-
1
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993;259:87-91
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
3
-
-
0030831210
-
A human homologue of the drosophila toll protein signals activation of adaptive immunity
-
Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997;388:394-397
-
(1997)
Nature
, vol.388
, pp. 394-397
-
-
Medzhitov, R.1
Preston-Hurlburt, P.2
Janeway Jr., C.A.3
-
4
-
-
0035907302
-
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through toll-like receptor 4
-
Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4. J Biol Chem 2001;276:16683-16689
-
(2001)
J Biol Chem
, vol.276
, pp. 16683-16689
-
-
Lee, J.Y.1
Sohn, K.H.2
Rhee, S.H.3
Hwang, D.4
-
5
-
-
37549013749
-
Inhibition or deletion of the lipopolysaccharide receptor toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle
-
Radin MS, Sinha S, Bhatt BA, Dedousis N, O'Doherty RM. Inhibition or deletion of the lipopolysaccharide receptor Toll-like receptor-4 confers partial protection against lipid-induced insulin resistance in rodent skeletal muscle. Diabetologia 2008;51:336-346
-
(2008)
Diabetologia
, vol.51
, pp. 336-346
-
-
Radin, M.S.1
Sinha, S.2
Bhatt, B.A.3
Dedousis, N.4
O'Doherty, R.M.5
-
6
-
-
34247884376
-
C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
-
Poggi M, Bastelica D, Gual P, et al. C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 2007;50:1267-1276
-
(2007)
Diabetologia
, vol.50
, pp. 1267-1276
-
-
Poggi, M.1
Bastelica, D.2
Gual, P.3
-
7
-
-
34547602916
-
Loss-of-function mutation in toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
Tsukumo DML, Carvalho-Filho MA, Carvalheira JBC, et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007;56:1986-1998
-
(2007)
Diabetes
, vol.56
, pp. 1986-1998
-
-
Tsukumo, D.M.L.1
Carvalho-Filho, M.A.2
Carvalheira, J.B.C.3
-
8
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky JM, Glass CK. Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 2010;72:219-246
-
(2010)
Annu Rev Physiol
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
9
-
-
77954672503
-
Adipose tissue macrophages: Their role in adipose tissue remodeling
-
Suganami T, Ogawa Y. Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol 2010;88:33-39
-
(2010)
J Leukoc Biol
, vol.88
, pp. 33-39
-
-
Suganami, T.1
Ogawa, Y.2
-
10
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 2006;116: 3015-3025
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
Flier, J.S.6
-
11
-
-
33846302361
-
Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a tolllike receptor 4 mutation
-
Suganami T, Mieda T, Itoh M, Shimoda Y, Kamei Y, Ogawa Y. Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Tolllike receptor 4 mutation. Biochem Biophys Res Commun 2007;354:45-49
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 45-49
-
-
Suganami, T.1
Mieda, T.2
Itoh, M.3
Shimoda, Y.4
Kamei, Y.5
Ogawa, Y.6
-
12
-
-
67949091182
-
Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue
-
Suganami T, Yuan X, Shimoda Y, et al. Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated fatty acid/Toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res 2009;105:25-32
-
(2009)
Circ Res
, vol.105
, pp. 25-32
-
-
Suganami, T.1
Yuan, X.2
Shimoda, Y.3
-
13
-
-
58149476609
-
Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice
-
Coenen KR, Gruen ML, Lee-Young RS, Puglisi MJ, Wasserman DH, Hasty AH. Impact of macrophage Toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue and the artery wall in mice. Diabetologia 2009;52: 318-328
