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Volumn 121, Issue 6, 2012, Pages 964-973

Gain of function by phosphorylation in Presenilin 1-mediated regulation of insulin signaling

Author keywords

Insulin receptor; Phophorylation; Presenilin 1

Indexed keywords

AMYLOID BETA PROTEIN; BETA CATENIN; CALCIUM; GAMMA SECRETASE; GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; INSULIN RECEPTOR; MUTANT PROTEIN; NERVE CELL ADHESION MOLECULE; PRESENILIN 1;

EID: 84862014676     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07741.x     Document Type: Article
Times cited : (11)

References (35)
  • 1
    • 44649198605 scopus 로고    scopus 로고
    • Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo
    • Chiu S. L., Chen C. M. and Cline H. T. (2008) Insulin receptor signaling regulates synapse number, dendritic plasticity, and circuit function in vivo. Neuron 58, 708-719.
    • (2008) Neuron , vol.58 , pp. 708-719
    • Chiu, S.L.1    Chen, C.M.2    Cline, H.T.3
  • 2
    • 0033593461 scopus 로고    scopus 로고
    • Signaling mechanisms that regulate glucose transport
    • Czech M. P. and Corvera S. (1999) Signaling mechanisms that regulate glucose transport. J. Biol. Chem. 274, 1865-1868.
    • (1999) J. Biol. Chem. , vol.274 , pp. 1865-1868
    • Czech, M.P.1    Corvera, S.2
  • 4
    • 0026487365 scopus 로고
    • Glycogen synthase kinase-3 induces Alzheimer's disease- Like phosphorylation of tau: Generation of paired helical filament epitopes and neuronal localisation of the kinase
    • Hanger D. P., Hughes K., Woodgett J. R., Brion J. P. and Anderton B. H. (1992) Glycogen synthase kinase-3 induces Alzheimer's disease- like phosphorylation of tau: generation of paired helical filament epitopes and neuronal localisation of the kinase. Neurosci. Lett. 147, 58-62.
    • (1992) Neurosci. Lett. , vol.147 , pp. 58-62
    • Hanger, D.P.1    Hughes, K.2    Woodgett, J.R.3    Brion, J.P.4    Anderton, B.H.5
  • 5
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • DOI 10.1038/272827a0
    • Havrankova J., Roth J. and Brownstein M. (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272, 827-829. (Pubitemid 8316991)
    • (1978) Nature , vol.272 , Issue.5656 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 6
    • 79956320988 scopus 로고    scopus 로고
    • Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model
    • Jimenez S., Torres M., Vizuete M. et al. (2011) Age-dependent accumulation of soluble amyloid beta (Abeta) oligomers reverses the neuroprotective effect of soluble amyloid precursor protein-alpha (sAPP(alpha)) by modulating phosphatidylinositol 3-kinase (PI3K)/Akt-GSK-3beta pathway in Alzheimer mouse model. J. Biol. Chem. 286, 18414-18425.
    • (2011) J. Biol. Chem. , vol.286 , pp. 18414-18425
    • Jimenez, S.1    Torres, M.2    Vizuete, M.3
  • 7
  • 8
    • 0035831453 scopus 로고    scopus 로고
    • Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling
    • Kirschenbaum F., Hsu S. C., Cordell B. and McCarthy J. V. (2001) Substitution of a glycogen synthase kinase-3beta phosphorylation site in presenilin 1 separates presenilin function from beta-catenin signaling. J. Biol. Chem. 276, 7366-7375.
    • (2001) J. Biol. Chem. , vol.276 , pp. 7366-7375
    • Kirschenbaum, F.1    Hsu, S.C.2    Cordell, B.3    McCarthy, J.V.4
  • 9
    • 0025761974 scopus 로고
    • Cellular trafficking and processing of the insulin receptor
    • Knutson V. P. (1991) Cellular trafficking and processing of the insulin receptor. FASEB J. 5, 2130-2138.
    • (1991) FASEB J. , vol.5 , pp. 2130-2138
    • Knutson, V.P.1
  • 11
    • 65249113325 scopus 로고    scopus 로고
    • The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid
    • Lee H. K., Kumar P., Fu Q., Rosen K. M. and Querfurth H. W. (2009) The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol. Biol. Cell 20, 1533-1544.
    • (2009) Mol. Biol. Cell , vol.20 , pp. 1533-1544
    • Lee, H.K.1    Kumar, P.2    Fu, Q.3    Rosen, K.M.4    Querfurth, H.W.5
  • 13
    • 79960119114 scopus 로고    scopus 로고
    • Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism
    • Maesako M., Uemura K., Kuzuya A. et al. (2011a) Presenilin regulates insulin signaling via a gamma-secretase-independent mechanism. J. Biol. Chem. 286, 25309-25316.
    • (2011) J. Biol. Chem. , vol.286 , pp. 25309-25316
    • Maesako, M.1    Uemura, K.2    Kuzuya, A.3
  • 14
    • 79952005561 scopus 로고    scopus 로고
    • Effect of glycogen synthase kinase 3 beta-mediated presenilin 1 phosphorylation on amyloid beta production is negatively regulated by insulin receptor cleavage
    • Maesako M., Uemura K., Kubota M. et al. (2011b) Effect of glycogen synthase kinase 3 beta-mediated presenilin 1 phosphorylation on amyloid beta production is negatively regulated by insulin receptor cleavage. Neuroscience 177, 298-307.
    • (2011) Neuroscience , vol.177 , pp. 298-307
    • Maesako, M.1    Uemura, K.2    Kubota, M.3
