25309-25316
-
-
Maesako, M.1
Uemura, K.2
Kuzuya, A.3
Sasaki, K.4
Asada, M.5
Watanabe, K.6
Ando, K.7
Kubota, M.8
Kihara, T.9
Kinoshita, A.10
-
148
-
-
0036310511
-
BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents
-
COI: 1:CAS:528:DC%2BD38XlsV2jsbo%3D, PID: 12091467
-
Mai L, Jope RS, Li X (2002) BDNF-mediated signal transduction is modulated by GSK3beta and mood stabilizing agents. J Neurochem 82(1):75–83
-
(2002)
J Neurochem
, vol.82
, Issue.1
, pp. 75-83
-
-
Mai, L.1
Jope, R.S.2
Li, X.3
-
149
-
-
0033681557
-
Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization
-
COI: 1:CAS:528:DC%2BD3cXisFKrtb0%3D, PID: 10774732
-
Man HY, Lin JW, Ju WH, Ahmadian G, Liu L, Becker LE, Sheng M, Wang YT (2000) Regulation of AMPA receptor-mediated synaptic transmission by clathrin-dependent receptor internalization. Neuron 25(3):649–662
-
(2000)
Neuron
, vol.25
, Issue.3
, pp. 649-662
-
-
Man, H.Y.1
Lin, J.W.2
Ju, W.H.3
Ahmadian, G.4
Liu, L.5
Becker, L.E.6
Sheng, M.7
Wang, Y.T.8
-
150
-
-
0026619584
-
Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau
-
COI: 1:CAS:528:DyaK3sXitFSlsbo%3D, PID: 1334849
-
Mandelkow EM, Drewes G, Biernat J, Gustke N, Van Lint J, Vandenheede JR, Mandelkow E (1992) Glycogen synthase kinase-3 and the Alzheimer-like state of microtubule-associated protein tau. FEBS Lett 314(3):315–321
-
(1992)
FEBS Lett
, vol.314
, Issue.3
, pp. 315-321
-
-
Mandelkow, E.M.1
Drewes, G.2
Biernat, J.3
Gustke, N.4
Van Lint, J.5
Vandenheede, J.R.6
Mandelkow, E.7
-
151
-
-
84863700380
-
IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation
-
PID: 21955917
-
Martin ED, Sanchez-Perez A, Trejo JL, Martin-Aldana JA, Cano Jaimez M, Pons S, Acosta Umanzor C, Menes L, White MF, Burks DJ (2012) IRS-2 Deficiency impairs NMDA receptor-dependent long-term potentiation. Cereb Cortex 22(8):1717–1727
-
(2012)
Cereb Cortex
, vol.22
, Issue.8
, pp. 1717-1727
-
-
Martin, E.D.1
Sanchez-Perez, A.2
Trejo, J.L.3
Martin-Aldana, J.A.4
Cano Jaimez, M.5
Pons, S.6
Acosta Umanzor, C.7
Menes, L.8
White, M.F.9
Burks, D.J.10
-
152
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
COI: 1:CAS:528:DyaL2MXktlGltr0%3D, PID: 3159021
-
Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, Beyreuther K (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 82(12):4245–4249
-
(1985)
Proc Natl Acad Sci U S A
, vol.82
, Issue.12
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
153
-
-
33644855216
-
Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1
-
COI: 1:CAS:528:DC%2BD28XjtVyju74%3D, PID: 16543145
-
Maurer U, Charvet C, Wagman AS, Dejardin E, Green DR (2006) Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1. Mol Cell 21(6):749–760
-
(2006)
Mol Cell
, vol.21
, Issue.6
, pp. 749-760
-
-
Maurer, U.1
Charvet, C.2
Wagman, A.S.3
Dejardin, E.4
Green, D.R.5
-
154
-
-
38049170722
-
Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2 A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau
-
COI: 1:CAS:528:DC%2BD1cXhtVOnuw%3D%3D
-
Meske V, Albert F, Ohm TG (2008) Coupling of mammalian target of rapamycin with phosphoinositide 3-kinase signaling pathway regulates protein phosphatase 2 A- and glycogen synthase kinase-3 -dependent phosphorylation of Tau. J Biolumin Chemilumin 283(1):100–109
-
(2008)
J Biolumin Chemilumin
, vol.283
, Issue.1
, pp. 100-109
-
-
Meske, V.1
Albert, F.2
Ohm, T.G.3
-
155
-
-
84945479161
-
Impact of diabetes on cognitive function and brain structure
-
PID: 26132277
-
Moheet A, Mangia S, Seaquist ER (2015) Impact of diabetes on cognitive function and brain structure. Ann N Y Acad Sci 1353(1):60–71
-
(2015)
Ann N Y Acad Sci
, vol.1353
, Issue.1
, pp. 60-71
-
-
Moheet, A.1
Mangia, S.2
Seaquist, E.R.3
-
156
-
-
71349085957
-
Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling
-
COI: 1:CAS:528:DC%2BD1MXhsFGrsL3O, PID: 18479783
-
Moloney AM, Griffin RJ, Timmons S, O’Connor R, Ravid R, O’Neill C (2010) Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer’s disease indicate possible resistance to IGF-1 and insulin signalling. Neurobiol Aging 31(2):224–243
-
(2010)
Neurobiol Aging
, vol.31
, Issue.2
, pp. 224-243
-
-
Moloney, A.M.1
Griffin, R.J.2
Timmons, S.3
O’Connor, R.4
Ravid, R.5
O’Neill, C.6
-
157
-
-
84857030932
-
National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
-
COI: 1:CAS:528:DC%2BC38Xkt1eqtQ%3D%3D, PID: 22101365
-
Montine TJ, Phelps CH, Beach TG, Bigio EH, Cairns NJ, Dickson DW, Duyckaerts C, Frosch MP, Masliah E, Mirra SS, Nelson PT, Schneider JA, Thal DR, Trojanowski JQ, Vinters HV, Hyman BT (2012) National Institute on Aging-Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach. Acta Neuropathol 123(1):1–11
-
(2012)
Acta Neuropathol
, vol.123
, Issue.1
, pp. 1-11
-
-
Montine, T.J.1
Phelps, C.H.2
Beach, T.G.3
Bigio, E.H.4
Cairns, N.J.5
Dickson, D.W.6
Duyckaerts, C.7
Frosch, M.P.8
Masliah, E.9
Mirra, S.S.10
Nelson, P.T.11
Schneider, J.A.12
Thal, D.R.13
Trojanowski, J.Q.14
Vinters, H.V.15
Hyman, B.T.16
-
158
-
-
84863002103
-
Alzheimer’s disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin
-
PID: 22269163
-
Moreira PI (2012) Alzheimer’s disease and diabetes: an integrative view of the role of mitochondria, oxidative stress, and insulin. J Alzheimers Dis 30(Suppl 2):S199–S215
-
(2012)
J Alzheimers Dis
, vol.30
, pp. S199-S215
-
-
Moreira, P.I.1
-
159
-
-
67649687039
-
An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer’s disease
-
PID: 19387110
-
