Aβ1-42 inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β

Nature Neuroscience

Volumn 14, Issue 5, 2011, Pages 545-547

  Jo, Jihoon ^a   Whitcomb, Daniel J ^a   Olsen, Kimberly Moore ^b   Kerrigan, Talitha L ^a   Lo, Shih Ching ^b   Bru Mercier, Gilles ^a   Dickinson, Bryony ^a   Scullion, Sarah ^a,c   Sheng, Morgan ^b   Collingridge, Graham ^c   Cho, Kwangwook ^a,c  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; CASPASE 3; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN AKT1; PROTEIN KINASE B; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HIPPOCAMPUS; LONG TERM POTENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; SIGNAL TRANSDUCTION;

AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, NEWBORN; BIOPHYSICS; CASPASE 3; ELECTRIC STIMULATION; ENZYME INHIBITORS; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; LONG-TERM POTENTIATION; MICE; MICE, KNOCKOUT; NEURONS; ORGAN CULTURE TECHNIQUES; PATCH-CLAMP TECHNIQUES; PEPTIDE FRAGMENTS; PROTO-ONCOGENE PROTEINS C-AKT; PYRIDINES; PYRIMIDINES; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TRANSFECTION; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 79955484857     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2785     Document Type: Article

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