메뉴 건너뛰기




Volumn 23, Issue 6, 2011, Pages 431-437

Tissular Tregs: A unique population of adipose-tissue-resident Foxp3+CD4+ T cells that impacts organismal metabolism

Author keywords

Adipose tissue; Inflammation; Obesity; Regulatory T cells; Type 2 diabetes

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; TRANSCRIPTION FACTOR FOXP3;

EID: 82755182907     PISSN: 10445323     EISSN: 10963618     Source Type: Journal    
DOI: 10.1016/j.smim.2011.06.002     Document Type: Review
Times cited : (108)

References (96)
  • 1
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 4
    • 73849097617 scopus 로고    scopus 로고
    • The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice
    • Xie J.J., Wang J., Tang T.T., Chen J., Gao X.L., Yuan J., et al. The Th17/Treg functional imbalance during atherogenesis in ApoE(-/-) mice. Cytokine 2010, 49:185-193.
    • (2010) Cytokine , vol.49 , pp. 185-193
    • Xie, J.J.1    Wang, J.2    Tang, T.T.3    Chen, J.4    Gao, X.L.5    Yuan, J.6
  • 5
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
    • Feuerer M., Herrero L., Cipolletta D., Naaz A., Wong J., Nayer A., et al. Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 2009, 15:930-939.
    • (2009) Nat Med , vol.15 , pp. 930-939
    • Feuerer, M.1    Herrero, L.2    Cipolletta, D.3    Naaz, A.4    Wong, J.5    Nayer, A.6
  • 6
    • 79551529432 scopus 로고    scopus 로고
    • Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers
    • Deiuliis J., Shah Z., Shah N., Needleman B., Mikami D., Narula V., et al. Visceral adipose inflammation in obesity is associated with critical alterations in tregulatory cell numbers. PLoS One 2011, 6:e16376.
    • (2011) PLoS One , vol.6
    • Deiuliis, J.1    Shah, Z.2    Shah, N.3    Needleman, B.4    Mikami, D.5    Narula, V.6
  • 7
    • 79958757212 scopus 로고    scopus 로고
    • Center for Disease Control and Prevention
    • Center for Disease Control and Prevention 2011 National diabetes fact sheet 2011.
    • (2011) 2011 National diabetes fact sheet
  • 9
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 10
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance
    • Hotamisligil G.S., Shargill N.S., Spiegelman B.M. Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993, 259:87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 12
    • 33845873659 scopus 로고    scopus 로고
    • Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression
    • Jager J., Gremeaux T., Cormont M., Le Marchand-Brustel Y., Tanti J.F. Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 2007, 148:241-251.
    • (2007) Endocrinology , vol.148 , pp. 241-251
    • Jager, J.1    Gremeaux, T.2    Cormont, M.3    Le Marchand-Brustel, Y.4    Tanti, J.F.5
  • 13
    • 0242580711 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects
    • Rotter V., Nagaev I., Smith U. Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 2003, 278:45777-45784.
    • (2003) J Biol Chem , vol.278 , pp. 45777-45784
    • Rotter, V.1    Nagaev, I.2    Smith, U.3
  • 14
    • 34548402222 scopus 로고    scopus 로고
    • Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion
    • Han C.Y., Subramanian S., Chan C.K., Omer M., Chiba T., Wight T.N., et al. Adipocyte-derived serum amyloid A3 and hyaluronan play a role in monocyte recruitment and adhesion. Diabetes 2007, 56:2260-2273.
    • (2007) Diabetes , vol.56 , pp. 2260-2273
    • Han, C.Y.1    Subramanian, S.2    Chan, C.K.3    Omer, M.4    Chiba, T.5    Wight, T.N.6
  • 15
    • 33748750917 scopus 로고    scopus 로고
    • Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
    • Kamei N., Tobe K., Suzuki R., Ohsugi M., Watanabe T., Kubota N., et al. Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 2006, 281:26602-26614.
    • (2006) J Biol Chem , vol.281 , pp. 26602-26614
    • Kamei, N.1    Tobe, K.2    Suzuki, R.3    Ohsugi, M.4    Watanabe, T.5    Kubota, N.6
  • 16
    • 5644231992 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes
    • Ozcan U., Cao Q., Yilmaz E., Lee A.H., Iwakoshi N.N., Ozdelen E., et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science 2004, 306:457-461.