Moreira PI, Duarte AI, Santos MS, Rego AC, Oliveira CR (2009) An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer’s disease. J Alzheimers Dis 16(4):741–761
-
(2009)
J Alzheimers Dis
, vol.16
, Issue.4
, pp. 741-761
-
-
Moreira, P.I.1
Duarte, A.I.2
Santos, M.S.3
Rego, A.C.4
Oliveira, C.R.5
-
160
-
-
0344097391
-
Streptozotocin increases free fatty acids and decreases phospholipids in rat brain
-
COI: 1:CAS:528:DyaK1MXhslGmsLw%3D, PID: 9928896
-
Muller D, Nitsch RM, Wurtman RJ, Hoyer S (1998) Streptozotocin increases free fatty acids and decreases phospholipids in rat brain. J Neural Transm 105(10–12):1271–1281
-
(1998)
J Neural Transm
, vol.105
, Issue.10-12
, pp. 1271-1281
-
-
Muller, D.1
Nitsch, R.M.2
Wurtman, R.J.3
Hoyer, S.4
-
161
-
-
79956216581
-
Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer’s-like phenotypes in mice
-
COI: 1:CAS:528:DC%2BC3MXmvFSqs74%3D, PID: 21549686
-
Murakami K, Yokoyama S, Murata N, Ozawa Y, Irie K, Shirasawa T, Shimizu T (2011) Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer’s-like phenotypes in mice. Biochem Biophys Res Commun 409(1):34–39
-
(2011)
Biochem Biophys Res Commun
, vol.409
, Issue.1
, pp. 34-39
-
-
Murakami, K.1
Yokoyama, S.2
Murata, N.3
Ozawa, Y.4
Irie, K.5
Shirasawa, T.6
Shimizu, T.7
-
162
-
-
84870573905
-
p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling
-
COI: 1:STN:280:DC%2BC3s%2FkslSrtA%3D%3D, PID: 23059819
-
Nayak G, Cooper GM (2012) p53 is a major component of the transcriptional and apoptotic program regulated by PI 3-kinase/Akt/GSK3 signaling. Cell Death Dis 3:e400
-
(2012)
Cell Death Dis
, vol.3
, pp. 400
-
-
Nayak, G.1
Cooper, G.M.2
-
163
-
-
84895775146
-
Diabetes mellitus and dementia
-
PID: 24623199
-
Ninomiya T (2014) Diabetes mellitus and dementia. Curr Diab Rep 14(5):487
-
(2014)
Curr Diab Rep
, vol.14
, Issue.5
, pp. 487
-
-
Ninomiya, T.1
-
164
-
-
0032905727
-
Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex
-
COI: 1:CAS:528:DyaK1MXntlWguw%3D%3D, PID: 9930863
-
Nishimura M, Yu G, Levesque G, Zhang DM, Ruel L, Chen F, Milman P, Holmes E, Liang Y, Kawarai T, Jo E, Supala A, Rogaeva E, Xu DM, Janus C, Levesque L, Bi Q, Duthie M, Rozmahel R, Mattila K, Lannfelt L, Westaway D, Mount HT, Woodgett J, St George-Hyslop P, et al. (1999) Presenilin mutations associated with Alzheimer disease cause defective intracellular trafficking of beta-catenin, a component of the presenilin protein complex. Nat Med 5(2):164–169
-
(1999)
Nat Med
, vol.5
, Issue.2
, pp. 164-169
-
-
Nishimura, M.1
Yu, G.2
Levesque, G.3
Zhang, D.M.4
Ruel, L.5
Chen, F.6
Milman, P.7
Holmes, E.8
Liang, Y.9
Kawarai, T.10
Jo, E.11
Supala, A.12
Rogaeva, E.13
Xu, D.M.14
Janus, C.15
Levesque, L.16
Bi, Q.17
Duthie, M.18
Rozmahel, R.19
Mattila, K.20
Lannfelt, L.21
Westaway, D.22
Mount, H.T.23
Woodgett, J.24
St George-Hyslop, P.25
more..
-
165
-
-
84864395390
-
Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer’s disease
-
PID: 22817723
-
O’Neill C, Kiely AP, Coakley MF, Manning S, Long-Smith CM (2012) Insulin and IGF-1 signalling: longevity, protein homoeostasis and Alzheimer’s disease. Biochem Soc Trans 40(4):721–727
-
(2012)
Biochem Soc Trans
, vol.40
, Issue.4
, pp. 721-727
-
-
O’Neill, C.1
Kiely, A.P.2
Coakley, M.F.3
Manning, S.4
Long-Smith, C.M.5
-
166
-
-
0036913187
-
Hypothalamic insulin signaling is required for inhibition of glucose production
-
COI: 1:CAS:528:DC%2BD38XptVSgsbY%3D, PID: 12426561
-
Obici S, Zhang BB, Karkanias G, Rossetti L (2002) Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 8(12):1376–1382
-
(2002)
Nat Med
, vol.8
, Issue.12
, pp. 1376-1382
-
-
Obici, S.1
Zhang, B.B.2
Karkanias, G.3
Rossetti, L.4
-
167
-
-
79960470913
-
mTOR complex 2 signaling and functions
-
COI: 1:CAS:528:DC%2BC38Xktlertw%3D%3D, PID: 21670596
-
Oh WJ, Jacinto E (2011) mTOR complex 2 signaling and functions. Cell Cycle 10(14):2305–2316
-
(2011)
Cell Cycle
, vol.10
, Issue.14
, pp. 2305-2316
-
-
Oh, W.J.1
Jacinto, E.2
-
168
-
-
84872326262
-
Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease
-
PID: 22695755
-
Ooi L, Sidhu K, Poljak A, Sutherland G, O’Connor MD, Sachdev P, Munch G (2013) Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer’s disease. J Neural Transm 120(1):103–111
-
(2013)
J Neural Transm
, vol.120
, Issue.1
, pp. 103-111
-
-
Ooi, L.1
Sidhu, K.2
Poljak, A.3
Sutherland, G.4
O’Connor, M.D.5
Sachdev, P.6
Munch, G.7
-
169
-
-
0032764016
-
Diabetes mellitus and the risk of dementia: The Rotterdam Study
-
COI: 1:STN:280:DC%2BD3c%2Fms1Ontg%3D%3D, PID: 10599761
-
Ott A, Stolk RP, van Harskamp F, Pols HA, Hofman A, Breteler MM (1999) Diabetes mellitus and the risk of dementia: The Rotterdam Study. Neurology 53(9):1937–1942
-
(1999)
Neurology
, vol.53
, Issue.9
, pp. 1937-1942
-
-
Ott, A.1
Stolk, R.P.2
van Harskamp, F.3
Pols, H.A.4
Hofman, A.5
Breteler, M.M.6
-
170
-
-
0025123704
-
Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization
-
COI: 1:CAS:528:DyaK3cXlvVyltrw%3D
-
Pardridge WM, Boado RJ, Farrell CR (1990) Brain-type glucose transporter (GLUT-1) is selectively localized to the blood-brain barrier. Studies with quantitative western blotting and in situ hybridization. J Biolumin Chemilumin 265(29):18035–18040
-
(1990)
J Biolumin Chemilumin
, vol.265
, Issue.29
, pp. 18035-18040
-
-
Pardridge, W.M.1
Boado, R.J.2
Farrell, C.R.3
-
171
-
-
0021841594
-
Human blood-brain barrier insulin receptor
-
COI: 1:CAS:528:DyaL2MXktFOiu70%3D, PID: 2859355
-
