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Volumn 170, Issue 11, 2003, Pages 5630-5635

IKKβ plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharide

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; SYNAPTOTAGMIN; UNCLASSIFIED DRUG;

EID: 0037851769     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.170.11.5630     Document Type: Article
Times cited : (349)

References (30)
  • 2
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh, S., M. May, and E. Kopp. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225
    • Ghosh, S.1    May, M.2    Kopp, E.3
  • 3
    • 0036234459 scopus 로고    scopus 로고
    • Missing pieces in the NF-κB puzzle
    • Ghosh, S., and K. Karin. 2002. Missing pieces in the NF-κB puzzle. Cell 109:S81.
    • (2002) Cell , vol.109
    • Ghosh, S.1    Karin, K.2
  • 4
    • 0028986193 scopus 로고
    • NF-κB: A lesson in family values
    • Thanos, D., and T. Maniatis. 1995. NF-κB: a lesson in family values. Cell 80:529.
    • (1995) Cell , vol.80 , pp. 529
    • Thanos, D.1    Maniatis, T.2
  • 5
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and I-κB proteins: New discoveries and insights
    • Baldwin, A. S. 1996. The NF-κB and I-κB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649.
    • (1996) Annu. Rev. Immunol. , vol.14 , pp. 649
    • Baldwin, A.S.1
  • 6
    • 0034661272 scopus 로고    scopus 로고
    • Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: Additional defect in neurulation
    • Li, Q., G. Estepa, S. Memet, A. Israel, and I. M. Verma. 2000. Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev. 14:1729.
    • (2000) Genes Dev. , vol.14 , pp. 1729
    • Li, Q.1    Estepa, G.2    Memet, S.3    Israel, A.4    Verma, I.M.5
  • 8
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IκB kinase 2 gene
    • Li, Q., D. Van Antwerp, F. Mercurio, K.-F. Lee, and I. M. Verma. 1999. Severe liver degeneration in mice lacking the IκB kinase 2 gene. Science 284:321.
    • (1999) Science , vol.284 , pp. 321
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3    Lee, K.-F.4    Verma, I.M.5
  • 10
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
    • Hu, Y., V. Baud, M. Delhase, P. Zhang, T. Deerinck, M. Ellisman, R. Johnson, and M. Karin. 1999. Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase. Science 284:316.
    • (1999) Science , vol.284 , pp. 316
    • Hu, Y.1    Baud, V.2    Delhase, M.3    Zhang, P.4    Deerinck, T.5    Ellisman, M.6    Johnson, R.7    Karin, M.8
  • 11
    • 0037024696 scopus 로고    scopus 로고
    • Regulation of IκB kinase (IKK)κ/NEMO function by IKKβ-mediated phosphorylation
    • Prajapati, S., and R. B. Gaynor. 2002. Regulation of IκB kinase (IKK)κ/NEMO function by IKKβ-mediated phosphorylation. J. Biol. Chem. 277:24331.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24331
    • Prajapati, S.1    Gaynor, R.B.2
  • 12
    • 0037192829 scopus 로고    scopus 로고
    • PTEN blocks tumor necrosis factorinduced NF-κB-dependent transcription by inhibiting the transactivation potential of the p65 subunit
    • Mayo, M. W., L. V. Madrid, S. D. Westerheide, D. R. Jones, X. J. Yuan, A. S. Baldwin, and Y. E. Whang. 2002. PTEN blocks tumor necrosis factorinduced NF-κB-dependent transcription by inhibiting the transactivation potential of the p65 subunit. J. Biol. Chem. 277:11116.
    • (2002) J. Biol. Chem. , vol.277 , pp. 11116
    • Mayo, M.W.1    Madrid, L.V.2    Westerheide, S.D.3    Jones, D.R.4    Yuan, X.J.5    Baldwin, A.S.6    Whang, Y.E.7
