GSK3 in Alzheimer's disease: Mind the isoforms

Journal of Alzheimer's Disease

Volumn 39, Issue 4, 2014, Pages 707-710

  Ma, Tao ^a  

^a NEW YORK UNIVERSITY   (United States)

Author keywords

Alzheimer's disease; amyloid ; GSK3 ; GSK3 ; memory; signal transduction

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3;

ALZHEIMER DISEASE; HUMAN; LEARNING; MEMORY; NERVE CELL PLASTICITY; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

ALZHEIMER'S DISEASE; AMYLOID-Β; GSK3Α; GSK3Β; MEMORY; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; ANIMALS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; ISOENZYMES; SIGNAL TRANSDUCTION;

EID: 84896808522     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-131661     Document Type: Review

References (32)

1. Alzheimer's, Association (2013) 2013 Alzheimer's disease facts and figures. Alzheimers Dement 9, 208-245.
2. Holtzman DM, Morris JC, Goate AM (2011) Alzheimer's disease: The challenge of the second century. Sci Transl Med 3, 77sr71.
3. Embi N, Rylatt D, Cohen P (1980) Glycogen synthase kinase-3 from rabbit skeletal muscle. Separation from cyclic-AMP-dependent protein kinase and phosphorylase kinase. Eur J Biochem 107, 519-527.
4. Frame S, Cohen P (2001) GSK3 takes centre stage more than 20 years after its discovery. Biochem J 359, 1-16.
5. Jope RS, Johnson GVW (2004) The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci 29, 95-102.
6. King MK, Pardo M, Cheng Y, Downey K, Jope RS, Beurel E (2013) Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments. Pharmacol Ther, doi: 10.1016/j.pharmthera.2013.07.010.
7. Hooper C, Killick R, Lovestone S (2008) The GSK3 hypothesis of Alzheimer's disease. J Neurochem 104, 1433-1439.
8. Jo J, Whitcomb DJ, Olsen KM, Kerrigan TL, Lo S-C, Bru-Mercier G, Dickinson B, Scullion S, Sheng M, Collingridge G, Cho K (2011) Afj(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3fj. Nat Neurosci 14, 545-547.
9. Ma T, Tzavaras N, Tsokas P, Landau EM, Blitzer RD (2011) Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3. J Neurosci 31, 17537-17546.
10. Phiel CJ, Wilson CA, Lee VM-Y, Klein PS (2003) GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature 423, 435-439.
11. Kremer A, Louis JV, Jaworski T, Leuven FV (2011) GSK3 and Alzheimer's disease: Facts and fiction Front Mol Neurosci 4, 17.
12. Force T, Woodgett JR (2009) Unique and overlapping functions of GSK-3 isoforms in cell differentiation and proliferation and cardiovascular development. J Biol Chem 284, 9643-9647.
13. Kaidanovich-Beilin O, Woodgett JR (2011) GSK-3: Functional insights from cell biology and animal models. Front Mol Neurosci 4, 1-25.
14. Kerkela R, Kockeritz L, MacAulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS (2008) Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest 118, 3609-3618.
15. Hoeflich KP, Luo J, Rubie EA, Tsao M-S, Jin O, Woodgett JR (2000) Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation. Nature 406, 86-90.
16. MacAulay K, Doble BW, Patel S, Hansotia T, Sinclair EM, Drucker DJ, Nagy A, Woodget JR (2007) Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism. Cell Metab 6, 329-337.
17. Woodgett JR (1990) Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J 9, 2431-2438.
18. Pandey GN, Dwivedi Y, Rizavi HS, Teppen T, Gaszner GL, Roberts RC, Conley RR (2009) GSK-3beta gene expression in human postmortem brain: Regional distribution, effects of age and suicide. Neurochem Res 34, 274-285.
19. Yao H-B, Shaw P-C, Wong C-C, Wan DC-C (2002) Expression of glycogen synthase kinase-3 isoforms in mouse tissues and their transcription in the brain. J Chem Neuroanat 23, 291-297.
20. Perez-Costas E, Gandy JC, Melendez-Ferro M, Roberts RC, Bijur NG (2010) Light and electron microscopy study of glycogen synthase kinase-3beta in the mouse brain. PLoS One 5, e8911.
21. Soutar MPM, Kim W-Y, Williamson R, Peggie M, Hastie CJ, McLauchlan H, Snider WD, Gordon-Weeks PR, Sutherland C (2010) Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain. J Neurochem 115, 974-983.
22. Hur E-M, Zhou F-Q (2010) GSK3 signalling in neural development. Nat Rev Neurosci 11, 539-551.
23. Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JTR, Bor-tolotto ZA, Wang YT, Collingridge GL (2007) LTP inhibits LTD in the hippocampus via regulation of GSK3beta. Neuron 53, 703-717.
24. Malenka RC (2003) The long-term potential of LTP. Nat Rev Neurosci 4, 923-926.
25. Hernandez F, Borrell J, Guaza C, Avila J, Lucas JJ (2002) Spatial learning deficit in transgenic mice that conditionally over-express GSK-3beta in the brain but do not form tau filaments. J Neurochem 83, 1529-1533.
26. Terwel D, Muyllaert D, Dewachter I, Borghgraef P, Croes S, Devijver H, Leuven FV (2008) Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. Am J Pathol 172, 786-798.
27. Leroy K, Boutajangout A, Authelet M, Woodgett JR, Ander-ton BH, Brion J-P (2002) The active form of glycogen synthase kinase-3beta is associated with granulovacuolar degeneration in neurons in Alzheimer's disease. Acta Neu-ropathol 103, 91-99.
28. Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK (2010) Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease. PLoS One 5, e12845.
29. Fiorentini A, Rosi MC, Grossi C, Luccarini I, Casamenti F (2010) Lithium improves hippocampal neurogenesis, neuropathology and cognitive functions in APP mutant mice. PLoS One 5, e14382.
30. Hurtado DE, Molina-Porcel L, Carroll JC, MacDonald C, Aboagye AK, Trojanowski JQ, Lee VM-Y (2012) Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. J Neurosci 32, 7392-7402.
31. Ly PTT, Wu Y, Zou H, Wang R, Zhou W, Kinoshita A, Zhang M, Yang Y, Cai F, Woodgett J, Song W (2013) Inhibition of GSK3fj-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest 123, 224-235.
32. Jaworski T, Dewachter I, Lechat B, Gees M, Kremer A, Demedts D, Borghgraef P, Devijver H, Kügler S, Patel S, Woodgett JR, Leuven FV (2011) GSK-3a/fj kinases and amyloid production in vivo. Nature 480, E4-E5.