-
(2009)
Diabetologia
, vol.52
, pp. 318-328
-
-
Coenen, K.R.1
Gruen, M.L.2
Lee-Young, R.S.3
Puglisi, M.J.4
Wasserman, D.H.5
Hasty, A.H.6
-
14
-
-
79959216069
-
Adipose tissue macrophages: Phenotypic plasticity and diversity in lean and obese states
-
Morris DL, Singer K, Lumeng CN. Adipose tissue macrophages: phenotypic plasticity and diversity in lean and obese states. Curr Opin Clin Nutr Metab Care 2011;14:341-346
-
(2011)
Curr Opin Clin Nutr Metab Care
, vol.14
, pp. 341-346
-
-
Morris, D.L.1
Singer, K.2
Lumeng, C.N.3
-
15
-
-
73949125691
-
MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity
-
Westcott DJ, Delproposto JB, Geletka LM, et al. MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity. J Exp Med 2009;206:3143-3156
-
(2009)
J Exp Med
, vol.206
, pp. 3143-3156
-
-
Westcott, D.J.1
Delproposto, J.B.2
Geletka, L.M.3
-
16
-
-
33847393688
-
Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue
-
Coenen KR, Gruen ML, Chait A, Hasty AH. Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into white adipose tissue. Diabetes 2007;56:564-573
-
(2007)
Diabetes
, vol.56
, pp. 564-573
-
-
Coenen, K.R.1
Gruen, M.L.2
Chait, A.3
Hasty, A.H.4
-
17
-
-
73949094213
-
Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages
-
Saraswathi V, Hasty AH. Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages. Arterioscler Thromb Vasc Biol 2009;29:1937-1943
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1937-1943
-
-
Saraswathi, V.1
Hasty, A.H.2
-
18
-
-
77956836852
-
Absence of macrophage inflammatory protein-1a does not impact macrophage accumulation in adipose tissue of diet-induced obese mice
-
Surmi BK, Webb CD, Ristau AC, Hasty AH. Absence of macrophage inflammatory protein-1a does not impact macrophage accumulation in adipose tissue of diet-induced obese mice. Am J Physiol Endocrinol Metab 2010;299:E437-E445.
-
(2010)
Am J Physiol Endocrinol Metab
, vol.299
-
-
Surmi, B.K.1
Webb, C.D.2
Ristau, A.C.3
Hasty, A.H.4
-
19
-
-
33746098574
-
The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages
-
Saraswathi V, Hasty AH. The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in mouse peritoneal macrophages. J Lipid Res 2006;47:1406-1415
-
(2006)
J Lipid Res
, vol.47
, pp. 1406-1415
-
-
Saraswathi, V.1
Hasty, A.H.2
-
20
-
-
72249092930
-
Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/-mice
-
Saraswathi V, Morrow JD, Hasty AH. Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-/-mice. J Nutr 2009;139:2380-2386
-
(2009)
J Nutr
, vol.139
, pp. 2380-2386
-
-
Saraswathi, V.1
Morrow, J.D.2
Hasty, A.H.3
-
21
-
-
33644778829
-
Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse
-
Ayala JE, Bracy DP, McGuinness OP, Wasserman DH. Considerations in the design of hyperinsulinemic-euglycemic clamps in the conscious mouse. Diabetes 2006;55:390-397
-
(2006)
Diabetes
, vol.55
, pp. 390-397
-
-
Ayala, J.E.1
Bracy, D.P.2
McGuinness, O.P.3
Wasserman, D.H.4
-
22
-
-
34047094881
-
Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice
-
Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH. Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 2007;56:1025-1033
-
(2007)
Diabetes
, vol.56
, pp. 1025-1033
-
-
Ayala, J.E.1
Bracy, D.P.2
Julien, B.M.3
Rottman, J.N.4
Fueger, P.T.5
Wasserman, D.H.6
-
23
-
-
0346157023
-
Distributed control of glucose uptake by working muscles of conscious mice: Roles of transport and phosphorylation
-
