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Volumn 106, Issue 44, 2009, Pages 18745-18750

Mechanisms of human insulin resistance and thiazolidinedione-mediated insulin sensitization

Author keywords

Branched chain amino acid (BCAA); Diabetes; Inflammation; Muscle and adipose tissue; Transcriptional mechanisms

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIGEN; GLUCOSE; HLA DR ANTIGEN; MLXIP ANTIGEN; UNCLASSIFIED DRUG;

EID: 73249123069     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0903032106     Document Type: Article
Times cited : (150)

References (35)
  • 1
    • 0029862973 scopus 로고    scopus 로고
    • Hyperinsulinemia as an independent risk factor for ischemic heart disease
    • Despres JP, et al. (1996) Hyperinsulinemia as an independent risk factor for ischemic heart disease. The New Eng J Med 334:952-957.
    • (1996) The New Eng J Med , vol.334 , pp. 952-957
    • Despres, J.P.1
  • 2
    • 0842277242 scopus 로고    scopus 로고
    • Grundy SM, Brewer HB, Jr, Cleeman JI, Smith SC, Jr, Lenfant C (2004) Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Associa-tion conference on scientific issues related to definition. Circulation 109:433-438.
    • Grundy SM, Brewer HB, Jr, Cleeman JI, Smith SC, Jr, Lenfant C (2004) Definition of metabolic syndrome: Report of the National Heart, Lung, and Blood Institute/American Heart Associa-tion conference on scientific issues related to definition. Circulation 109:433-438.
  • 3
    • 0036224883 scopus 로고    scopus 로고
    • Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: Relationships to insulin sensitivity, total body fat, and central adiposity
    • Sinha R, et al. (2002) Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: Relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51:1022-1027.
    • (2002) Diabetes , vol.51 , pp. 1022-1027
    • Sinha, R.1
  • 4
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 5
    • 33646572904 scopus 로고    scopus 로고
    • The metabolic syndrome and adipocytokines
    • Matsuzawa Y (2006) The metabolic syndrome and adipocytokines. FEBS Lett 580:2917-2921.
    • (2006) FEBS Lett , vol.580 , pp. 2917-2921
    • Matsuzawa, Y.1
  • 6
    • 33748305621 scopus 로고    scopus 로고
    • Down-regulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha
    • Dahlman I, et al. (2006) Down-regulation of electron transport chain genes in visceral adipose tissue in type 2 diabetes independent of obesity and possibly involving tumor necrosis factor-alpha. Diabetes 55:1792-1799.
    • (2006) Diabetes , vol.55 , pp. 1792-1799
    • Dahlman, I.1
  • 7
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • Mootha VK, et al. (2003) PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nature Genet 34:267-273.
    • (2003) Nature Genet , vol.34 , pp. 267-273
    • Mootha, V.K.1
  • 8
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
    • Olefsky JM (2000) Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 106:467-472.
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 9
    • 34547654459 scopus 로고    scopus 로고
    • Effect of pioglitazone on atherogenic outcomes in type 2 diabetic patients: A comparison of responders and non-responders
    • Igarashi M, et al. (2007) Effect of pioglitazone on atherogenic outcomes in type 2 diabetic patients: A comparison of responders and non-responders. Diabetes Res Clin Pract 77:389-398.
    • (2007) Diabetes Res Clin Pract , vol.77 , pp. 389-398
    • Igarashi, M.1
  • 11
    • 0034527587 scopus 로고    scopus 로고
    • Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor gamma expression in human skeletal muscle
    • Lapsys NM, et al. (2000) Expression of genes involved in lipid metabolism correlate with peroxisome proliferator-activated receptor gamma expression in human skeletal muscle. J Clin Endocrinol Metab 85:4293-4297.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 4293-4297
    • Lapsys, N.M.1
  • 12
    • 33645863768 scopus 로고    scopus 로고
    • Transcriptional regulation of metabolism
    • Desvergne B, Michalik L, Wahli W (2006) Transcriptional regulation of metabolism. Physiol Rev 86:465-514.
