Isomerase Pin1 stimulates dephosphorylation of Tau protein at cyclin-dependent kinase (Cdk5)-dependent Alzheimer phosphorylation sites

Journal of Biological Chemistry

Volumn 288, Issue 11, 2013, Pages 7968-7977

  Kimura, Taeko ^a   Tsutsumi, Koji ^a   Taoka, Masato ^b   Saito, Taro ^a   Masuda Suzukake, Masami ^c   Ishiguro, Koichi ^d   Plattner, Florian ^e   Uchida, Takafumi ^f   Isobe, Toshiaki ^b   Hasegawa, Masato ^c   Hisanaga, Shin Ichi ^a  

^a Laboratory of Molecular Neuroscience   (Japan)

^b TOKYO METROPOLITAN UNIVERSITY   (Japan)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d MITSUBISHI KAGAKU INSTITUTE OF LIFE SCIENCES   (Japan)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f TOHOKU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN-DEPENDENT KINASE; FRONTOTEMPORAL DEMENTIAS; HYPERPHOSPHORYLATION; MICROTUBULE ASSOCIATED PROTEIN; NEUROFIBRILLARY TANGLES; PHOSPHORYLATION SITES; PROTEIN PHOSPHATASE 2A; TAU HYPERPHOSPHORYLATION;

BINDING SITES; DISEASE CONTROL; ENZYMES; PHOSPHORYLATION; PROTEINS;

NEURODEGENERATIVE DISEASES;

CYCLIN DEPENDENT KINASE 5; ISOPROTEIN; JUGLONE; PEPTIDYLPROLYL ISOMERASE PIN1; PHOSPHOPROTEIN PHOSPHATASE 2A; PROLINE; SERINE; TAU PROTEIN; THREONINE;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN DISEASE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EXON; FRONTOTEMPORAL DEMENTIA AND PARKINSONISM LINKED TO CHROMOSOME 17; HUMAN; HUMAN TISSUE; LIGAND BINDING; MOUSE; MUTANT; NEUROPATHOLOGY; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION;

ALZHEIMER DISEASE; ANIMALS; BASE SEQUENCE; BRAIN; CERCOPITHECUS AETHIOPS; COS CELLS; CYCLIN-DEPENDENT KINASE 5; HUMANS; KINETICS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDYLPROLYL ISOMERASE; PHOSPHORYLATION; PLASMIDS; PROTEIN BINDING; PROTEIN ISOFORMS; TAU PROTEINS; TAUOPATHIES;

EID: 84875179717     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.433326     Document Type: Article

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