Pardridge WM, Eisenberg J, Yang J (1985) Human blood-brain barrier insulin receptor. J Neurochem 44(6):1771–1778
-
(1985)
J Neurochem
, vol.44
, Issue.6
, pp. 1771-1778
-
-
Pardridge, W.M.1
Eisenberg, J.2
Yang, J.3
-
172
-
-
78650637178
-
Amyloid-beta as a modulator of synaptic plasticity
-
COI: 1:CAS:528:DC%2BC3cXhsFSqt7zE, PID: 20847424
-
Parihar MS, Brewer GJ (2010) Amyloid-beta as a modulator of synaptic plasticity. J Alzheimers Dis 22(3):741–763
-
(2010)
J Alzheimers Dis
, vol.22
, Issue.3
, pp. 741-763
-
-
Parihar, M.S.1
Brewer, G.J.2
-
173
-
-
33746809372
-
Physiological roles for amyloid beta peptides
-
COI: 1:CAS:528:DC%2BD28Xpslait7s%3D, PID: 16809372
-
Pearson HA, Peers C (2006) Physiological roles for amyloid beta peptides. J Physiol 575(Pt 1):5–10
-
(2006)
J Physiol
, vol.575
, pp. 5-10
-
-
Pearson, H.A.1
Peers, C.2
-
174
-
-
0032850599
-
Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes
-
COI: 1:CAS:528:DyaK1MXmsFOlsL4%3D, PID: 10499443
-
Pei JJ, Braak E, Braak H, Grundke-Iqbal I, Iqbal K, Winblad B, Cowburn RF (1999) Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes. J Neuropathol Exp Neurol 58(9):1010–1019
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, Issue.9
, pp. 1010-1019
-
-
Pei, J.J.1
Braak, E.2
Braak, H.3
Grundke-Iqbal, I.4
Iqbal, K.5
Winblad, B.6
Cowburn, R.F.7
-
175
-
-
0038100358
-
Role of protein kinase B in Alzheimer’s neurofibrillary pathology
-
COI: 1:CAS:528:DC%2BD3sXhvVyktbg%3D, PID: 12624792
-
Pei JJ, Khatoon S, An WL, Nordlinder M, Tanaka T, Braak H, Tsujio I, Takeda M, Alafuzoff I, Winblad B, Cowburn RF, Grundke-Iqbal I, Iqbal K (2003) Role of protein kinase B in Alzheimer’s neurofibrillary pathology. Acta Neuropathol 105(4):381–392
-
(2003)
Acta Neuropathol
, vol.105
, Issue.4
, pp. 381-392
-
-
Pei, J.J.1
Khatoon, S.2
An, W.L.3
Nordlinder, M.4
Tanaka, T.5
Braak, H.6
Tsujio, I.7
Takeda, M.8
Alafuzoff, I.9
Winblad, B.10
Cowburn, R.F.11
Grundke-Iqbal, I.12
Iqbal, K.13
-
176
-
-
0030635495
-
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain
-
COI: 1:STN:280:DyaK2s7ksVelsQ%3D%3D, PID: 8990130
-
Pei JJ, Tanaka T, Tung YC, Braak E, Iqbal K, Grundke-Iqbal I (1997) Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain. J Neuropathol Exp Neurol 56(1):70–78
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, Issue.1
, pp. 70-78
-
-
Pei, J.J.1
Tanaka, T.2
Tung, Y.C.3
Braak, E.4
Iqbal, K.5
Grundke-Iqbal, I.6
-
177
-
-
33847113902
-
LTP inhibits LTD in the hippocampus via regulation of GSK3beta
-
COI: 1:CAS:528:DC%2BD2sXjsVymt7w%3D, PID: 17329210
-
Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JT, Bortolotto ZA, Wang YT, Collingridge GL (2007) LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53(5):703–717
-
(2007)
Neuron
, vol.53
, Issue.5
, pp. 703-717
-
-
Peineau, S.1
Taghibiglou, C.2
Bradley, C.3
Wong, T.P.4
Liu, L.5
Lu, J.6
Lo, E.7
Wu, D.8
Saule, E.9
Bouschet, T.10
Matthews, P.11
Isaac, J.T.12
Bortolotto, Z.A.13
Wang, Y.T.14
Collingridge, G.L.15
-
178
-
-
0038187674
-
GSK-3alpha regulates production of Alzheimer’s disease amyloid-beta peptides
-
COI: 1:CAS:528:DC%2BD3sXjvFaltLY%3D, PID: 12761548
-
Phiel CJ, Wilson CA, Lee VM, Klein PS (2003) GSK-3alpha regulates production of Alzheimer’s disease amyloid-beta peptides. Nature 423(6938):435–439
-
(2003)
Nature
, vol.423
, Issue.6938
, pp. 435-439
-
-
Phiel, C.J.1
Wilson, C.A.2
Lee, V.M.3
Klein, P.S.4
-
179
-
-
0025993361
-
BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer’s disease
-
COI: 1:CAS:528:DyaK38Xht1KisLo%3D, PID: 1742020
-
Phillips HS, Hains JM, Armanini M, Laramee GR, Johnson SA, Winslow JW (1991) BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer’s disease. Neuron 7(5):695–702
-
(1991)
Neuron
, vol.7
, Issue.5
, pp. 695-702
-
-
Phillips, H.S.1
Hains, J.M.2
Armanini, M.3
Laramee, G.R.4
Johnson, S.A.5
Winslow, J.W.6
-
180
-
-
33846031988
-
Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation
-
COI: 1:CAS:528:DC%2BD28XhtlCrtrfO
-
Pierrot N, Santos SF, Feyt C, Morel M, Brion JP, Octave JN (2006) Calcium-mediated transient phosphorylation of tau and amyloid precursor protein followed by intraneuronal amyloid-beta accumulation. J Biolumin Chemilumin 281(52):39907–39914
-
(2006)
J Biolumin Chemilumin
, vol.281
, Issue.52
, pp. 39907-39914
-
-
Pierrot, N.1
Santos, S.F.2
Feyt, C.3
Morel, M.4
Brion, J.P.5
Octave, J.N.6
-
181
-
-
0027304893
-
Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus
-
COI: 1:CAS:528:DyaK2cXhs1Slt7g%3D, PID: 8237464
-
Plaschke K, Hoyer S (1993) Action of the diabetogenic drug streptozotocin on glycolytic and glycogenolytic metabolism in adult rat brain cortex and hippocampus. Int J Dev Neurosci 11(4):477–483
-
(1993)
Int J Dev Neurosci
, vol.11
, Issue.4
, pp. 477-483
-
-
Plaschke, K.1
Hoyer, S.2
-
182
-
-
13944272576
-
The role of insulin receptor signaling in the brain
-
COI: 1:CAS:528:DC%2BD2MXhslegsbo%3D, PID: 15734146
-
Plum L, Schubert M, Bruning JC (2005) The role of insulin receptor signaling in the brain. Trends Endocrinol Metab 16(2):59–65
-
(2005)
Trends Endocrinol Metab
, vol.16
, Issue.2
, pp. 59-65
-
-
Plum, L.1
Schubert, M.2
Bruning, J.C.3
-
183
-
-
84872158502
-
Vascular complications of diabetes: mechanisms of injury and protective factors
-
COI: 1:CAS:528:DC%2BC3sXmvVOisQ%3D%3D, PID: 23312281
-
Rask-Madsen C, King GL (2013) Vascular complications of diabetes: mechanisms of injury and protective factors. Cell Metab 17(1):20–33
-
(2013)
Cell Metab
, vol.17
, Issue.1
, pp. 20-33
