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Volumn 8, Issue MAY, 2014, Pages

Deregulated expression of cytoskeleton related genes in the spinal cord and sciatic nerve of presymptomatic SOD1G93A Amyotrophic Lateral Sclerosis mouse model

Author keywords

ALS; Kif1b microarray; Pre symptomatic; Sciatic nerve; Spinal cord

Indexed keywords

ALPHA ACTININ 3; CYTOSKELETON PROTEIN; DYNACTIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; TAU PROTEIN; TREMPAMOTIDE;

EID: 84901590710     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2014.00148     Document Type: Article
Times cited : (27)

References (115)
  • 1
    • 0033018506 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis
    • doi: 10.1046/j.1471-4159.1999.0722415.x
    • Almer, G., Vukosavic, S., Romero, N., and Przedborski, S. (1999). Inducible nitric oxide synthase up-regulation in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 72, 2415-2425. doi: 10.1046/j.1471-4159.1999.0722415.x
    • (1999) J. Neurochem , vol.72 , pp. 2415-2425
    • Almer, G.1    Vukosavic, S.2    Romero, N.3    Przedborski, S.4
  • 2
    • 79956266554 scopus 로고    scopus 로고
    • Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender differences on clinical outcome
    • doi: 10.1016/j.brainres.2011.02.060
    • Alves, C. J., De Santana, L. P., Dos Santos, A. J., De Oliveira, G. P., Duobles, T., Scorisa, J. M., et al. (2011). Early motor and electrophysiological changes in transgenic mouse model of amyotrophic lateral sclerosis and gender differences on clinical outcome. Brain Res. 1394, 90-104. doi: 10.1016/j.brainres.2011.02.060
    • (2011) Brain Res , vol.1394 , pp. 90-104
    • Alves, C.J.1    De Santana, L.P.2    Dos Santos, A.J.3    De Oliveira, G.P.4    Duobles, T.5    Scorisa, J.M.6
  • 3
    • 0036798495 scopus 로고    scopus 로고
    • Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules
    • doi: 10.1242/jcs.00058
    • Aronov, S., Aranda, G., Behar, L., and Ginzburg, I. (2002). Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. J. Cell Sci. 115, 3817-3827. doi: 10.1242/jcs.00058
    • (2002) J. Cell Sci , vol.115 , pp. 3817-3827
    • Aronov, S.1    Aranda, G.2    Behar, L.3    Ginzburg, I.4
  • 4
    • 84866524866 scopus 로고    scopus 로고
    • The LO-BaFL method and ALS microarray expression analysis
    • doi: 10.1186/1471-2105-13-244
    • Baciu, C., Thompson, K. J., Mougeot, J. L., Brooks, B. R., and Weller, J. W. (2012). The LO-BaFL method and ALS microarray expression analysis. BMC Bioinformatics 13, 244. doi: 10.1186/1471-2105-13-244
    • (2012) BMC Bioinformatics , vol.13 , pp. 244
    • Baciu, C.1    Thompson, K.J.2    Mougeot, J.L.3    Brooks, B.R.4    Weller, J.W.5
  • 5
    • 84884913775 scopus 로고    scopus 로고
    • Zebrafish embryonic neurons transport messenger RNA to axons and growth cones in vivo
    • doi: 10.1523/JNEUROSCI.1510-13.2013
    • Baraban, M., Anselme, I., Schneider-Maunoury, S., and Giudicelli, F. (2013). Zebrafish embryonic neurons transport messenger RNA to axons and growth cones in vivo. J. Neurosci. 33, 15726-15734. doi: 10.1523/JNEUROSCI.1510-13.2013
    • (2013) J. Neurosci , vol.33 , pp. 15726-15734
