Insulin receptor mutation results in insulin resistance and hyperinsulinemia but does not exacerbate Alzheimer's-like phenotypes in mice

Biochemical and Biophysical Research Communications

Volumn 409, Issue 1, 2011, Pages 34-39

  Murakami, Kazuma ^a,b   Yokoyama, Shin ichi ^a   Murata, Nakaba ^a,c   Ozawa, Yusuke ^a   Irie, Kazuhiro ^b   Shirasawa, Takuji ^d   Shimizu, Takahiko ^a,c  

^a TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^d JUNTENDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Alzheimer's disease; Amyloid ; Hyperinsulinemia; Insulin resistance; Insulin signaling; Senile plaque

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; INSULIN RECEPTOR;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN DAMAGE; COGNITIVE DEFECT; DIABETES MELLITUS; DISEASE EXACERBATION; FEMALE; GENE MUTATION; HETEROZYGOSITY; HYPERINSULINEMIA; INSULIN RESISTANCE; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR GENE; RISK FACTOR; SENILE PLAQUE; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; HYPERINSULINISM; INSULIN RESISTANCE; MEMORY DISORDERS; MICE; RECEPTOR, INSULIN;

MUS;

EID: 79956216581     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.04.101     Document Type: Article

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