  • 13
    • 0031972761 scopus 로고    scopus 로고
    • Transforming growth factor β stimulates the human immunodeficiency virus 1 enhancer and requires NF-κB activity
    • Li, J., X. Shen, P. P. Hu, and X. F. Wang. 1998. Transforming growth factor β stimulates the human immunodeficiency virus 1 enhancer and requires NF-κB activity. Mol. Cell. Biol. 18:110.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 110
    • Li, J.1    Shen, X.2    Hu, P.P.3    Wang, X.F.4
  • 14
    • 0032039076 scopus 로고    scopus 로고
    • Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
    • Zhong, H., R. E. Voll, and S. Ghosh. 1998. Phosphorylation of NF-κB p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300. Mol. Cell 1:661.
    • (1998) Mol. Cell , vol.1 , pp. 661
    • Zhong, H.1    Voll, R.E.2    Ghosh, S.3
  • 15
    • 0036203419 scopus 로고    scopus 로고
    • The Phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-I
    • Zhong, H., M. J. May, E. Jimi, and S. Ghosh. 2002. The Phosphorylation status of nuclear NF-κB determines its association with CBP/p300 or HDAC-I. Mol. Cell 9:625.
    • (2002) Mol. Cell , vol.9 , pp. 625
    • Zhong, H.1    May, M.J.2    Jimi, E.3    Ghosh, S.4
  • 16
    • 0032491485 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB-dependent transcription by tumor necrosis factor-α is mediated through phosphorylation of Re1A/p65 on serine 529
    • Wang, D., and A. S. Baldwin. 1998. Activation of nuclear factor-κB-dependent transcription by tumor necrosis factor-α is mediated through phosphorylation of Re1A/p65 on serine 529. J. Biol. Chem. 273:29411.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29411
    • Wang, D.1    Baldwin, A.S.2
  • 17
    • 0032589462 scopus 로고    scopus 로고
    • IκB kinases phosphorylate NF-κB p65 subunit on Serine 536 in the transactivation domain
    • Sakurai, H., H. Chiba, H. Miyoshi, T. Sugita, and W. Toriumi. 1999. IκB kinases phosphorylate NF-κB p65 subunit on Serine 536 in the transactivation domain. J. Biol. Chem. 274:30353.
    • (1999) J. Biol. Chem. , vol.274 , pp. 30353
    • Sakurai, H.1    Chiba, H.2    Miyoshi, H.3    Sugita, T.4    Toriumi, W.5
  • 19
    • 0035379555 scopus 로고    scopus 로고
    • Akt stimulates the transactivation potential of the Re1A/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38
    • Madrid, L. V., M. W. Mayo, J. Y. Reuther, and A. S. Baldwin. 2001. Akt stimulates the transactivation potential of the Re1A/p65 subunit of NF-κB through utilization of the IκB kinase and activation of the mitogen-activated protein kinase p38. J. Biol. Chem. 276:18934.
    • (2001) J. Biol. Chem. , vol.276 , pp. 18934
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3    Baldwin, A.S.4
  • 20
    • 0033038491 scopus 로고    scopus 로고
    • Activation of phosphatidylinositol 3-kinase in response to interleukin-I leads to phosphorylation and activation of the NF-κB p65/RelA subunit
    • Sizemore, N., S. Leung, and G. R. Stark. 1999. Activation of phosphatidylinositol 3-kinase in response to interleukin-I leads to phosphorylation and activation of the NF-κB p65/RelA subunit. Mol. Cell. Biol. 19:4798.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4798
    • Sizemore, N.1    Leung, S.2    Stark, G.R.3
  • 21
    • 0037039665 scopus 로고    scopus 로고
    • Distinct roles of the IκB kinase αand β-subunits in liberating nuclear factor κB (NF-κB) from IκB and in phosphorylating the p65 subunit of NF-κB
