Pharmacological induction of mitochondrial biogenesis as a therapeutic strategy for the treatment of type 2 diabetes

Biochemical Pharmacology

Volumn 98, Issue 1, 2015, Pages 16-28

  Zamora, Mònica ^a   Pardo, Rosario ^b   Villena, Josep A ^b  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Insulin resistance; Mitochondrial biogenesis; Oxidative metabolism; Pharmacological target; Type 2 diabetes

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; 6,7 DIHYDRO 4 HYDROXY 3 (2' HYDROXY 1,1' BIPHENYL 4 YL) 6 OXOTHIENO[2,3 B]PYRIDINE 5 CARBONITRILE; ANTIDIABETIC AGENT; DNA BINDING PROTEIN; ELAFIBRANOR; ENGLITAZONE; GLUCOSE; HYDROLASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; INSULIN; INSULIN SENSITIZING AGENT; METFORMIN; MITOCHONDRIAL DNA; MITOCHONDRIAL PROTEIN; N [2 [3 (1 PIPERAZINYLMETHYL)IMIDAZO[2,1 B]THIAZOL 6 YL]PHENYL] 2 QUINOXALINECARBOXAMIDE; NICOTINAMIDE RIBOSIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PIOGLITAZONE; RESVERATROL; ROSIGLITAZONE; SALICYLIC ACID DERIVATIVE; SIRTUIN 1; SIRTUIN 1 ACTIVATOR; THIENOPYRIDINE DERIVATIVE; TRANSCRIPTION FACTOR; TROGLITAZONE; UNCLASSIFIED DRUG; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID;

AEROBIC METABOLISM; ARTICLE; BIOGENESIS; CELL DIFFERENTIATION; CORRELATIONAL STUDY; DIABETIC PATIENT; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG EFFICACY; FATTY ACID OXIDATION; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPID STORAGE; METABOLIC DISORDER; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL DNA REPLICATION; MITOCHONDRIAL DYNAMICS; MITOCHONDRION; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; TARGET ORGAN; DIABETES MELLITUS, TYPE 2; DRUG EFFECTS; GENE EXPRESSION REGULATION; PHYSIOLOGY;

DIABETES MELLITUS, TYPE 2; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MITOCHONDRIA;

EID: 84943582003     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2015.06.032     Document Type: Note

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