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Volumn 6, Issue JAN, 2016, Pages

The macrophage switch in obesity development

Author keywords

Adipokines; Adipose tissue; Adipose tissue inflammation; Insulin resistance; Macrophage; Macrophage polarization; Obesity

Indexed keywords

CXCL9 CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERFERON REGULATORY FACTOR; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 23; INTERLEUKIN 6; PATHOGEN ASSOCIATED MOLECULAR PATTERN; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 84958225366     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2015.00637     Document Type: Review
Times cited : (414)

References (157)
  • 1
    • 0034611791 scopus 로고    scopus 로고
    • Obesity as a medical problem
    • Kopelman PG. Obesity as a medical problem. Nature (2000) 404:635-43. doi: 10.1038/35007508
    • (2000) Nature , vol.404 , pp. 635-643
    • Kopelman, P.G.1
  • 2
    • 0037223174 scopus 로고    scopus 로고
    • Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001
    • Mokdad AH, Ford ES, Bowman BA, Dietz WH, Vinicor F, Bales VS, et al. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA (2003) 289:76-9. doi:10.1001/jama.289.1.76
    • (2003) JAMA , vol.289 , pp. 76-79
    • Mokdad, A.H.1    Ford, E.S.2    Bowman, B.A.3    Dietz, W.H.4    Vinicor, F.5    Bales, V.S.6
  • 3
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science (1993) 259:87-91. doi:10.1126/science.7678183
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 4
    • 9144223683 scopus 로고    scopus 로고
    • Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
    • Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest (2003) 112:1821-30. doi:10.1172/JCI200319451
    • (2003) J Clin Invest , vol.112 , pp. 1821-1830
    • Xu, H.1    Barnes, G.T.2    Yang, Q.3    Tan, G.4    Yang, D.5    Chou, C.J.6
  • 5
    • 34250773451 scopus 로고    scopus 로고
    • Mechanisms of obesity-associated insulin resistance: many choices on the menu
    • Qatanani M, Lazar MA. Mechanisms of obesity-associated insulin resistance: many choices on the menu. Genes Dev (2007) 21:1443-55. doi:10.1101/gad.1550907
    • (2007) Genes Dev , vol.21 , pp. 1443-1455
    • Qatanani, M.1    Lazar, M.A.2
  • 6
    • 56749164791 scopus 로고    scopus 로고
    • Nutrient sensing and inflammation in metabolic diseases
    • Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol (2008) 8:923-34. doi:10.1038/nri2449
    • (2008) Nat Rev Immunol , vol.8 , pp. 923-934
    • Hotamisligil, G.S.1    Erbay, E.2
  • 7
    • 4444228888 scopus 로고    scopus 로고
    • WHO. World Health Organization. Obesity and Overweight, 2015 [Online] (2015). Available from: http://www.who.int/mediacentre/factsheets/fs311/en/
    • (2015) Obesity and Overweight, 2015
  • 8
    • 2942650969 scopus 로고    scopus 로고
    • Adipose tissue as an endocrine organ
    • Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab (2004) 89(6):2548-56. doi:10.1210/jc.2004-0395
    • (2004) J Clin Endocrinol Metab , vol.89 , Issue.6 , pp. 2548-2556
    • Kershaw, E.E.1    Flier, J.S.2
  • 9
    • 84928242180 scopus 로고    scopus 로고
    • Adipokines as drug targets in diabetes and underlying disturbances
    • Andrade-Oliveira V, Camara NO, Moraes-Vieira PM. Adipokines as drug targets in diabetes and underlying disturbances. J Diabetes Res (2015) 2015:681612. doi:10.1155/2015/681612
    • (2015) J Diabetes Res , vol.2015
    • Andrade-Oliveira, V.1    Camara, N.O.2    Moraes-Vieira, P.M.3
  • 10
    • 84864009689 scopus 로고    scopus 로고
    • Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant?
    • Moraes-Vieira PM, Bassi EJ, Araujo RC, Camara NO. Leptin as a link between the immune system and kidney-related diseases: leading actor or just a coadjuvant? Obes Rev (2012) 13:733-43. doi:10.1111/j.1467-789X.2012.00997.x
    • (2012) Obes Rev , vol.13 , pp. 733-743
    • Moraes-Vieira, P.M.1    Bassi, E.J.2    Araujo, R.C.3    Camara, N.O.4
  • 11
    • 0035159865 scopus 로고    scopus 로고
    • Insulin resistance: cellular and clinical concepts
    • Cefalu WT. Insulin resistance: cellular and clinical concepts. Exp Biol Med (Maywood) (2001) 226:13-26.
    • (2001) Exp Biol Med (Maywood) , vol.226 , pp. 13-26
    • Cefalu, W.T.1
  • 12
    • 80355133234 scopus 로고    scopus 로고
    • Macrophage-mediated inflammation in metabolic disease
    • Chawla A, Nguyen KD, Goh YP. Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol (2011) 11:738-49. doi:10.1038/nri3071
    • (2011) Nat Rev Immunol , vol.11 , pp. 738-749
    • Chawla, A.1    Nguyen, K.D.2    Goh, Y.P.3
  • 13
    • 84893663418 scopus 로고    scopus 로고
    • Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance
    • Lee BC, Lee J. Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance. Biochim Biophys Acta (2014) 1842:446-62. doi:10.1016/j.bbadis.2013.05.017
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 446-462
    • Lee, B.C.1    Lee, J.2
  • 14
    • 84899490570 scopus 로고    scopus 로고
    • Insulin resistance and hyperglycaemia in cardiovascular disease development
    • Laakso M, Kuusisto J. Insulin resistance and hyperglycaemia in cardiovascular disease development. Nat Rev Endocrinol (2014) 10:293-302. doi:10.1038/nrendo.2014.29
    • (2014) Nat Rev Endocrinol , vol.10 , pp. 293-302
    • Laakso, M.1    Kuusisto, J.2
  • 15
    • 33745216724 scopus 로고    scopus 로고
    • MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    • Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest (2006) 116:1494-505. doi:10.1172/JCI26498
    • (2006) J Clin Invest , vol.116 , pp. 1494-1505
    • Kanda, H.1    Tateya, S.2    Tamori, Y.3    Kotani, K.4    Hiasa, K.5    Kitazawa, R.6
  • 16
    • 84922569444 scopus 로고    scopus 로고
    • Lipid signaling in adipose tissue: connecting inflammation & metabolism
    • Masoodi M, Kuda O, Rossmeisl M, Flachs P, Kopecky J. Lipid signaling in adipose tissue: connecting inflammation & metabolism. Biochim Biophys Acta (2015) 1851:503-18. doi:10.1016/j.bbalip.2014.09.023
    • (2015) Biochim Biophys Acta , vol.1851 , pp. 503-518
    • Masoodi, M.1    Kuda, O.2    Rossmeisl, M.3    Flachs, P.4    Kopecky, J.5
  • 17
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest (2007) 117:175-84. doi:10.1172/JCI29881
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 18
    • 84890011257 scopus 로고    scopus 로고
    • Macrophages, fat, and the emergence of immunometabolism
    • Ferrante AW Jr. Macrophages, fat, and the emergence of immunometabolism. J Clin Invest (2013) 123:4992-3. doi:10.1172/JCI73658
    • (2013) J Clin Invest , vol.123 , pp. 4992-4993
    • Ferrante, A.W.1
  • 19
    • 84925873107 scopus 로고    scopus 로고
    • Immune regulation of metabolic homeostasis in health and disease
    • BrestoffJR, Artis D. Immune regulation of metabolic homeostasis in health and disease. Cell (2015) 161:146-60. doi:10.1016/j.cell.2015.02.022
    • (2015) Cell , vol.161 , pp. 146-160
    • Brestoff, J.R.1    Artis, D.2
  • 20
    • 0027972524 scopus 로고
    • Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance
    • Hofmann C, Lorenz K, Braithwaite SS, Colca JR, Palazuk BJ, Hotamisligil GS, et al. Altered gene expression for tumor necrosis factor-alpha and its receptors during drug and dietary modulation of insulin resistance. Endocrinology (1994) 134:264-70. doi:10.1210/en.134.1.264
    • (1994) Endocrinology , vol.134 , pp. 264-270
    • Hofmann, C.1    Lorenz, K.2    Braithwaite, S.S.3    Colca, J.R.4    Palazuk, B.J.5    Hotamisligil, G.S.6
  • 21
    • 0028031569 scopus 로고
    • Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha
    • Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest (1994) 94:1543-9. doi:10.1172/JCI117495
    • (1994) J Clin Invest , vol.94 , pp. 1543-1549
    • Hotamisligil, G.S.1    Budavari, A.2    Murray, D.3    Spiegelman, B.M.4
  • 22
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: a key component of the obesity-diabetes link
    • Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes (1994) 43:1271-8. doi:10.2337/diab.43.11.1271
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 24
  • 25
    • 44449124672 scopus 로고    scopus 로고
    • The secretory function of adipocytes in the physiology of white adipose tissue
    • Wang P, Mariman E, Renes J, Keijer J. The secretory function of adipocytes in the physiology of white adipose tissue. J Cell Physiol (2008) 216:3-13. doi:10.1002/jcp.21386
    • (2008) J Cell Physiol , vol.216 , pp. 3-13
    • Wang, P.1    Mariman, E.2    Renes, J.3    Keijer, J.4
  • 26
    • 77957838795 scopus 로고    scopus 로고
    • Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
    • Kosteli A, Sugaru E, Haemmerle G, Martin JF, Lei J, Zechner R, et al. Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest (2010) 120:3466-79. doi:10.1172/JCI42845
    • (2010) J Clin Invest , vol.120 , pp. 3466-3479
    • Kosteli, A.1    Sugaru, E.2    Haemmerle, G.3    Martin, J.F.4    Lei, J.5    Zechner, R.6
  • 27
    • 77951918926 scopus 로고    scopus 로고
    • Macrophages, inflammation, and insulin resistance
    • Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol (2010) 72:219-46. doi:10.1146/annurev-physiol-021909-135846
    • (2010) Annu Rev Physiol , vol.72 , pp. 219-246
    • Olefsky, J.M.1    Glass, C.K.2
  • 28
    • 63149088164 scopus 로고    scopus 로고
    • Trophic macrophages in development and disease
    • Pollard JW. Trophic macrophages in development and disease. Nat Rev Immunol (2009) 9:259-70. doi:10.1038/nri2528
    • (2009) Nat Rev Immunol , vol.9 , pp. 259-270
    • Pollard, J.W.1
  • 29
    • 0037851769 scopus 로고    scopus 로고
    • IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide
    • Yang F, Tang E, Guan K, Wang CY. IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide. J Immunol (2003) 170:5630-5. doi:10.4049/jimmunol.170.11.5630
    • (2003) J Immunol , vol.170 , pp. 5630-5635
    • Yang, F.1    Tang, E.2    Guan, K.3    Wang, C.Y.4
  • 30
    • 20044387026 scopus 로고    scopus 로고
    • IKK-beta links inflammation to obesity-induced insulin resistance
    • Arkan MC, Hevener AL, Greten FR, Maeda S, Li ZW, Long JM, et al. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med (2005) 11:191-8. doi:10.1038/nm1185
    • (2005) Nat Med , vol.11 , pp. 191-198
    • Arkan, M.C.1    Hevener, A.L.2    Greten, F.R.3    Maeda, S.4    Li, Z.W.5    Long, J.M.6
  • 31
    • 84889663497 scopus 로고    scopus 로고
    • Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation
    • Xu X, Grijalva A, Skowronski A, Van Eijk M, Serlie MJ, Ferrante AW Jr. Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation. Cell Metab (2013) 18:816-30. doi:10.1016/j.cmet.2013.11.001
    • (2013) Cell Metab , vol.18 , pp. 816-830
    • Xu, X.1    Grijalva, A.2    Skowronski, A.3    Van Eijk, M.4    Serlie, M.J.5    Ferrante, A.W.6
  • 32
    • 84872166765 scopus 로고    scopus 로고
    • Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis
    • Odegaard JI, Chawla A. Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis. Science (2013) 339:172-7. doi:10.1126/science.1230721
    • (2013) Science , vol.339 , pp. 172-177
    • Odegaard, J.I.1    Chawla, A.2
  • 33
    • 84876746655 scopus 로고    scopus 로고
    • Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages
    • Molofsky AB, Nussbaum JC, Liang HE, Van Dyken SJ, Cheng LE, Mohapatra A, et al. Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages. J Exp Med (2013) 210:535-49. doi:10.1084/jem.20121964
    • (2013) J Exp Med , vol.210 , pp. 535-549
    • Molofsky, A.B.1    Nussbaum, J.C.2    Liang, H.E.3    Van Dyken, S.J.4    Cheng, L.E.5    Mohapatra, A.6
  • 34
    • 84878785347 scopus 로고    scopus 로고
    • Immunological goings-on in visceral adipose tissue
    • Mathis D. Immunological goings-on in visceral adipose tissue. Cell Metab (2013) 17:851-9. doi:10.1016/j.cmet.2013.05.008
    • (2013) Cell Metab , vol.17 , pp. 851-859
    • Mathis, D.1
  • 35
    • 84928407438 scopus 로고    scopus 로고
    • Antigen-and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice
    • Kolodin D, Van Panhuys N, Li C, Magnuson AM, Cipolletta D, Miller CM, et al. Antigen-and cytokine-driven accumulation of regulatory T cells in visceral adipose tissue of lean mice. Cell Metab (2015) 21:543-57. doi:10.1016/j.cmet.2015.03.005
    • (2015) Cell Metab , vol.21 , pp. 543-557
    • Kolodin, D.1    Van Panhuys, N.2    Li, C.3    Magnuson, A.M.4    Cipolletta, D.5    Miller, C.M.6
  • 36
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol (2009) 27:451-83. doi:10.1146/annurev.immunol.021908.132532
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 37
    • 84907991703 scopus 로고    scopus 로고
    • Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages
    • Kratz M, Coats BR, Hisert KB, Hagman D, Mutskov V, Peris E, et al. Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages. Cell Metab (2014) 20:614-25. doi:10.1016/j.cmet.2014.08.010
    • (2014) Cell Metab , vol.20 , pp. 614-625
    • Kratz, M.1    Coats, B.R.2    Hisert, K.B.3    Hagman, D.4    Mutskov, V.5    Peris, E.6
  • 38
    • 7644231561 scopus 로고    scopus 로고
    • The chemokine system in diverse forms of macrophage activation and polarization
    • Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol (2004) 25:677-86. doi:10.1016/j.it.2004.09.015
    • (2004) Trends Immunol , vol.25 , pp. 677-686
    • Mantovani, A.1    Sica, A.2    Sozzani, S.3    Allavena, P.4    Vecchi, A.5    Locati, M.6
  • 40
  • 42
    • 84895741552 scopus 로고    scopus 로고
    • RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance
    • Moraes-Vieira PM, Yore MM, Dwyer PM, Syed I, Aryal P, Kahn BB. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab (2014) 19:512-26. doi:10.1016/j.cmet.2014.01.018
    • (2014) Cell Metab , vol.19 , pp. 512-526
    • Moraes-Vieira, P.M.1    Yore, M.M.2    Dwyer, P.M.3    Syed, I.4    Aryal, P.5    Kahn, B.B.6
  • 43
    • 84897019577 scopus 로고    scopus 로고
    • Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization
    • Cucak H, Grunnet LG, Rosendahl A. Accumulation of M1-like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization. J Leukoc Biol (2014) 95:149-60. doi:10.1189/jlb.0213075
    • (2014) J Leukoc Biol , vol.95 , pp. 149-160
    • Cucak, H.1    Grunnet, L.G.2    Rosendahl, A.3
  • 44
    • 33750813483 scopus 로고    scopus 로고
    • Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    • Martinez FO, Gordon S, Locati M, Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol (2006) 177:7303-11. doi:10.4049/jimmunol.177.10.7303
    • (2006) J Immunol , vol.177 , pp. 7303-7311
    • Martinez, F.O.1    Gordon, S.2    Locati, M.3    Mantovani, A.4
  • 45
  • 46
    • 84889632645 scopus 로고    scopus 로고
    • A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo
    • Arnold CE, Whyte CS, Gordon P, Barker RN, Rees AJ, Wilson HM. A critical role for suppressor of cytokine signalling 3 in promoting M1 macrophage activation and function in vitro and in vivo. Immunology (2014) 141:96-110. doi:10.1111/imm.12173
    • (2014) Immunology , vol.141 , pp. 96-110
    • Arnold, C.E.1    Whyte, C.S.2    Gordon, P.3    Barker, R.N.4    Rees, A.J.5    Wilson, H.M.6
  • 47
    • 0033968432 scopus 로고    scopus 로고