    • Baraban, M.1    Anselme, I.2    Schneider-Maunoury, S.3    Giudicelli, F.4
  • 6
    • 84874566621 scopus 로고    scopus 로고
    • Mitochondrial network genes in the skeletal muscle of amyotrophic lateral sclerosis patients
    • doi: 10.1371/journal.pone.0057739
    • Bernardini, C., Censi, F., Lattanzi, W., Barba, M., Calcagnini, G., Giuliani, A., et al. (2013). Mitochondrial network genes in the skeletal muscle of amyotrophic lateral sclerosis patients. PLoS ONE 8:e57739. doi: 10.1371/journal.pone.0057739
    • (2013) PLoS ONE , vol.8
    • Bernardini, C.1    Censi, F.2    Lattanzi, W.3    Barba, M.4    Calcagnini, G.5    Giuliani, A.6
  • 7
    • 33749056809 scopus 로고    scopus 로고
    • ALS: A disease of motor neurons and their nonneuronal neighbors
    • doi: 10.1016/j.neuron.2006.09.018
    • Boillee, S., Vande Velde, C., and Cleveland, D. W. (2006a). ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52, 39-59. doi: 10.1016/j.neuron.2006.09.018
    • (2006) Neuron , vol.52 , pp. 39-59
    • Boillee, S.1    Vande Velde, C.2    Cleveland, D.W.3
  • 8
    • 33744798774 scopus 로고    scopus 로고
    • Onset and progression in inherited ALS determined by motor neurons and microglia
    • doi: 10.1126/science.1123511
    • Boillee, S., Yamanaka, K., Lobsiger, C. S., Copeland, N. G., Jenkins, N. A., Kassiotis, G., et al. (2006b). Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312, 1389-1392. doi: 10.1126/science.1123511
    • (2006) Science , vol.312 , pp. 1389-1392
    • Boillee, S.1    Yamanaka, K.2    Lobsiger, C.S.3    Copeland, N.G.4    Jenkins, N.A.5    Kassiotis, G.6
  • 9
    • 67650487534 scopus 로고    scopus 로고
    • Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination
    • doi: 10.1523/JNEUROSCI.1423-09.2009
    • Bolis, A., Coviello, S., Visigalli, I., Taveggia, C., Bachi, A., Chishti, A. H., et al. (2009). Dlg1, Sec8, and Mtmr2 regulate membrane homeostasis in Schwann cell myelination. J. Neurosci. 29, 8858-8870. doi: 10.1523/JNEUROSCI.1423-09.2009
    • (2009) J. Neurosci , vol.29 , pp. 8858-8870
    • Bolis, A.1    Coviello, S.2    Visigalli, I.3    Taveggia, C.4    Bachi, A.5    Chishti, A.H.6
  • 10
    • 79960054836 scopus 로고    scopus 로고
    • Differential effect of oxidative or excitotoxic stress on the transcriptional profile of amyotrophic lateral sclerosis-linked mutant SOD1 cultured neurons
    • doi: 10.1002/jnr.22672
    • Boutahar, N., Wierinckx, A., Camdessanche, J. P., Antoine, J. C., Reynaud, E., Lassabliere, F., et al. (2011). Differential effect of oxidative or excitotoxic stress on the transcriptional profile of amyotrophic lateral sclerosis-linked mutant SOD1 cultured neurons. J. Neurosci. Res. 89, 1439-1450. doi: 10.1002/jnr.22672
    • (2011) J. Neurosci. Res , vol.89 , pp. 1439-1450
    • Boutahar, N.1    Wierinckx, A.2    Camdessanche, J.P.3    Antoine, J.C.4    Reynaud, E.5    Lassabliere, F.6
  • 11
    • 0018381233 scopus 로고
    • Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve
    • Brockes, J. P., Fields, K. L., and Raff, M. C. (1979). Studies on cultured rat Schwann cells. I. Establishment of purified populations from cultures of peripheral nerve. Brain Res. 165, 105-118.
