Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism

Molecular and Cellular Biology

Volumn 32, Issue 10, 2012, Pages 2010-2019

  Norseen, Julie ^a   Hosooka, Tetsuya ^a,e   Hammarstedt, Ann ^b   Yore, Mark M ^a   Kant, Shashi ^c   Aryal, Pratik ^a   Kiernan, Urban A ^d   Phillips, David A ^d   Maruyama, Hiroshi ^a,g   Kraus, Bettina J ^a,f   Usheva, Anny ^a   Davis, Roger J ^c   Smith, Ulf ^b   Kahn, Barbara B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d Thermo Fisher Scientific   (United States)

^e KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^f UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^g MITSUBISHI TANABE PHARMA CORPORATION   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; RECEPTOR PROTEIN; RETINOL; RETINOL BINDING PROTEIN 4; STRA6 PROTEIN; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN RESISTANCE; LEAN BODY WEIGHT; MACROPHAGE; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

3T3 CELLS; ADIPOCYTES; ANIMALS; CELL COMMUNICATION; COCULTURE TECHNIQUES; CYTOKINES; HUMANS; INSULIN; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGE ACTIVATION; MACROPHAGES; MEMBRANE PROTEINS; MICE; RETINOL-BINDING PROTEINS, PLASMA; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4; VITAMIN A;

EID: 84861403641     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.06193-11     Document Type: Article

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