Metabolic reprogramming of macrophages: Glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype

Journal of Biological Chemistry

Volumn 289, Issue 11, 2014, Pages 7884-7896

  Freemerman, Alex J ^a   Johnson, Amy R ^a   Sacks, Gina N ^a   Milner, J Justin ^a   Kirk, Erin L ^b   Troester, Melissa A ^b,c   Macintyre, Andrew N ^e   Goraksha Hicks, Pankuri ^e   Rathmell, Jeffery C ^e   Makowski, Liza ^a,c,d  

^a University of North Carolina at Chapel Hill   (United States)

^b The University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF NORTH CAROLINA   (United States)

^d UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; ENZYME INHIBITION; GENE EXPRESSION; MACROPHAGES; MAMMALS; METABOLISM; NUTRITION; PATHOLOGY; PHYSIOLOGY;

ANTIOXIDANT TREATMENT; GLUCOSE TRANSPORTER-1; INFLAMMATORY MEDIATORS; INFLAMMATORY RESPONSE; PENTOSE PHOSPHATE PATHWAY; PLASMINOGEN ACTIVATOR INHIBITOR-1; PROINFLAMMATORY RESPONSE; REACTIVE OXYGEN SPECIES;

GLUCOSE;

GLUCOSE TRANSPORTER; GLUCOSE TRANSPORTER 1; OXYGEN; PENTOSE PHOSPHATE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEOME; REACTIVE OXYGEN METABOLITE; TRACER;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOENERGY; CELL ENERGY; CELL POLARITY; CELL STRUCTURE; CONTROLLED STUDY; DIABETES MELLITUS; DNA FINGERPRINTING; FEMALE; GENE EXPRESSION; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; GLYCOLYSIS; IMMUNOCOMPETENT CELL; INFLAMMATION; INSULIN RESISTANCE; LIPID DIET; LIVER; MACROPHAGE; MALE; MEDIATOR RELEASE; METABOLOMICS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; OBESITY; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN STABILITY; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION;

CROWN-LIKE STRUCTURE; GLUCOSE TRANSPORT; GLYCOLYSIS; INFLAMMATION; MACROPHAGES; METABOLOMICS; MITOCHONDRIAL METABOLISM; OBESITY; PENTOSE PHOSPHATE PATHWAY;

ADIPOSE TISSUE; ANIMALS; BIOLOGICAL TRANSPORT; BONE MARROW CELLS; CELLS, CULTURED; FEMALE; GENE EXPRESSION REGULATION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LIVER; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; OBESITY; PENTOSE PHOSPHATE PATHWAY; PHENOTYPE; PROTEOMICS; REACTIVE OXYGEN SPECIES;

EID: 84896269174     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.522037     Document Type: Article

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