    • (1979) Brain Res , vol.165 , pp. 105-118
    • Brockes, J.P.1    Fields, K.L.2    Raff, M.C.3
  • 12
    • 84865063394 scopus 로고    scopus 로고
    • Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis
    • doi: 10.1093/hmg/dds215
    • Bryson, J. B., Hobbs, C., Parsons, M. J., Bosch, K. D., Pandraud, A., Walsh, F. S., et al. (2012). Amyloid precursor protein (APP) contributes to pathology in the SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Hum. Mol. Genet. 21, 3871-3882. doi: 10.1093/hmg/dds215
    • (2012) Hum. Mol. Genet , vol.21 , pp. 3871-3882
    • Bryson, J.B.1    Hobbs, C.2    Parsons, M.J.3    Bosch, K.D.4    Pandraud, A.5    Walsh, F.S.6
  • 13
    • 77950458426 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice
    • doi: 10.1007/s00429-009-0226-4
    • Chen, K., Northington, F. J., and Martin, L. J. (2010). Inducible nitric oxide synthase is present in motor neuron mitochondria and Schwann cells and contributes to disease mechanisms in ALS mice. Brain Struct. Funct. 214, 219-234. doi: 10.1007/s00429-009-0226-4
    • (2010) Brain Struct. Funct , vol.214 , pp. 219-234
    • Chen, K.1    Northington, F.J.2    Martin, L.J.3
  • 14
    • 0037332593 scopus 로고    scopus 로고
    • Kif1Bbeta isoform is enriched in motor neurons but does not change in a mouse model of amyotrophic lateral sclerosis
    • doi: 10.1002/jnr.10517
    • Conforti, L., Dell'agnello, C., Calvaresi, N., Tortarolo, M., Giorgini, A., Coleman, M. P., et al. (2003). Kif1Bbeta isoform is enriched in motor neurons but does not change in a mouse model of amyotrophic lateral sclerosis. J. Neurosci. Res. 71, 732-739. doi: 10.1002/jnr.10517
    • (2003) J. Neurosci. Res , vol.71 , pp. 732-739
    • Conforti, L.1    Dell'agnello, C.2    Calvaresi, N.3    Tortarolo, M.4    Giorgini, A.5    Coleman, M.P.6
  • 15
    • 84866062627 scopus 로고    scopus 로고
    • Gene expression profiling in human neurodegenerative disease
    • doi: 10.1038/nrneurol.2012.156
    • Cooper-Knock, J., Kirby, J., Ferraiuolo, L., Heath, P. R., Rattray, M., and Shaw, P. J. (2012). Gene expression profiling in human neurodegenerative disease. Nat. Rev. Neurol. 8, 518-530. doi: 10.1038/nrneurol.2012.156
    • (2012) Nat. Rev. Neurol , vol.8 , pp. 518-530
    • Cooper-Knock, J.1    Kirby, J.2    Ferraiuolo, L.3    Heath, P.R.4    Rattray, M.5    Shaw, P.J.6
  • 16
    • 77956392186 scopus 로고    scopus 로고
    • Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS)
    • doi: 10.1371/journal.pone.0009872
    • Cox, L. E., Ferraiuolo, L., Goodall, E. F., Heath, P. R., Higginbottom, A., Mortiboys, H., et al. (2010). Mutations in CHMP2B in lower motor neuron predominant amyotrophic lateral sclerosis (ALS). PLoS ONE 5:e9872. doi: 10.1371/journal.pone.0009872
    • (2010) PLoS ONE , vol.5
    • Cox, L.E.1    Ferraiuolo, L.2    Goodall, E.F.3    Heath, P.R.4    Higginbottom, A.5    Mortiboys, H.6
  • 17
    • 0034001356 scopus 로고    scopus 로고
    • Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs
    • doi: 10.1006/geno.1999.6061
    • Cox, P. R., and Zoghbi, H. Y. (2000). Sequencing, expression analysis, and mapping of three unique human tropomodulin genes and their mouse orthologs. Genomics 63, 97-107. doi: 10.1006/geno.1999.6061
    • (2000) Genomics , vol.63 , pp. 97-107
    • Cox, P.R.1    Zoghbi, H.Y.2
  • 18
    • 79955824241 scopus 로고    scopus 로고
