-
1
-
-
0027370108
-
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus
-
The Diabetes Control and Complications Trial Research Group: The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 329:977-986, 1993
-
(1993)
N Engl J Med
, vol.329
, pp. 977-986
-
-
-
2
-
-
0032511583
-
Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33)
-
UK Prospective Diabetes Study (UKPDS) Group: Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 352:837-853, 1998
-
(1998)
Lancet
, vol.352
, pp. 837-853
-
-
-
3
-
-
0029147687
-
Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: A randomized prospective 6-year study
-
Ohkubo Y, Kishikawa H, Araki E, Miyata T, Isami S, Motoyoshi S, Kojima Y, Furuyoshi N, Shichiri M: Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin-dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res Clin Pract 28:103-117, 1995
-
(1995)
Diabetes Res Clin Pract
, vol.28
, pp. 103-117
-
-
Ohkubo, Y.1
Kishikawa, H.2
Araki, E.3
Miyata, T.4
Isami, S.5
Motoyoshi, S.6
Kojima, Y.7
Furuyoshi, N.8
Shichiri, M.9
-
4
-
-
0034071036
-
Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients
-
Shichiri M, Kishikawa H, Ohkubo Y, Wake N: Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care 23 (Suppl. 2):B21-B29, 2000
-
(2000)
Diabetes Care
, vol.23
, Issue.2 SUPPL.
-
-
Shichiri, M.1
Kishikawa, H.2
Ohkubo, Y.3
Wake, N.4
-
5
-
-
0034053584
-
Cost-effectiveness of intensive insulin therapy for type 2 diabetes: A 10-year follow-up of the Kumamoto study
-
Wake N, Hisashige A, Katayama T, Kishikawa H, Ohkubo Y, Sakai M, Araki E, Shichiri M: Cost-effectiveness of intensive insulin therapy for type 2 diabetes: a 10-year follow-up of the Kumamoto study. Diabetes Res Clin Pract 48:201-210, 2000
-
(2000)
Diabetes Res Clin Pract
, vol.48
, pp. 201-210
-
-
Wake, N.1
Hisashige, A.2
Katayama, T.3
Kishikawa, H.4
Ohkubo, Y.5
Sakai, M.6
Araki, E.7
Shichiri, M.8
-
6
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
Nishikawa T, Edelstein D, Du XL, Yamagishi S, Matsumura T, Kaneda Y, Yorek MA, Beebe D, Oates PJ, Hammes HP, Giardino I, Brownlee M: Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 404:787-790, 2000
-
(2000)
Nature
, vol.404
, pp. 787-790
-
-
Nishikawa, T.1
Edelstein, D.2
Du, X.L.3
Yamagishi, S.4
Matsumura, T.5
Kaneda, Y.6
Yorek, M.A.7
Beebe, D.8
Oates, P.J.9
Hammes, H.P.10
Giardino, I.11
Brownlee, M.12
-
7
-
-
0141755317
-
Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: Potential role in diabetic nephropathy
-
Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Senokuchi T, Matsuo T, Matsumura T, Tokunaga H, Brownlee M, Araki E: Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. Diabetes 52:2570-2577, 2003
-
(2003)
Diabetes
, vol.52
, pp. 2570-2577
-
-
Kiritoshi, S.1
Nishikawa, T.2
Sonoda, K.3
Kukidome, D.4
Senokuchi, T.5
Matsuo, T.6
Matsumura, T.7
Tokunaga, H.8
Brownlee, M.9
Araki, E.10
-
8
-
-
0032511566
-
Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
-
UK Prospective Diabetes Study (UKPDS) Group: Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 352:854-865, 1998
-
(1998)
Lancet
, vol.352
, pp. 854-865
-
-
-
9
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE: Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108:1167-1174, 2001
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
Musi, N.11
Hirshman, M.F.12
Goodyear, L.J.13
Moller, D.E.14
-
10
-
-
0034880181
-
Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: Effects of AICAR
-
