Gut microbiota and diabetes: From pathogenesis to therapeutic perspective

Acta Diabetologica

Volumn 48, Issue 4, 2011, Pages 257-273

  Burcelin, Rémy ^a   Serino, Matteo ^a   Chabo, Chantal ^a   Blasco Baque, Vincent ^a   Amar, Jacques ^b  

^a University Hospital of Toulouse   (France)

^b CHU RANGUEIL   (France)

Author keywords

Gut microbiota dysbiosis; High throughput sequencing; Inflammation; Obesity; Prebiotic and probiotic; Type 2 diabetes

Indexed keywords

BIOLOGICAL MARKER; CHOLINE; PREBIOTIC AGENT; PROBIOTIC AGENT; SYNBIOTIC AGENT;

ADIPOSE TISSUE; BACTERIAL SECRETION SYSTEM; CARDIOVASCULAR RISK; DIABETES MELLITUS; DIET SUPPLEMENTATION; DISEASE CONTROL; DISEASE MARKER; DISEASE TRANSMISSION; ENVIRONMENTAL FACTOR; FATTY LIVER; FEEDING BEHAVIOR; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HYPERGLYCEMIA; IMMUNE RESPONSE; INFLAMMATION; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; INTESTINE FLORA; LIPID METABOLISM; LIPID STORAGE; METABOLIC DISORDER; METAGENOME; MICROBIAL COLONIZATION; MICROBIAL COMMUNITY; MICROBIOME; MOLECULAR DYNAMICS; NONHUMAN; PATHOGENESIS; PERIODONTITIS; PLASTICITY; PREDICTIVE VALUE; PRIORITY JOURNAL; REVIEW; RISK FACTOR; SOCIAL BEHAVIOR; WEIGHT GAIN;

ANIMALS; BACTERIA; DIABETES MELLITUS; GASTROINTESTINAL TRACT; HUMANS; METAGENOME;

EID: 84355166655     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-011-0333-6     Document Type: Review

References (170)

1. KM Pantalone MW Kattan C Yu BJ Wells S Arrigain A Jain, et al. 2009 The risk of developing coronary artery disease or congestive heart failure, and overall mortality, in type 2 diabetic patients receiving rosiglitazone, pioglitazone, metformin, or sulfonylureas: a retrospective analysis Acta Diabetol 46 2 145 154 19194648 1:CAS:528:DC%2BD1MXlsFKlu7c%3D 10.1007/s00592-008-0090-3
2. G Danaei CM Lawes S Vander Hoorn CJ Murray M Ezzati 2006 Global and regional mortality from ischaemic heart disease and stroke attributable to higher-than-optimum blood glucose concentration: comparative risk assessment Lancet 368 9548 1651 1659 17098083 10.1016/S0140-6736(06)69700-6 (Pubitemid 46048553)
3. PD Cani J Amar MA Iglesias M Poggi C Knauf D Bastelica, et al. 2007 Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 7 1761 1772 17456850 1:CAS:528:DC%2BD2sXnvVWjurk%3D 10.2337/db06-1491 (Pubitemid 47025442)
4. WHO (2004) Comparative quantification of health risks: global and regional burden of disease attributable to selected major risk factors. WHO, Geneva
5. SM Ruchat CE Elks RJ Loos MC Vohl SJ Weisnagel T Rankinen, et al. 2009 Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies Acta Diabetol 46 3 217 226 19082521 1:CAS:528:DC%2BD1MXptVGmsrk%3D 10.1007/s00592-008-0080-5
6. RI Amann B Zarda DA Stahl KH Schleifer 1992 Identification of individual prokaryotic cells by using enzyme-labeled, rRNA-targeted oligonucleotide probes Appl Environ Microbiol 58 9 3007 3011 1444414 1:CAS:528:DyaK38XlvVGks74%3D
7. AL Goodman G Kallstrom JJ Faith A Reyes A Moore G Dantas, et al. 2011 Extensive personal human gut microbiota culture collections characterized and manipulated in gnotobiotic mice Proc Natl Acad Sci USA 108 15 6252 6257 21436049 1:CAS:528:DC%2BC3MXltVOqurc%3D 10.1073/pnas.1102938108
8. D Knights E Costello R Knight 2010 Supervised classication of human microbiota FEMS Microbiol Rev 35 343 359 21039646 10.1111/j.1574-6976.2010. 00251.x 1:CAS:528:DC%2BC3MXjtVaitbY%3D
9. L Dethlefsen PB Eckburg EM Bik DA Relman 2006 Assembly of the human intestinal microbiota Trends Ecol Evol 21 9 517 523 16820245 10.1016/j.tree.2006.06.013 (Pubitemid 44233957)
10. L Dethlefsen M McFall-Ngai DA Relman 2007 An ecological and evolutionary perspective on human-microbe mutualism and disease Nature 449 7164 811 818 17943117 1:CAS:528:DC%2BD2sXhtFOjt7nM 10.1038/nature06245 (Pubitemid 47598621)
11. PJ Turnbaugh RE Ley M Hamady CM Fraser-Liggett R Knight JI Gordon 2007 The human microbiome project Nature 449 7164 804 810 17943116 1:CAS:528:DC%2BD2sXhtFOjt7nP 10.1038/nature06244 (Pubitemid 47598620)
12. J Qin R Li J Raes M Arumugam KS Burgdorf C Manichanh, et al. 2010 A human gut microbial gene catalogue established by metagenomic sequencing Nature 464 7285 59 65 20203603 1:CAS:528:DC%2BC3cXislahsLc%3D 10.1038/nature08821
13. RI Mackie A Sghir HR Gaskins 1999 Developmental microbial ecology of the neonatal gastrointestinal tract Am J Clin Nutr 69 5 1035S 1045S 10232646 1:CAS:528:DyaK1MXislGntbg%3D (Pubitemid 29205082)
14. CF Favier EE Vaughan WM De Vos AD Akkermans 2002 Molecular monitoring of succession of bacterial communities in human neonates Appl Environ Microbiol 68 1 219 226 11772630 1:CAS:528:DC%2BD38Xjt1Wntw%3D%3D 10.1128/AEM.68.1.219-226. 2002 (Pubitemid 34031183)
15. C Palmer EM Bik DB DiGiulio DA Relman PO Brown 2007 Development of the human infant intestinal microbiota PLoS Biol 5 7 e177 17594176 10.1371/journal.pbio.0050177 1:CAS:528:DC%2BD2sXps1anu70%3D (Pubitemid 47105346)
16. EG Zoetendal M Rajilic-Stojanovic WM de Vos 2008 High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota Gut 57 11 1605 1615 18941009 1:CAS:528:DC%2BD1cXhtl2gtr%2FI 10.1136/gut.2007. 133603
