Inhibition of the neuronal insulin receptor causes Alzheimer-like disturbances in oxidative/energy brain metabolism and in behavior in adult rats

Annals of the New York Academy of Sciences

Volumn 893, Issue , 1999, Pages 301-303

  Hoyer, Siegfried ^a   Lannert, Heinrich ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ESTRADIOL; GINKGO BILOBA EXTRACT; INSULIN RECEPTOR; STREPTOZOCIN;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; BRAIN METABOLISM; COGNITION; CONFERENCE PAPER; ENERGY METABOLISM; LEARNING; MEMORY; NONHUMAN; RAT;

ANIMALIA; GINKGO BILOBA;

EID: 0033380660     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb07842.x     Document Type: Conference Paper

References (8)

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2. 2. Hoyer, S. 1998. Is sporadic Alzheimer disease the brain type of non-insulin dependent diabetes mellitus? A challenging hypothesis. J. Neural Transm. 105: 415-422.
3. 3. Hoyer, S., D. Müller & K. Plaschke. 1994. Desensitization of brain insulin receptor. Effect on glucose/energy and related metabolism. J. Neural Transm. (Suppl.) 44: 259-268.
4. 4. Lannert, H., P. Wirtz, V. Schuhmann & R. Galmbacher. 1998. Effects of estradiol (-17β) on learning, memory and cerebral energy metabolism in male rats after intracerebroventricular administration of streptozotocin. J. Neural Transm. 105: 1045-1063.
5. 5. Kostanyan, A. & K. Nazaryan. 1992. Rat brain glycolysis regulation by estradiol-17ß. Biochim. Biophys. Acta 1133: 301-306.
6. 6. De Feudis, F.V. 1998. Ginkgo Biloba Extract (EGb761). From Chemistry to Clinic. Ullstein Medical Verlagsgesellschaft. Wiesbaden, Germany.
7. 7. Le Bars, P.L., M.M. Katz, N. Berman, T.M. Itil, A.M. Freedman & A.F. Schatzberg. 1997. A placebo-controlled, double blind, randomized trial of an extract of Ginkgo biloba for dementia. J. Am. Med. Assoc. 278: 1327-1332.
8. 8. Lannert, H. & S. Hoyer. 1998. Intracerebroventricular administration of streptozotocin causes long-term diminutions in learning and memory abilities and in cerebral energy metabolism in adult rats. Behav. Neurosci. 112: 1199-1208.