    • (2004) Science , vol.306 , pp. 457-461
    • Ozcan, U.1    Cao, Q.2    Yilmaz, E.3    Lee, A.H.4    Iwakoshi, N.N.5    Ozdelen, E.6
  • 17
    • 68949159760 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue
    • Halberg N., Khan T., Trujillo M.E., Wernstedt-Asterholm I., Attie A.D., Sherwani S., et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol 2009, 29:4467-4483.
    • (2009) Mol Cell Biol , vol.29 , pp. 4467-4483
    • Halberg, N.1    Khan, T.2    Trujillo, M.E.3    Wernstedt-Asterholm, I.4    Attie, A.D.5    Sherwani, S.6
  • 18
    • 69949150673 scopus 로고    scopus 로고
    • A crucial role for adipose tissue p53 in the regulation of insulin resistance
    • Minamino T., Orimo M., Shimizu I., Kunieda T., Yokoyama M., Ito T., et al. A crucial role for adipose tissue p53 in the regulation of insulin resistance. Nat Med 2009, 15:1082-1087.
    • (2009) Nat Med , vol.15 , pp. 1082-1087
    • Minamino, T.1    Orimo, M.2    Shimizu, I.3    Kunieda, T.4    Yokoyama, M.5    Ito, T.6
  • 19
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M., Konstantopoulos N., Lee J., Hansen L., Li Z.W., Karin M., et al. Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science 2001, 293:1673-1677.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6
  • 21
    • 0033525870 scopus 로고    scopus 로고
    • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    • Elchebly M., Payette P., Michaliszyn E., Cromlish W., Collins S., Loy A.L., et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999, 283:1544-1548.
    • (1999) Science , vol.283 , pp. 1544-1548
    • Elchebly, M.1    Payette, P.2    Michaliszyn, E.3    Cromlish, W.4    Collins, S.5    Loy, A.L.6
  • 22
    • 0027332738 scopus 로고
    • Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates
    • Feinstein R., Kanety H., Papa M.Z., Lunenfeld B., Karasik A. Tumor necrosis factor-alpha suppresses insulin-induced tyrosine phosphorylation of insulin receptor and its substrates. J Biol Chem 1993, 268:26055-26058.
    • (1993) J Biol Chem , vol.268 , pp. 26055-26058
    • Feinstein, R.1    Kanety, H.2    Papa, M.Z.3    Lunenfeld, B.4    Karasik, A.5
  • 23
    • 53149119231 scopus 로고    scopus 로고
    • Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
    • Elgazar-Carmon V., Rudich A., Hadad N., Levy R. Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res 2008, 49:1894-1903.
    • (2008) J Lipid Res , vol.49 , pp. 1894-1903
    • Elgazar-Carmon, V.1    Rudich, A.2    Hadad, N.3    Levy, R.4
  • 24
    • 68349160704 scopus 로고    scopus 로고
    • Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
    • Liu J., Divoux A., Sun J., Zhang J., Clement K., Glickman J.N., et al. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 2009, 15:940-945.
    • (2009) Nat Med , vol.15 , pp. 940-945
    • Liu, J.1    Divoux, A.2    Sun, J.3    Zhang, J.4    Clement, K.5    Glickman, J.N.6
  • 25
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S., Mitchell G., Barbatelli G., Murano I., Ceresi E., Faloia E., et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005, 46:2347-2355.
    • (2005) J Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3    Murano, I.4    Ceresi, E.5    Faloia, E.6
  • 27
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • Mosser D.M., Edwards J.P. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008, 8:958-969.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 29
    • 70350560546 scopus 로고    scopus 로고
    • Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
    • Fujisaka S., Usui I., Bukhari A., Ikutani M., Oya T., Kanatani Y., et al. Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 2009, 58:2574-2582.
    • (2009) Diabetes , vol.58 , pp. 2574-2582
    • Fujisaka, S.1    Usui, I.2    Bukhari, A.3    Ikutani, M.4    Oya, T.5    Kanatani, Y.6
  • 30
    • 33846026712 scopus 로고    scopus 로고
    • Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    • Lumeng C.N., Bodzin J.L., Saltiel A.R. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 2007, 117:175-184.