17. MJ Claesson S Cusack O O'Sullivan R Greene-Diniz H de Weerd E Flannery, et al. 2011 Composition, variability, and temporal stability of the intestinal microbiota of the elderly Proc Natl Acad Sci USA 108 Suppl 1 4586 4591 20571116 1:CAS:528:DC%2BC3MXjvVCkurg%3D 10.1073/pnas.1000097107
18. EG Zoetendal AD Akkermans WM De Vos 1998 Temperature gradient gel electrophoresis analysis of 16S rRNA from human fecal samples reveals stable and host-specific communities of active bacteria Appl Environ Microbiol 64 10 3854 3859 9758810 1:CAS:528:DyaK1cXms1entLY%3D (Pubitemid 28462983)
19. J Tap S Mondot F Levenez E Pelletier C Caron JP Furet, et al. 2009 Towards the human intestinal microbiota phylogenetic core Environ Microbiol 11 10 2574 2584 19601958 10.1111/j.1462-2920.2009.01982.x
20. RE Ley DA Peterson JI Gordon 2006 Ecological and evolutionary forces shaping microbial diversity in the human intestine Cell 124 4 837 848 16497592 1:CAS:528:DC%2BD28Xit1Kltbs%3D 10.1016/j.cell.2006.02.017 (Pubitemid 43261456)
21. JM Wells O Rossi M Meijerink P van Baarlen 2011 Epithelial crosstalk at the microbiota-mucosal interface Proc Natl Acad Sci USA 108 Suppl 1 4607 4614 20826446 1:CAS:528:DC%2BC3MXjvVCkurc%3D 10.1073/pnas.1000092107
22. ME Johansson M Phillipson J Petersson A Velcich L Holm GC Hansson 2008 The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria Proc Natl Acad Sci USA 105 39 15064 15069 18806221 1:CAS:528: DC%2BD1cXht1alsLvF 10.1073/pnas.0803124105
23. G Musso R Gambino M Cassader 2010 Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded? Diabetes Care 33 10 2277 2284 20876708 10.2337/dc10-0556
24. MT Asquith JR Harrod 1979 Reduction of bacterial contamination in banked human milk J Pediatr 95 6 993 994 501505 1:STN:280:DyaL3c%2FltFGisw%3D%3D 10.1016/S0022-3476(79)80291-7 (Pubitemid 10249790)
25. VO Rotimi SA Olowe I Ahmed 1985 The development of bacterial flora of premature neonates J Hyg (Lond) 94 3 309 318 1:STN:280:DyaL2M3jsFGitg%3D%3D 10.1017/S0022172400061532 (Pubitemid 15064118)
26. M Kalliomaki MC Collado S Salminen E Isolauri 2008 Early differences in fecal microbiota composition in children may predict overweight Am J Clin Nutr 87 3 534 538 18326589 1:CAS:528:DC%2BD1cXjsVagt7w%3D (Pubitemid 351364532)
27. C Manichanh J Reeder P Gibert E Varela M Llopis M Antolin, et al. 2010 Reshaping the gut microbiome with bacterial transplantation and antibiotic intake Genome Res 20 10 1411 1419 20736229 1:CAS:528:DC%2BC3cXht12jsrnL 10.1101/gr.107987.110
28. V Gaboriau-Routhiau S Rakotobe E Lecuyer I Mulder A Lan C Bridonneau, et al. 2009 The key role of segmented filamentous bacteria in the coordinated maturation of gut helper T cell responses Immunity 31 4 677 689 19833089 1:CAS:528:DC%2BD1MXhsVChtLrF 10.1016/j.immuni.2009.08.020
29. S Hapfelmeier MA Lawson E Slack JK Kirundi M Stoel M Heikenwalder, et al. 2010 Reversible microbial colonization of germ-free mice reveals the dynamics of IgA immune responses Science 328 5986 1705 1709 20576892 1:CAS:528: DC%2BC3cXnvVektbc%3D 10.1126/science.1188454
30. A Cerutti M Rescigno 2008 The biology of intestinal immunoglobulin A responses Immunity 28 6 740 750 18549797 1:CAS:528:DC%2BD1cXnsF2gu74%3D 10.1016/j.immuni.2008.05.001 (Pubitemid 351784512)
31. A Cerutti 2010 Immunology. IgA changes the rules of memory Science 328 5986 1646 1647 20576880 1:CAS:528:DC%2BC3cXot1yjsr0%3D 10.1126/science.1192488
32. RE Ley PJ Turnbaugh S Klein JI Gordon 2006 Human gut microbes associated with obesity Nature 444 1022 1023 17183309 1:CAS:528:DC%2BD28XhtlemtLvM 10.1038/4441022a (Pubitemid 46018512)
33. N Larsen FK Vogensen FW van den Berg DS Nielsen AS Andreasen BK Pedersen, et al. 2010 Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults PLoS One 5 2 e9085 20140211 10.1371/journal.pone.0009085 1:CAS:528:DC%2BC3cXhsl2rsbk%3D
34. M Serino E Luche C Chabo J Amar R Burcelin 2009 Intestinal microflora and metabolic diseases Diabetes Metab 35 4 262 272 19419895 1:STN:280: DC%2BD1Mnksl2ltQ%3D%3D 10.1016/j.diabet.2009.03.003
35. RE Ley M Hamady C Lozupone PJ Turnbaugh RR Ramey JS Bircher, et al. 2008 Evolution of mammals and their gut microbes Science 320 5883 1647 1651 18497261 1:CAS:528:DC%2BD1cXnt1Oju7o%3D 10.1126/science.1155725 (Pubitemid 351931256)
36. ED Sonnenburg H Zheng P Joglekar SK Higginbottom SJ Firbank DN Bolam, et al. 2010 Specificity of polysaccharide use in intestinal Bacteroides species determines diet-induced microbiota alterations Cell 141 7 1241 1252 20603004 1:CAS:528:DC%2BC3cXovFarur0%3D 10.1016/j.cell.2010.05.005
37. S Shoelson J Lee A Goldfine 2006 Inflammation and insulin resistance J Clin Invest 116 1793 1801 16823477 1:CAS:528:DC%2BD28XmvV2ltLo%3D 10.1172/JCI29069
38. GS Hotamisligil 2006 Inflammation and metabolic disorders Nature 444 7121 860 867 17167474 1:CAS:528:DC%2BD28XhtlShtrzK 10.1038/nature05485 (Pubitemid 46024993)
39. LG Ooi R Ahmad KH Yuen MT Liong 2010 Lactobacillus acidophilus CHO-220 and inulin reduced plasma total cholesterol and low-density lipoprotein cholesterol via alteration of lipid transporters J Dairy Sci 93 11 5048 5058 20965319 1:CAS:528:DC%2BC3MXnsl2ltw%3D%3D 10.3168/jds.2010-3311