    • The role of nitric oxide in innate immunity
    • Bogdan C, RollinghoffM, Diefenbach A. The role of nitric oxide in innate immunity. Immunol Rev (2000) 173:17-26. doi:10.1034/j.1600-065X.2000.917307.x
    • (2000) Immunol Rev , vol.173 , pp. 17-26
    • Bogdan, C.1    Rollinghoff, M.2    Diefenbach, A.3
  • 48
    • 33750374586 scopus 로고    scopus 로고
    • Role of nitric oxide in the regulation of T cell functions
    • Niedbala W, Cai B, Liew FY. Role of nitric oxide in the regulation of T cell functions. Ann Rheum Dis (2006) 65(Suppl 3):iii37-40. doi:10.1136/ard.2006.058446
    • (2006) Ann Rheum Dis , vol.65 , pp. iii37-iii40
    • Niedbala, W.1    Cai, B.2    Liew, F.Y.3
  • 49
    • 84869128422 scopus 로고    scopus 로고
    • MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages
    • Braga TT, Correa-Costa M, Guise YF, Castoldi A, De Oliveira CD, Hyane MI, et al. MyD88 signaling pathway is involved in renal fibrosis by favoring a TH2 immune response and activating alternative M2 macrophages. Mol Med (2012) 18:1231-9. doi:10.2119/molmed.2012.00131
    • (2012) Mol Med , vol.18 , pp. 1231-1239
    • Braga, T.T.1    Correa-Costa, M.2    Guise, Y.F.3    Castoldi, A.4    De Oliveira, C.D.5    Hyane, M.I.6
  • 50
    • 84919457872 scopus 로고    scopus 로고
    • Molecular mechanisms that influence the macrophage m1-m2 polarization balance
    • Wang N, Liang H, Zen K. Molecular mechanisms that influence the macrophage m1-m2 polarization balance. Front Immunol (2014) 5:614. doi:10.3389/fimmu.2014.00614
    • (2014) Front Immunol , vol.5 , pp. 614
    • Wang, N.1    Liang, H.2    Zen, K.3
  • 51
    • 84868026167 scopus 로고    scopus 로고
    • Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages
    • Orr JS, Puglisi MJ, Ellacott KL, Lumeng CN, Wasserman DH, Hasty AH. Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes (2012) 61:2718-27. doi:10.2337/db11-1595
    • (2012) Diabetes , vol.61 , pp. 2718-2727
    • Orr, J.S.1    Puglisi, M.J.2    Ellacott, K.L.3    Lumeng, C.N.4    Wasserman, D.H.5    Hasty, A.H.6
  • 52
    • 70350560546 scopus 로고    scopus 로고
    • Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
    • Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, Kanatani Y, et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes (2009) 58:2574-82. doi:10.2337/db08-1475
    • (2009) Diabetes , vol.58 , pp. 2574-2582
    • Fujisaka, S.1    Usui, I.2    Bukhari, A.3    Ikutani, M.4    Oya, T.5    Kanatani, Y.6
  • 53
    • 77951822653 scopus 로고    scopus 로고
    • Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice
    • Shaul ME, Bennett G, Strissel KJ, Greenberg AS, Obin MS. Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice. Diabetes (2010) 59:1171-81. doi:10.2337/db09-1402
    • (2010) Diabetes , vol.59 , pp. 1171-1181
    • Shaul, M.E.1    Bennett, G.2    Strissel, K.J.3    Greenberg, A.S.4    Obin, M.S.5
  • 54
    • 84856533216 scopus 로고    scopus 로고
    • Increased macrophage migration into adipose tissue in obese mice
    • Oh DY, Morinaga H, Talukdar S, Bae EJ, Olefsky JM. Increased macrophage migration into adipose tissue in obese mice. Diabetes (2012) 61:346-54. doi:10.2337/db11-0860
    • (2012) Diabetes , vol.61 , pp. 346-354
    • Oh, D.Y.1    Morinaga, H.2    Talukdar, S.3    Bae, E.J.4    Olefsky, J.M.5
  • 55
  • 56
    • 84863223829 scopus 로고    scopus 로고
    • CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status
    • Kitade H, Sawamoto K, Nagashimada M, Inoue H, Yamamoto Y, Sai Y, et al. CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Diabetes (2012) 61:1680-90. doi:10.2337/db11-1506
    • (2012) Diabetes , vol.61 , pp. 1680-1690
    • Kitade, H.1    Sawamoto, K.2    Nagashimada, M.3    Inoue, H.4    Yamamoto, Y.5    Sai, Y.6
  • 58
    • 84891890600 scopus 로고    scopus 로고
    • Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation
    • Amano SU, Cohen JL, Vangala P, Tencerova M, Nicoloro SM, Yawe JC, et al. Local proliferation of macrophages contributes to obesity-associated adipose tissue inflammation. Cell Metab (2014) 19:162-71. doi:10.1016/j.cmet.2013.11.017
    • (2014) Cell Metab , vol.19 , pp. 162-171
    • Amano, S.U.1    Cohen, J.L.2    Vangala, P.3    Tencerova, M.4    Nicoloro, S.M.5    Yawe, J.C.6
  • 59
    • 4243150843 scopus 로고    scopus 로고
    • The role of TNF-alpha in insulin resistance
    • Borst SE. The role of TNF-alpha in insulin resistance. Endocrine (2004) 23(2-3):177. doi:10.1385/ENDO
    • (2004) Endocrine , vol.23 , Issue.2-3 , pp. 177
    • Borst, S.E.1
  • 60
    • 3242889982 scopus 로고    scopus 로고
    • Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women
    • Maachi M, Pieroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, et al. Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women. Int J Obes Relat Metab Disord (2004) 28:993-7. doi:10.1038/sj.ijo.0802718
    • (2004) Int J Obes Relat Metab Disord , vol.28 , pp. 993-997
    • Maachi, M.1    Pieroni, L.2    Bruckert, E.3    Jardel, C.4    Fellahi, S.5    Hainque, B.6
  • 61
    • 77955362775 scopus 로고    scopus 로고
    • Chronic inflammation in obesity and the metabolic syndrome
    • Monteiro R, Azevedo I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm (2010) 2010:289645. doi:10.1155/2010/289645
    • (2010) Mediators Inflamm , vol.2010
    • Monteiro, R.1    Azevedo, I.2
  • 62
  • 63
    • 0028342686 scopus 로고
    • Mechanisms of fatty acid-induced inhibition of glucose uptake
    • Boden G, Chen X, Ruiz J, White JV, Rossetti L. Mechanisms of fatty acid-induced inhibition of glucose uptake. J Clin Invest (1994) 93:2438-46. doi:10.1172/JCI117252
    • (1994) J Clin Invest , vol.93 , pp. 2438-2446
    • Boden, G.1    Chen, X.2    Ruiz, J.3    White, J.V.4    Rossetti, L.5
  • 64
    • 50449086746 scopus 로고    scopus 로고
    • Obesity and free fatty acids
    • viii-ix
    • Boden G. Obesity and free fatty acids. Endocrinol Metab Clin North Am (2008) 37:635-646, viii-ix. doi:10.1016/j.ecl.2008.06.007
    • (2008) Endocrinol Metab Clin North Am , vol.37 , pp. 635-646
    • Boden, G.1
  • 65
    • 84872142459 scopus 로고    scopus 로고
    • JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation
    • Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, et al. JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science (2013) 339:218-22. doi:10.1126/science.1227568
    • (2013) Science , vol.339 , pp. 218-222
    • Han, M.S.1    Jung, D.Y.2    Morel, C.3    Lakhani, S.A.4    Kim, J.K.5    Flavell, R.A.6
  • 66
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
    • Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, et al. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem (2002) 277:48115-21. doi:10.1074/jbc. M209459200
    • (2002) J Biol Chem , vol.277 , pp. 48115-48121
    • Gao, Z.1    Hwang, D.2    Bataille, F.3    Lefevre, M.4    York, D.5    Quon, M.J.6
  • 68
    • 0037341276 scopus 로고    scopus 로고
    • Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression
    • Carlson CJ, Koterski S, Sciotti RJ, Poccard GB, Rondinone CM. Enhanced basal activation of mitogen-activated protein kinases in adipocytes from type 2 diabetes: potential role of p38 in the downregulation of GLUT4 expression. Diabetes (2003) 52:634-41. doi:10.2337/diabetes.52.3.634
    • (2003) Diabetes , vol.52 , pp. 634-641
    • Carlson, C.J.1    Koterski, S.2    Sciotti, R.J.3    Poccard, G.B.4    Rondinone, C.M.5
  • 69
    • 0037153158 scopus 로고    scopus 로고
    • A central role for JNK in obesity and insulin resistance
    • Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, et al. A central role for JNK in obesity and insulin resistance. Nature (2002) 420:333-6. doi:10.1038/nature01137
    • (2002) Nature , vol.420 , pp. 333-336
    • Hirosumi, J.1    Tuncman, G.2    Chang, L.3    Gorgun, C.Z.4    Uysal, K.T.5    Maeda, K.6
  • 70
    • 0036470213 scopus 로고    scopus 로고
    • Insulin signaling pathways in time and space
    • Saltiel AR, Pessin JE. Insulin signaling pathways in time and space. Trends Cell Biol (2002) 12:65-71. doi:10.1016/S0962-8924(01)02207-3
    • (2002) Trends Cell Biol , vol.12 , pp. 65-71
    • Saltiel, A.R.1    Pessin, J.E.2
  • 72
    • 33845873659 scopus 로고    scopus 로고
    • Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
    • Jager J, Gremeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF. Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology (2007) 148:241-51. doi:10.1210/en.2006-0692
    • (2007) Endocrinology , vol.148 , pp. 241-251
    • Jager, J.1    Gremeaux, T.2    Cormont, M.3    Le Marchand-Brustel, Y.4    Tanti, J.F.5
  • 73
    • 33746101818 scopus 로고    scopus 로고
    • Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
    • Tuncman G, Hirosumi J, Solinas G, Chang L, Karin M, Hotamisligil GS. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc Natl Acad Sci U S A (2006) 103:10741-6. doi:10.1073/pnas.0603509103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10741-10746
    • Tuncman, G.1    Hirosumi, J.2    Solinas, G.3    Chang, L.4    Karin, M.5    Hotamisligil, G.S.6
  • 74
    • 35548943962 scopus 로고    scopus 로고
    • JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
    • Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, et al. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab (2007) 6:386-97. doi:10.1016/j.cmet.2007.09.011
    • (2007) Cell Metab , vol.6 , pp. 386-397
    • Solinas, G.1    Vilcu, C.2    Neels, J.G.3    Bandyopadhyay, G.K.4    Luo, J.L.5    Naugler, W.6
  • 75
    • 52349105273 scopus 로고    scopus 로고
    • A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
    • Vallerie SN, Furuhashi M, Fucho R, Hotamisligil GS. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS One (2008) 3:e3151. doi:10.1371/journal.pone.0003151
    • (2008) PLoS One , vol.3
    • Vallerie, S.N.1    Furuhashi, M.2    Fucho, R.3    Hotamisligil, G.S.4
  • 76
    • 67650604595 scopus 로고    scopus 로고
    • The role of the gut microbiota in energy metabolism and metabolic disease
    • Cani PD, Delzenne NM. The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des (2009) 15:1546-58. doi:10.2174/138161209788168164
    • (2009) Curr Pharm Des , vol.15 , pp. 1546-1558
    • Cani, P.D.1    Delzenne, N.M.2
  • 77
    • 77951260924 scopus 로고    scopus 로고
    • The role of pattern-recognition receptors in innate immunity: update on toll-like receptors
    • Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on toll-like receptors. Nat Immunol (2010) 11:373-84. doi:10.1038/ni.1863
    • (2010) Nat Immunol , vol.11 , pp. 373-384
    • Kawai, T.1    Akira, S.2
  • 78
    • 84355166655 scopus 로고    scopus 로고
    • Gut microbiota and diabetes: from pathogenesis to therapeutic perspective
    • Burcelin R, Serino M, Chabo C, Blasco-Baque V, Amar J. Gut microbiota and diabetes: from pathogenesis to therapeutic perspective. Acta Diabetol (2011) 48:257-73. doi:10.1007/s00592-011-0333-6
    • (2011) Acta Diabetol , vol.48 , pp. 257-273
    • Burcelin, R.1    Serino, M.2    Chabo, C.3    Blasco-Baque, V.4    Amar, J.5
  • 79
    • 84861098748 scopus 로고    scopus 로고
    • The role of toll-like receptors in diabetes-induced inflammation: implications for vascular complications
    • Jialal I, Kaur H. The role of toll-like receptors in diabetes-induced inflammation: implications for vascular complications. Curr Diab Rep (2012) 12:172-9. doi:10.1007/s11892-012-0258-7
    • (2012) Curr Diab Rep , vol.12 , pp. 172-179
    • Jialal, I.1    Kaur, H.2
  • 80
    • 84861403641 scopus 로고    scopus 로고
    • Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase-and toll-like receptor 4-dependent and retinol-independent mechanism
    • Norseen J, Hosooka T, Hammarstedt A, Yore MM, Kant S, Aryal P, et al. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase-and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol (2012) 32:2010-9. doi:10.1128/MCB.06193-11
    • (2012) Mol Cell Biol , vol.32 , pp. 2010-2019
    • Norseen, J.1    Hosooka, T.2    Hammarstedt, A.3    Yore, M.M.4    Kant, S.5    Aryal, P.6
  • 81
    • 0036222241 scopus 로고    scopus 로고
    • TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages
    • Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, Zhang S, et al. TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol (2002) 3:392-8. doi:10.1038/ni774
    • (2002) Nat Immunol , vol.3 , pp. 392-398
    • Toshchakov, V.1    Jones, B.W.2    Perera, P.Y.3    Thomas, K.4    Cody, M.J.5    Zhang, S.6
  • 82
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med (2011) 17:179-88. doi:10.1038/nm.2279
    • (2011) Nat Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3    Galgani, J.E.4    Stadler, K.5    Mynatt, R.L.6
  • 83
    • 33750584214 scopus 로고    scopus 로고
    • TLR4 links innate immunity and fatty acid-induced insulin resistance
    • Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest (2006) 116:3015-25. doi:10.1172/JCI28898
    • (2006) J Clin Invest , vol.116 , pp. 3015-3025
    • Shi, H.1    Kokoeva, M.V.2    Inouye, K.3    Tzameli, I.4    Yin, H.5    Flier, J.S.6
  • 84
    • 84919457872 scopus 로고    scopus 로고
    • Molecular mechanisms that influence the macrophage M1-M2 polarization balance
    • Nanwang H, Liang H, Zen K. Molecular mechanisms that influence the macrophage M1-M2 polarization balance. Front Immunol (2014) 5:614. doi:10.3389/fimmu.2014.00614
    • (2014) Front Immunol , vol.5 , pp. 614
    • Nanwang, H.1    Liang, H.2    Zen, K.3
  • 85
    • 34547602916 scopus 로고    scopus 로고
    • Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    • Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, et al. Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes (2007) 56:1986-98. doi:10.2337/db06-1595
    • (2007) Diabetes , vol.56 , pp. 1986-1998
    • Tsukumo, D.M.1    Carvalho-Filho, M.A.2    Carvalheira, J.B.3    Prada, P.O.4    Hirabara, S.M.5    Schenka, A.A.6
  • 86
    • 79959267977 scopus 로고    scopus 로고
    • Toll-like receptors, inflammation, metabolism and obesity
    • Fresno M, Alvarez R, Cuesta N. Toll-like receptors, inflammation, metabolism and obesity. Arch Physiol Biochem (2011) 117:151-64. doi:10.3109/13813455.2011.562514
    • (2011) Arch Physiol Biochem , vol.117 , pp. 151-164
    • Fresno, M.1    Alvarez, R.2    Cuesta, N.3
  • 87
    • 44449110675 scopus 로고    scopus 로고
    • Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
    • Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) (2008) 16:1248-55. doi:10.1038/oby.2008.210
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1248-1255
    • Davis, J.E.1    Gabler, N.K.2    Walker-Daniels, J.3    Spurlock, M.E.4
  • 88
    • 84860555433 scopus 로고    scopus 로고
    • The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation
    • Watanabe Y, Nakamura T, Ishikawa S, Fujisaka S, Usui I, Tsuneyama K, et al. The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. Diabetes (2012) 61:1199-209. doi:10.2337/db11-1182
    • (2012) Diabetes , vol.61 , pp. 1199-1209
    • Watanabe, Y.1    Nakamura, T.2    Ishikawa, S.3    Fujisaka, S.4    Usui, I.5    Tsuneyama, K.6
  • 89
    • 84858630049 scopus 로고    scopus 로고
    • A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation?