    • (2007) J Clin Invest , vol.117 , pp. 175-184
    • Lumeng, C.N.1    Bodzin, J.L.2    Saltiel, A.R.3
  • 31
    • 33847073149 scopus 로고    scopus 로고
    • Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    • Lumeng C.N., Deyoung S.M., Bodzin J.L., Saltiel A.R. Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity. Diabetes 2007, 56:16-23.
    • (2007) Diabetes , vol.56 , pp. 16-23
    • Lumeng, C.N.1    Deyoung, S.M.2    Bodzin, J.L.3    Saltiel, A.R.4
  • 32
    • 77951822653 scopus 로고    scopus 로고
    • Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice
    • Shaul M.E., Bennett G., Strissel K.J., Greenberg A.S., Obin M.S. Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice. Diabetes 2010, 59:1171-1181.
    • (2010) Diabetes , vol.59 , pp. 1171-1181
    • Shaul, M.E.1    Bennett, G.2    Strissel, K.J.3    Greenberg, A.S.4    Obin, M.S.5
  • 34
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B., Youm Y.H., Ravussin A., Galgani J.E., Stadler K., Mynatt R.L., et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011, 17:179-188.
    • (2011) Nat Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3    Galgani, J.E.4    Stadler, K.5    Mynatt, R.L.6
  • 35
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K., Tschopp J. The inflammasomes. Cell 2010, 140:821-832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tschopp, J.2
  • 36
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
    • Duewell P., Kono H., Rayner K.J., Sirois C.M., Vladimer G., Bauernfeind F.G., et al. NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 2010, 464:1357-1361.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1    Kono, H.2    Rayner, K.J.3    Sirois, C.M.4    Vladimer, G.5    Bauernfeind, F.G.6
  • 37
    • 77955356552 scopus 로고    scopus 로고
    • Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation
    • Rajamaki K., Lappalainen J., Oorni K., Valimaki E., Matikainen S., Kovanen P.T., et al. Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One 2010, 5:e11765.
    • (2010) PLoS One , vol.5
    • Rajamaki, K.1    Lappalainen, J.2    Oorni, K.3    Valimaki, E.4    Matikainen, S.5    Kovanen, P.T.6
  • 38
    • 36849005372 scopus 로고    scopus 로고
    • A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways
    • Nguyen M.T., Favelyukis S., Nguyen A.K., Reichart D., Scott P.A., Jenn A., et al. A subpopulation of macrophages infiltrates hypertrophic adipose tissue and is activated by free fatty acids via Toll-like receptors 2 and 4 and JNK-dependent pathways. J Biol Chem 2007, 282:35279-35292.
    • (2007) J Biol Chem , vol.282 , pp. 35279-35292
    • Nguyen, M.T.1    Favelyukis, S.2    Nguyen, A.K.3    Reichart, D.4    Scott, P.A.5    Jenn, A.6
  • 39
    • 46249117032 scopus 로고    scopus 로고
    • T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
    • Kintscher U., Hartge M., Hess K., Foryst-Ludwig A., Clemenz M., Wabitsch M., et al. T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 2008, 28:1304-1310.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 1304-1310
    • Kintscher, U.1    Hartge, M.2    Hess, K.3    Foryst-Ludwig, A.4    Clemenz, M.5    Wabitsch, M.6
  • 40
    • 68349150756 scopus 로고    scopus 로고
    • CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    • Nishimura S., Manabe I., Nagasaki M., Eto K., Yamashita H., Ohsugi M., et al. CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 2009, 15:914-920.
    • (2009) Nat Med , vol.15 , pp. 914-920
    • Nishimura, S.1    Manabe, I.2    Nagasaki, M.3    Eto, K.4    Yamashita, H.5    Ohsugi, M.6
  • 41
    • 77956396699 scopus 로고    scopus 로고
    • Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance
    • Yang H., Youm Y.H., Vandanmagsar B., Ravussin A., Gimble J.M., Greenway F., et al. Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance. J Immunol 2010, 185:1836-1845.