40. R Ley M Hamady C Lozupone P Turnbaugh R Ramey J Bircher, et al. 2008 Evolution of mammals and their gut microbes Science 320 1647 1651 18497261 1:CAS:528:DC%2BD1cXnt1Oju7o%3D 10.1126/science.1155725 (Pubitemid 351931256)
41. F Backhed RE Ley JL Sonnenburg DA Peterson JI Gordon 2005 Host-bacterial mutualism in the human intestine Science 307 5717 1915 1920 15790844 10.1126/science.1104816 1:CAS:528:DC%2BD2MXisVyiu78%3D (Pubitemid 40404694)
42. F Backhed H Ding T Wang LV Hooper GY Koh A Nagy, et al. 2004 The gut microbiota as an environmental factor that regulates fat storage Proc Natl Acad Sci USA 101 44 15718 15723 15505215 10.1073/pnas.0407076101 1:CAS:528: DC%2BD2cXhtVWisLjE (Pubitemid 39473554)
43. RE Ley F Backhed P Turnbaugh CA Lozupone RD Knight JI Gordon 2005 Obesity alters gut microbial ecology Proc Natl Acad Sci USA 102 31 11070 11075 16033867 1:CAS:528:DC%2BD2MXnvVWju7g%3D 10.1073/pnas.0504978102 (Pubitemid 41105994)
44. GC Baker JJ Smith DA Cowan 2003 Review and re-analysis of domain-specific 16S primers J Microbiol Methods 55 3 541 555 14607398 1:CAS:528: DC%2BD3sXos1KmsLw%3D 10.1016/j.mimet.2003.08.009 (Pubitemid 37357207)
45. JM Neefs Y Van de Peer P De Rijk S Chapelle R De Wachter 1993 Compilation of small ribosomal subunit RNA structures Nucleic Acids Res 21 13 3025 3049 8332525 1:CAS:528:DyaK3sXkvV2itL4%3D 10.1093/nar/21.13.3025 (Pubitemid 23223603)
46. Q Wang G Garrity J Tiedje J Cole 2007 Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy Appl Environ Microbiol 73 5261 5267 17586664 1:CAS:528:DC%2BD2sXpsleqtrc%3D 10.1128/AEM.00062-07 (Pubitemid 47326658)
47. C von Mering LJ Jensen B Snel SD Hooper M Krupp M Foglierini, et al. 2005 STRING: known and predicted protein-protein associations, integrated and transferred across organisms Nucleic Acids Res 33 Database issue D433 D437 10.1093/nar/gki005 1:CAS:528:DC%2BD2MXisVeisw%3D%3D (Pubitemid 40207910)
48. M Kanehisa S Goto S Kawashima Y Okuno M Hattori 2004 The KEGG resource for deciphering the genome Nucleic Acids Res 32 Database issue D277 D280 14681412 1:CAS:528:DC%2BD3sXhtVSrurvO 10.1093/nar/gkh063
49. PJ Turnbaugh RE Ley MA Mahowald V Magrini ER Mardis JI Gordon 2006 An obesity-associated gut microbiome with increased capacity for energy harvest Nature 444 7122 1027 1031 17183312 10.1038/nature05414 (Pubitemid 46018515)
50. RE Ley PJ Turnbaugh S Klein JI Gordon 2006 Microbial ecology: human gut microbes associated with obesity Nature 444 7122 1022 1023 17183309 1:CAS:528:DC%2BD28XhtlemtLvM 10.1038/4441022a (Pubitemid 46018512)
51. PJ Turnbaugh M Hamady T Yatsunenko BL Cantarel A Duncan RE Ley, et al. 2009 A core gut microbiome in obese and lean twins Nature 457 7228 480 484 19043404 1:CAS:528:DC%2BD1MXotlOlsw%3D%3D 10.1038/nature07540
52. JG Caporaso CL Lauber WA Walters D Berg-Lyons CA Lozupone PJ Turnbaugh, et al. 2011 Global patterns of 16S rRNA diversity at a depth of millions of sequences per sample Proc Natl Acad Sci USA 108 Suppl 1 4516 4522 20534432 1:CAS:528:DC%2BC3MXjvVCktL0%3D 10.1073/pnas.1000080107
53. H Buchwald Y Avidor E Braunwald MD Jensen W Pories K Fahrbach, et al. 2004 Bariatric surgery: a systematic review and meta-analysis Jama 292 14 1724 1737 15479938 1:CAS:528:DC%2BD2cXos1OjtLg%3D 10.1001/jama.292.14.1724 (Pubitemid 39346675)
54. A Bjorneklett K Viddal T Midtvedt K Nygaard 1981 Intestinal and gastric bypass. Changes in intestinal microecology after surgical treatment of morbid obesity in man Scand J Gastroenterol 16 681 687 7323701 1:STN:280: DyaL387gslKjtA%3D%3D 10.3109/00365528109182030 (Pubitemid 11026139)
55. Y Nishizawa T Imaizumi H Tanishita I Yano Y Kawai H Mormii 1988 Relationship of fat deposition and intestinal microflora in VMH rats Int J Obes 12 2 103 110 3384556 1:STN:280:DyaL1c3ls1CrtQ%3D%3D
56. RD Heijtz S Wang F Anuar Y Qian B Bjorkholm A Samuelsson, et al. 2011 Normal gut microbiota modulates brain development and behavior Proc Natl Acad Sci USA 108 7 3047 3052 21282636 1:CAS:528:DC%2BC3MXisVans7k%3D 10.1073/pnas.1010529108
57. L Wen R Ley P Volchkov P Stranges L Avanesyan A Stonebraker, et al. 2008 Innate immunity and intestinal microbiota in the development of type 1 diabetes Nature 455 7216 1109 1113 18806780 1:CAS:528:DC%2BD1cXht1yju7%2FK 10.1038/nature07336
58. LV Hooper TS Stappenbeck CV Hong JI Gordon 2003 Angiogenins: a new class of microbicidal proteins involved in innate immunity Nat Immunol 4 3 269 273 12548285 1:CAS:528:DC%2BD3sXhsVGisLg%3D 10.1038/ni888 (Pubitemid 36322137)
59. LV Hooper JI Gordon 2001 Commensal host-bacterial relationships in the gut Science 292 5519 1115 1118 11352068 1:CAS:528:DC%2BD3MXjs1Chtbk%3D 10.1126/science.1058709 (Pubitemid 32440925)
60. L Bry PG Falk T Midtvedt JI Gordon 1996 A model of host-microbial interactions in an open mammalian ecosystem Science 273 5280 1380 1383 8703071 1:CAS:528:DyaK28XlsVCnu78%3D 10.1126/science.273.5280.1380 (Pubitemid 26296524)
61. M Schenk C Mueller 2008 The mucosal immune system at the gastrointestinal barrier Best Pract Res Clin Gastroenterol 22 3 391 409 18492562 1:CAS:528:DC%2BD1cXlvF2rtbg%3D 10.1016/j.bpg.2007.11.002 (Pubitemid 351676810)