Fueger PT, Bracy DP, Malabanan CM, Pencek RR, Wasserman DH. Distributed control of glucose uptake by working muscles of conscious mice: roles of transport and phosphorylation. Am J Physiol Endocrinol Metab 2004;286:E77-E84
-
(2004)
Am J Physiol Endocrinol Metab
, vol.286
-
-
Fueger, P.T.1
Bracy, D.P.2
Malabanan, C.M.3
Pencek, R.R.4
Wasserman, D.H.5
-
24
-
-
0141844653
-
Reciprocal modulation of toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
-
Lee JY, Ye J, Gao Z, et al. Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids. J Biol Chem 2003;278: 37041-37051
-
(2003)
J Biol Chem
, vol.278
, pp. 37041-37051
-
-
Lee, J.Y.1
Ye, J.2
Gao, Z.3
-
25
-
-
0035204665
-
Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways
-
Hwang D. Modulation of the expression of cyclooxygenase-2 by fatty acids mediated through toll-like receptor 4-derived signaling pathways. FASEB J 2001;15:2556-2564
-
(2001)
FASEB J
, vol.15
, pp. 2556-2564
-
-
Hwang, D.1
-
26
-
-
58849149821
-
Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: Implications for the pathogenesis of obesity
-
Milanski M, Degasperi G, Coope A, et al. Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity. J Neurosci 2009;29:359-370
-
(2009)
J Neurosci
, vol.29
, pp. 359-370
-
-
Milanski, M.1
Degasperi, G.2
Coope, A.3
-
27
-
-
73949110679
-
Saturated fatty acids do not directly stimulate toll-like receptor signaling
-
Erridge C, Samani NJ. Saturated fatty acids do not directly stimulate Toll-like receptor signaling. Arterioscler Thromb Vasc Biol 2009;29: 1944-1949
-
(2009)
Arterioscler Thromb Vasc Biol
, vol.29
, pp. 1944-1949
-
-
Erridge, C.1
Samani, N.J.2
-
28
-
-
48249125862
-
Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice
-
Cani PD, Bibiloni R, Knauf C, et al. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 2008;57:1470-1481
-
(2008)
Diabetes
, vol.57
, pp. 1470-1481
-
-
Cani, P.D.1
Bibiloni, R.2
Knauf, C.3
-
29
-
-
44449110675
-
Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
-
Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 2008;16:1248-1255
-
(2008)
Obesity (Silver Spring)
, vol.16
, pp. 1248-1255
-
-
Davis, J.E.1
Gabler, N.K.2
Walker-Daniels, J.3
Spurlock, M.E.4
-
30
-
-
79751535591
-
Loss of function mutation in toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice
-
Vijay-Kumar M, Aitken JD, Carvalho FA, Ziegler TR, Gewirtz AT, Ganji V. Loss of function mutation in Toll-like receptor-4 does not offer protection against obesity and insulin resistance induced by a diet high in trans fat in mice. J Inflamm (Lond) 2011;8:2
-
(2011)
J Inflamm (Lond)
, vol.8
, pp. 2
-
-
Vijay-Kumar, M.1
Aitken, J.D.2
Carvalho, F.A.3
Ziegler, T.R.4
Gewirtz, A.T.5
Ganji, V.6
-
31
-
-
34250169823
-
Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
-
Kim F, Pham M, Luttrell I, et al. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 2007; 100:1589-1596
-
(2007)
Circ Res
, vol.100
, pp. 1589-1596
-
-
Kim, F.1
Pham, M.2
Luttrell, I.3
-
32
-
-
70350389389
-
Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
-
Saberi M, Woods N-B, de Luca C, et al. Hematopoietic cell-specific deletion of Toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab 2009;10:419-429
-
(2009)
Cell Metab
, vol.10
, pp. 419-429
-
-
Saberi, M.1
Woods, N.-B.2
De Luca, C.3
-
33
-
-
79955487247
-
Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice
-
Holland WL, Bikman BT, Wang LP, et al. Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice. J Clin Invest 2011;121:1858-1870
-
(2011)
J Clin Invest
, vol.121
, pp. 1858-1870
-
-
Holland, W.L.1
Bikman, B.T.2
Wang, L.P.3
|