    • (2010) J Immunol , vol.185 , pp. 1836-1845
    • Yang, H.1    Youm, Y.H.2    Vandanmagsar, B.3    Ravussin, A.4    Gimble, J.M.5    Greenway, F.6
  • 42
    • 68349137821 scopus 로고    scopus 로고
    • Normalization of obesity-associated insulin resistance through immunotherapy
    • Winer S., Chan Y., Paltser G., Truong D., Tsui H., Bahrami J., et al. Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 2009, 15:921-929.
    • (2009) Nat Med , vol.15 , pp. 921-929
    • Winer, S.1    Chan, Y.2    Paltser, G.3    Truong, D.4    Tsui, H.5    Bahrami, J.6
  • 44
    • 54049086276 scopus 로고    scopus 로고
    • Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity
    • Rocha V.Z., Folco E.J., Sukhova G., Shimizu K., Gotsman I., Vernon A.H., et al. Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity. Circ Res 2008, 103:467-476.
    • (2008) Circ Res , vol.103 , pp. 467-476
    • Rocha, V.Z.1    Folco, E.J.2    Sukhova, G.3    Shimizu, K.4    Gotsman, I.5    Vernon, A.H.6
  • 45
    • 0032572722 scopus 로고    scopus 로고
    • Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
    • Lord G.M., Matarese G., Howard J.K., Baker R.J., Bloom S.R., Lechler R.I. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998, 394:897-901.
    • (1998) Nature , vol.394 , pp. 897-901
    • Lord, G.M.1    Matarese, G.2    Howard, J.K.3    Baker, R.J.4    Bloom, S.R.5    Lechler, R.I.6
  • 46
    • 78650667201 scopus 로고    scopus 로고
    • An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo
    • Wang Y., Souabni A., Flavell R.A., Wan Y.Y. An intrinsic mechanism predisposes Foxp3-expressing regulatory T cells to Th2 conversion in vivo. J Immunol 2010, 185:5983-5992.
    • (2010) J Immunol , vol.185 , pp. 5983-5992
    • Wang, Y.1    Souabni, A.2    Flavell, R.A.3    Wan, Y.Y.4
  • 48
    • 0028519015 scopus 로고
    • Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells
    • Powrie F., Leach M.W., Mauze S., Menon S., Caddle L.B., Coffman R.L. Inhibition of Th1 responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells. Immunity 1994, 1:553-562.
    • (1994) Immunity , vol.1 , pp. 553-562
    • Powrie, F.1    Leach, M.W.2    Mauze, S.3    Menon, S.4    Caddle, L.B.5    Coffman, R.L.6
  • 49
    • 0030018186 scopus 로고    scopus 로고
    • T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice
    • Davidson N.J., Leach M.W., Fort M.M., Thompson-Snipes L., Kuhn R., Muller W., et al. T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice. J Exp Med 1996, 184:241-251.
    • (1996) J Exp Med , vol.184 , pp. 241-251
    • Davidson, N.J.1    Leach, M.W.2    Fort, M.M.3    Thompson-Snipes, L.4    Kuhn, R.5    Muller, W.6
  • 50
    • 77953486362 scopus 로고    scopus 로고
    • Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis
    • Feng T., Wang L., Schoeb T.R., Elson C.O., Cong Y. Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis. J Exp Med 2010, 207:1321-1332.
    • (2010) J Exp Med , vol.207 , pp. 1321-1332
    • Feng, T.1    Wang, L.2    Schoeb, T.R.3    Elson, C.O.4    Cong, Y.5
  • 51
    • 38149142633 scopus 로고    scopus 로고
    • Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration
    • Rausch M.E., Weisberg S., Vardhana P., Tortoriello D.V. Obesity in C57BL/6J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond) 2008, 32:451-463.
    • (2008) Int J Obes (Lond) , vol.32 , pp. 451-463
    • Rausch, M.E.1    Weisberg, S.2    Vardhana, P.3    Tortoriello, D.V.4
  • 52
    • 65649117802 scopus 로고    scopus 로고
    • Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity
    • Duffaut C., Galitzky J., Lafontan M., Bouloumie A. Unexpected trafficking of immune cells within the adipose tissue during the onset of obesity. Biochem Biophys Res Commun 2009, 384:482-485.