-
-
Rask-Madsen, C.1
King, G.L.2
-
184
-
-
0033546439
-
Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B
-
COI: 1:CAS:528:DyaK1MXjvVGku7o%3D
-
Rena G, Guo S, Cichy SC, Unterman TG, Cohen P (1999) Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J Biolumin Chemilumin 274(24):17179–17183
-
(1999)
J Biolumin Chemilumin
, vol.274
, Issue.24
, pp. 17179-17183
-
-
Rena, G.1
Guo, S.2
Cichy, S.C.3
Unterman, T.G.4
Cohen, P.5
-
185
-
-
2342558065
-
Akt activity in Alzheimer’s disease and other neurodegenerative disorders
-
COI: 1:CAS:528:DC%2BD2cXkvFajuro%3D, PID: 15076714
-
Rickle A, Bogdanovic N, Volkman I, Winblad B, Ravid R, Cowburn RF (2004) Akt activity in Alzheimer’s disease and other neurodegenerative disorders. Neuroreport 15(6):955–959
-
(2004)
Neuroreport
, vol.15
, Issue.6
, pp. 955-959
-
-
Rickle, A.1
Bogdanovic, N.2
Volkman, I.3
Winblad, B.4
Ravid, R.5
Cowburn, R.F.6
-
186
-
-
29244482770
-
PTEN levels in Alzheimer’s disease medial temporal cortex
-
COI: 1:CAS:528:DC%2BD28XktFyj, PID: 16239049
-
Rickle A, Bogdanovic N, Volkmann I, Zhou X, Pei JJ, Winblad B, Cowburn RF (2006) PTEN levels in Alzheimer’s disease medial temporal cortex. Neurochem Int 48(2):114–123
-
(2006)
Neurochem Int
, vol.48
, Issue.2
, pp. 114-123
-
-
Rickle, A.1
Bogdanovic, N.2
Volkmann, I.3
Zhou, X.4
Pei, J.J.5
Winblad, B.6
Cowburn, R.F.7
-
187
-
-
78651506630
-
Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BC3MXht1arsrk%3D, PID: 21228179
-
Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F, Wu T, Hamto P, Devidze N, Yu GQ, Palop JJ, Noebels JL, Mucke L (2011) Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer’s disease. J Neurosci 31(2):700–711
-
(2011)
J Neurosci
, vol.31
, Issue.2
, pp. 700-711
-
-
Roberson, E.D.1
Halabisky, B.2
Yoo, J.W.3
Yao, J.4
Chin, J.5
Yan, F.6
Wu, T.7
Hamto, P.8
Devidze, N.9
Yu, G.Q.10
Palop, J.J.11
Noebels, J.L.12
Mucke, L.13
-
188
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model
-
COI: 1:CAS:528:DC%2BD2sXkvVWrtrw%3D, PID: 17478722
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer’s disease mouse model. Science 316(5825):750–754
-
(2007)
Science
, vol.316
, Issue.5825
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.Q.8
Mucke, L.9
-
189
-
-
33847214486
-
Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer’s disease are associated with reduced amyloid precursor protein phosphorylation
-
COI: 1:CAS:528:DC%2BD2sXivV2jur8%3D, PID: 17314294
-
Rockenstein E, Torrance M, Adame A, Mante M, Bar-on P, Rose JB, Crews L, Masliah E (2007) Neuroprotective effects of regulators of the glycogen synthase kinase-3beta signaling pathway in a transgenic model of Alzheimer’s disease are associated with reduced amyloid precursor protein phosphorylation. J Neurosci 27(8):1981–1991
-
(2007)
J Neurosci
, vol.27
, Issue.8
, pp. 1981-1991
-
-
Rockenstein, E.1
Torrance, M.2
Adame, A.3
Mante, M.4
Bar-on, P.5
Rose, J.B.6
Crews, L.7
Masliah, E.8
-
190
-
-
29444442794
-
APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy
-
COI: 1:CAS:528:DC%2BD2MXhtlCmtrzO, PID: 16369530
-
Rovelet-Lecrux A, Hannequin D, Raux G, Le Meur N, Laquerriere A, Vital A, Dumanchin C, Feuillette S, Brice A, Vercelletto M, Dubas F, Frebourg T, Campion D (2006) APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy. Nat Genet 38(1):24–26
-
(2006)
Nat Genet
, vol.38
, Issue.1
, pp. 24-26
-
-
Rovelet-Lecrux, A.1
Hannequin, D.2
Raux, G.3
Le Meur, N.4
Laquerriere, A.5
Vital, A.6
Dumanchin, C.7
Feuillette, S.8
Brice, A.9
Vercelletto, M.10
Dubas, F.11
Frebourg, T.12
Campion, D.13
-
191
-
-
0019025978
-
Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase
-
COI: 1:CAS:528:DyaL3cXkvFWjt7o%3D, PID: 6772446
-
Rylatt DB, Aitken A, Bilham T, Condon GD, Embi N, Cohen P (1980) Glycogen synthase from rabbit skeletal muscle. Amino acid sequence at the sites phosphorylated by glycogen synthase kinase-3, and extension of the N-terminal sequence containing the site phosphorylated by phosphorylase kinase. Eur J Biochem 107(2):529–537
-
(1980)
Eur J Biochem
, vol.107
, Issue.2
, pp. 529-537
-
-
Rylatt, D.B.1
Aitken, A.2
Bilham, T.3
Condon, G.D.4
Embi, N.5
Cohen, P.6
-
192
-
-
84872282685
-
What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research
-
COI: 1:CAS:528:DC%2BC3sXktFSktA%3D%3D, PID: 22886150
-
Salkovic-Petrisic M, Knezovic A, Hoyer S, Riederer P (2013) What have we learned from the streptozotocin-induced animal model of sporadic Alzheimer’s disease, about the therapeutic strategies in Alzheimer’s research. J Neural Transm 120(1):233–252
-
(2013)
J Neural Transm
, vol.120
, Issue.1
, pp. 233-252
-
-
Salkovic-Petrisic, M.1
Knezovic, A.2
Hoyer, S.3
Riederer, P.4
-
193
-
-
49849088654
-
Antioxidant capacity in rat brain after intracerebroventricular treatment with streptozotocin and alloxan–a preliminary study
-
COI: 1:CAS:528:DC%2BD1cXosFGhu7k%3D, PID: 18515212
-
Sapcanin A, Sofic E, Tahirovic I, Salkovic-Petrisic M, Hoyer S, Riederer P (2008) Antioxidant capacity in rat brain after intracerebroventricular treatment with streptozotocin and alloxan–a preliminary study. Neurotox Res 13(2):97–104
-
(2008)
Neurotox Res
, vol.13
, Issue.2
, pp. 97-104
-
-
Sapcanin, A.1
Sofic, E.2
Tahirovic, I.3
Salkovic-Petrisic, M.4
Hoyer, S.5
Riederer, P.6
-
194
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
COI: 1:CAS:528:DC%2BD2MXhtlSrtbY%3D, PID: 15718470
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307(5712):1098–1101