    • Wen H, Ting JP, O'neill LA. A role for the NLRP3 inflammasome in metabolic diseases-did Warburg miss inflammation? Nat Immunol (2012) 13:352-7. doi:10.1038/ni.2228
    • (2012) Nat Immunol , vol.13 , pp. 352-357
    • Wen, H.1    Ting, J.P.2    O'neill, L.A.3
  • 90
    • 78649498271 scopus 로고    scopus 로고
    • The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
    • Stienstra R, Joosten LA, Koenen T, Van Tits B, Van Diepen JA, Van Den Berg SA, et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab (2010) 12:593-605. doi:10.1016/j.cmet.2010.11.011
    • (2010) Cell Metab , vol.12 , pp. 593-605
    • Stienstra, R.1    Joosten, L.A.2    Koenen, T.3    Van Tits, B.4    Van Diepen, J.A.5    Van Den Berg, S.A.6
  • 91
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT, et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol (2011) 12:408-15. doi:10.1038/ni.2022
    • (2011) Nat Immunol , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3    Jha, S.4    Zhang, L.5    Huang, M.T.6
  • 92
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol (2010) 11:136-40. doi:10.1038/ni.1831
    • (2010) Nat Immunol , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 93
    • 79952104568 scopus 로고    scopus 로고
    • mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
    • Howell JJ, Manning BD. mTOR couples cellular nutrient sensing to organismal metabolic homeostasis. Trends Endocrinol Metab (2011) 22:94-102. doi:10.1016/j.tem.2010.12.003
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 94-102
    • Howell, J.J.1    Manning, B.D.2
  • 94
    • 84859778293 scopus 로고    scopus 로고
    • mTOR signaling in growth control and disease
    • Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell (2012) 149:274-93. doi:10.1016/j.cell.2012.03.017
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 95
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 4:648-57. doi:10.1038/ncb839
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 96
    • 0036342294 scopus 로고    scopus 로고
    • Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
    • Manning BD, Tee AR, Logsdon MN, Blenis J, Cantley LC. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 10:151-62. doi:10.1016/S1097-2765(02)00568-3
    • (2002) Mol Cell , vol.10 , pp. 151-162
    • Manning, B.D.1    Tee, A.R.2    Logsdon, M.N.3    Blenis, J.4    Cantley, L.C.5
  • 97
    • 80054811005 scopus 로고    scopus 로고
    • PI3Kgamma within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance
    • Becattini B, Marone R, Zani F, Arsenijevic D, Seydoux J, Montani JP, et al. PI3Kgamma within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance. Proc Natl Acad Sci U S A (2011) 108:E854-63. doi:10.1073/pnas.1106698108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. E854-E863
    • Becattini, B.1    Marone, R.2    Zani, F.3    Arsenijevic, D.4    Seydoux, J.5    Montani, J.P.6
  • 98
    • 79955012753 scopus 로고    scopus 로고
    • Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance
    • Kobayashi N, Ueki K, Okazaki Y, Iwane A, Kubota N, Ohsugi M, et al. Blockade of class IB phosphoinositide-3 kinase ameliorates obesity-induced inflammation and insulin resistance. Proc Natl Acad Sci U S A (2011) 108:5753-8. doi:10.1073/pnas.1016430108
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 5753-5758
    • Kobayashi, N.1    Ueki, K.2    Okazaki, Y.3    Iwane, A.4    Kubota, N.5    Ohsugi, M.6
  • 99
    • 84919965563 scopus 로고    scopus 로고
    • Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice
    • Jiang H, Westerterp M, Wang C, Zhu Y, Ai D. Macrophage mTORC1 disruption reduces inflammation and insulin resistance in obese mice. Diabetologia (2014) 57:2393-404. doi:10.1007/s00125-014-3350-5
    • (2014) Diabetologia , vol.57 , pp. 2393-2404
    • Jiang, H.1    Westerterp, M.2    Wang, C.3    Zhu, Y.4    Ai, D.5
  • 100
    • 84937513657 scopus 로고    scopus 로고
    • mTORC1-Induced HK1-dependent glycolysis regulates nlrp3 inflammasome activation
    • Moon JS, Hisata S, Park MA, Denicola GM, Ryter SW, Nakahira K, et al. mTORC1-Induced HK1-dependent glycolysis regulates nlrp3 inflammasome activation. Cell Rep (2015) 12:102-15. doi:10.1016/j.celrep.2015.05.046
    • (2015) Cell Rep , vol.12 , pp. 102-115
    • Moon, J.S.1    Hisata, S.2    Park, M.A.3    Denicola, G.M.4    Ryter, S.W.5    Nakahira, K.6
  • 102
    • 84907363576 scopus 로고    scopus 로고
    • TSC1 controls macrophage polarization to prevent inflammatory disease
    • Zhu L, Yang T, Li L, Sun L, Hou Y, Hu X, et al. TSC1 controls macrophage polarization to prevent inflammatory disease. Nat Commun (2014) 5:4696. doi:10.1038/ncomms5696
    • (2014) Nat Commun , vol.5 , pp. 4696
    • Zhu, L.1    Yang, T.2    Li, L.3    Sun, L.4    Hou, Y.5    Hu, X.6
  • 103
    • 84880617814 scopus 로고    scopus 로고
    • Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
    • Fabbrini E, Cella M, McCartney SA, Fuchs A, Abumrad NA, Pietka TA, et al. Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology (2013) 145:.e361-3. doi:10.1053/j.gastro.2013.04.010
    • (2013) Gastroenterology , vol.145 , pp. e361-e363
    • Fabbrini, E.1    Cella, M.2    McCartney, S.A.3    Fuchs, A.4    Abumrad, N.A.5    Pietka, T.A.6
  • 104
    • 84875883411 scopus 로고    scopus 로고
    • Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet
    • Stolarczyk E, Vong CT, Perucha E, Jackson I, Cawthorne MA, Wargent ET, et al. Improved insulin sensitivity despite increased visceral adiposity in mice deficient for the immune cell transcription factor T-bet. Cell Metab (2013) 17:520-33. doi:10.1016/j.cmet.2013.02.019
    • (2013) Cell Metab , vol.17 , pp. 520-533
    • Stolarczyk, E.1    Vong, C.T.2    Perucha, E.3    Jackson, I.4    Cawthorne, M.A.5    Wargent, E.T.6
  • 105
    • 84901367595 scopus 로고    scopus 로고
    • T cell-derived IL-22 amplifies IL-1beta-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes
    • Dalmas E, Venteclef N, Caer C, Poitou C, Cremer I, Aron-Wisnewsky J, et al. T cell-derived IL-22 amplifies IL-1beta-driven inflammation in human adipose tissue: relevance to obesity and type 2 diabetes. Diabetes (2014) 63:1966-77. doi:10.2337/db13-1511
    • (2014) Diabetes , vol.63 , pp. 1966-1977
    • Dalmas, E.1    Venteclef, N.2    Caer, C.3    Poitou, C.4    Cremer, I.5    Aron-Wisnewsky, J.6
  • 106
    • 84896267299 scopus 로고    scopus 로고
    • Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency
    • Khan IM, Dai Perrard XY, Perrard JL, Mansoori A, Smith CW, Wu H, et al. Attenuated adipose tissue and skeletal muscle inflammation in obese mice with combined CD4+ and CD8+ T cell deficiency. Atherosclerosis (2014) 233:419-28. doi:10.1016/j.atherosclerosis.2014.01.011
    • (2014) Atherosclerosis , vol.233 , pp. 419-428
    • Khan, I.M.1    Dai Perrard, X.Y.2    Perrard, J.L.3    Mansoori, A.4    Smith, C.W.5    Wu, H.6
  • 107
    • 79952985551 scopus 로고    scopus 로고
    • The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