    • (2009) Biochem Biophys Res Commun , vol.384 , pp. 482-485
    • Duffaut, C.1    Galitzky, J.2    Lafontan, M.3    Bouloumie, A.4
  • 53
    • 85027938385 scopus 로고    scopus 로고
    • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
    • Winer D.A., Winer S., Shen L., Wadia P.P., Yantha J., Paltser G., et al. B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 2011, 17:610-617.
    • (2011) Nat Med , vol.17 , pp. 610-617
    • Winer, D.A.1    Winer, S.2    Shen, L.3    Wadia, P.P.4    Yantha, J.5    Paltser, G.6
  • 54
    • 0035803465 scopus 로고    scopus 로고
    • Splenic T zone development is B cell dependent
    • Ngo V.N., Cornall R.J., Cyster J.G. Splenic T zone development is B cell dependent. J Exp Med 2001, 194:1649-1660.
    • (2001) J Exp Med , vol.194 , pp. 1649-1660
    • Ngo, V.N.1    Cornall, R.J.2    Cyster, J.G.3
  • 55
    • 0034712736 scopus 로고    scopus 로고
    • CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools
    • Baumgarth N., Jager G.C., Herman O.C., Herzenberg L.A. CD4+ T cells derived from B cell-deficient mice inhibit the establishment of peripheral B cell pools. Proc Natl Acad Sci U S A 2000, 97:4766-4771.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4766-4771
    • Baumgarth, N.1    Jager, G.C.2    Herman, O.C.3    Herzenberg, L.A.4
  • 56
    • 0034668824 scopus 로고    scopus 로고
    • A critical role for B cells in the development of memory CD4 cells
    • Linton P.J., Harbertson J., Bradley L.M. A critical role for B cells in the development of memory CD4 cells. J Immunol 2000, 165:5558-5565.
    • (2000) J Immunol , vol.165 , pp. 5558-5565
    • Linton, P.J.1    Harbertson, J.2    Bradley, L.M.3
  • 57
    • 36048978911 scopus 로고    scopus 로고
    • Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature
    • Hill J.A., Feuerer M., Tash K., Haxhinasto S., Perez J., Melamed R., et al. Foxp3 transcription-factor-dependent and -independent regulation of the regulatory T cell transcriptional signature. Immunity 2007, 27:786-800.
    • (2007) Immunity , vol.27 , pp. 786-800
    • Hill, J.A.1    Feuerer, M.2    Tash, K.3    Haxhinasto, S.4    Perez, J.5    Melamed, R.6
  • 61
    • 67649170980 scopus 로고    scopus 로고
    • Foxp3+ regulatory T cells: differentiation, specification, subphenotypes
    • Feuerer M., Hill J.A., Mathis D., Benoist C. Foxp3+ regulatory T cells: differentiation, specification, subphenotypes. Nat Immunol 2009, 10:689-695.
    • (2009) Nat Immunol , vol.10 , pp. 689-695
    • Feuerer, M.1    Hill, J.A.2    Mathis, D.3    Benoist, C.4
  • 62
    • 62649165369 scopus 로고    scopus 로고
    • Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses
    • Zheng Y., Chaudhry A., Kas A., Deroos P., Kim J.M., Chu T.T., et al. Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responses. Nature 2009, 458:351-356.
    • (2009) Nature , vol.458 , pp. 351-356
    • Zheng, Y.1    Chaudhry, A.2    Kas, A.3    Deroos, P.4    Kim, J.M.5    Chu, T.T.6
  • 63
    • 70049113279 scopus 로고    scopus 로고
    • CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner
    • Chaudhry A., Rudra D., Treuting P., Samstein R.M., Liang Y., Kas A., et al. CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner. Science 2009, 326:986-991.
    • (2009) Science , vol.326 , pp. 986-991
    • Chaudhry, A.1    Rudra, D.2    Treuting, P.3    Samstein, R.M.4    Liang, Y.5    Kas, A.6
  • 64
    • 65749103365 scopus 로고    scopus 로고
    • The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation
    • Koch M.A., Tucker-Heard G., Perdue N.R., Killebrew J.R., Urdahl K.B., Campbell D.J. The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation. Nat Immunol 2009, 10:595-602.
