Gene expression profiling for human iPS-derived motor neurons from sporadic ALS patients reveals a strong association between mitochondrial functions and neurodegeneration

Frontiers in Cellular Neuroscience

Volumn 9, Issue AUGUST, 2015, Pages

  Alves, Chrystian J ^a   Dariolli, Rafael ^a   Jorge, Frederico M ^a   Monteiro, Matheus R ^a   Maximino, Jessica R ^a   Martins, Roberto S ^a   Strauss, Bryan E ^a   Krieger, José E ^a   Callegaro, Dagoberto ^a   Chadi, Gerson ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Amyotrophic lateral sclerosis; Induced pluripotent stem cells; Microarray; Motor neuron differentiation; Sporadic ALS

Indexed keywords

ALKALINE PHOSPHATASE; CASPASE 9; CHOLINE ACETYLTRANSFERASE; COPPER ZINC SUPEROXIDE DISMUTASE; DEVELOPMENTAL PLURIPOTENCY ASSOCIATED 2; DEVELOPMENTAL PLURIPOTENCY ASSOCIATED 4; DEVELOPMENTAL PLURIPOTENCY ASSOCIATED 5; DIACYLGLYCEROL ACYLTRANSFERASE 2; DUAL SPECIFICITY PHOSPHATASE 6; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GROWTH DIFFERENTIATION FACTOR 3; HOMEOBOX 9 PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; OCTAMER TRANSCRIPTION FACTOR 4; OLIGODENDROCYTE TRANSCRIPTION FACTOR 2; REX1 PROTEIN; RNA BINDING PROTEIN; SOMATOMEDIN B RECEPTOR; TAR DNA BINDING PROTEIN; TRANSCRIPTION FACTOR NANOG; TRANSCRIPTION FACTOR PAX6; TRANSCRIPTION FACTOR SOX2; UNCLASSIFIED DRUG;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BIOPSY; CASE REPORT; CELL DIFFERENTIATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; GENE EXPRESSION PROFILING; GENE MUTATION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; KARYOTYPING; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; MITOCHONDRION; NERVE DEGENERATION; PARKINSON DISEASE; PLURIPOTENT STEM CELL; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; UPREGULATION;

EID: 84940204339     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2015.00289     Document Type: Article

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