    • The "dying-back" phenomenon of motor neurons in ALS
    • doi: 10.1007/s12031-010-9467-1
    • Dadon-Nachum, M., Melamed, E., and Offen, D. (2011). The "dying-back" phenomenon of motor neurons in ALS. J. Mol. Neurosci. 43, 470-477. doi: 10.1007/s12031-010-9467-1
    • (2011) J. Mol. Neurosci , vol.43 , pp. 470-477
    • Dadon-Nachum, M.1    Melamed, E.2    Offen, D.3
  • 19
    • 1442282943 scopus 로고    scopus 로고
    • Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter
    • doi: 10.1152/physiolgenomics.00087.2001
    • Dangond, F., Hwang, D., Camelo, S., Pasinelli, P., Frosch, M. P., Stephanopoulos, G., et al. (2004). Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. Physiol. Genomics 16, 229-239. doi: 10.1152/physiolgenomics.00087.2001
    • (2004) Physiol. Genomics , vol.16 , pp. 229-239
    • Dangond, F.1    Hwang, D.2    Camelo, S.3    Pasinelli, P.4    Frosch, M.P.5    Stephanopoulos, G.6
  • 20
    • 35748930544 scopus 로고    scopus 로고
    • Distal axonopathy in an alsin-deficient mouse model
    • doi: 10.1093/hmg/ddm251
    • Deng, H. X., Zhai, H., Fu, R., Shi, Y., Gorrie, G. H., Yang, Y., et al. (2007). Distal axonopathy in an alsin-deficient mouse model. Hum. Mol. Genet. 16, 2911-2920. doi: 10.1093/hmg/ddm251
    • (2007) Hum. Mol. Genet , vol.16 , pp. 2911-2920
    • Deng, H.X.1    Zhai, H.2    Fu, R.3    Shi, Y.4    Gorrie, G.H.5    Yang, Y.6
  • 21
    • 84888161010 scopus 로고    scopus 로고
    • Early gene expression changes in spinal cord from SOD1(G93A) Amyotrophic Lateral Sclerosis animal model
    • doi: 10.3389/fncel.2013.00216
    • De Oliveira, G. P., Alves, C. J., and Chadi, G. (2013). Early gene expression changes in spinal cord from SOD1(G93A) Amyotrophic Lateral Sclerosis animal model. Front. Cell Neurosci. 7:216. doi: 10.3389/fncel.2013.00216
    • (2013) Front. Cell Neurosci , vol.7 , pp. 216
    • De Oliveira, G.P.1    Alves, C.J.2    Chadi, G.3
  • 22
    • 72349092499 scopus 로고    scopus 로고
    • A method to immunolabel rodent spinal cord neurons and glia for molecular study in specific laser microdissected cells involved in neurodegenerative disorders
    • doi: 10.1007/s10735-009-9233-2
    • De Oliveira, G. P., Maximino, J. R., Lin, C. J., and Chadi, G. (2009). A method to immunolabel rodent spinal cord neurons and glia for molecular study in specific laser microdissected cells involved in neurodegenerative disorders. J. Mol. Histol. 40, 217-225. doi: 10.1007/s10735-009-9233-2
    • (2009) J. Mol. Histol , vol.40 , pp. 217-225
    • De Oliveira, G.P.1    Maximino, J.R.2    Lin, C.J.3    Chadi, G.4
  • 23
    • 84896488834 scopus 로고    scopus 로고
    • Early gene expression changes in skeletal muscle from SOD1(G93A) amyotrophic lateral sclerosis animal model
    • doi: 10.1007/s10571-014-0029-x
    • De Oliveira, G. P., Maximino, J. R., Maschietto, M., Zanoteli, E., Puga, R. D., Lima, L., et al. (2014). Early gene expression changes in skeletal muscle from SOD1(G93A) amyotrophic lateral sclerosis animal model. Cell. Mol. Neurobiol. 34, 451-462. doi: 10.1007/s10571-014-0029-x
    • (2014) Cell. Mol. Neurobiol , vol.34 , pp. 451-462
    • De Oliveira, G.P.1    Maximino, J.R.2    Maschietto, M.3    Zanoteli, E.4    Puga, R.D.5    Lima, L.6
  • 24
    • 33646569146 scopus 로고    scopus 로고
    • The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease
    • doi: 10.1016/j.mcn.2006.03.002