62. JC Pickup MA Crook 1998 Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41 10 1241 1248 9794114 1:CAS:528: DyaK1cXmtlais70%3D 10.1007/s001250051058 (Pubitemid 28449093)
63. PD Cani NM Delzenne J Amar R Burcelin 2008 Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding Pathol Biol (Paris) 56 5 305 309 1:CAS:528:DC%2BD1cXoslOhu74%3D 10.1016/j.patbio.2007.09.008
64. P Turnbaugh V Ridaura J Faith F Rey R Knight J Gordon 2009 The effect of diet on the human gut microbiome: a metagenomic analysis in humanized gnotobiotic mice Sci Transl Med 1 6 14 10.1126/scitranslmed.3000322 1:CAS:528:DC%2BC3cXhtVWkt7zI
65. PD Cani R Bibiloni C Knauf A Waget AM Neyrinck NM Delzenne, et al. 2008 Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice Diabetes 57 6 1470 1481 18305141 1:CAS:528:DC%2BD1cXnsF2ju78%3D 10.2337/db07-1403
66. M Bukoff S Carlson 1981 Diet modifications and behavioral changes for bariatric gastric surgery J Am Diet Assoc 78 2 158 161 7217572 1:STN:280:DyaL3M7mvFSrsQ%3D%3D
67. CM Edwards JF Todd M Mahmoudi Z Wang RM Wang MA Ghatei, et al. 1999 Glucagon-like peptide 1 has a physiological role in the control of postprandial glucose in humans: studies with the antagonist exendin 9-39 Diabetes 48 1 86 93 9892226 1:CAS:528:DyaK1MXhvV2qtQ%3D%3D 10.2337/diabetes.48.1.86 (Pubitemid 29019356)
68. JP Furet LC Kong J Tap C Poitou A Basdevant JL Bouillot, et al. 2010 Differential adaptation of human gut microbiota to bariatric surgery-induced weight loss: links with metabolic and low-grade inflammation markers Diabetes 59 12 3049 3057 20876719 1:CAS:528:DC%2BC3MXlsVamtg%3D%3D 10.2337/db10-0253
69. H Zhang JK DiBaise A Zuccolo D Kudrna M Braidotti Y Yu, et al. 2009 Human gut microbiota in obesity and after gastric bypass Proc Natl Acad Sci USA 106 7 2365 2370 19164560 1:CAS:528:DC%2BD1MXit12jtL4%3D 10.1073/pnas.0812600106
70. R Calvani A Miccheli G Capuani A Tomassini Miccheli C Puccetti M Delfini, et al. 2010 Gut microbiome-derived metabolites characterize a peculiar obese urinary metabotype Int J Obes (Lond) 34 6 1095 1098 1:CAS:528: DC%2BC3cXnsVOmsLg%3D 10.1038/ijo.2010.44
71. F Backhed JK Manchester CF Semenkovich JI Gordon 2007 Mechanisms underlying the resistance to diet-induced obesity in germ-free mice Proc Natl Acad Sci USA 104 3 979 984 17210919 1:CAS:528:DC%2BD2sXhtVSitbo%3D 10.1073/pnas.0605374104 (Pubitemid 46154722)
72. ME Dumas RH Barton A Toye O Cloarec C Blancher A Rothwell, et al. 2006 Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice Proc Natl Acad Sci USA 103 33 12511 12516 16895997 1:CAS:528:DC%2BD28Xos12qu7s%3D 10.1073/pnas.0601056103 (Pubitemid 44267289)
73. M Spencer T Hamp R Reid L Fischer S Zeisel A Fodor 2011 Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency Gastroenterology 140 3 976 986 21129376 1:CAS:528:DC%2BC3MXjs1Wksb4%3D 10.1053/j.gastro.2010.11.049
74. EF Murphy PD Cotter S Healy TM Marques O O'Sullivan F Fouhy, et al. 2010 Composition and energy harvesting capacity of the gut microbiota: relationship to diet, obesity and time in mouse models Gut 59 12 1635 1642 20926643 1:STN:280:DC%2BC3cbmsVSqug%3D%3D 10.1136/gut.2010.215665
75. S Caspar-Bauguil B Cousin A Galinier C Segafredo M Nibbelink M Andre, et al. 2005 Adipose tissues as an ancestral immune organ: site-specific change in obesity FEBS Lett 579 17 3487 3492 15953605 1:CAS:528:DC%2BD2MXlvVWrtr0%3D 10.1016/j.febslet.2005.05.031 (Pubitemid 40897681)
76. M Feuerer L Herrero D Cipolletta A Naaz J Wong A Nayer, et al. 2009 Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters Nat Med 15 930 939 19633656 1:CAS:528:DC%2BD1MXovFyltr4%3D 10.1038/nm.2002
77. SP Weisberg D McCann M Desai M Rosenbaum RL Leibel AW Ferrante Jr 2003 Obesity is associated with macrophage accumulation in adipose tissue J Clin Invest 112 12 1796 1808 14679176 1:CAS:528:DC%2BD3sXhtVSmtLvO (Pubitemid 38063703)
78. S Winer Y Chan G Paltser D Truong H Tsui J Bahrami, et al. 2009 Normalization of obesity-associated insulin resistance through immunotherapy Nat Med 15 8 921 929 19633657 1:CAS:528:DC%2BD1MXovFylurw%3D 10.1038/nm.2001
79. S Rakoff-Nahoum J Paglino F Eslami-Varzaneh S Edberg R Medzhitov 2004 Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis Cell 118 2 229 241 15260992 1:CAS:528: DC%2BD2cXmtlKntrg%3D 10.1016/j.cell.2004.07.002 (Pubitemid 38962578)
80. JH Fritz L Le Bourhis G Sellge JG Magalhaes H Fsihi TA Kufer, et al. 2007 Nod1-mediated innate immune recognition of peptidoglycan contributes to the onset of adaptive immunity Immunity 26 4 445 459 17433730 1:CAS:528: DC%2BD2sXltVKjs74%3D 10.1016/j.immuni.2007.03.009 (Pubitemid 46604867)
81. TA Kufer PJ Sansonetti 2007 Sensing of bacteria: NOD a lonely job Curr Opin Microbiol 10 1 62 69 17161646 1:CAS:528:DC%2BD2sXhsFOhsbg%3D 10.1016/j.mib.2006.11.003 (Pubitemid 46216870)
82. J Amar R Burcelin J Ruidavets P Cani J Fauvel M Alessi, et al. 2008 Energy intake is associated with endotoxemia in apparently healthy men Am J Clin Nutr 87 1219 1223 18469242 1:CAS:528:DC%2BD1cXmtFWjsr8%3D (Pubitemid 351679761)