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
195
-
-
78650029989
-
Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study
-
COI: 1:CAS:528:DC%2BC3cXhsFSlu7rJ, PID: 21115952
-
Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM (2010) Insulin metabolism and the risk of Alzheimer disease: the Rotterdam Study. Neurology 75(22):1982–1987
-
(2010)
Neurology
, vol.75
, Issue.22
, pp. 1982-1987
-
-
Schrijvers, E.M.1
Witteman, J.C.2
Sijbrands, E.J.3
Hofman, A.4
Koudstaal, P.J.5
Breteler, M.M.6
-
196
-
-
0043127453
-
Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation
-
COI: 1:CAS:528:DC%2BD3sXmtlyhsbs%3D, PID: 12904469
-
Schubert M, Brazil DP, Burks DJ, Kushner JA, Ye J, Flint CL, Farhang-Fallah J, Dikkes P, Warot XM, Rio C, Corfas G, White MF (2003) Insulin receptor substrate-2 deficiency impairs brain growth and promotes tau phosphorylation. J Neurosci 23(18):7084–7092
-
(2003)
J Neurosci
, vol.23
, Issue.18
, pp. 7084-7092
-
-
Schubert, M.1
Brazil, D.P.2
Burks, D.J.3
Kushner, J.A.4
Ye, J.5
Flint, C.L.6
Farhang-Fallah, J.7
Dikkes, P.8
Warot, X.M.9
Rio, C.10
Corfas, G.11
White, M.F.12
-
197
-
-
12144290448
-
Role for neuronal insulin resistance in neurodegenerative diseases
-
COI: 1:CAS:528:DC%2BD2cXitlWht7Y%3D, PID: 14981233
-
Schubert M, Gautam D, Surjo D, Ueki K, Baudler S, Schubert D, Kondo T, Alber J, Galldiks N, Kustermann E, Arndt S, Jacobs AH, Krone W, Kahn CR, Bruning JC (2004) Role for neuronal insulin resistance in neurodegenerative diseases. Proc Natl Acad Sci U S A 101(9):3100–3105
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, Issue.9
, pp. 3100-3105
-
-
Schubert, M.1
Gautam, D.2
Surjo, D.3
Ueki, K.4
Baudler, S.5
Schubert, D.6
Kondo, T.7
Alber, J.8
Galldiks, N.9
Kustermann, E.10
Arndt, S.11
Jacobs, A.H.12
Krone, W.13
Kahn, C.R.14
Bruning, J.C.15
-
198
-
-
0025063027
-
Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid
-
Schwartz MW, Sipols A, Kahn SE, Lattemann DF, Taborsky GJ Jr, Bergman RN, Woods SC, Porte D Jr (1990) Kinetics and specificity of insulin uptake from plasma into cerebrospinal fluid. Am J Phys 259(3 Pt 1):E378–E383
-
(1990)
Am J Phys
, vol.259
, Issue.3
, pp. E378-E383
-
-
Schwartz, M.W.1
Sipols, A.2
Kahn, S.E.3
Lattemann, D.F.4
Taborsky, G.J.5
Bergman, R.N.6
Woods, S.C.7
Porte, D.8
-
199
-
-
0037174618
-
Alzheimer’s disease is a synaptic failure
-
COI: 1:CAS:528:DC%2BD38XotFSnur0%3D, PID: 12399581
-
Selkoe DJ (2002) Alzheimer’s disease is a synaptic failure. Science 298(5594):789–791
-
(2002)
Science
, vol.298
, Issue.5594
, pp. 789-791
-
-
Selkoe, D.J.1
-
200
-
-
0035893251
-
Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity
-
COI: 1:STN:280:DC%2BD3MnptlejsQ%3D%3D, PID: 11734601
-
Shanley LJ, Irving AJ, Harvey J (2001) Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J Neurosci 21(24):RC186
-
(2001)
J Neurosci
, vol.21
, Issue.24
, pp. 186
-
-
Shanley, L.J.1
Irving, A.J.2
Harvey, J.3
-
201
-
-
0031914762
-
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity
-
COI: 1:CAS:528:DyaK1cXjtl2hsg%3D%3D, PID: 9419373
-
Sibson NR, Dhankhar A, Mason GF, Rothman DL, Behar KL, Shulman RG (1998) Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci U S A 95(1):316–321
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, Issue.1
, pp. 316-321
-
-
Sibson, N.R.1
Dhankhar, A.2
Mason, G.F.3
Rothman, D.L.4
Behar, K.L.5
Shulman, R.G.6
-
202
-
-
0035835824
-
PTEN: life as a tumor suppressor
-
COI: 1:CAS:528:DC%2BD3MXhsFOhtbk%3D, PID: 11237521
-
Simpson L, Parsons R (2001) PTEN: life as a tumor suppressor. Exp Cell Res 264(1):29–41
-
(2001)
Exp Cell Res
, vol.264
, Issue.1
, pp. 29-41
-
-
Simpson, L.1
Parsons, R.2
-
203
-
-
77958597709
-
Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain
-
COI: 1:CAS:528:DC%2BC3cXhsVKktrjO, PID: 20831597
-
Soutar MP, Kim WY, Williamson R, Peggie M, Hastie CJ, McLauchlan H, Snider WD, Gordon-Weeks PR, Sutherland C (2010) Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain. J Neurochem 115(4):974–983
-
(2010)
J Neurochem
, vol.115
, Issue.4
, pp. 974-983
-
-
Soutar, M.P.1
Kim, W.Y.2
Williamson, R.3
Peggie, M.4
Hastie, C.J.5
McLauchlan, H.6
Snider, W.D.7
Gordon-Weeks, P.R.8
Sutherland, C.9
-
204
-
-
78650914558
-
Tubulin-independent tau in Alzheimer’s disease and cancer: implications for disease pathogenesis and treatment
-
COI: 1:CAS:528:DC%2BC3MXis1Onsw%3D%3D, PID: 20678073
-
Souter S, Lee G (2010) Tubulin-independent tau in Alzheimer’s disease and cancer: implications for disease pathogenesis and treatment. Curr Alzheimer Res 7(8):697–707
-
(2010)
Curr Alzheimer Res
, vol.7
, Issue.8
, pp. 697-707
-
-
Souter, S.1
Lee, G.2
-
205
-
-
0028981873
-
Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells
-
COI: 1:CAS:528:DyaK2MXos1WktL0%3D, PID: 8552282
-
Sperber BR, Leight S, Goedert M, Lee VM (1995) Glycogen synthase kinase-3 beta phosphorylates tau protein at multiple sites in intact cells. Neurosci Lett 197(2):149–153
-
(1995)
Neurosci Lett
, vol.197
, Issue.2
, pp. 149-153
-
-
Sperber, B.R.1
Leight, S.2
Goedert, M.3
Lee, V.M.4
-
206
-
-
0033968306
-
Molecular genetics of Alzheimer’s disease
-
COI: 1:CAS:528:DC%2BD3cXpsFansQ%3D%3D, PID: 10682216
-
St George-Hyslop PH (2000) Molecular genetics of Alzheimer’s disease. Biol Psychiatry 47(3):183–199
-
(2000)
Biol Psychiatry
, vol.47
, Issue.3
, pp. 183-199
-
-
St George-Hyslop, P.H.1
-
207
-
-
15244351255
-
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease–is this type 3 diabetes?