    • De Winter, F., Vo, T., Stam, F. J., Wisman, L. A., Bar, P. R., Niclou, S. P., et al. (2006). The expression of the chemorepellent Semaphorin 3A is selectively induced in terminal Schwann cells of a subset of neuromuscular synapses that display limited anatomical plasticity and enhanced vulnerability in motor neuron disease. Mol. Cell. Neurosci. 32, 102-117. doi: 10.1016/j.mcn.2006.03.002
    • (2006) Mol. Cell. Neurosci , vol.32 , pp. 102-117
    • De Winter, F.1    Vo, T.2    Stam, F.J.3    Wisman, L.A.4    Bar, P.R.5    Niclou, S.P.6
  • 25
    • 79952792761 scopus 로고    scopus 로고
    • In Vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS
    • doi: 10.1371/journal.pone.0017910
    • Dibaj, P., Steffens, H., Zschuntzsch, J., Nadrigny, F., Schomburg, E. D., Kirchhoff, F., et al. (2011). In Vivo imaging reveals distinct inflammatory activity of CNS microglia versus PNS macrophages in a mouse model for ALS. PLoS ONE 6:e17910. doi: 10.1371/journal.pone.0017910
    • (2011) PLoS ONE , vol.6
    • Dibaj, P.1    Steffens, H.2    Zschuntzsch, J.3    Nadrigny, F.4    Schomburg, E.D.5    Kirchhoff, F.6
  • 26
    • 0033562801 scopus 로고    scopus 로고
    • Schwann cell development in embryonic mouse nerves
    • doi: 10.1002/(SICI)1097-4547(19990515)56:4<334::AID-JNR2>3.0.CO;2-#
    • Dong, Z., Sinanan, A., Parkinson, D., Parmantier, E., Mirsky, R., and Jessen, K. R. (1999). Schwann cell development in embryonic mouse nerves. J. Neurosci. Res. 56, 334-348. doi: 10.1002/(SICI)1097-4547(19990515)56:4<334::AID-JNR2>3.0.CO;2-#
    • (1999) J. Neurosci. Res , vol.56 , pp. 334-348
    • Dong, Z.1    Sinanan, A.2    Parkinson, D.3    Parmantier, E.4    Mirsky, R.5    Jessen, K.R.6
  • 27
    • 0033826065 scopus 로고    scopus 로고
    • Differential screening of mutated SOD1 transgenic mice reveals early up-regulation of a fast axonal transport component in spinal cord motor neurons
    • doi: 10.1006/nbdi.2000.0292
    • Dupuis, L., De Tapia, M., Rene, F., Lutz-Bucher, B., Gordon, J. W., Mercken, L., et al. (2000). Differential screening of mutated SOD1 transgenic mice reveals early up-regulation of a fast axonal transport component in spinal cord motor neurons. Neurobiol. Dis. 7, 274-285. doi: 10.1006/nbdi.2000.0292
    • (2000) Neurobiol. Dis , vol.7 , pp. 274-285
    • Dupuis, L.1    De Tapia, M.2    Rene, F.3    Lutz-Bucher, B.4    Gordon, J.W.5    Mercken, L.6
  • 28
    • 65949090754 scopus 로고    scopus 로고
    • Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS
    • doi: 10.1111/j.1471-4159.2009.06080.x
    • Ferraiuolo, L., De Bono, J. P., Heath, P. R., Holden, H., Kasher, P., Channon, K. M., et al. (2009). Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS. J. Neurochem. 109, 1714-1724. doi: 10.1111/j.1471-4159.2009.06080.x
    • (2009) J. Neurochem , vol.109 , pp. 1714-1724
    • Ferraiuolo, L.1    De Bono, J.P.2    Heath, P.R.3    Holden, H.4    Kasher, P.5    Channon, K.M.6
  • 29
    • 34548157024 scopus 로고    scopus 로고
    • Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS
    • doi: 10.1523/JNEUROSCI.1470-07.2007
    • Ferraiuolo, L., Heath, P. R., Holden, H., Kasher, P., Kirby, J., and Shaw, P. J. (2007). Microarray analysis of the cellular pathways involved in the adaptation to and progression of motor neuron injury in the SOD1 G93A mouse model of familial ALS. J. Neurosci. 27, 9201-9219. doi: 10.1523/JNEUROSCI.1470-07.2007