    • (2009) Nat Immunol , vol.10 , pp. 595-602
    • Koch, M.A.1    Tucker-Heard, G.2    Perdue, N.R.3    Killebrew, J.R.4    Urdahl, K.B.5    Campbell, D.J.6
  • 65
    • 42649144463 scopus 로고    scopus 로고
    • Beneficial effects of subcutaneous fat transplantation on metabolism
    • Tran T.T., Yamamoto Y., Gesta S., Kahn C.R. Beneficial effects of subcutaneous fat transplantation on metabolism. Cell Metab 2008, 7:410-420.
    • (2008) Cell Metab , vol.7 , pp. 410-420
    • Tran, T.T.1    Yamamoto, Y.2    Gesta, S.3    Kahn, C.R.4
  • 67
    • 0037312490 scopus 로고    scopus 로고
    • Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein
    • Thorburn J., Frankel A.E., Thorburn A. Apoptosis by leukemia cell-targeted diphtheria toxin occurs via receptor-independent activation of Fas-associated death domain protein. Clin Cancer Res 2003, 9:861-865.
    • (2003) Clin Cancer Res , vol.9 , pp. 861-865
    • Thorburn, J.1    Frankel, A.E.2    Thorburn, A.3
  • 68
    • 33645465526 scopus 로고    scopus 로고
    • Selective stimulation of T cell subsets with antibody-cytokine immune complexes
    • Boyman O., Kovar M., Rubinstein M.P., Surh C.D., Sprent J. Selective stimulation of T cell subsets with antibody-cytokine immune complexes. Science 2006, 311:1924-1927.
    • (2006) Science , vol.311 , pp. 1924-1927
    • Boyman, O.1    Kovar, M.2    Rubinstein, M.P.3    Surh, C.D.4    Sprent, J.5
  • 70
    • 0029004532 scopus 로고
    • Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur
    • Klebig M.L., Wilkinson J.E., Geisler J.G., Woychik R.P. Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl Acad Sci U S A 1995, 92:4728-4732.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4728-4732
    • Klebig, M.L.1    Wilkinson, J.E.2    Geisler, J.G.3    Woychik, R.P.4
  • 73
    • 0035873418 scopus 로고    scopus 로고
    • Requirement for leptin in the induction and progression of autoimmune encephalomyelitis
    • Matarese G., Di G.A., Sanna V., Lord G.M., Howard J.K., Di T.A., et al. Requirement for leptin in the induction and progression of autoimmune encephalomyelitis. J Immunol 2001, 166:5909-5916.
    • (2001) J Immunol , vol.166 , pp. 5909-5916
    • Matarese, G.1    Di, G.A.2    Sanna, V.3    Lord, G.M.4    Howard, J.K.5    Di, T.A.6
  • 74
    • 33847312289 scopus 로고    scopus 로고
    • A key role of leptin in the control of regulatory T cell proliferation
    • De R.V., Procaccini C., Cali G., Pirozzi G., Fontana S., Zappacosta S., et al. A key role of leptin in the control of regulatory T cell proliferation. Immunity 2007, 26:241-255.
    • (2007) Immunity , vol.26 , pp. 241-255
    • De, R.V.1    Procaccini, C.2    Cali, G.3    Pirozzi, G.4    Fontana, S.5    Zappacosta, S.6
  • 75
    • 67650215353 scopus 로고    scopus 로고
    • Atheroprotective effects of alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells
    • Wigren M., Bengtsson D., Duner P., Olofsson K., Bjorkbacka H., Bengtsson E., et al. Atheroprotective effects of alum are associated with capture of oxidized LDL antigens and activation of regulatory T cells. Circ Res 2009, 104:e62-e70.
    • (2009) Circ Res , vol.104
    • Wigren, M.1    Bengtsson, D.2    Duner, P.3    Olofsson, K.4    Bjorkbacka, H.5    Bengtsson, E.6
  • 76
    • 33750692702 scopus 로고    scopus 로고
    • Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule
    • Gotsman I., Grabie N., Gupta R., Dacosta R., MacConmara M., Lederer J., et al. Impaired regulatory T-cell response and enhanced atherosclerosis in the absence of inducible costimulatory molecule. Circulation 2006, 114:2047-2055.