    • Delgoffe GM, Pollizzi KN, Waickman AT, Heikamp E, Meyers DJ, Horton MR, et al. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol (2011) 12:295-303. doi:10.1038/ni.2005
    • (2011) Nat Immunol , vol.12 , pp. 295-303
    • Delgoffe, G.M.1    Pollizzi, K.N.2    Waickman, A.T.3    Heikamp, E.4    Meyers, D.J.5    Horton, M.R.6
  • 108
    • 84871719656 scopus 로고    scopus 로고
    • Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected]
    • Moraes-Vieira PM, Bassi EJ, Larocca RA, Castoldi A, Burghos M, Lepique AP, et al. Leptin deficiency modulates allograft survival by favoring a Th2 and a regulatory immune profile. [corrected]. Am J Transplant (2013) 13:36-44. doi:10.1111/j.1600-6143.2012.04283.x
    • (2013) Am J Transplant , vol.13 , pp. 36-44
    • Moraes-Vieira, P.M.1    Bassi, E.J.2    Larocca, R.A.3    Castoldi, A.4    Burghos, M.5    Lepique, A.P.6
  • 109
    • 84911164076 scopus 로고    scopus 로고
    • A decade of progress in adipose tissue macrophage biology
    • Hill AA, Reid Bolus W, Hasty AH. A decade of progress in adipose tissue macrophage biology. Immunol Rev (2014) 262:134-52. doi:10.1111/imr.12216
    • (2014) Immunol Rev , vol.262 , pp. 134-152
    • Hill, A.A.1    Reid Bolus, W.2    Hasty, A.H.3
  • 110
    • 84871076444 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization in tissue repair and remodelling
    • Mantovani A, Biswas SK, Galdiero MR, Sica A, Locati M. Macrophage plasticity and polarization in tissue repair and remodelling. J Pathol (2013) 229:176-85. doi:10.1002/path.4133
    • (2013) J Pathol , vol.229 , pp. 176-185
    • Mantovani, A.1    Biswas, S.K.2    Galdiero, M.R.3    Sica, A.4    Locati, M.5
  • 111
    • 77953493182 scopus 로고    scopus 로고
    • Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages
    • Fuentes L, Roszer T, Ricote M. Inflammatory mediators and insulin resistance in obesity: role of nuclear receptor signaling in macrophages. Mediators Inflamm (2010) 2010:219583. doi:10.1155/2010/219583
    • (2010) Mediators Inflamm , vol.2010
    • Fuentes, L.1    Roszer, T.2    Ricote, M.3
  • 112
    • 84926638214 scopus 로고    scopus 로고
    • Complement, c1q, and c1q-related molecules regulate macrophage polarization
    • Bohlson SS, O'conner SD, Hulsebus HJ, Ho MM, Fraser DA. Complement, c1q, and c1q-related molecules regulate macrophage polarization. Front Immunol (2014) 5:402. doi:10.3389/fimmu.2014.00402
    • (2014) Front Immunol , vol.5 , pp. 402
    • Bohlson, S.S.1    O'conner, S.D.2    Hulsebus, H.J.3    Ho, M.M.4    Fraser, D.A.5
  • 113
    • 0035903306 scopus 로고    scopus 로고
    • Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)
    • Lee CG, Homer RJ, Zhu Z, Lanone S, Wang X, Koteliansky V, et al. Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1). J Exp Med (2001) 194:809-21. doi:10.1084/jem.194.6.809
    • (2001) J Exp Med , vol.194 , pp. 809-821
    • Lee, C.G.1    Homer, R.J.2    Zhu, Z.3    Lanone, S.4    Wang, X.5    Koteliansky, V.6
  • 114
    • 77955412821 scopus 로고    scopus 로고
    • Heme oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release
    • Sierra-Filardi E, Vega MA, Sanchez-Mateos P, Corbi AL, Puig-Kroger A. Heme oxygenase-1 expression in M-CSF-polarized M2 macrophages contributes to LPS-induced IL-10 release. Immunobiology (2010) 215:788-95. doi:10.1016/j.imbio.2010.05.020
    • (2010) Immunobiology , vol.215 , pp. 788-795
    • Sierra-Filardi, E.1    Vega, M.A.2    Sanchez-Mateos, P.3    Corbi, A.L.4    Puig-Kroger, A.5
  • 115
    • 78649652068 scopus 로고    scopus 로고
    • Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation
    • Spencer M, Yao-Borengasser A, Unal R, Rasouli N, Gurley CM, Zhu B, et al. Adipose tissue macrophages in insulin-resistant subjects are associated with collagen VI and fibrosis and demonstrate alternative activation. Am J Physiol Endocrinol Metab (2010) 299:E1016-27. doi:10.1152/ajpendo.00329.2010
    • (2010) Am J Physiol Endocrinol Metab , vol.299 , pp. E1016-E1027
    • Spencer, M.1    Yao-Borengasser, A.2    Unal, R.3    Rasouli, N.4    Gurley, C.M.5    Zhu, B.6
  • 116
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 8:958-69. doi:10.1038/nri2448
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 117
    • 84929161751 scopus 로고    scopus 로고
    • The PPAR-gamma antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-gamma in human macrophage polarization
    • Zizzo G, Cohen PL. The PPAR-gamma antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: a key role for PPAR-gamma in human macrophage polarization. J Inflamm (Lond) (2015) 12:36. doi:10.1186/s12950-015-0081-4
    • (2015) J Inflamm (Lond) , vol.12 , pp. 36
    • Zizzo, G.1    Cohen, P.L.2
  • 118
    • 58149347227 scopus 로고    scopus 로고
    • Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
    • Lumeng CN, Delproposto JB, Westcott DJ, Saltiel AR. Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes (2008) 57:3239-46. doi:10.2337/db08-0872
    • (2008) Diabetes , vol.57 , pp. 3239-3246
    • Lumeng, C.N.1    Delproposto, J.B.2    Westcott, D.J.3    Saltiel, A.R.4
  • 119
    • 79953815551 scopus 로고    scopus 로고
    • Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis
    • Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, et al. Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science (2011) 332:243-7. doi:10.1126/science.1201475
    • (2011) Science , vol.332 , pp. 243-247
    • Wu, D.1    Molofsky, A.B.2    Liang, H.E.3    Ricardo-Gonzalez, R.R.4    Jouihan, H.A.5    Bando, J.K.6
  • 120
    • 84902094655 scopus 로고    scopus 로고
    • Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat
    • Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, et al. Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell (2014) 157:1292-308. doi:10.1016/j.cell.2014.03.066
    • (2014) Cell , vol.157 , pp. 1292-1308
    • Qiu, Y.1    Nguyen, K.D.2    Odegaard, J.I.3    Cui, X.4    Tian, X.5    Locksley, R.M.6
  • 121
    • 84908037199 scopus 로고    scopus 로고
    • Inflammation and macrophage modulation in adipose tissues
    • Vieira-Potter VJ. Inflammation and macrophage modulation in adipose tissues. Cell Microbiol (2014) 16:1484-92. doi:10.1111/cmi.12336
    • (2014) Cell Microbiol , vol.16 , pp. 1484-1492
    • Vieira-Potter, V.J.1
  • 122
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, Nayer A, et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med (2009) 15:930-9. doi:10.1038/nm.2002
    • (2009) Nat Med , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4    Wong, J.5    Nayer, A.6
  • 123
    • 82755182907 scopus 로고    scopus 로고
    • Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism
    • Cipolletta D, Kolodin D, Benoist C, Mathis D. Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. Semin Immunol (2011) 23:431-7. doi:10.1016/j.smim.2011.06.002
    • (2011) Semin Immunol , vol.23 , pp. 431-437
    • Cipolletta, D.1    Kolodin, D.2    Benoist, C.3    Mathis, D.4
  • 124
    • 78651062856 scopus 로고    scopus 로고
    • Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice
    • Liu G, Ma H, Qiu L, Li L, Cao Y, Ma J, et al. Phenotypic and functional switch of macrophages induced by regulatory CD4+CD25+ T cells in mice. Immunol Cell Biol (2011) 89:130-42. doi:10.1038/icb.2010.70
    • (2011) Immunol Cell Biol , vol.89 , pp. 130-142
    • Liu, G.1    Ma, H.2    Qiu, L.3    Li, L.4    Cao, Y.5    Ma, J.6
  • 125
    • 84859384082 scopus 로고    scopus 로고
    • Innate lymphoid cells: emerging insights in development, lineage relationships, and function
    • Spits H, Cupedo T. Innate lymphoid cells: emerging insights in development, lineage relationships, and function. Annu Rev Immunol (2012) 30:647-75. doi:10.1146/annurev-immunol-020711-075053
    • (2012) Annu Rev Immunol , vol.30 , pp. 647-675
    • Spits, H.1    Cupedo, T.2
  • 126
    • 84889100314 scopus 로고    scopus 로고
    • Innate lymphoid cells and allergic inflammation
    • Kim BS, Wojno ED, Artis D. Innate lymphoid cells and allergic inflammation. Curr Opin Immunol (2013) 25:738-44. doi:10.1016/j.coi.2013.07.013
    • (2013) Curr Opin Immunol , vol.25 , pp. 738-744
    • Kim, B.S.1    Wojno, E.D.2    Artis, D.3
  • 128
    • 84930454789 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells in health and disease
    • Kim BS, Artis D. Group 2 innate lymphoid cells in health and disease. Cold Spring Harb Perspect Biol (2015) 7:a016337. doi:10.1101/cshperspect.a016337
    • (2015) Cold Spring Harb Perspect Biol , vol.7
    • Kim, B.S.1    Artis, D.2
  • 129
    • 75749122181 scopus 로고    scopus 로고
    • Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
    • Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, Kawamoto H, et al. Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature (2010) 463:540-4. doi:10.1038/nature08636
    • (2010) Nature , vol.463 , pp. 540-544
    • Moro, K.1    Yamada, T.2    Tanabe, M.3    Takeuchi, T.4    Ikawa, T.5    Kawamoto, H.6
  • 130
    • 53749093767 scopus 로고    scopus 로고
    • The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'?
    • Moussion C, Ortega N, Girard JP. The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel 'alarmin'? PLoS One (2008) 3:e3331. doi:10.1371/journal.pone.0003331
    • (2008) PLoS One , vol.3
    • Moussion, C.1    Ortega, N.2    Girard, J.P.3
  • 131
    • 84859378165 scopus 로고    scopus 로고
    • Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain
    • Pichery M, Mirey E, Mercier P, Lefrancais E, Dujardin A, Ortega N, et al. Endogenous IL-33 is highly expressed in mouse epithelial barrier tissues, lymphoid organs, brain, embryos, and inflamed tissues: in situ analysis using a novel Il-33-LacZ gene trap reporter strain. J Immunol (2012) 188:3488-95. doi:10.4049/jimmunol.1101977
    • (2012) J Immunol , vol.188 , pp. 3488-3495
    • Pichery, M.1    Mirey, E.2    Mercier, P.3    Lefrancais, E.4    Dujardin, A.5    Ortega, N.6
  • 132
    • 84920950343 scopus 로고    scopus 로고
    • IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy
    • Cayrol C, Girard JP. IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy. Curr Opin Immunol (2014) 31:31-7. doi:10.1016/j.coi.2014.09.004
    • (2014) Curr Opin Immunol , vol.31 , pp. 31-37
    • Cayrol, C.1    Girard, J.P.2
  • 133
    • 84929093918 scopus 로고    scopus 로고
    • IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2+ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance
    • Han JM, Wu D, Denroche HC, Yao Y, Verchere CB, Levings MK. IL-33 reverses an obesity-induced deficit in visceral adipose tissue ST2+ T regulatory cells and ameliorates adipose tissue inflammation and insulin resistance. J Immunol (2015) 194:4777-83. doi:10.4049/jimmunol.1500020
    • (2015) J Immunol , vol.194 , pp. 4777-4783
    • Han, J.M.1    Wu, D.2    Denroche, H.C.3    Yao, Y.4    Verchere, C.B.5    Levings, M.K.6
  • 134
    • 77957043879 scopus 로고    scopus 로고
    • Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice
    • Miller AM, Asquith DL, Hueber AJ, Anderson LA, Holmes WM, McKenzie AN, et al. Interleukin-33 induces protective effects in adipose tissue inflammation during obesity in mice. Circ Res (2010) 107:650-8. doi:10.1161/CIRCRESAHA.110.218867
    • (2010) Circ Res , vol.107 , pp. 650-658
    • Miller, A.M.1    Asquith, D.L.2    Hueber, A.J.3    Anderson, L.A.4    Holmes, W.M.5    McKenzie, A.N.6
  • 135
    • 84924969384 scopus 로고    scopus 로고
    • Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
    • BrestoffJR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, et al. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature (2015) 519:242-6. doi:10.1038/nature14115
    • (2015) Nature , vol.519 , pp. 242-246
    • Brestoff, J.R.1    Kim, B.S.2    Saenz, S.A.3    Stine, R.R.4    Monticelli, L.A.5    Sonnenberg, G.F.6
  • 136
    • 84887431711 scopus 로고    scopus 로고
    • Brown and beige fat: development, function and therapeutic potential
    • Harms M, Seale P. Brown and beige fat: development, function and therapeutic potential. Nat Med (2013) 19:1252-63. doi:10.1038/nm.3361
    • (2013) Nat Med , vol.19 , pp. 1252-1263
    • Harms, M.1    Seale, P.2
  • 137
    • 84892702771 scopus 로고    scopus 로고
    • Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch
    • Cohen P, Levy DJ, Zhang Y, Frontini A, Kolodin PD, Svensson KJ, et al. Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch. Cell (2014) 156:304-16. doi:10.1016/j.cell.2013.12.021
    • (2014) Cell , vol.156 , pp. 304-316
    • Cohen, P.1    Levy, D.J.2    Zhang, Y.3    Frontini, A.4    Kolodin, P.D.5    Svensson, K.J.6
  • 138
    • 84920940721 scopus 로고    scopus 로고
    • Activated type 2 innate lymphoid cells regulate beige fat biogenesis
    • Lee MW, Odegaard JI, Mukundan L, Qiu Y, Molofsky AB, Nussbaum JC, et al. Activated type 2 innate lymphoid cells regulate beige fat biogenesis. Cell (2015) 160:74-87. doi:10.1016/j.cell.2014.12.011
    • (2015) Cell , vol.160 , pp. 74-87
    • Lee, M.W.1    Odegaard, J.I.2    Mukundan, L.3    Qiu, Y.4    Molofsky, A.B.5    Nussbaum, J.C.6
  • 139
    • 84896905991 scopus 로고    scopus 로고
    • Metabolic regulation of immune responses
    • Ganeshan K, Chawla A. Metabolic regulation of immune responses. Annu Rev Immunol (2014) 32:609-34. doi:10.1146/annurev-immunol-032713-120236
    • (2014) Annu Rev Immunol , vol.32 , pp. 609-634
    • Ganeshan, K.1    Chawla, A.2
  • 140
    • 84916898719 scopus 로고    scopus 로고
    • Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects
    • Yore MM, Syed I, Moraes-Vieira PM, Zhang T, Herman MA, Homan EA, et al. Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. Cell (2014) 159:318-32. doi:10.1016/j.cell.2014.09.035
    • (2014) Cell , vol.159 , pp. 318-332
    • Yore, M.M.1    Syed, I.2    Moraes-Vieira, P.M.3    Zhang, T.4    Herman, M.A.5    Homan, E.A.6
  • 141
    • 84893116082 scopus 로고    scopus 로고
    • Obesity alters adipose tissue macrophage iron content and tissue iron distribution
    • Orr JS, Kennedy A, Anderson-Baucum EK, Webb CD, Fordahl SC, Erikson KM, et al. Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes (2014) 63:421-32. doi:10.2337/db13-0213