Kaushik VK, Young ME, Dean DJ, Kurowski TG, Saha AK, Ruderman NB: Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. Am J Physiol Endocrinol Metab 281:E335-E340, 2001
-
(2001)
Am J Physiol Endocrinol Metab
, vol.281
-
-
Kaushik, V.K.1
Young, M.E.2
Dean, D.J.3
Kurowski, T.G.4
Saha, A.K.5
Ruderman, N.B.6
-
11
-
-
0028073143
-
Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase
-
Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK: Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett 353:33-36, 1994
-
(1994)
FEBS Lett
, vol.353
, pp. 33-36
-
-
Sullivan, J.E.1
Brocklehurst, K.J.2
Marley, A.E.3
Carey, F.4
Carling, D.5
Beri, R.K.6
-
12
-
-
0036386911
-
Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle
-
Terada S, Goto M, Kato M, Kawanaka K, Shimokawa T, Tabata I: Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Biochem Biophys Res Commun 296:350-354, 2002
-
(2002)
Biochem Biophys Res Commun
, vol.296
, pp. 350-354
-
-
Terada, S.1
Goto, M.2
Kato, M.3
Kawanaka, K.4
Shimokawa, T.5
Tabata, I.6
-
13
-
-
0038419818
-
PGC-1alpha at the crossroads of type 2 diabetes
-
Attie AD, Kendziorski CM: PGC-1alpha at the crossroads of type 2 diabetes. Nat Genet 34:244-245, 2003
-
(2003)
Nat Genet
, vol.34
, pp. 244-245
-
-
Attie, A.D.1
Kendziorski, C.M.2
-
14
-
-
0033538473
-
Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
-
Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, Spiegelman BM: Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115-124, 1999
-
(1999)
Cell
, vol.98
, pp. 115-124
-
-
Wu, Z.1
Puigserver, P.2
Andersson, U.3
Zhang, C.4
Adelmant, G.5
Mootha, V.6
Troy, A.7
Cinti, S.8
Lowell, B.9
Scarpulla, R.C.10
Spiegelman, B.M.11
-
15
-
-
3142680906
-
Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo
-
Uchiba M, Okajima K, Oike Y, Ito Y, Fukudome K, Isobe H, Suda T: Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ Res 95:34-41, 2004
-
(2004)
Circ Res
, vol.95
, pp. 34-41
-
-
Uchiba, M.1
Okajima, K.2
Oike, Y.3
Ito, Y.4
Fukudome, K.5
Isobe, H.6
Suda, T.7
-
16
-
-
0036088128
-
Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes
-
Sakoda H, Ogihara T, Anai M, Fujishiro M, Ono H, Onishi Y, Katagiri H, Abe M, Fukushima Y, Shojima N, Inukai K, Kikuchi M, Oka Y, Asano T: Activation of AMPK is essential for AICAR-induced glucose uptake by skeletal muscle but not adipocytes. Am J Physiol Endocrinol Metab 282:E1239-E1244, 2002
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
-
-
Sakoda, H.1
Ogihara, T.2
Anai, M.3
Fujishiro, M.4
Ono, H.5
Onishi, Y.6
Katagiri, H.7
Abe, M.8
Fukushima, Y.9
Shojima, N.10
Inukai, K.11
Kikuchi, M.12
Oka, Y.13
Asano, T.14
-
17
-
-
0033803048
-
Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
-
Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, Kelly DP: Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106:847-856, 2000
-
(2000)
J Clin Invest
, vol.106
, pp. 847-856
-
-
Lehman, J.J.1
Barger, P.M.2
Kovacs, A.3
Saffitz, J.E.4
Medeiros, D.M.5
Kelly, D.P.6
-
18
-
-
0033569747
-
Bcl-2 and mitochondrial oxygen radicals: New approaches with reactive oxygen species-sensitive probes
-
Esposti MD, Hatzinisiriou I, McLennan H, Ralph S: Bcl-2 and mitochondrial oxygen radicals: new approaches with reactive oxygen species-sensitive probes. J Biol Chem 274:29831-29837, 1999
-
(1999)
J Biol Chem
, vol.274
, pp. 29831-29837
-
-
Esposti, M.D.1
Hatzinisiriou, I.2
McLennan, H.3
Ralph, S.4
-
19
-
-
85047691537
-
Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells
-
Du X, Matsumura T, Edelstein D, Rossetti L, Zsengeller Z, Szabo C, Brownlee M: Inhibition of GAPDH activity by poly(ADP-ribose) polymerase activates three major pathways of hyperglycemic damage in endothelial cells. J Clin Invest 112:1049-1057, 2003
