Age-dependent accumulation of soluble amyloid β (Aβ) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-α (sAPPα) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK- 3β pathway in Alzheimer mouse model

Journal of Biological Chemistry

Volumn 286, Issue 21, 2011, Pages 18414-18425

  Jimenez, Sebastian ^a,c,d   Torres, Manuel ^a,c,d   Vizuete, Marisa ^a,c,d   Sanchez Varo, Raquel ^b,c   Sanchez Mejias, Elisabeth ^b,c   Trujillo Estrada, Laura ^b,c   Carmona Cuenca, Irene ^a,c,d   Caballero, Cristina ^a,c,d   Ruano, Diego ^a,c,d   Gutierrez, Antonia ^b,c   Vitorica, Javier ^a,c,d  

^a UNIVERSITY OF SEVILLE   (Spain)

^b UNIVERSITY OF MÁLAGA   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED SOBRE ENFERMEDADES NEURODEGENERATIVAS CIBERNED   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER; ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEINS; HIGH SELECTIVITY; INSULIN RECEPTORS; INSULIN SIGNALING; MOUSE MODELS; NEURODEGENERATION; NEURONAL CELL CULTURE; NEURONAL GROUPS; NEURONAL SURVIVAL; NEUROPROTECTIVE EFFECTS; NEUROTROPHIN RECEPTOR; NEUROTROPHINS; PHOSPHATIDYLINOSITOL 3-KINASE; PYRAMIDAL CELL; SIGNALING PATHWAYS; SOLUBLE FRACTION; TRANSGENIC MICE;

ANIMAL CELL CULTURE; ANIMALS; BRAIN; ENZYME INHIBITION; GLYCOPROTEINS; INSULIN; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION; PROTEINS; SIGNALING;

OLIGOMERS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN ALPHA; BRAIN DERIVED NEUROTROPHIC FACTOR; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR; NERVE GROWTH FACTOR; NEUROTROPHIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; SOMATOMEDIN C; UNCLASSIFIED DRUG;

AGE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; MALE; MOUSE; NERVE CELL CULTURE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; CELL SURVIVAL; GLYCOGEN SYNTHASE KINASE 3; HUMANS; MICE; MICE, TRANSGENIC; NERVE GROWTH FACTORS; NEURONS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA; MUS; MUS MUSCULUS;

EID: 79956320988     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.209718     Document Type: Article

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