-
COI: 1:CAS:528:DC%2BD2MXhvVSrtL8%3D, PID: 15750215
-
Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM (2005) Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer’s disease–is this type 3 diabetes? J Alzheimers Dis 7(1):63–80
-
(2005)
J Alzheimers Dis
, vol.7
, Issue.1
, pp. 63-80
-
-
Steen, E.1
Terry, B.M.2
Rivera, E.J.3
Cannon, J.L.4
Neely, T.R.5
Tavares, R.6
Xu, X.J.7
Wands, J.R.8
de la Monte, S.M.9
-
208
-
-
79952446517
-
Understanding the pathogenesis of Alzheimer’s disease: will RNA-Seq realize the promise of transcriptomics?
-
COI: 1:CAS:528:DC%2BC3MXjvFWntro%3D, PID: 21175619
-
Sutherland GT, Janitz M, Kril JJ (2011a) Understanding the pathogenesis of Alzheimer’s disease: will RNA-Seq realize the promise of transcriptomics? J Neurochem 116(6):937–946
-
(2011)
J Neurochem
, vol.116
, Issue.6
, pp. 937-946
-
-
Sutherland, G.T.1
Janitz, M.2
Kril, J.J.3
-
209
-
-
0027515127
-
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling
-
COI: 1:CAS:528:DyaK2cXks1ehtw%3D%3D, PID: 8250835
-
Sutherland C, Leighton IA, Cohen P (1993) Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling. Biochem J 296(Pt 1):15–19
-
(1993)
Biochem J
, vol.296
, pp. 15-19
-
-
Sutherland, C.1
Leighton, I.A.2
Cohen, P.3
-
210
-
-
79960772040
-
Knowing me, knowing you: can a knowledge of risk factors for Alzheimer’s disease prove useful in understanding the pathogenesis of Parkinson’s disease?
-
PID: 21441655
-
Sutherland GT, Siebert GA, Kril JJ, Mellick GD (2011b) Knowing me, knowing you: can a knowledge of risk factors for Alzheimer’s disease prove useful in understanding the pathogenesis of Parkinson’s disease? J Alzheimers Dis 25(3):395–415
-
(2011)
J Alzheimers Dis
, vol.25
, Issue.3
, pp. 395-415
-
-
Sutherland, G.T.1
Siebert, G.A.2
Kril, J.J.3
Mellick, G.D.4
-
211
-
-
84859718265
-
Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
-
COI: 1:CAS:528:DC%2BC38Xlt1egtbY%3D, PID: 22476197
-
Talbot K, Wang HY, Kazi H, Han LY, Bakshi KP, Stucky A, Fuino RL, Kawaguchi KR, Samoyedny AJ, Wilson RS, Arvanitakis Z, Schneider JA, Wolf BA, Bennett DA, Trojanowski JQ, Arnold SE (2012) Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J Clin Invest 122(4):1316–1338
-
(2012)
J Clin Invest
, vol.122
, Issue.4
, pp. 1316-1338
-
-
Talbot, K.1
Wang, H.Y.2
Kazi, H.3
Han, L.Y.4
Bakshi, K.P.5
Stucky, A.6
Fuino, R.L.7
Kawaguchi, K.R.8
Samoyedny, A.J.9
Wilson, R.S.10
Arvanitakis, Z.11
Schneider, J.A.12
Wolf, B.A.13
Bennett, D.A.14
Trojanowski, J.Q.15
Arnold, S.E.16
-
212
-
-
47149092572
-
Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory
-
COI: 1:CAS:528:DC%2BD1cXoslOhtrY%3D, PID: 18585048
-
Taylor CJ, Ireland DR, Ballagh I, Bourne K, Marechal NM, Turner PR, Bilkey DK, Tate WP, Abraham WC (2008) Endogenous secreted amyloid precursor protein-alpha regulates hippocampal NMDA receptor function, long-term potentiation and spatial memory. Neurobiol Dis 31(2):250–260
-
(2008)
Neurobiol Dis
, vol.31
, Issue.2
, pp. 250-260
-
-
Taylor, C.J.1
Ireland, D.R.2
Ballagh, I.3
Bourne, K.4
Marechal, N.M.5
Turner, P.R.6
Bilkey, D.K.7
Tate, W.P.8
Abraham, W.C.9
-
213
-
-
80054702312
-
The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling
-
COI: 1:CAS:528:DC%2BC3MXhtlSqt7bI
-
Terragni J, Nayak G, Banerjee S, Medrano JL, Graham JR, Brennan JF, Sepulveda S, Cooper GM (2011) The E-box binding factors Max/Mnt, MITF, and USF1 act coordinately with FoxO to regulate expression of proapoptotic and cell cycle control genes by phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3 signaling. J Biolumin Chemilumin 286(42):36215–36227
-
(2011)
J Biolumin Chemilumin
, vol.286
, Issue.42
, pp. 36215-36227
-
-
Terragni, J.1
Nayak, G.2
Banerjee, S.3
Medrano, J.L.4
Graham, J.R.5
Brennan, J.F.6
Sepulveda, S.7
Cooper, G.M.8
-
214
-
-
0033582266
-
PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A
-
COI: 1:CAS:528:DyaK1MXmtlCgug%3D%3D, PID: 9892651
-
Tezuka T, Umemori H, Akiyama T, Nakanishi S, Yamamoto T (1999) PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A. Proc Natl Acad Sci U S A 96(2):435–440
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, Issue.2
, pp. 435-440
-
-
Tezuka, T.1
Umemori, H.2
Akiyama, T.3
Nakanishi, S.4
Yamamoto, T.5
-
215
-
-
0037172826
-
Phases of A beta-deposition in the human brain and its relevance for the development of AD
-
PID: 12084879
-
Thal DR, Rub U, Orantes M, Braak H (2002) Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 58(12):1791–1800
-
(2002)
Neurology
, vol.58
, Issue.12
, pp. 1791-1800
-
-
Thal, D.R.1
Rub, U.2
Orantes, M.3
Braak, H.4
-
216
-
-
84883402644
-
Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre
-
PID: 23842566
-
Toledo JB, Arnold SE, Raible K, Brettschneider J, Xie SX, Grossman M, Monsell SE, Kukull WA, Trojanowski JQ (2013) Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre. Brain 136(Pt 9):2697–2706
-
(2013)
Brain
, vol.136
, pp. 2697-2706
-
-
Toledo, J.B.1
Arnold, S.E.2
Raible, K.3
Brettschneider, J.4
Xie, S.X.5
Grossman, M.6
Monsell, S.E.7
Kukull, W.A.8
Trojanowski, J.Q.9
-
217
-
-
36348935683
-
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
-
COI: 1:CAS:528:DC%2BD2sXht1Oru7bL
-