83. M Poggi D Bastelica P Gual MA Iglesias T Gremeaux C Knauf, et al. 2007 C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet Diabetologia 50 6 1267 1276 17426960 1:CAS:528: DC%2BD2sXkvFKjurc%3D 10.1007/s00125-007-0654-8 (Pubitemid 46701560)
84. MJ Song KH Kim JM Yoon JB Kim 2006 Activation of toll-like receptor 4 is associated with insulin resistance in adipocytes Biochem Biophys Res Commun 346 3 739 745 16781673 1:CAS:528:DC%2BD28XmtlWrsLs%3D 10.1016/j.bbrc.2006.05.170
85. S Ding MM Chi BP Scull R Rigby NM Schwerbrock S Magness, et al. 2010 High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse PLoS One 5 8 e12191 20808947 10.1371/journal.pone.0012191 1:CAS:528:DC%2BC3cXhtVGntrfI
86. M Membrez F Blancher M Jaquet R Bibiloni PD Cani RG Burcelin, et al. 2008 Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice Faseb J 22 7 2416 2426 18326786 1:CAS:528:DC%2BD1cXotlGntL8%3D 10.1096/fj.07-102723 (Pubitemid 351948659)
87. Laugerette F, Vors C, Geloen A, Chauvin MA, Soulage C, Lambert-Porcheron S et al (2010) Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation. J Nutr Biochem 22(1):53-59
88. Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, Rottier O et al (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58(8):1091-1103
89. M Vijay-Kumar JD Aitken FA Carvalho TC Cullender S Mwangi S Srinivasan, et al. 2010 Metabolic syndrome and altered gut microbiota in mice lacking toll-like receptor 5 Science 328 5975 228 231 20203013 1:CAS:528: DC%2BC3cXkt1Cgt7o%3D 10.1126/science.1179721
90. DD Black P Tso S Weidman SM Sabesin 1983 Intestinal lipoproteins in the rat with D-(+)-galactosamine hepatitis J Lipid Res 24 8 977 992 6631239 1:CAS:528:DyaL3sXlt1Shtrk%3D (Pubitemid 13002336)
91. I Pappo H Becovier EM Berry HR Freund 1991 Polymyxin B reduces cecal flora, TNF production and hepatic steatosis during total parenteral nutrition in the rat J Surg Res 51 2 106 112 1907698 1:STN:280:DyaK3MzisFGlsQ%3D%3D 10.1016/0022-4804(91)90078-Z
92. HW Harris SE Brady JH Rapp 2002 Hepatic endosomal trafficking of lipoprotein-bound endotoxin in rats J Surg Res 106 1 188 195 12127825 1:CAS:528:DC%2BD38XltlKhu7k%3D 10.1006/jsre.2002.6413
93. S Ghoshal J Witta J Zhong W de Villiers E Eckhardt 2009 Chylomicrons promote intestinal absorption of lipopolysaccharides J Lipid Res 50 1 90 97 18815435 1:CAS:528:DC%2BD1MXptFOhuw%3D%3D 10.1194/jlr.M800156-JLR200
94. PC Rensen M Oosten E Bilt M Eck J Kuiper TJ Berkel 1997 Human recombinant apolipoprotein E redirects lipopolysaccharide from Kupffer cells to liver parenchymal cells in rats in vivo J Clin Invest 99 10 2438 2445 9153287 1:CAS:528:DyaK2sXjsVGqtrk%3D 10.1172/JCI119427 (Pubitemid 27227722)
95. ZL Kumwenda CB Wong JA Johnson JE Gosnell WJ Welch HW Harris 2002 Chylomicron-bound endotoxin selectively inhibits NF-kappaB activation in rat hepatocytes Shock 18 2 182 188 12166784 10.1097/00024382-200208000-00016
96. M Westerterp JF Berbee NM Pires GJ van Mierlo R Kleemann JA Romijn, et al. 2007 Apolipoprotein C-I is crucially involved in lipopolysaccharide-induced atherosclerosis development in apolipoprotein E-knockout mice Circulation 116 19 2173 2181 17967778 1:CAS:528:DC%2BD2sXht1elsrvL 10.1161/CIRCULATIONAHA.107. 693382 (Pubitemid 350060355)
97. D Thabut KA Tazi D Bonnefont-Rousselot M Aller O Farges MC Guimont, et al. 2007 High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats Hepatology 46 6 1893 1906 17918268 1:CAS:528:DC%2BD2sXhsVGiurzN 10.1002/hep.21875
98. AC Vreugdenhil CH Rousseau T Hartung JW Greve C van 't Veer WA Buurman 2003 Lipopolysaccharide (LPS)-binding protein mediates LPS detoxification by chylomicrons J Immunol 170 3 1399 1405 12538700 1:CAS:528:DC%2BD3sXnvVOksQ%3D%3D (Pubitemid 36139507)
99. VR Velagapudi R Hezaveh CS Reigstad P Gopalacharyulu L Yetukuri S Islam, et al. 2010 The gut microbiota modulates host energy and lipid metabolism in mice J Lipid Res 51 5 1101 1112 20040631 1:CAS:528:DC%2BC3cXltlWktL8%3D 10.1194/jlr.M002774
100. BE Gustafsson K Einarsson J Gustafsson 1975 Influence of cholesterol feeding on liver microsomal metabolism of steroids and bile acids in conventional and germ-free rats J Biol Chem 250 21 8496 8502 811655 1:CAS:528:DyaE28Xhs1SjtQ%3D%3D
101. P Gerard P Lepercq M Leclerc F Gavini P Raibaud C Juste 2007 Bacteroides sp. strain D8, the first cholesterol-reducing bacterium isolated from human feces Appl Environ Microbiol 73 5742 5749 17616613 1:CAS:528:DC%2BD2sXhtV2gtLrE 10.1128/AEM.02806-06 (Pubitemid 47462984)
102. Gustafsson B, Swenander Lanke L (1960) Bilirubin and urobilins in germfree, ex-germfree, and conventional rats. J Exp Med 112:975-981
103. M Oresic T Seppanen-Laakso L Yetukuri F Backhed V Hanninen 2009 Gut microbiota affects lens and retinal lipid composition Exp Eye Res 89 5 604 607 19591827 1:CAS:528:DC%2BD1MXht1aisbzF 10.1016/j.exer.2009.06.018
104. R Caesar F Fak F Backhed 2010 Effects of gut microbiota on obesity and atherosclerosis via modulation of inflammation and lipid metabolism J Intern Med 268 4 320 328 21050286 1:CAS:528:DC%2BC3cXht12mtr7K 10.1111/j.1365-2796.2010. 02270.x