    • (2006) Physiol Rev , vol.86 , pp. 465-514
    • Desvergne, B.1    Michalik, L.2    Wahli, W.3
  • 13
    • 0037732481 scopus 로고    scopus 로고
    • The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones
    • Arner P (2003) The adipocyte in insulin resistance: Key molecules and the impact of the thiazolidinediones. Trends Endocrinol Metab 14:137-145.
    • (2003) Trends Endocrinol Metab , vol.14 , pp. 137-145
    • Arner, P.1
  • 14
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis J, et al. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc Natl Acad Sci USA 98:2005-2010.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 2005-2010
    • Fruebis, J.1
  • 15
    • 33745848775 scopus 로고    scopus 로고
    • Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony
    • Herman MA,Kahn BB (2006) Glucose transport and sensing in the maintenance of glucose homeostasis and metabolic harmony. J Clin Invest 116:1767-1775.
    • (2006) J Clin Invest , vol.116 , pp. 1767-1775
    • Herman, M.A.1    Kahn, B.B.2
  • 16
    • 23844556589 scopus 로고    scopus 로고
    • Leptin improves insulin resistance and hyperglycemia in amouse model of type 2 diabetes
    • Toyoshima Y, et al. (2005) Leptin improves insulin resistance and hyperglycemia in amouse model of type 2 diabetes. Endocrinology 146:4024-4035.
    • (2005) Endocrinology , vol.146 , pp. 4024-4035
    • Toyoshima, Y.1
  • 17
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7:941-946.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1
  • 18
    • 23144442351 scopus 로고    scopus 로고
    • VAMPIRE microarray suite:Aweb-based platform for the interpretation of gene expression data
    • Hsiao A, Ideker T, Olefsky JM, Subramaniam S (2005) VAMPIRE microarray suite:Aweb-based platform for the interpretation of gene expression data. Nucleic Acids Res 33:W627-632.
    • (2005) Nucleic Acids Res , vol.33
    • Hsiao, A.1    Ideker, T.2    Olefsky, J.M.3    Subramaniam, S.4
  • 19
    • 33644874819 scopus 로고    scopus 로고
    • From genomics to chemical genomics: New developments in KEGG
    • Kanehisa M, et al. (2006) From genomics to chemical genomics: New developments in KEGG. Nucleic Acids Res 34:D354-357.
    • (2006) Nucleic Acids Res , vol.34
    • Kanehisa, M.1
  • 20
    • 33644666743 scopus 로고    scopus 로고
    • Insulin resistance index as a predictor for pioglitazone treatment in type 2 diabetes
    • Araki T, et al. (2005) Insulin resistance index as a predictor for pioglitazone treatment in type 2 diabetes. Osaka City Med J 51:19-25.
    • (2005) Osaka City Med J , vol.51 , pp. 19-25
    • Araki, T.1
  • 21
    • 33745458797 scopus 로고    scopus 로고
    • MondoA-Mlx het-erodimers are candidate sensors of cellular energy status: Mitochondrial localization and direct regulation of glycolysis
    • Sans CL, Satterwhite DJ, Stoltzman CA, Breen KT, Ayer DE (2006) MondoA-Mlx het-erodimers are candidate sensors of cellular energy status: Mitochondrial localization and direct regulation of glycolysis. Mol Cell Biol 26:4863-4871.
    • (2006) Mol Cell Biol , vol.26 , pp. 4863-4871
    • Sans, C.L.1    Satterwhite, D.J.2    Stoltzman, C.A.3    Breen, K.T.4    Ayer, D.E.5
  • 22
    • 39749147110 scopus 로고    scopus 로고
    • Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes
    • Muoio DM, Newgard CB (2008)Mechanisms of disease: Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol 9:193-205.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 193-205
    • Muoio, D.M.1    Newgard, C.B.2
  • 23
    • 33749370466 scopus 로고    scopus 로고
    • Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects
    • Bandyopadhyay GK, Yu JG, Ofrecio J, Olefsky JM (2006) Increased malonyl-CoA levels in muscle from obese and type 2 diabetic subjects lead to decreased fatty acid oxidation and increased lipogenesis; thiazolidinedione treatment reverses these defects. Diabetes 55:2277-2285.
    • (2006) Diabetes , vol.55 , pp. 2277-2285
    • Bandyopadhyay, G.K.1    Yu, J.G.2    Ofrecio, J.3    Olefsky, J.M.4
  • 24
    • 31044447347 scopus 로고    scopus 로고