Townsend M, Mehta T, Selkoe DJ (2007) Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J Biolumin Chemilumin 282(46):33305–33312
-
(2007)
J Biolumin Chemilumin
, vol.282
, Issue.46
, pp. 33305-33312
-
-
Townsend, M.1
Mehta, T.2
Selkoe, D.J.3
-
218
-
-
83655192092
-
Regulation of NMDA receptors by the tyrosine kinase Fyn
-
COI: 1:CAS:528:DC%2BC38Xit1SnsA%3D%3D, PID: 21985328
-
Trepanier CH, Jackson MF, MacDonald JF (2012) Regulation of NMDA receptors by the tyrosine kinase Fyn. FEBS J 279(1):12–19
-
(2012)
FEBS J
, vol.279
, Issue.1
, pp. 12-19
-
-
Trepanier, C.H.1
Jackson, M.F.2
MacDonald, J.F.3
-
219
-
-
33745853091
-
Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate
-
COI: 1:CAS:528:DC%2BD28XntV2rtr0%3D, PID: 16814287
-
Twomey C, McCarthy JV (2006) Presenilin-1 is an unprimed glycogen synthase kinase-3beta substrate. FEBS Lett 580(17):4015–4020
-
(2006)
FEBS Lett
, vol.580
, Issue.17
, pp. 4015-4020
-
-
Twomey, C.1
McCarthy, J.V.2
-
220
-
-
0034920989
-
Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence
-
COI: 1:CAS:528:DC%2BD3MXlslGlu7o%3D, PID: 11515780
-
Uchihara T, Nakamura A, Yamazaki M, Mori O (2001) Evolution from pretangle neurons to neurofibrillary tangles monitored by thiazin red combined with Gallyas method and double immunofluorescence. Acta Neuropathol 101(6):535–539
-
(2001)
Acta Neuropathol
, vol.101
, Issue.6
, pp. 535-539
-
-
Uchihara, T.1
Nakamura, A.2
Yamazaki, M.3
Mori, O.4
-
221
-
-
0030908590
-
Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly
-
COI: 1:CAS:528:DyaK2sXjtFGltbw%3D, PID: 9169608
-
Utton MA, Vandecandelaere A, Wagner U, Reynolds CH, Gibb GM, Miller CC, Bayley PM, Anderton BH (1997) Phosphorylation of tau by glycogen synthase kinase 3beta affects the ability of tau to promote microtubule self-assembly. Biochem J 323(Pt 3):741–747
-
(1997)
Biochem J
, vol.323
, pp. 741-747
-
-
Utton, M.A.1
Vandecandelaere, A.2
Wagner, U.3
Reynolds, C.H.4
Gibb, G.M.5
Miller, C.C.6
Bayley, P.M.7
Anderton, B.H.8
-
222
-
-
23844470857
-
Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner
-
PID: 16092951
-
van der Heide LP, Kamal A, Artola A, Gispen WH, Ramakers GM (2005) Insulin modulates hippocampal activity-dependent synaptic plasticity in a N-methyl-d-aspartate receptor and phosphatidyl-inositol-3-kinase-dependent manner. J Neurochem 94(4):1158–1166
-
(2005)
J Neurochem
, vol.94
, Issue.4
, pp. 1158-1166
-
-
van der Heide, L.P.1
Kamal, A.2
Artola, A.3
Gispen, W.H.4
Ramakers, G.M.5
-
223
-
-
0030805703
-
Phosphoinositide 3-kinases: a conserved family of signal transducers
-
COI: 1:CAS:528:DyaK2sXks1yksbs%3D, PID: 9255069
-
Vanhaesebroeck B, Leevers SJ, Panayotou G, Waterfield MD (1997) Phosphoinositide 3-kinases: a conserved family of signal transducers. Trends Biochem Sci 22(7):267–272
-
(1997)
Trends Biochem Sci
, vol.22
, Issue.7
, pp. 267-272
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Panayotou, G.3
Waterfield, M.D.4
-
224
-
-
73949093736
-
Regulation of Wnt/beta-catenin signaling by protein kinases
-
COI: 1:CAS:528:DC%2BC3cXhsFCksb0%3D, PID: 19623618
-
Verheyen EM, Gottardi CJ (2010) Regulation of Wnt/beta-catenin signaling by protein kinases. Dev Dyn 239(1):34–44
-
(2010)
Dev Dyn
, vol.239
, Issue.1
, pp. 34-44
-
-
Verheyen, E.M.1
Gottardi, C.J.2
-
225
-
-
84890660655
-
Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-beta
-
COI: 1:CAS:528:DC%2BC3sXhvVyitb%2FK, PID: 24136243
-
Wang ZC, Zhao J, Li S (2013) Dysregulation of synaptic and extrasynaptic N-methyl-D-aspartate receptors induced by amyloid-beta. Neurosci Bull 29(6):752–760
-
(2013)
Neurosci Bull
, vol.29
, Issue.6
, pp. 752-760
-
-
Wang, Z.C.1
Zhao, J.2
Li, S.3
-
226
-
-
0344305782
-
Insulin signaling in health and disease
-
COI: 1:CAS:528:DC%2BD3sXpsVWns7s%3D, PID: 14657487
-
White MF (2003) Insulin signaling in health and disease. Science 302(5651):1710–1711
-
(2003)
Science
, vol.302
, Issue.5651
, pp. 1710-1711
-
-
White, M.F.1
-
227
-
-
84964697985
-
Insulin resistance predicts medial temporal hypermetabolism in mild cognitive impairment conversion to Alzheimer disease
-
COI: 1:CAS:528:DC%2BC2MXhtVSjsrjJ, PID: 25576061
-
Willette AA, Modanlo N, Kapogiannis D, Alzheimer’s Disease Neuroimaging I (2015) Insulin resistance predicts medial temporal hypermetabolism in mild cognitive impairment conversion to Alzheimer disease. Diabetes 64(6):1933–1940
-
(2015)
Diabetes
, vol.64
, Issue.6
, pp. 1933-1940
-
-
Willette, A.A.1
Modanlo, N.2
Kapogiannis, D.3
Alzheimer’s Disease Neuroimaging, I.4
-
228
-
-
18744438248
-
Alzheimer’s beta-amyloid peptides compete for insulin binding to the insulin receptor
-
PID: 12006603
-
Xie L, Helmerhorst E, Taddei K, Plewright B, Van Bronswijk W, Martins R (2002) Alzheimer’s beta-amyloid peptides compete for insulin binding to the insulin receptor. J Neurosci 22(10):RC221
-
(2002)
J Neurosci
, vol.22
, Issue.10
, pp. 221
-
-
Xie, L.1
Helmerhorst, E.2
Taddei, K.3
Plewright, B.4
Van Bronswijk, W.5
Martins, R.6
-
229
-
-
16844369740
-
PI3K integrates the action of insulin and leptin on hypothalamic neurons
-
COI: 1:CAS:528:DC%2BD2MXjtFylt78%3D, PID: 15761497
-