105. S Epstein J Zhu M Burnett Y Zhou G Vercellotti D Hajjar 2000 Infectionand atherosclerosis: potential roles of pathogen burden and molecular mimicry Arterioscler Thromb Vasc Biol 20 1417 1420 10845851 1:STN:280: DC%2BD3czgsFGlug%3D%3D 10.1161/01.ATV.20.6.1417 (Pubitemid 30353867)
106. S Ott N El Mokhtari M Musfeldt 2006 Detection of diverse bacterial signatures in atherosclerotic lesions of patients with coronary heart disease Circulation 113 929 937 16490835 10.1161/CIRCULATIONAHA.105.579979 (Pubitemid 43879467)
107. O Koren A Spor J Felin F Fak J Stombaugh V Tremaroli, et al. 2011 Human oral, gut, and plaque microbiota in patients with atherosclerosis Proc Natl Acad Sci USA 108 Suppl 1 4592 4598 20937873 1:CAS:528:DC%2BC3MXjvVCkurk%3D 10.1073/pnas.1011383107
108. C Maziere MA Conte F Dantin JC Maziere 1999 Lipopolysaccharide enhances oxidative modification of low density lipoprotein by copper ions, endothelial and smooth muscle cells Atherosclerosis 143 1 75 80 10208481 1:CAS:528:DyaK1MXht1Oitbk%3D 10.1016/S0021-9150(98)00277-9 (Pubitemid 29138704)
109. CJ Wiedermann S Kiechl S Dunzendorfer P Schratzberger G Egger F Oberhollenzer, et al. 1999 Association of endotoxemia with carotid atherosclerosis and cardiovascular disease: prospective results from the bruneck study J Am Coll Cardiol 34 7 1975 1981 10588212 1:STN:280: DC%2BD3c%2FltlCgsQ%3D%3D 10.1016/S0735-1097(99)00448-9 (Pubitemid 30002653)
110. J Amar JB Ruidavets C Bal Dit Sollier V Bongard H Boccalon B Chamontin, et al. 2003 Soluble CD14 and aortic stiffness in a population-based study J Hypertens 21 10 1869 1877 14508193 1:CAS:528:DC%2BD3sXnsFSnsr4%3D 10.1097/00004872-200310000-00014 (Pubitemid 37290105)
111. R Andraws JS Berger DL Brown 2005 Effects of antibiotic therapy on outcomes of patients with coronary artery disease: ameta-analysis of randomized controlled trials JAMA 293 2641 2647 15928286 1:CAS:528:DC%2BD2MXkslSmtbs%3D 10.1001/jama.293.21.2641 (Pubitemid 40741201)
112. SA Kocaman A Sahinarslan A Akyel T Timurkaynak B Boyaci A Cengel 2010 The association of circulating monocyte count with coronary collateral growth in patients with diabetes mellitus Acta Diabetol 47 1 49 54 19219401 10.1007/s00592-009-0097-4
113. G Dalmasso HT Nguyen Y Yan H Laroui MA Charania S Ayyadurai, et al. 2011 Microbiota modulate host gene expression via microRNAs PLoS One 6 4 e19293 21559394 1:CAS:528:DC%2BC3MXls1KktLw%3D 10.1371/journal.pone.0019293
114. R Menghini V Casagrande M Cardellini E Martelli A Terrinoni F Amati, et al. 2009 MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1 Circulation 120 15 1524 1532 19786632 1:CAS:528:DC%2BD1MXht1Wmsr%2FE 10.1161/CIRCULATIONAHA.109.864629
115. Ferre P, Foufelle F (2010) Hepatic steatosis: a role for de novo lipogenesis and the transcription factor SREBP-1c. Diabetes Obes Metab Suppl 2:83-92
116. C Postic J Girard 2008 The role of the lipogenic pathway in the development of hepatic steatosis Diabetes Metab 34 6 Pt 2 643 648 19195625 1:CAS:528:DC%2BD1MXitVyqsbY%3D 10.1016/S1262-3636(08)74599-3
117. CP Day 2010 Genetic and environmental susceptibility to non-alcoholic fatty liver disease Dig Dis 28 1 255 260 20460920 10.1159/000282098
118. DW Han 2002 Intestinal endotoxemia as a pathogenetic mechanism in liver failure World J Gastroenterol 8 6 961 965 12439906
119. HY Zhang W de Han AR Su LT Zhang ZF Zhao JQ Ji, et al. 2007 Intestinal endotoxemia plays a central role in development of hepatopulmonary syndrome in a cirrhotic rat model induced by multiple pathogenic factors World J Gastroenterol 13 47 6385 6395 18081228 1:CAS:528:DC%2BD1cXhtlekur0%3D 10.3748/wjg.13.6385
120. YH Paik RF Schwabe R Bataller MP Russo C Jobin DA Brenner 2003 Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells Hepatology 37 5 1043 1055 12717385 1:CAS:528:DC%2BD3sXktVWns7Y%3D 10.1053/jhep.2003.50182 (Pubitemid 36538681)
121. G Eisenbarth 1986 Type I diabetes mellitus: a chronic auto-immune disease? N Engl J Med 314 1360 1368 3517648 1:STN:280:DyaL283gtlCrsw%3D%3D 10.1056/NEJM198605223142106 (Pubitemid 16122469)
122. R Assan G Feutren J Sirmai C Laborie C Boitard P Vexiau, et al. 1990 Plasma C-peptide levels and clinical remissions in recent-onset type I diabetic patients treated with cyclosporin A and insulin Diabetes 39 768 774 2191883 1:STN:280:DyaK3c3osVKisQ%3D%3D 10.2337/diabetes.39.7.768 (Pubitemid 20211423)
123. RG Burcelin M Eddouks M Beylot S Normand C Boitard G Feutren, et al. 1993 Hypersensitivity to insulin during remissions in cyclosporin-treated IDDM patients Diabetes Care 16 6 881 888 8325202 1:STN:280:DyaK3szhsVGhsg%3D%3D 10.2337/diacare.16.6.881
124. C King N Sarvetnick 2011 The incidence of type-1 diabetes in NOD mice is modulated by restricted flora not germ-free conditions PLoS One 6 2 e17049 21364875 1:CAS:528:DC%2BC3MXjtVylsL0%3D 10.1371/journal.pone.0017049
125. P Pozzilli A Signore AJ Williams PE Beales 1993 NOD mouse colonies around the world-recent facts and figures Immunol Today 14 5 193 196 8517916 1:STN:280:DyaK3s3pvVahsw%3D%3D 10.1016/0167-5699(93)90160-M (Pubitemid 23124509)
126. MF McInerney SB Pek DW Thomas 1991 Prevention of insulitis and diabetes onset by treatment with complete Freund's adjuvant in NOD mice Diabetes 40 6 715 725 2040388 1:STN:280:DyaK3M3ltVShug%3D%3D 10.2337/diabetes.40.6.715
