-
1
-
-
33745216724
-
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
-
Kanda H, Tateya S, Tamori Y, et al. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 2006;116:1494-1505
-
(2006)
J Clin Invest
, vol.116
, pp. 1494-1505
-
-
Kanda, H.1
Tateya, S.2
Tamori, Y.3
-
2
-
-
34948813665
-
Osteopontin mediates obesityinduced adipose tissue macrophage infiltration and insulin resistance in mice
-
Nomiyama T, Perez-Tilve D, Ogawa D, et al. Osteopontin mediates obesityinduced adipose tissue macrophage infiltration and insulin resistance in mice. J Clin Invest 2007;117:2877-2888
-
(2007)
J Clin Invest
, vol.117
, pp. 2877-2888
-
-
Nomiyama, T.1
Perez-Tilve, D.2
Ogawa, D.3
-
3
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, et al. Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 2003; 112:1821-1830
-
(2003)
J Clin Invest
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
-
4
-
-
51649088497
-
Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects
-
Apovian CM, Bigornia S, Mott M, et al. Adipose macrophage infiltration is associated with insulin resistance and vascular endothelial dysfunction in obese subjects. Arterioscler Thromb Vasc Biol 2008;28:1654-1659
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1654-1659
-
-
Apovian, C.M.1
Bigornia, S.2
Mott, M.3
-
6
-
-
67649380355
-
Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: Influence of glycemic status
-
Tordjman J, Poitou C, Hugol D, et al. Association between omental adipose tissue macrophages and liver histopathology in morbid obesity: influence of glycemic status. J Hepatol 2009;51:354-362
-
(2009)
J Hepatol
, vol.51
, pp. 354-362
-
-
Tordjman, J.1
Poitou, C.2
Hugol, D.3
-
7
-
-
82755182907
-
A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism
-
Cipolletta D, Kolodin D, Benoist C, Mathis D. Tissular T(regs): a unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism. Semin Immunol 2011;23:431-437
-
(2011)
Semin Immunol
, vol.23
, pp. 431-437
-
-
Cipolletta, D.1
Kolodin, D.2
Benoist, C.3
Mathis, D.4
Tissular, T.5
-
8
-
-
46249117032
-
T-lymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
-
Kintscher U, Hartge M, Hess K, et al. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 2008;28:1304-1310
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1304-1310
-
-
Kintscher, U.1
Hartge, M.2
Hess, K.3
-
9
-
-
65649117802
-
Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
-
Duffaut C, Galitzky J, Lafontan M, Bouloumié A. Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun 2009;384:482-485
-
(2009)
Biochem Biophys Res Commun
, vol.384
, pp. 482-485
-
-
Duffaut, C.1
Galitzky, J.2
Lafontan, M.3
Bouloumié, A.4
-
10
-
-
84865461206
-
Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients
-
Bertola A, Ciucci T, Rousseau D, et al. Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients. Diabetes 2012;61:2238-2247
-
(2012)
Diabetes
, vol.61
, pp. 2238-2247
-
-
Bertola, A.1
Ciucci, T.2
Rousseau, D.3
-
11
-
-
84880617814
-
Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals
-
Fabbrini E, Cella M, McCartney SA, et al. Association between specific adipose tissue CD4+ T-cell populations and insulin resistance in obese individuals. Gastroenterology 2013;145:366-374
-
(2013)
Gastroenterology
, vol.145
, pp. 366-374
-
-
Fabbrini, E.1
Cella, M.2
McCartney, S.A.3
-
12
-
-
84878800136
-
Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice
-
Morris DL, Cho KW, Delproposto JL, et al. Adipose tissue macrophages function as antigen-presenting cells and regulate adipose tissue CD4+ T cells in mice. Diabetes 2013;62:2762-2772
-
(2013)
Diabetes
, vol.62
, pp. 2762-2772
-
-
Morris, D.L.1
Cho, K.W.2
Delproposto, J.L.3
-
13
-
-
79960873697
-
Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction
-
Dalmas E, Rouault C, Abdennour M, et al. Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction. Am J Clin Nutr 2011;94: 450-458
-
(2011)
Am J Clin Nutr
, vol.94
, pp. 450-458
-
-
Dalmas, E.1