Xu AW, Kaelin CB, Takeda K, Akira S, Schwartz MW, Barsh GS (2005) PI3K integrates the action of insulin and leptin on hypothalamic neurons. J Clin Invest 115(4):951–958
-
(2005)
J Clin Invest
, vol.115
, Issue.4
, pp. 951-958
-
-
Xu, A.W.1
Kaelin, C.B.2
Takeda, K.3
Akira, S.4
Schwartz, M.W.5
Barsh, G.S.6
-
230
-
-
84872431424
-
Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes
-
COI: 1:CAS:528:DC%2BC38XhvVeks7%2FN, PID: 22936005
-
Yang Y, Ma D, Wang Y, Jiang T, Hu S, Zhang M, Yu X, Gong CX (2013) Intranasal insulin ameliorates tau hyperphosphorylation in a rat model of type 2 diabetes. J Alzheimers Dis 33(2):329–338
-
(2013)
J Alzheimers Dis
, vol.33
, Issue.2
, pp. 329-338
-
-
Yang, Y.1
Ma, D.2
Wang, Y.3
Jiang, T.4
Hu, S.5
Zhang, M.6
Yu, X.7
Gong, C.X.8
-
231
-
-
0036523102
-
Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis
-
COI: 1:CAS:528:DC%2BD38XhvValsr8%3D, PID: 11880483
-
Ying SW, Futter M, Rosenblum K, Webber MJ, Hunt SP, Bliss TV, Bramham CR (2002) Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis. J Neurosci 22(5):1532–1540
-
(2002)
J Neurosci
, vol.22
, Issue.5
, pp. 1532-1540
-
-
Ying, S.W.1
Futter, M.2
Rosenblum, K.3
Webber, M.J.4
Hunt, S.P.5
Bliss, T.V.6
Bramham, C.R.7
-
232
-
-
52949140814
-
Making insulin-deficient type 1 diabetic rodents thrive without insulin
-
COI: 1:CAS:528:DC%2BD1cXhtFKiurjM, PID: 18779578
-
Yu X, Park BH, Wang MY, Wang ZV, Unger RH (2008) Making insulin-deficient type 1 diabetic rodents thrive without insulin. Proc Natl Acad Sci U S A 105(37):14070–14075
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, Issue.37
, pp. 14070-14075
-
-
Yu, X.1
Park, B.H.2
Wang, M.Y.3
Wang, Z.V.4
Unger, R.H.5
-
233
-
-
84887928967
-
The role of APP and BACE1 trafficking in APP processing and amyloid-beta generation
-
PID: 24103387
-
Zhang X, Song W (2013) The role of APP and BACE1 trafficking in APP processing and amyloid-beta generation. Alzheimers Res Ther 5(5):46
-
(2013)
Alzheimers Res Ther
, vol.5
, Issue.5
, pp. 46
-
-
Zhang, X.1
Song, W.2
-
234
-
-
33845619414
-
Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules
-
COI: 1:CAS:528:DC%2BD28XlvFKksrY%3D, PID: 16645045
-
Zhang X, Li F, Bulloj A, Zhang YW, Tong G, Zhang Z, Liao FF, Xu H (2006) Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules. FASEB J 20(8):1272–1274
-
(2006)
FASEB J
, vol.20
, Issue.8
, pp. 1272-1274
-
-
Zhang, X.1
Li, F.2
Bulloj, A.3
Zhang, Y.W.4
Tong, G.5
Zhang, Z.6
Liao, F.F.7
Xu, H.8
-
235
-
-
84861877424
-
Amyloid-beta induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway
-
COI: 1:CAS:528:DC%2BC38XotlGqurw%3D, PID: 22522613
-
Zhang Y, Zhou B, Zhang F, Wu J, Hu Y, Liu Y, Zhai Q (2012) Amyloid-beta induces hepatic insulin resistance by activating JAK2/STAT3/SOCS-1 signaling pathway. Diabetes 61(6):1434–1443
-
(2012)
Diabetes
, vol.61
, Issue.6
, pp. 1434-1443
-
-
Zhang, Y.1
Zhou, B.2
Zhang, F.3
Wu, J.4
Hu, Y.5
Liu, Y.6
Zhai, Q.7
-
236
-
-
1842633872
-
Insulin and the insulin receptor in experimental models of learning and memory
-
COI: 1:CAS:528:DC%2BD2cXjt1Shsb8%3D, PID: 15094074
-
Zhao WQ, Chen H, Quon MJ, Alkon DL (2004b) Insulin and the insulin receptor in experimental models of learning and memory. Eur J Pharmacol 490(1–3):71–81
-
(2004)
Eur J Pharmacol
, vol.490
, Issue.1-3
, pp. 71-81
-
-
Zhao, W.Q.1
Chen, H.2
Quon, M.J.3
Alkon, D.L.4
-
237
-
-
38049110692
-
Amyloid beta oligomers induce impairment of neuronal insulin receptors
-
COI: 1:CAS:528:DC%2BD1cXkslWntw%3D%3D, PID: 17720802
-
Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL (2008) Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J 22(1):246–260
-
(2008)
FASEB J
, vol.22
, Issue.1
, pp. 246-260
-
-
Zhao, W.Q.1
De Felice, F.G.2
Fernandez, S.3
Chen, H.4
Lambert, M.P.5
Quon, M.J.6
Krafft, G.A.7
Klein, W.L.8
-
238
-
-
10944228564
-
Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer’s disease intervention
-
COI: 1:CAS:528:DC%2BD2cXhtFagurfP, PID: 15590928
-
Zhao L, Teter B, Morihara T, Lim GP, Ambegaokar SS, Ubeda OJ, Frautschy SA, Cole GM (2004a) Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer’s disease intervention. J Neurosci 24(49):11120–11126
-
(2004)
J Neurosci
, vol.24
, Issue.49
, pp. 11120-11126
-
-
Zhao, L.1
Teter, B.2
Morihara, T.3
Lim, G.P.4
Ambegaokar, S.S.5
Ubeda, O.J.6
Frautschy, S.A.7
Cole, G.M.8
-
239
-
-
79953657859
-
Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats
-
COI: 1:CAS:528:DC%2BC3MXktFWktbg%3D, PID: 21346324
-
Zhao W, Wu X, Xie H, Ke Y, Yung WH (2010) Permissive role of insulin in the expression of long-term potentiation in the hippocampus of immature rats. Neurosignals 18(4):236–245
-
(2010)
Neurosignals
, vol.18
, Issue.4
, pp. 236-245
-
-
Zhao, W.1
Wu, X.2
Xie, H.3
Ke, Y.4
Yung, W.H.5
-
240
-
-
33845975305
-
Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration
-
COI: 1:CAS:528:DC%2BD28Xht1ajt73P
-
Zhou GL, Tucker DF, Bae SS, Bhatheja K, Birnbaum MJ, Field J (2006) Opposing roles for Akt1 and Akt2 in Rac/Pak signaling and cell migration. J Biolumin Chemilumin 281(47):36443–36453
-
(2006)
J Biolumin Chemilumin
, vol.281
, Issue.47
, pp. 36443-36453
-
-
Zhou, G.L.1
Tucker, D.F.2
Bae, S.S.3
Bhatheja, K.4
Birnbaum, M.J.5
Field, J.6
|