127. MW Sadelain HY Qin J Lauzon B Singh 1990 Prevention of type I diabetes in NOD mice by adjuvant immunotherapy Diabetes 39 5 583 589 2139617 1:CAS:528:DyaK3cXktVCnt70%3D 10.2337/diabetes.39.5.583 (Pubitemid 20223784)
128. Karvonen M, Tuomilehto J, Libman I, LaPorte R (1993) A review of the recent epidemiological data on the worldwide incidence of type 1 (insulin-dependent) diabetes mellitus. World Health Organization DIAMOND Project Group. Diabetologia 36(10):883-892 (Pubitemid 23288746)
129. CC Patterson G Dahlquist G Soltesz A Green 2001 Is childhood-onset type I diabetes a wealth-related disease? An ecological analysis of European incidence rates Diabetologia 44 Suppl 3 B9 B16 11724424 10.1007/PL00002961
130. C Levy-Marchal CC Patterson A Green 2001 Geographical variation of presentation at diagnosis of type I diabetes in children: the EURODIAB study. European and dibetes Diabetologia 44 Suppl 3 B75 B80 11724421 10.1007/PL00002958
131. A Green CC Patterson 2001 Trends in the incidence of childhood-onset diabetes in Europe 1989-1998 Diabetologia 44 Suppl 3 B3 B8 11724413 10.1007/PL00002950
132. PG Holt C Somerville MJ Baron-Hay BJ Holt PD Sly 1995 Functional assessment of CD2, CD3 and CD28 on the surface of peripheral blood T-cells from infants at low versus high genetic risk for atopy Pediatr Allergy Immunol 6 2 80
133. PG Holt 1995 Postnatal maturation of immune competence during infancy and childhood Pediatr Allergy Immunol 6 2 59 70 7581722 1:STN:280: DyaK28%2Fos1Cksw%3D%3D 10.1111/j.1399-3038.1995.tb00261.x
134. S Akira S Uematsu O Takeuchi 2006 Pathogen recognition and innate immunity Cell 124 4 783 801 16497588 1:CAS:528:DC%2BD28Xit1Kltb8%3D 10.1016/j.cell.2006.02.015 (Pubitemid 43261452)
135. R Valladares D Sankar N Li E Williams KK Lai AS Abdelgeliel, et al. 2010 Lactobacillus johnsonii N6.2 mitigates the development of type 1 diabetes in BB-DP rats PLoS One 5 5 e10507 20463897 10.1371/journal.pone.0010507 1:CAS:528:DC%2BC3cXmt1Oktrk%3D
136. S Brugman FA Klatter JT Visser AC Wildeboer-Veloo HJ Harmsen J Rozing, et al. 2006 Antibiotic treatment partially protects against type 1 diabetes in the bio-breeding diabetes-prone rat. Is the gut flora involved in the development of type 1 diabetes? Diabetologia 49 9 2105 2108 16816951 1:CAS:528: DC%2BD28XnslSitb8%3D 10.1007/s00125-006-0334-0 (Pubitemid 44168478)
137. T Pischon F Hu K Rexrode C Girman J Manson E Rimm 2008 Inflammation, the metabolic syndrome, and risk of coronary heart disease in women and men Atherosclerosis 197 392 399 17681508 1:CAS:528:DC%2BD1cXisVSlsb4%3D 10.1016/j.atherosclerosis.2007.06.022 (Pubitemid 351273261)
138. E Firatli 1997 The relationship between clinical periodontal status and insulin-dependent diabetes mellitus. Results after 5 years J Periodontol 68 136 140 9058330 1:STN:280:DyaK2s3htFegsA%3D%3D (Pubitemid 127518255)
139. F D'Aiuto W Sabbah G Netuveli N Donos A Hingorani J Deanfield 2008 Association of the metabolic syndrome with severe periodontitis in a large US population-based survey J Clin Endocrinol Metab 93 3989 3994 18682518 10.1210/jc.2007-2522 1:CAS:528:DC%2BD1cXht1Gmur3F
140. Vergnes JN, Kaminski M, Lelong N, Musset AM, Sixou M, Nabet C (2011) Maternal dental caries and pre-term birth: results from the EPIPAP study. Acta Odontol Scand 69(4):248-256
141. H Löe 1993 Periodontal disease. The sixth complication of diabetes mellitus Diabetes Care 16 1 329 334 8422804 (Pubitemid 23013872)
142. M Soell M Hassan A Miliauskaite Y Haïkel D Selimovic 2007 The oral cavity of elderly patients in diabetes Diabetes Metab 33 Suppl 1 S10 S18 17702095 10.1016/S1262-3636(07)80053-X (Pubitemid 47268802)
143. J Slots 1986 Rapid identification of important periodontal microorganisms by cultivation Oral Microbiol Immunol 1 48 57 3295680 1:STN:280: DyaL2s3jtVClsQ%3D%3D 10.1111/j.1399-302X.1986.tb00318.x
144. N Doan A Contreras J Flynn J Morrison J Slots 1999 Proficiencies of three anaerobic culture systems for recovering periodontal pathogenic bacteria J Clin Microbiol 37 171 174 9854085 1:STN:280:DyaK1M7gt1Cltw%3D%3D (Pubitemid 29004201)
145. T Saito Y Shimazaki 2007 Metabolic disorders related to obesity and periodontal disease Periodontology 43 254 266 10.1111/j.1600-0757.2006.00186.x
146. K Hettne M Weeber M Laine H Ten Cate S Boyer J Kors 2007 Automatic mining of the literature to generate new hypotheses for the possible link between periodontitis and atherosclerosis: lipopolysaccharide as a case study J Clin Periodontol 34 1016 1024 18028194 1:CAS:528:DC%2BD1cXls1Slsw%3D%3D 10.1111/j.1600-051X.2007.01152.x
147. L Darré J-N Vergnes P Gourdy M Sixou 2008 Efficacy of periodontal treatment on glycaemic control in diabetic patients: a meta-analysis of interventional studies Diabetes Metab 34 497 506 18948050 10.1016/j.diabet.2008. 03.006
148. S Grossi 2001 Treatment of periodontal disease and control of diabetes: an assessment of the evidence and need for future research Ann Periodontol 6 138 145 11887456 1:STN:280:DC%2BD387lsFKkug%3D%3D 10.1902/annals.2001.6.1.138
