Adipose tissue hypoxia induces inflammatory M1 polarity of macrophages in an HIF-1α-dependent and HIF-1α-independent manner in obese mice

Diabetologia

Volumn 56, Issue 6, 2013, Pages 1403-1412

  Fujisaka, S ^a   Usui, I ^a   Ikutani, M ^b   Aminuddin, A ^a   Takikawa, A ^a   Tsuneyama, K ^a   Mahmood, A ^a   Goda, N ^c   Nagai, Y ^b   Takatsu, K ^b,d   Tobe, K ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c WASEDA UNIVERSITY   (Japan)

^d Toyama Prefectural Institute for Pharmaceutical Research   (Japan)

Author keywords

Adipose tissue macrophage; HIF 1 ; Hypoxia; Inflammatory cytokine; M1 macrophage

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PIMONIDAZOLE; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POLARITY; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION; HIF1ALPHA GENE; HYPOXEMIA; IL1BETA GENE; IL6 GENE; IN VITRO STUDY; INFLAMMATION; MACROPHAGE FUNCTION; MALE; MOUSE; NONHUMAN; NOS2 GENE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; RAT; TNF GENE;

ADIPOSE TISSUE; ALLELES; ANIMALS; ANOXIA; BONE MARROW CELLS; CELL POLARITY; FLOW CYTOMETRY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, OBESE; NITROIMIDAZOLES; PHENOTYPE;

EID: 84877725490     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-2885-1     Document Type: Article

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