Rouault, C.2
Abdennour, M.3
-
14
-
-
24644518893
-
Cathepsin S, a novel biomarker of adiposity: Relevance to atherogenesis
-
DOI 10.1096/fj.05-3673fje
-
Taleb S, Lacasa D, Bastard JP, et al. Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis. FASEB J 2005;19:1540-1542 (Pubitemid 41279024)
-
(2005)
FASEB Journal
, vol.19
, Issue.11
, pp. 1540-1542
-
-
Taleb, S.1
Lacasa, D.2
Bastard, J.-P.3
Poitou, C.4
Cancello, R.5
Pelloux, V.6
Viguerie, N.7
Benis, A.8
Zucker, J.-D.9
Bouillot, J.-L.10
Coussieu, C.11
Basdevant, A.12
Langin, D.13
Clement, K.14
-
15
-
-
55749087379
-
FunNet: An integrative tool for exploring transcriptional interactions
-
Prifti E, Zucker JD, Clement K, Henegar C. FunNet: an integrative tool for exploring transcriptional interactions. Bioinformatics 2008;24:2636-2638
-
(2008)
Bioinformatics
, vol.24
, pp. 2636-2638
-
-
Prifti, E.1
Zucker, J.D.2
Clement, K.3
Henegar, C.4
-
16
-
-
84873846887
-
SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation
-
Toubal A, Clément K, Fan R, et al. SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation. J Clin Invest 2013;123:362-379
-
(2013)
J Clin Invest
, vol.123
, pp. 362-379
-
-
Toubal, A.1
Clément, K.2
Fan, R.3
-
17
-
-
84862695017
-
Th17 cells: Biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies
-
Maddur MS, Miossec P, Kaveri SV, Bayry J. Th17 cells: biology, pathogenesis of autoimmune and inflammatory diseases, and therapeutic strategies. Am J Pathol 2012;181:8-18
-
(2012)
Am J Pathol
, vol.181
, pp. 8-18
-
-
Maddur, M.S.1
Miossec, P.2
Kaveri, S.V.3
Bayry, J.4
-
18
-
-
0025707532
-
IV. IFN-g suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1
-
Schindler R, Ghezzi P, Dinarello CA. IL-1 induces IL-1. IV. IFN-gamma suppresses IL-1 but not lipopolysaccharide-induced transcription of IL-1. J Immunol 1990;144:2216-2222 (Pubitemid 20106563)
-
(1990)
Journal of Immunology
, vol.144
, Issue.6
, pp. 2216-2222
-
-
Schindler, R.1
Ghezzi, P.2
Dinarello, C.A.3
-
19
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91 (Pubitemid 23036092)
-
(1993)
Science
, vol.259
, Issue.5091
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
20
-
-
79959438318
-
Lack of interleukin-1 receptor i (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis
-
McGillicuddy FC, Harford KA, Reynolds CM, et al. Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis. Diabetes 2011;60: 1688-1698
-
(2011)
Diabetes
, vol.60
, pp. 1688-1698
-
-
McGillicuddy, F.C.1
Harford, K.A.2
Reynolds, C.M.3
-
21
-
-
80053087484
-
Inflammasome is a central player in the induction of obesity and insulin resistance
-
Stienstra R, van Diepen JA, Tack CJ, et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci USA 2011; 108:15324-15329
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 15324-15329
-
-
Stienstra, R.1
Van Diepen, J.A.2
Tack, C.J.3
-
22
-
-
84857364150
-
Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans
-
Goossens GH, Blaak EE, Theunissen R, et al. Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in humans. Mol Immunol 2012;50:142-149
-
(2012)
Mol Immunol
, vol.50
, pp. 142-149
-
-
Goossens, G.H.1
Blaak, E.E.2
Theunissen, R.3
-
23
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar B, Youm YH, Ravussin A, et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011; 17:179-188
-
(2011)
Nat Med
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
Youm, Y.H.2
Ravussin, A.3
-
24
-
-
52949129811
-
Treatment with an Interleukin 1 beta antibody improves glycemic control in dietinduced obesity
-
Osborn O, Brownell SE, Sanchez-Alavez M, Salomon D, Gram H, Bartfai T. Treatment with an Interleukin 1 beta antibody improves glycemic control in dietinduced obesity. Cytokine 2008;44:141-148
-
(2008)
Cytokine
, vol.44
, pp. 141-148
-
-
Osborn, O.1
Brownell, S.E.2
Sanchez-Alavez, M.3
Salomon, D.4
Gram, H.5
Bartfai, T.6
-
25
-
-
77954495751
-
XOMA 052, an anti-IL-1beta monoclonal antibody, improves glucose control and beta-cell function in the dietinduced obesity mouse model