    • Sizemore, N. N. Lerner, N. Dombrowski, H. Sakurai, and G. R. Stark. 2002. Distinct roles of the IκB kinase αand β-subunits in liberating nuclear factor κB (NF-κB) from IκB and in phosphorylating the p65 subunit of NF-κB. J. Biol. Chem. 277:3863.
    • (2002) J. Biol. Chem. , vol.277 , pp. 3863
    • Sizemore1    Lerner, N.N.2    Dombrowski, N.3    Sakurai, H.4    Stark, G.R.5
  • 22
    • 0029858387 scopus 로고    scopus 로고
    • TNF- and cancer therapyinduced apoptosis: Potentiation by inhibition of NF-κB
    • Wang, C.-Y., M. W. Mayo, and A. S. Baldwin. 1996. TNF- and cancer therapyinduced apoptosis: potentiation by inhibition of NF-κB. Science 274:784.
    • (1996) Science , vol.274 , pp. 784
    • Wang, C.-Y.1    Mayo, M.W.2    Baldwin, A.S.3
  • 23
    • 0032508414 scopus 로고    scopus 로고
    • NF-κB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAPI and c-IAP2 to suppress caspase-8 activation
    • Wang, C.-Y., M. W. Mayo, R. C. Komeluk, D. V. Goeddel, and A. S. Baldwin. 1998. NF-κB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAPI and c-IAP2 to suppress caspase-8 activation. Science 281:1680.
    • (1998) Science , vol.281 , pp. 1680
    • Wang, C.-Y.1    Mayo, M.W.2    Komeluk, R.C.3    Goeddel, D.V.4    Baldwin, A.S.5
  • 24
    • 0035854749 scopus 로고    scopus 로고
    • Nuclear factor-κb-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity
    • You, Z., H. Ouyang, D. Lopatin, P. J. Polverini, and C.-Y. Wang. 2001. Nuclear factor-κb-inducible death effector domain-containing protein suppresses tumor necrosis factor-mediated apoptosis by inhibiting caspase-8 activity J. Biol. Chem. 276:26398.
    • (2001) J. Biol. Chem. , vol.276 , pp. 26398
    • You, Z.1    Ouyang, H.2    Lopatin, D.3    Polverini, P.J.4    Wang, C.-Y.5
  • 26
    • 0028986075 scopus 로고
    • Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation
    • Brown, K., S. Gerstberger, L. Carlson, G. Franzoso, and U. Siebenlist. 1995. Control of IκB-α proteolysis by site-specific, signal-induced phosphorylation. Science 267:1485.
    • (1995) Science , vol.267 , pp. 1485
    • Brown, K.1    Gerstberger, S.2    Carlson, L.3    Franzoso, G.4    Siebenlist, U.5
  • 27
    • 0034662239 scopus 로고    scopus 로고
    • Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2
    • Hirschfeld, M., Y. Ma, J. H. Weis, S. N. Vogel, and J. J. Weis. 2000. Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2. J. Immunol. 165:618.
    • (2000) J. Immunol. , vol.165 , pp. 618
    • Hirschfeld, M.1    Ma, Y.2    Weis, J.H.3    Vogel, S.N.4    Weis, J.J.5
  • 29
    • 0035021123 scopus 로고    scopus 로고
    • The α and β subunits of IκB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF
    • Devin, A., Y. Lin, S. Yamaoka, Z. Li, M. Karin, and Z. G. Liu. 2001. The α and β subunits of IκB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF. Mol. Cell. Biol. 21:3986.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3986
    • Devin, A.1    Lin, Y.2    Yamaoka, S.3    Li, Z.4    Karin, M.5    Liu, Z.G.6
  • 30
    • 0033725155 scopus 로고    scopus 로고
    • The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
    • Devin, A., A. Cook, Y. Lin, Y. Rodriguez, M. Kelliher, and Z. G. Liu. 2000. The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation Immunity 12:419.
    • (2000) Immunity , vol.12 , pp. 419
    • Devin, A.1    Cook, A.2    Lin, Y.3    Rodriguez, Y.4    Kelliher, M.5    Liu, Z.G.6


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