  • 17
    • 80051988063 scopus 로고    scopus 로고
    • Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling
    • Muller M., Cardenas C., Mei L., Cheung K. H. and Foskett J. K. (2011) Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling. Proc. Natl Acad. Sci. USA 108, 13293-13298.
    • (2011) Proc. Natl Acad. Sci. USA , vol.108 , pp. 13293-13298
    • Muller, M.1    Cardenas, C.2    Mei, L.3    Cheung, K.H.4    Foskett, J.K.5
  • 19
    • 0028811653 scopus 로고
    • Protein kinase C: Structure, function, and regulation
    • Newton A. C. (1995) Protein kinase C: structure, function, and regulation. J. Biol. Chem. 270, 28495-28498.
    • (1995) J. Biol. Chem. , vol.270 , pp. 28495-28498
    • Newton, A.C.1
  • 20
    • 35748940970 scopus 로고    scopus 로고
    • Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway
    • DOI 10.1074/jbc.M704273200
    • Repetto E., Yoon I. S., Zheng H. and Kang D. E. (2007) Presenilin 1 regulates epidermal growth factor receptor turnover and signaling in the endosomal-lysosomal pathway. J. Biol. Chem. 282, 31504-31516. (Pubitemid 350044898)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.43 , pp. 31504-31516
    • Repetto, E.1    Yoon, I.-S.2    Zheng, H.3    Kang, D.E.4
  • 21
    • 78651063834 scopus 로고    scopus 로고
    • Dyrk1A-mediated phosphorylation of Presenilin 1: A functional link between Down syndrome and Alzheimer's disease
    • Ryu Y. S., Park S. Y., Jung M. S. et al. (2010) Dyrk1A-mediated phosphorylation of Presenilin 1: a functional link between Down syndrome and Alzheimer's disease. J. Neurochem. 115, 574-584.
    • (2010) J. Neurochem. , vol.115 , pp. 574-584
    • Ryu, Y.S.1    Park, S.Y.2    Jung, M.S.3
  • 22
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • DOI 10.1038/414799a
    • Saltiel A. R. and Kahn C. R. (2001) Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806. (Pubitemid 34000783)
    • (2001) Nature , vol.414 , Issue.6865 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 24
    • 0026075701 scopus 로고
    • Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs: Quantitative aspects and implications for transport
    • Schwartz M. W., Bergman R. N., Kahn S. E., Taborsky G. J., Jr, Fisher L. D., Sipols A. J., Woods S. C., Steil G. M. and Porte D. Jr, (1991) Evidence for entry of plasma insulin into cerebrospinal fluid through an intermediate compartment in dogs: quantitative aspects and implications for transport. J. Clin. Invest. 88, 1272-1281.
    • (1991) J. Clin. Invest. , vol.88 , pp. 1272-1281
    • Schwartz, M.W.1    Bergman, R.N.2    Kahn, S.E.3    Taborsky Jr., G.J.4    Fisher, L.D.5    Sipols, A.J.6    Woods, S.C.7    Steil, G.M.8    Porte Jr., D.9
  • 25
    • 0036171986 scopus 로고    scopus 로고
    • Calcineurin as a multi-functional regulator
    • Shibasaki F., Hallin U. and Uchino H. (2002) Calcineurin as a multi-functional regulator. J. Biochem. 131, 1-15.
    • (2002) J. Biochem. , vol.131 , pp. 1-15
    • Shibasaki, F.1    Hallin, U.2    Uchino, H.3
  • 26
    • 0033535508 scopus 로고    scopus 로고
    • Presenilin is required for activity and nuclear access of Notch in Drosophila
    • Struhl G. and Greenwald I. (1999) Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature 398, 522-525.
    • (1999) Nature , vol.398 , pp. 522-525
    • Struhl, G.1    Greenwald, I.2
  • 27
    • 36348935683 scopus 로고    scopus 로고
    • Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
    • DOI 10.1074/jbc.M610390200
    • Townsend M., Mehta T. and Selkoe D. J. (2007) Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J. Biol. Chem. 282, 33305-33312. (Pubitemid 350159548)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.46 , pp. 33305-33312
    • Townsend, M.1    Mehta, T.2    Selkoe, D.J.3
  • 30
    • 0344305782 scopus 로고    scopus 로고
    • Insulin signaling in health and disease
    • White M. F. (2003) Insulin signaling in health and disease. Science 302, 1710-1711.
    • (2003) Science , vol.302 , pp. 1710-1711
    • White, M.F.1
  • 31
    • 33947242870 scopus 로고    scopus 로고
    • When loss is gain: Reduced presenilin proteolytic function leads to increased Abeta42/Abeta40 Talking Point on the role of presenilin mutations in Alzheimer disease
    • Wolfe M. S. (2007) When loss is gain: reduced presenilin proteolytic function leads to increased Abeta42/Abeta40 Talking Point on the role of presenilin mutations in Alzheimer disease. EMBO Rep. 8, 136-140.
    • (2007) EMBO Rep. , vol.8 , pp. 136-140
    • Wolfe, M.S.1
  • 34
    • 0035947044 scopus 로고    scopus 로고
    • Role of insulin and insulin receptor in learning and memory
    • Zhao W. Q. and Alkon D. L. (2001) Role of insulin and insulin receptor in learning and memory. Mol. Cell. Endocrinol. 177, 125-134.
    • (2001) Mol. Cell. Endocrinol. , vol.177 , pp. 125-134
    • Zhao, W.Q.1    Alkon, D.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.