149. L Miller M Manwell D Newbold M Reding A Rasheed J Blodgett 1992 The relationship between reduction in periodontal inflammation and diabetes control: a report of 9 cases J Periodontol 63 843 848 1403592 1:STN:280: DyaK3s%2FitVWjsw%3D%3D
150. M Roberfroid 2007 Prebiotics: the concept revisited J Nutr 137 3 Suppl 2 830S 837S 17311983 1:CAS:528:DC%2BD2sXisVygtrY%3D (Pubitemid 46397526)
151. MB Roberfroid 2007 Inulin-type fructans: functional food ingredients J Nutr 137 11 Suppl 2493S 2502S 17951492 1:CAS:528:DC%2BD2sXht1ynsbvI (Pubitemid 350058725)
152. GR Gibson 1998 Dietary modulation of the human gut microflora using prebiotics Br J Nutr 80 4 S209 S212 9924286 1:CAS:528:DyaK1cXnvVKksLw%3D
153. F Guarner 2007 Studies with inulin-type fructans on intestinal infections, permeability, and inflammation J Nutr 137 2568S 2571S 17951504 1:CAS:528:DC%2BD2sXht1ynsbjK (Pubitemid 350058737)
154. PD Cani AM Neyrinck N Maton NM Delzenne 2005 Oligofructose promotes satiety in rats fed a high-fat diet: involvement of glucagon-like peptide-1 Obes Res 13 6 1000 1007 15976142 1:CAS:528:DC%2BD2MXmvFWls7k%3D 10.1038/oby.2005.117
155. C Knauf PD Cani DH Kim MA Iglesias C Chabo A Waget, et al. 2008 Role of central nervous system glucagon-like peptide-1 receptors in enteric glucose sensing Diabetes 57 10 2603 2612 18519802 1:CAS:528:DC%2BD1MXhs1Knsb8%3D 10.2337/db07-1788
156. M Boirivant W Strober 2007 The mechanism of action of probiotics Curr Opin Gastroenterol 23 6 679 692 17906447 10.1097/MOG.0b013e3282f0cffc (Pubitemid 47508800)
157. MC Collado J Meriluoto S Salminen 2007 Role of commercial probiotic strains against human pathogen adhesion to intestinal mucus Lett Appl Microbiol 45 4 454 460 17897389 1:STN:280:DC%2BD2srns1emtg%3D%3D 10.1111/j.1472-765X.2007. 02212.x (Pubitemid 47493153)
158. Y Fukushima Y Kawata K Mizumachi J Kurisaki T Mitsuoka 1999 Effect of bifidobacteria feeding on fecal flora and production of immunoglobulins in lactating mouse Int J Food Microbiol 46 3 193 197 10100899 1:STN:280: DyaK1M7pvV2qug%3D%3D 10.1016/S0168-1605(98)00183-4 (Pubitemid 29104873)
159. J McCarthy L O'Mahony L O'Callaghan B Sheil EE Vaughan N Fitzsimons, et al. 2003 Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance Gut 52 7 975 980 12801954 1:STN:280:DC%2BD3s3psV2jtg%3D%3D 10.1136/gut.52.7.975 (Pubitemid 36765289)
160. S Menard C Candalh JC Bambou K Terpend N Cerf-Bensussan M Heyman 2004 Lactic acid bacteria secrete metabolites retaining anti-inflammatory properties after intestinal transport Gut 53 6 821 828 15138208 1:CAS:528: DC%2BD2cXlt1eltr4%3D 10.1136/gut.2003.026252 (Pubitemid 38662131)
161. N Osman D Adawi G Molin S Ahrne A Berggren B Jeppsson 2006 Bifidobacterium infantis strains with and without a combination of oligofructose and inulin (OFI) attenuate inflammation in DSS-induced colitis in rats BMC Gastroenterol 6 31 17069659 10.1186/1471-230X-6-31 1:CAS:528:DC%2BD28Xht1ajsrbF (Pubitemid 44734294)
162. Trevisi P, De Filippi S, Minieri L, Mazzoni M, Modesto M, Biavati B et al (2008) Effect of fructo-oligosaccharides and different doses of Bifidobacterium animalis in a weaning diet on bacterial translocation and toll-like receptor gene expression in pigs. Nutrition 24(10):1023-1029
163. S Fukuda H Toh K Hase K Oshima Y Nakanishi K Yoshimura, et al. 2011 Bifidobacteria can protect from enteropathogenic infection through production of acetate Nature 469 7331 543 547 21270894 1:CAS:528:DC%2BC3MXhtFShtLs%3D 10.1038/nature09646
164. SK Mazmanian JL Round DL Kasper 2008 A microbial symbiosis factor prevents intestinal inflammatory disease Nature 453 7195 620 625 18509436 1:CAS:528:DC%2BD1cXmsVKqurw%3D 10.1038/nature07008 (Pubitemid 351769307)
165. S Kondo J Xiao T Satoh T Odamaki S Takahashi H Sugahara, et al. 2010 Antiobesity effects of bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity Biosci Biotechnol Biochem 74 8 1656 1661 20699581 1:CAS:528:DC%2BC3cXhtlCktL%2FN 10.1271/bbb.100267
166. A Velayudham A Dolganiuc M Ellis J Petrasek K Kodys P Mandrekar, et al. 2009 VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice Hepatology 49 989 997 19115316 1:CAS:528:DC%2BD1MXjvFOmsb0%3D 10.1002/hep.22711
167. J Medina L Fernandez-salazar L Garcia-Buey R Moreno-Otero 2004 Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis Diabetes Care 27 2057 2066 15277442 10.2337/diacare.27.8.2057 (Pubitemid 38989257)
168. E Esposito A Iacono G Bianco G Autore S Cuzzocrea P Vajro, et al. 2009 Probiotics reduce the inflammatory response induced by a high-fat diet in the liver of young rats J Nutr 139 905 911 19321579 1:CAS:528:DC%2BD1MXhtlCltrzE 10.3945/jn.108.101808
169. Andreasen A, Larsen N, Pedersen-Skovsgaard M, Møller M, Svendsen K, Jakobsen M et al (2010) Effects of Lactobacillus acidophilus NCFM on insulin sensitivity and the systemic inflammatory response in human subjects. Br J Nutr 104(12):1831-1838
170. Laitinen K, Poussa T, Isolauri E, Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota Group (2009) Probiotics and dietary counselling contribute to glucose regulation during and after pregnancy: a randomised controlled trial. Br J Nutr 101:1679-1687