-
(2003)
J Clin Invest
, vol.112
, pp. 1049-1057
-
-
Du, X.1
Matsumura, T.2
Edelstein, D.3
Rossetti, L.4
Zsengeller, Z.5
Szabo, C.6
Brownlee, M.7
-
20
-
-
0043170878
-
Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes
-
Nishikawa T, Sasahara T, Kiritoshi S, Sonoda K, Senokuchi T, Matsuo T, Kukidome D, Wake N, Matsumura T, Miyamura N, Sakakida M, Kishikawa H, Araki E: Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes. Diabetes Care 26:1507-1512, 2003
-
(2003)
Diabetes Care
, vol.26
, pp. 1507-1512
-
-
Nishikawa, T.1
Sasahara, T.2
Kiritoshi, S.3
Sonoda, K.4
Senokuchi, T.5
Matsuo, T.6
Kukidome, D.7
Wake, N.8
Matsumura, T.9
Miyamura, N.10
Sakakida, M.11
Kishikawa, H.12
Araki, E.13
-
21
-
-
0030048496
-
Oxidative stress and diabetic vascular complications
-
Giugliano D, Ceriello A, Paolisso G: Oxidative stress and diabetic vascular complications. Diabetes Care 19:257-267, 1996
-
(1996)
Diabetes Care
, vol.19
, pp. 257-267
-
-
Giugliano, D.1
Ceriello, A.2
Paolisso, G.3
-
22
-
-
0032913309
-
Role of oxidative stress in diabetic complications: A new perspective on an old paradigm
-
Baynes JW, Thorpe SR: Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes 48:1-9, 1999
-
(1999)
Diabetes
, vol.48
, pp. 1-9
-
-
Baynes, J.W.1
Thorpe, S.R.2
-
23
-
-
0035856980
-
Biochemistry and molecular cell biology of diabetic complications
-
Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820, 2001
-
(2001)
Nature
, vol.414
, pp. 813-820
-
-
Brownlee, M.1
-
24
-
-
0031768586
-
Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy
-
Imano E, Kanda T, Nakatani Y, Nishida T, Arai K, Motomura M, Kajimoto Y, Yamasaki Y, Hori M: Effect of troglitazone on microalbuminuria in patients with incipient diabetic nephropathy. Diabetes Care 21:2135-2139, 1998
-
(1998)
Diabetes Care
, vol.21
, pp. 2135-2139
-
-
Imano, E.1
Kanda, T.2
Nakatani, Y.3
Nishida, T.4
Arai, K.5
Motomura, M.6
Kajimoto, Y.7
Yamasaki, Y.8
Hori, M.9
-
25
-
-
10744225126
-
Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect
-
Satoh N, Ogawa Y, Usui T, Tagami T, Kono S, Uesugi H, Sugiyama H, Sugawara A, Yamada K, Shimatsu A, Kuzuya H, Nakao K: Antiatherogenic effect of pioglitazone in type 2 diabetic patients irrespective of the responsiveness to its antidiabetic effect. Diabetes Care 26:2493-2499, 2003
-
(2003)
Diabetes Care
, vol.26
, pp. 2493-2499
-
-
Satoh, N.1
Ogawa, Y.2
Usui, T.3
Tagami, T.4
Kono, S.5
Uesugi, H.6
Sugiyama, H.7
Sugawara, A.8
Yamada, K.9
Shimatsu, A.10
Kuzuya, H.11
Nakao, K.12
-
26
-
-
0032820452
-
Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader
-
Wang H, Joseph JA: Quantifying cellular oxidative stress by dichlorofluorescein assay using microplate reader. Free Radic Biol Med 27:612-616, 1999
-
(1999)
Free Radic Biol Med
, vol.27
, pp. 612-616
-
-
Wang, H.1
Joseph, J.A.2
-
27
-
-
0032529139
-
AMP-activated protein kinase: Greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform
-
Salt I, Celler JW, Hawley SA, Prescott A, Woods A, Carling D, Hardie DG: AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the alpha2 isoform. Biochem J 334:177-187, 1998
-
(1998)
Biochem J
, vol.334
, pp. 177-187
-
-
Salt, I.1
Celler, J.W.2
Hawley, S.A.3
Prescott, A.4
Woods, A.5
Carling, D.6
Hardie, D.G.7
-
28
-
-
0037136563
-
Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress
-
Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM: Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316-321, 2002
