The PPAR-γ antagonist GW9662 elicits differentiation of M2c-like cells and upregulation of the MerTK/Gas6 axis: A key role for PPAR-γ in human macrophage polarization

Journal of Inflammation (United Kingdom)

Volumn 12, Issue 1, 2015, Pages

  Zizzo, Gaetano ^a,b   Cohen, Philip L ^a,b  

^a TEMPLE UNIVERSITY   (United States)

^b TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD163; Gas6; Liver X Receptor (LXR); M2; Macrophages; Mer receptor Tyrosine Kinase (MerTK); Peroxisome Proliferator Activated Receptor gamma (PPAR )

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; CD16 ANTIGEN; CD163 ANTIGEN; CD206 ANTIGEN; DEXAMETHASONE; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH ARREST SPECIFIC PROTEIN 6; INTERLEUKIN 10; INTERLEUKIN 4; LEUKOCYTE ANTIGEN; LIVER X RECEPTOR; MER RECEPTOR TYROSINE KINASE; N (2,2,2 TRIFLUOROETHYL) N [4 (2,2,2 TRIFLUORO 1 HYDROXY 1 TRIFLUOROMETHYLETHYL)PHENYL]BENZENESULFONAMIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN TYROSINE KINASE; ROSIGLITAZONE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL EXPANSION; CELL MATURATION; CELL PHAGOCYTOSIS; CELL TRANSDIFFERENTIATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VITRO STUDY; MACROPHAGE ACTIVATION; MACROPHAGE CULTURE; MONOCYTE; NEUTROPHIL; NORMAL HUMAN; PHENOTYPE; POLARIZATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SECRETION; UPREGULATION;

EID: 84929161751     PISSN: None     EISSN: 14769255     Source Type: Journal    
DOI: 10.1186/s12950-015-0081-4     Document Type: Article

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