-
Owyang AM, Maedler K, Gross L, et al. XOMA 052, an anti-IL-1beta monoclonal antibody, improves glucose control and beta-cell function in the dietinduced obesity mouse model. Endocrinology 2010;151:2515-2527
-
(2010)
Endocrinology
, vol.151
, pp. 2515-2527
-
-
Owyang, A.M.1
Maedler, K.2
Gross, L.3
-
26
-
-
84864386088
-
Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes
-
Cavelti-Weder C, Babians-Brunner A, Keller C, et al. Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes. Diabetes Care 2012; 35:1654-1662
-
(2012)
Diabetes Care
, vol.35
, pp. 1654-1662
-
-
Cavelti-Weder, C.1
Babians-Brunner, A.2
Keller, C.3
-
27
-
-
34247170807
-
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
-
DOI 10.1056/NEJMoa065213
-
Larsen CM, Faulenbach M, Vaag A, et al. Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007;356:1517-1526 (Pubitemid 46588416)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.15
, pp. 1517-1526
-
-
Larsen, C.M.1
Faulenbach, M.2
Vaag, A.3
Volund, A.4
Ehses, J.A.5
Seifert, B.6
Mandrup-Poulsen, T.7
Donath, M.Y.8
-
28
-
-
84878774925
-
Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1b antibody, in patients with type 2 diabetes
-
Sloan-Lancaster J, Abu-Raddad E, Polzer J, et al. Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1b antibody, in patients with type 2 diabetes. Diabetes Care 2013;36:2239-2246
-
(2013)
Diabetes Care
, vol.36
, pp. 2239-2246
-
-
Sloan-Lancaster, J.1
Abu-Raddad, E.2
Polzer, J.3
-
29
-
-
78649498271
-
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
-
Stienstra R, Joosten LA, Koenen T, et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 2010;12:593-605
-
(2010)
Cell Metab
, vol.12
, pp. 593-605
-
-
Stienstra, R.1
Joosten, L.A.2
Koenen, T.3
-
30
-
-
84859516946
-
Macrophages participate in IL-17- mediated inflammation
-
Barin JG, Baldeviano GC, Talor MV, et al. Macrophages participate in IL-17- mediated inflammation. Eur J Immunol 2012;42:726-736
-
(2012)
Eur J Immunol
, vol.42
, pp. 726-736
-
-
Barin, J.G.1
Baldeviano, G.C.2
Talor, M.V.3
-
31
-
-
33749318470
-
Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides
-
DOI 10.1084/jem.20061308
-
Liang SC, Tan XY, Luxenberg DP, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med 2006;203:2271-2279 (Pubitemid 44498362)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.10
, pp. 2271-2279
-
-
Liang, S.C.1
Tan, X.-Y.2
Luxenberg, D.P.3
Karim, R.4
Dunussi-Joannopoulos, K.5
Collins, M.6
Fouser, L.A.7
-
32
-
-
77953495368
-
Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A
-
Sonnenberg GF, Nair MG, Kirn TJ, Zaph C, Fouser LA, Artis D. Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A. J Exp Med 2010;207:1293-1305
-
(2010)
J Exp Med
, vol.207
, pp. 1293-1305
-
-
Sonnenberg, G.F.1
Nair, M.G.2
Kirn, T.J.3
Zaph, C.4
Fouser, L.A.5
Artis, D.6
-
34
-
-
78649757427
-
Interleukin-22: A cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection
-
Witte E, Witte K, Warszawska K, Sabat R, Wolk K. Interleukin-22: a cytokine produced by T, NK and NKT cell subsets, with importance in the innate immune defense and tissue protection. Cytokine Growth Factor Rev 2010;21:365-379
-
(2010)
Cytokine Growth Factor Rev
, vol.21
, pp. 365-379
-
-
Witte, E.1
Witte, K.2
Warszawska, K.3
Sabat, R.4
Wolk, K.5
-
35
-
-
79951743212
-
Functional specialization of interleukin-17 family members
-
Iwakura Y, Ishigame H, Saijo S, Nakae S. Functional specialization of interleukin-17 family members. Immunity 2011;34:149-162
-
(2011)
Immunity
, vol.34
, pp. 149-162
-
-
Iwakura, Y.1
Ishigame, H.2
Saijo, S.3
Nakae, S.4
-
36
-
-
84857511355
-
IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1b by keratinocytes via the ROSNLRP3- caspase-1 pathway
-
Cho KA, Suh JW, Lee KH, Kang JL, Woo SY. IL-17 and IL-22 enhance skin inflammation by stimulating the secretion of IL-1b by keratinocytes via the ROSNLRP3- caspase-1 pathway. Int Immunol 2012;24:147-158
-
(2012)
Int Immunol