    • (2014) Diabetes , vol.63 , pp. 421-432
    • Orr, J.S.1    Kennedy, A.2    Anderson-Baucum, E.K.3    Webb, C.D.4    Fordahl, S.C.5    Erikson, K.M.6
  • 142
    • 33745428666 scopus 로고    scopus 로고
    • Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
    • Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, Morel CR, et al. Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab (2006) 4:13-24. doi:10.1016/j.cmet.2006.05.011
    • (2006) Cell Metab , vol.4 , pp. 13-24
    • Vats, D.1    Mukundan, L.2    Odegaard, J.I.3    Zhang, L.4    Smith, K.L.5    Morel, C.R.6
  • 143
    • 70249099576 scopus 로고    scopus 로고
    • Interdependence of hypoxic and innate immune responses
    • Nizet V, Johnson RS. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol (2009) 9:609-17. doi:10.1038/nri2607
    • (2009) Nat Rev Immunol , vol.9 , pp. 609-617
    • Nizet, V.1    Johnson, R.S.2
  • 144
    • 84919452312 scopus 로고    scopus 로고
    • Metabolic reprograming in macrophage polarization
    • Galvan-Pena S, O'neill LA. Metabolic reprograming in macrophage polarization. Front Immunol (2014) 5:420. doi:10.3389/fimmu.2014.00420
    • (2014) Front Immunol , vol.5 , pp. 420
    • Galvan-Pena, S.1    O'neill, L.A.2
  • 145
    • 84896269174 scopus 로고    scopus 로고
    • Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype
    • Freemerman AJ, Johnson AR, Sacks GN, Milner JJ, Kirk EL, Troester MA, et al. Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. J Biol Chem (2014) 289:7884-96. doi:10.1074/jbc. M113.522037
    • (2014) J Biol Chem , vol.289 , pp. 7884-7896
    • Freemerman, A.J.1    Johnson, A.R.2    Sacks, G.N.3    Milner, J.J.4    Kirk, E.L.5    Troester, M.A.6
  • 146
    • 84877725490 scopus 로고    scopus 로고
    • Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1alpha-dependent and HIF-1alpha-independent manner in obese mice
    • Fujisaka S, Usui I, Ikutani M, Aminuddin A, Takikawa A, Tsuneyama K, et al. Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1alpha-dependent and HIF-1alpha-independent manner in obese mice. Diabetologia (2013) 56:1403-12. doi:10.1007/s00125-013-2885-1
    • (2013) Diabetologia , vol.56 , pp. 1403-1412
    • Fujisaka, S.1    Usui, I.2    Ikutani, M.3    Aminuddin, A.4    Takikawa, A.5    Tsuneyama, K.6
  • 147
    • 84863254048 scopus 로고    scopus 로고
    • PI3K/Akt contributes to increased expression of toll-like receptor 4 in macrophages exposed to hypoxic stress
    • Kim SY, Jeong E, Joung SM, Lee JY. PI3K/Akt contributes to increased expression of toll-like receptor 4 in macrophages exposed to hypoxic stress. Biochem Biophys Res Commun (2012) 419:466-71. doi:10.1016/j.bbrc.2012.02.015
    • (2012) Biochem Biophys Res Commun , vol.419 , pp. 466-471
    • Kim, S.Y.1    Jeong, E.2    Joung, S.M.3    Lee, J.Y.4
  • 148
    • 77949383238 scopus 로고    scopus 로고
    • Hypoxic stress up-regulates the expression of toll-like receptor 4 in macrophages via hypoxia-inducible factor
    • Kim SY, Choi YJ, Joung SM, Lee BH, Jung YS, Lee JY. Hypoxic stress up-regulates the expression of toll-like receptor 4 in macrophages via hypoxia-inducible factor. Immunology (2010) 129:516-24. doi:10.1111/j.1365-2567.2009.03203.x
    • (2010) Immunology , vol.129 , pp. 516-524
    • Kim, S.Y.1    Choi, Y.J.2    Joung, S.M.3    Lee, B.H.4    Jung, Y.S.5    Lee, J.Y.6
  • 149
    • 38149142633 scopus 로고    scopus 로고
    • Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
    • Rausch ME, Weisberg S, Vardhana P, Tortoriello DV. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) (2008) 32:451-63. doi:10.1038/sj.ijo.0803744
    • (2008) Int J Obes (Lond) , vol.32 , pp. 451-463
    • Rausch, M.E.1    Weisberg, S.2    Vardhana, P.3    Tortoriello, D.V.4
  • 151
    • 84920591180 scopus 로고    scopus 로고
    • Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages
    • Palsson-McDermott EM, Curtis AM, Goel G, Lauterbach MA, Sheedy FJ, Gleeson LE, et al. Pyruvate kinase M2 regulates Hif-1alpha activity and IL-1beta induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab (2015) 21:65-80. doi:10.1016/j.cmet.2014.12.005
    • (2015) Cell Metab , vol.21 , pp. 65-80
    • Palsson-McDermott, E.M.1    Curtis, A.M.2    Goel, G.3    Lauterbach, M.A.4    Sheedy, F.J.5    Gleeson, L.E.6
  • 152
    • 77956213727 scopus 로고    scopus 로고
    • Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation
    • Rodriguez-Prados JC, Traves PG, Cuenca J, Rico D, Aragones J, Martin-Sanz P, et al. Substrate fate in activated macrophages: a comparison between innate, classic, and alternative activation. J Immunol (2010) 185:605-14. doi:10.4049/jimmunol.0901698
    • (2010) J Immunol , vol.185 , pp. 605-614
    • Rodriguez-Prados, J.C.1    Traves, P.G.2    Cuenca, J.3    Rico, D.4    Aragones, J.5    Martin-Sanz, P.6
  • 153
    • 84862000246 scopus 로고    scopus 로고
    • Polarizing macrophages through reprogramming of glucose metabolism
    • Blagih J, Jones RG. Polarizing macrophages through reprogramming of glucose metabolism. Cell Metab (2012) 15:793-5. doi:10.1016/j.cmet.2012.05.008
    • (2012) Cell Metab , vol.15 , pp. 793-795
    • Blagih, J.1    Jones, R.G.2
  • 154
    • 84862016400 scopus 로고    scopus 로고
    • The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism
    • Haschemi A, Kosma P, Gille L, Evans CR, Burant CF, Starkl P, et al. The sedoheptulose kinase CARKL directs macrophage polarization through control of glucose metabolism. Cell Metab (2012) 15:813-26. doi:10.1016/j.cmet.2012.04.023
    • (2012) Cell Metab , vol.15 , pp. 813-826
    • Haschemi, A.1    Kosma, P.2    Gille, L.3    Evans, C.R.4    Burant, C.F.5    Starkl, P.6
  • 155
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    • Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, Mukundan L, et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature (2007) 447:1116-20. doi:10.1038/nature05894
    • (2007) Nature , vol.447 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3    Morel, C.R.4    Subramanian, V.5    Mukundan, L.6
  • 156
    • 44349112305 scopus 로고    scopus 로고
    • Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
    • Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, Hatano B, et al. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab (2008) 7:485-95. doi:10.1016/j.cmet.2008.04.002
    • (2008) Cell Metab , vol.7 , pp. 485-495
    • Kang, K.1    Reilly, S.M.2    Karabacak, V.3    Gangl, M.R.4    Fitzgerald, K.5    Hatano, B.6
  • 157
    • 68249140395 scopus 로고    scopus 로고
    • Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
    • Fang HY, Hughes R, Murdoch C, Coffelt SB, Biswas SK, Harris AL, et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood (2009) 114:844-59. doi:10.1182/blood-2008-12-195941
    • (2009) Blood , vol.114 , pp. 844-859
    • Fang, H.Y.1    Hughes, R.2    Murdoch, C.3    Coffelt, S.B.4    Biswas, S.K.5    Harris, A.L.6


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