-
(2002)
Nature
, vol.419
, pp. 316-321
-
-
Kops, G.J.1
Dansen, T.B.2
Polderman, P.E.3
Saarloos, I.4
Wirtz, K.W.5
Coffer, P.J.6
Huang, T.T.7
Bos, J.L.8
Medema, R.H.9
Burgering, B.M.10
-
29
-
-
0038187621
-
Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction
-
Puigserver P, Rhee J, Donovan J, Walkey CJ, Yoon JC, Oriente F, Kitamura Y, Altomonte J, Dong H, Accili D, Spiegelman BM: Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction. Nature 423:550-555, 2003
-
(2003)
Nature
, vol.423
, pp. 550-555
-
-
Puigserver, P.1
Rhee, J.2
Donovan, J.3
Walkey, C.J.4
Yoon, J.C.5
Oriente, F.6
Kitamura, Y.7
Altomonte, J.8
Dong, H.9
Accili, D.10
Spiegelman, B.M.11
-
30
-
-
0029802258
-
Mitochondrial respiratory impairment in streptozotocin-induced diabetic rat heart
-
Tomita M, Mukae S, Geshi E, Umetsu K, Nakatani M, Katagiri T: Mitochondrial respiratory impairment in streptozotocin-induced diabetic rat heart. Jpn Circ J 60:673-682, 1996
-
(1996)
Jpn Circ J
, vol.60
, pp. 673-682
-
-
Tomita, M.1
Mukae, S.2
Geshi, E.3
Umetsu, K.4
Nakatani, M.5
Katagiri, T.6
-
31
-
-
0034468824
-
Ultrastructural characteristics of diabetic nephropathy
-
Nishi S, Ueno M, Hisaki S, Iino N, Iguchi S, Oyama Y, Imai N, Arakawa M, Gejyo F: Ultrastructural characteristics of diabetic nephropathy. Med Electron Microsc 33:65-73, 2000
-
(2000)
Med Electron Microsc
, vol.33
, pp. 65-73
-
-
Nishi, S.1
Ueno, M.2
Hisaki, S.3
Iino, N.4
Iguchi, S.5
Oyama, Y.6
Imai, N.7
Arakawa, M.8
Gejyo, F.9
-
32
-
-
0032702965
-
Neurons undergo apoptosis in animal and cell culture models of diabetes
-
Russell JW, Sullivan KA, Windebank AJ, Herrmann DN, Feldman EL: Neurons undergo apoptosis in animal and cell culture models of diabetes. Neurobiol Dis 6:347-363, 1999
-
(1999)
Neurobiol Dis
, vol.6
, pp. 347-363
-
-
Russell, J.W.1
Sullivan, K.A.2
Windebank, A.J.3
Herrmann, D.N.4
Feldman, E.L.5
-
33
-
-
11444259403
-
Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients
-
Vanhorebeek I, De Vos R, Mesotten D, Wouters PJ, De Wolf-Peeters C, Van den Berghe G: Protection of hepatocyte mitochondrial ultrastructure and function by strict blood glucose control with insulin in critically ill patients. Lancet 365:53-59, 2005
-
(2005)
Lancet
, vol.365
, pp. 53-59
-
-
Vanhorebeek, I.1
De Vos, R.2
Mesotten, D.3
Wouters, P.J.4
De Wolf-Peeters, C.5
Van Den Berghe, G.6
-
34
-
-
0036845661
-
High glucose-induced oxidative stress and mitochondrial dysfunction in neurons
-
Russell JW, Golovoy D, Vincent AM, Mahendru P, Olzmann JA, Mentzer A, Feldman EL: High glucose-induced oxidative stress and mitochondrial dysfunction in neurons. FASEB J 16:1738-1748, 2002
-
(2002)
FASEB J
, vol.16
, pp. 1738-1748
-
-
Russell, J.W.1
Golovoy, D.2
Vincent, A.M.3
Mahendru, P.4
Olzmann, J.A.5
Mentzer, A.6
Feldman, E.L.7
-
35
-
-
0037686243
-
Megamitochondria formation: Physiology and pathology
-
Wakabayashi T: Megamitochondria formation: physiology and pathology. J Cell Mol Med 6:497-538, 2002
-
(2002)
J Cell Mol Med
, vol.6
, pp. 497-538
-
-
Wakabayashi, T.1
-
36
-
-
0036081457
-
Reduced activity of mtTFA decreases the transcription in mitochondria isolated from diabetic rat heart
-
Kanazawa A, Nishio Y, Kashiwagi A, Inagaki H, Kikkawa R, Horiike K: Reduced activity of mtTFA decreases the transcription in mitochondria isolated from diabetic rat heart. Am J Physiol Endocrinol Metab 282:E778-E785, 2002
-
(2002)
Am J Physiol Endocrinol Metab
, vol.282
-
-
Kanazawa, A.1
Nishio, Y.2
Kashiwagi, A.3
Inagaki, H.4
Kikkawa, R.5
Horiike, K.6
|