, vol.24
, pp. 147-158
-
-
Cho, K.A.1
Suh, J.W.2
Lee, K.H.3
Kang, J.L.4
Woo, S.Y.5
-
37
-
-
79952584368
-
Recent advances in IL-22 biology
-
Zenewicz LA, Flavell RA. Recent advances in IL-22 biology. Int Immunol 2011;23:159-163
-
(2011)
Int Immunol
, vol.23
, pp. 159-163
-
-
Zenewicz, L.A.1
Flavell, R.A.2
-
38
-
-
33746736936
-
Long-term treatment with interleukin-1betainduces insulin resistance in murine and human adipocytes
-
DOI 10.1007/s00125-006-0335-z
-
Lagathu C, Yvan-Charvet L, Bastard JP, et al. Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes. Diabetologia 2006;49:2162-2173 (Pubitemid 44168485)
-
(2006)
Diabetologia
, vol.49
, Issue.9
, pp. 2162-2173
-
-
Lagathu, C.1
Yvan-Charvet, L.2
Bastard, J.-P.3
Maachi, M.4
Quignard-Boulange, A.5
Capeau, J.6
Caron, M.7
-
39
-
-
78650655167
-
IL-17 regulates adipogenesis, glucose homeostasis, and obesity
-
Zúñiga LA, Shen WJ, Joyce-Shaikh B, et al. IL-17 regulates adipogenesis, glucose homeostasis, and obesity. J Immunol 2010;185:6947-6959
-
(2010)
J Immunol
, vol.185
, pp. 6947-6959
-
-
Zúñiga, L.A.1
Shen, W.J.2
Joyce-Shaikh, B.3
-
40
-
-
80052301263
-
High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin
-
Wang Z, Yang L, Jiang Y, et al. High fat diet induces formation of spontaneous liposarcoma in mouse adipose tissue with overexpression of interleukin PLoS One 2011;6:e23737
-
(2011)
PLoS One
, vol.6
-
-
Wang, Z.1
Yang, L.2
Jiang, Y.3
-
42
-
-
0032521933
-
+ T lymphocytes
-
Barbulescu K, Becker C, Schlaak JF, Schmitt E, Meyer zum Büschenfelde KH, Neurath MF. IL-12 and IL-18 differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4+ T lymphocytes. J Immunol 1998;160:3642-3647 (Pubitemid 28176063)
-
(1998)
Journal of Immunology
, vol.160
, Issue.8
, pp. 3642-3647
-
-
Barbulescu, K.1
Becker, C.2
Schlaak, J.F.3
Schmitt, E.4
Meyer Zum Buschenfelde, K.-H.5
Neurath, M.F.6
-
43
-
-
0034453105
-
Interferon-g induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism
-
DOI 10.1210/jc.85.2.830
-
Karlsen AE, Pavlovic D, Nielsen K, et al. Interferon-gamma induces interleukin-1 converting enzyme expression in pancreatic islets by an interferon regulatory factor-1-dependent mechanism. J Clin Endocrinol Metab 2000;85: 830-836 (Pubitemid 32273675)
-
(2000)
Journal of Clinical Endocrinology and Metabolism
, vol.85
, Issue.2
, pp. 830-836
-
-
Karlsen, A.E.1
Pavlovic, D.2
Nielsen, K.3
Jensen, J.4
Andersen, H.U.5
Pociot, F.6
Mandrup-Poulsen, T.7
Eizirik, D.L.8
Nerup, J.9
-
44
-
-
0033935467
-
++ cells derived in vitro from peripheral blood monocytes exhibit phenotypic and functional dendritic cell-like characteristics
-
Ancuta P, Weiss L, Haeffner-Cavaillon N. CD14+CD16++ cells derived in vitro from peripheral blood monocytes exhibit phenotypic and functional dendritic cell-like characteristics. Eur J Immunol 2000;30:1872-1883 (Pubitemid 30456183)
-
(2000)
European Journal of Immunology
, vol.30
, Issue.7
, pp. 1872-1883
-
-
Ancuta, P.1
Weiss, L.2
Haeffner-Cavaillon, N.3
-
45
-
-
84878782369
-
Inflammation in obesity and diabetes: Islet dysfunction and therapeutic opportunity
-
Donath MY, Dalmas E, Sauter NS, Böni-Schnetzler M. Inflammation in obesity and diabetes: islet dysfunction and therapeutic opportunity. Cell Metab 2013;17:860-872
-
(2013)
Cell Metab
, vol.17
, pp. 860-872
-
-
Donath, M.Y.1
Dalmas, E.2
Sauter, N.S.3
Böni-Schnetzler, M.4
-
46
-
-
84872327440
-
Pathophysiology of human visceral obesity: An update
-
Tchernof A, Després JP. Pathophysiology of human visceral obesity: an update. Physiol Rev 2013;93:359-404
-
(2013)
Physiol Rev
, vol.93
, pp. 359-404
-
-
Tchernof, A.1
Després, J.P.2
-
47
-
-
84876292569
-
Effect of IL-17A blockade with secukinumab in autoimmune diseases
-
Patel DD, Lee DM, Kolbinger F, Antoni C. Effect of IL-17A blockade with secukinumab in autoimmune diseases. Ann Rheum Dis 2013;72(Suppl. 2):ii116- ii123
-
(2013)
Ann Rheum Dis
, vol.72
, Issue.SUPPL. 2
-
-
Patel, D.D.1
Lee, D.M.2
Kolbinger, F.3
Antoni, C.4
|