Residual Expression of Reprogramming Factors Affects the Transcriptional Program and Epigenetic Signatures of Induced Pluripotent Stem Cells

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Sommer, Cesar A ^a   Christodoulou, Constantina ^a   Gianotti Sommer, Andreia ^a   Shen, Steven S ^a   Sailaja, Badi Sri ^b   Hezroni, Hadas ^b   Spira, Avrum ^a   Meshorer, Eran ^b   Kotton, Darrell N ^a   Mostoslavsky, Gustavo ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; LENTIVIRUS VECTOR; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; RNA; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; EMBRYONIC STEM CELL; EPIGENETICS; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE LOCUS; GENE SILENCING; GENETIC TRANSCRIPTION; GTL2 GENE; IN VITRO STUDY; LIVER CELL; METHYLATION; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; PROMOTER REGION; PROTEIN BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TRANSGENE;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; CLUSTER ANALYSIS; DNA METHYLATION; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE SILENCING; HEPATOCYTES; INDUCED PLURIPOTENT STEM CELLS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; MICE; NUCLEAR REPROGRAMMING; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-MYC; RNA, LONG UNTRANSLATED; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSGENES;

EID: 84871339130     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051711     Document Type: Article

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