PI3Kγ within a nonhematopoietic cell type negatively regulates diet-induced thermogenesis and promotes obesity and insulin resistance

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 42, 2011, Pages

  Becattini, Barbara ^a   Marone, Romina ^b   Zani, Fabio ^a   Arsenijevic, Denis ^a   Seydoux, Josiane ^c   Montani, Jean Pierre ^a   Dulloo, Abdul G ^a   Thorens, Bernard ^d   Preitner, Frédéric ^d   Wymann, Matthias P ^b   Solinas, Giovanni ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

^b UNIVERSITY OF BASEL   (Switzerland)

^c UNIVERSITY OF GENEVA   (Switzerland)

^d UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Ectopic lipids; Energy balance; Metabolic stress

Indexed keywords

HORMONE SENSITIVE LIPASE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA;

ANIMAL EXPERIMENT; ARTICLE; BROWN ADIPOSE TISSUE; CALORIC INTAKE; CONTROLLED STUDY; ENERGY EXPENDITURE; FATTY LIVER; GLUCOSE INTOLERANCE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; MOUSE; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THERMOGENESIS; WEIGHT GAIN; WHITE ADIPOSE TISSUE;

ADIPOSE TISSUE, WHITE; ANIMALS; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; DIET, HIGH-FAT; FATTY LIVER; INFLAMMATION; INSULIN RESISTANCE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; OBESITY; PHENOTYPE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEROL ESTERASE; THERMOGENESIS; THINNESS;

MUS;

EID: 80054811005     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1106698108     Document Type: Article

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