    • Inflamed fat: What starts the fire?
    • Neels JG, Olefsky JM (2006) Inflamed fat: What starts the fire? J Clin Invest 116:33-35.
    • (2006) J Clin Invest , vol.116 , pp. 33-35
    • Neels, J.G.1    Olefsky, J.M.2
  • 25
    • 17844385363 scopus 로고    scopus 로고
    • Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
    • Bogacka I, Xie H, Bray GA, Smith SR (2005) Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo. Diabetes 54:1392-1399.
    • (2005) Diabetes , vol.54 , pp. 1392-1399
    • Bogacka, I.1    Xie, H.2    Bray, G.A.3    Smith, S.R.4
  • 26
    • 33644821858 scopus 로고    scopus 로고
    • Mitochondria are impaired in the adipocytes of type 2 diabetic mice
    • Choo HJ, et al. (2006) Mitochondria are impaired in the adipocytes of type 2 diabetic mice. Diabetologia 49:784-791.
    • (2006) Diabetologia , vol.49 , pp. 784-791
    • Choo, H.J.1
  • 27
    • 34347391646 scopus 로고    scopus 로고
    • Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone
    • Rong JX, et al. (2007) Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone. Diabetes 56:1751-1760.
    • (2007) Diabetes , vol.56 , pp. 1751-1760
    • Rong, J.X.1
  • 28
    • 85047689659 scopus 로고    scopus 로고
    • Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
    • Wilson-Fritch L, et al. (2004) Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone. J Clin Invest 114:1281-1289.
    • (2004) J Clin Invest , vol.114 , pp. 1281-1289
    • Wilson-Fritch, L.1
  • 29
    • 0036789137 scopus 로고    scopus 로고
    • The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects
    • Yu JG, et al. (2002)The effect of thiazolidinediones on plasma adiponectin levels in normal, obese, and type 2 diabetic subjects. Diabetes 51:2968-2974.
    • (2002) Diabetes , vol.51 , pp. 2968-2974
    • Yu, J.G.1
  • 30
    • 0033980466 scopus 로고    scopus 로고
    • Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects
    • Frias JP,Yu JG, Kruszynska YT, Olefsky JM(2000) Metabolic effects of troglitazone therapy in type 2 diabetic, obese, and lean normal subjects. Diabetes Care 23:64-69.
    • (2000) Diabetes Care , vol.23 , pp. 64-69
    • Frias, J.P.1    Yu, J.G.2    Kruszynska, Y.T.3    Olefsky, J.M.4
  • 31
    • 0000648085 scopus 로고
    • Influences of glucose loading and of injected insulin on hepatic glucose output
    • Steele R (1959) Influences of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci 82:420-430.
    • (1959) Ann N Y Acad Sci , vol.82 , pp. 420-430
    • Steele, R.1
  • 32
    • 0021311455 scopus 로고
    • Tracers in metabolic research: Radioisotope and stable isotope/mass spectrometry methods
    • Wolfe RR (1984) Tracers in metabolic research: Radioisotope and stable isotope/mass spectrometry methods. Lab Res Methods Biol Med 9:1-287.
    • (1984) Lab Res Methods Biol Med , vol.9 , pp. 1-287
    • Wolfe, R.R.1
  • 33
    • 0015146643 scopus 로고
    • Use of polyethylene glycol to separate free and anti-body-bound peptide hormones in radioimmunoassays
    • Desbuquois B, Aurbach GD (1971) Use of polyethylene glycol to separate free and anti-body-bound peptide hormones in radioimmunoassays. J Clin Endocrinol Metab 33:732-738.
    • (1971) J Clin Endocrinol Metab , vol.33 , pp. 732-738
    • Desbuquois, B.1    Aurbach, G.D.2
  • 34
    • 10244251720 scopus 로고    scopus 로고
    • Variance-modeled posterior inference of microarray data: Detecting gene-expression changes in 3T3-L1 adipocytes
    • Hsiao A, Worrall DS, Olefsky JM, Subramaniam S (2004) Variance-modeled posterior inference of microarray data: Detecting gene-expression changes in 3T3-L1 adipocytes. Bioinformatics 20:3108-3127.
    • (2004) Bioinformatics , vol.20 , pp. 3108-3127
    • Hsiao, A.1    Worrall, D.S.2    Olefsky, J.M.3    Subramaniam, S.4
  • 35
    • 0004285343 scopus 로고    scopus 로고
    • McGraw-Hill Medical Pub Division, New York 6th Ed, p
    • Glantz SA (2005) Primer of Biostatistics (McGraw-Hill Medical Pub Division, New York) 6th Ed, p 520.
    • (2005) Primer of Biostatistics , pp. 520
    • Glantz, S.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.