    • (2006) Circulation , vol.114 , pp. 2047-2055
    • Gotsman, I.1    Grabie, N.2    Gupta, R.3    Dacosta, R.4    MacConmara, M.5    Lederer, J.6
  • 77
    • 36348967350 scopus 로고    scopus 로고
    • Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions
    • de Boer O.J., van der Meer J.J., Teeling P., van der Loos C.M., van der Wal A.C. Low numbers of FOXP3 positive regulatory T cells are present in all developmental stages of human atherosclerotic lesions. PLoS One 2007, 2:e779.
    • (2007) PLoS One , vol.2
    • de Boer, O.J.1    van der Meer, J.J.2    Teeling, P.3    van der Loos, C.M.4    van der Wal, A.C.5
  • 79
    • 16844369607 scopus 로고    scopus 로고
    • Natural regulatory T cells in infectious disease
    • Belkaid Y., Rouse B.T. Natural regulatory T cells in infectious disease. Nat Immunol 2005, 6:353-360.
    • (2005) Nat Immunol , vol.6 , pp. 353-360
    • Belkaid, Y.1    Rouse, B.T.2
  • 80
    • 29144516273 scopus 로고    scopus 로고
    • Global natural regulatory T cell depletion in active systemic lupus erythematosus
    • Miyara M., Amoura Z., Parizot C., Badoual C., Dorgham K., Trad S., et al. Global natural regulatory T cell depletion in active systemic lupus erythematosus. J Immunol 2005, 175:8392-8400.
    • (2005) J Immunol , vol.175 , pp. 8392-8400
    • Miyara, M.1    Amoura, Z.2    Parizot, C.3    Badoual, C.4    Dorgham, K.5    Trad, S.6
  • 82
    • 0035806276 scopus 로고    scopus 로고
    • CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade
    • Taylor P.A., Noelle R.J., Blazar B.R. CD4(+)CD25(+) immune regulatory cells are required for induction of tolerance to alloantigen via costimulatory blockade. J Exp Med 2001, 193:1311-1318.
    • (2001) J Exp Med , vol.193 , pp. 1311-1318
    • Taylor, P.A.1    Noelle, R.J.2    Blazar, B.R.3
  • 84
    • 1842732224 scopus 로고    scopus 로고
    • Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis
    • Viglietta V., Baecher-Allan C., Weiner H.L., Hafler D.A. Loss of functional suppression by CD4+CD25+ regulatory T cells in patients with multiple sclerosis. J Exp Med 2004, 199:971-979.
    • (2004) J Exp Med , vol.199 , pp. 971-979
    • Viglietta, V.1    Baecher-Allan, C.2    Weiner, H.L.3    Hafler, D.A.4
  • 85
    • 3543140687 scopus 로고    scopus 로고
    • Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy
    • Ehrenstein M.R., Evans J.G., Singh A., Moore S., Warnes G., Isenberg D.A., et al. Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNFalpha therapy. J Exp Med 2004, 200:277-285.
    • (2004) J Exp Med , vol.200 , pp. 277-285
    • Ehrenstein, M.R.1    Evans, J.G.2    Singh, A.3    Moore, S.4    Warnes, G.5    Isenberg, D.A.6
  • 86
    • 2942642383 scopus 로고    scopus 로고
    • In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes
    • Tang Q., Henriksen K.J., Bi M., Finger E.B., Szot G., Ye J., et al. In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes. J Exp Med 2004, 199:1455-1465.
    • (2004) J Exp Med , vol.199 , pp. 1455-1465
    • Tang, Q.1    Henriksen, K.J.2    Bi, M.3    Finger, E.B.4    Szot, G.5    Ye, J.6
  • 87
    • 2942692039 scopus 로고    scopus 로고
    • CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide suppress autoimmune diabetes
    • Tarbell K.V., Yamazaki S., Olson K., Toy P., Steinman R.M. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide suppress autoimmune diabetes. J Exp Med 2004, 199:1467-1477.
    • (2004) J Exp Med , vol.199 , pp. 1467-1477
    • Tarbell, K.V.1    Yamazaki, S.2    Olson, K.3    Toy, P.4    Steinman, R.M.5
  • 88
    • 34547230077 scopus 로고    scopus 로고
    • CD3-specific antibodies: a portal to the treatment of autoimmunity
    • Chatenoud L., Bluestone J.A. CD3-specific antibodies: a portal to the treatment of autoimmunity. Nat Rev Immunol 2007, 7:622-632.
    • (2007) Nat Rev Immunol , vol.7 , pp. 622-632
    • Chatenoud, L.1    Bluestone, J.A.2
  • 89
    • 77953110535 scopus 로고    scopus 로고
    • Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice
    • Ilan Y., Maron R., Tukpah A.M., Maioli T.U., Murugaiyan G., Yang K., et al. Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice. Proc Natl Acad Sci U S A 2010, 107:9765-9770.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 9765-9770
    • Ilan, Y.1    Maron, R.2    Tukpah, A.M.3    Maioli, T.U.4    Murugaiyan, G.5    Yang, K.6
  • 91
    • 33744990181 scopus 로고    scopus 로고
    • Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+
    • Ochi H., Abraham M., Ishikawa H., Frenkel D., Yang K., Basso A.S., et al. Oral CD3-specific antibody suppresses autoimmune encephalomyelitis by inducing CD4+. Nat Med 2006, 12:627-635.
    • (2006) Nat Med , vol.12 , pp. 627-635
    • Ochi, H.1    Abraham, M.2    Ishikawa, H.3    Frenkel, D.4    Yang, K.5    Basso, A.S.6
  • 92
    • 34547563816 scopus 로고    scopus 로고
    • Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody
    • Ishikawa H., Ochi H., Chen M.L., Frenkel D., Maron R., Weiner H.L. Inhibition of autoimmune diabetes by oral administration of anti-CD3 monoclonal antibody. Diabetes 2007, 56:2103-2109.
    • (2007) Diabetes , vol.56 , pp. 2103-2109
    • Ishikawa, H.1    Ochi, H.2    Chen, M.L.3    Frenkel, D.4    Maron, R.5    Weiner, H.L.6
  • 93
    • 65649117701 scopus 로고    scopus 로고
    • Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells
    • Wu H.Y., Center E.M., Tsokos G.C., Weiner H.L. Suppression of murine SLE by oral anti-CD3: inducible CD4+CD25-LAP+ regulatory T cells control the expansion of IL-17+ follicular helper T cells. Lupus 2009, 18:586-596.
    • (2009) Lupus , vol.18 , pp. 586-596
    • Wu, H.Y.1    Center, E.M.2    Tsokos, G.C.3    Weiner, H.L.4
  • 94
    • 33745486749 scopus 로고    scopus 로고
    • CD4+CD25+ Tregs and NKT cells: regulators regulating regulators
    • La C.A., Van K.L., Fu D.S. CD4+CD25+ Tregs and NKT cells: regulators regulating regulators. Trends Immunol 2006, 27:322-327.
    • (2006) Trends Immunol , vol.27 , pp. 322-327
    • La, C.A.1    Van, K.L.2    Fu, D.S.3
  • 95
    • 33750515883 scopus 로고    scopus 로고
    • Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice
    • Steffens S., Burger F., Pelli G., Dean Y., Elson G., Kosco-Vilbois M., et al. Short-term treatment with anti-CD3 antibody reduces the development and progression of atherosclerosis in mice. Circulation 2006, 114:1977-1984.
    • (2006) Circulation , vol.114 , pp. 1977-1984
    • Steffens, S.1    Burger, F.2    Pelli, G.3    Dean, Y.4    Elson, G.5    Kosco-Vilbois, M.6
  • 96
    • 20444373376 scopus 로고    scopus 로고
    • Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells
    • Battaglia M., Stabilini A., Roncarolo M.G. Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells. Blood 2005, 105:4743-4748.
    • (2005) Blood , vol.105 , pp. 4743-4748
    • Battaglia, M.1    Stabilini, A.2    Roncarolo, M.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.