    • (2007) J. Neurosci , vol.27 , pp. 9201-9219
    • Ferraiuolo, L.1    Heath, P.R.2    Holden, H.3    Kasher, P.4    Kirby, J.5    Shaw, P.J.6
  • 30
    • 80755163102 scopus 로고    scopus 로고
    • Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
    • doi: 10.1038/nrneurol.2011.152
    • Ferraiuolo, L., Kirby, J., Grierson, A. J., Sendtner, M., and Shaw, P. J. (2011). Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis. Nat. Rev. Neurol. 7, 616-630. doi: 10.1038/nrneurol.2011.152
    • (2011) Nat. Rev. Neurol , vol.7 , pp. 616-630
    • Ferraiuolo, L.1    Kirby, J.2    Grierson, A.J.3    Sendtner, M.4    Shaw, P.J.5
  • 31
    • 0345742771 scopus 로고    scopus 로고
    • Amyotrophic lateral sclerosis is a distal axonopathy: Evidence in mice and man
    • doi: 10.1016/j.expneurol.2003.10.004
    • Fischer, L. R., Culver, D. G., Tennant, P., Davis, A. A., Wang, M., Castellano-Sanchez, A., et al. (2004). Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp. Neurol. 185, 232-240. doi: 10.1016/j.expneurol.2003.10.004
    • (2004) Exp. Neurol , vol.185 , pp. 232-240
    • Fischer, L.R.1    Culver, D.G.2    Tennant, P.3    Davis, A.A.4    Wang, M.5    Castellano-Sanchez, A.6
  • 32
    • 34447294839 scopus 로고    scopus 로고
    • Gene expression analysis of the murine model of amyotrophic lateral sclerosis: Studies of the Leu126delTT mutation in SOD1
    • doi: 10.1016/j.brainres.2007.05.044
    • Fukada, Y., Yasui, K., Kitayama, M., Doi, K., Nakano, T., Watanabe, Y., et al. (2007). Gene expression analysis of the murine model of amyotrophic lateral sclerosis: studies of the Leu126delTT mutation in SOD1. Brain Res. 1160, 1-10. doi: 10.1016/j.brainres.2007.05.044
    • (2007) Brain Res , vol.1160 , pp. 1-10
    • Fukada, Y.1    Yasui, K.2    Kitayama, M.3    Doi, K.4    Nakano, T.5    Watanabe, Y.6
  • 33
    • 84860859564 scopus 로고    scopus 로고
    • Modeling human neurodegenerative diseases in transgenic systems
    • doi: 10.1007/s00439-011-1119-1
    • Gama Sosa, M. A., De Gasperi, R., and Elder, G. A. (2012). Modeling human neurodegenerative diseases in transgenic systems. Hum. Genet. 131, 535-563. doi: 10.1007/s00439-011-1119-1
    • (2012) Hum. Genet , vol.131 , pp. 535-563
    • Gama Sosa, M.A.1    De Gasperi, R.2    Elder, G.A.3
  • 34
    • 84862529764 scopus 로고    scopus 로고
    • Molecular basis of axonal dysfunction and traffic impairments in CMT
    • doi: 10.1016/j.brainresbull.2012.05.003
    • Gentil, B. J., and Cooper, L. (2012). Molecular basis of axonal dysfunction and traffic impairments in CMT. Brain Res. Bull. 88, 444-453. doi: 10.1016/j.brainresbull.2012.05.003
    • (2012) Brain Res. Bull , vol.88 , pp. 444-453
    • Gentil, B.J.1    Cooper, L.2
  • 35
    • 28744458859 scopus 로고    scopus 로고
    • Bioconductor: Open software development for computational biology and bioinformatics
    • doi: 10.1186/gb-2004-5-10-r80
    • Gentleman, R. C., Carey, V. J., Bates, D. M., Bolstad, B., Dettling, M., Dudoit, S., et al. (2004). Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 5, R80. doi: 10.1186/gb-2004-5-10-r80
    • (2004) Genome Biol , vol.5
    • Gentleman, R.C.1    Carey, V.J.2    Bates, D.M.3    Bolstad, B.4    Dettling, M.5    Dudoit, S.6
  • 36
    • 84875278532 scopus 로고    scopus 로고
    • Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts
    • doi: 10.1016/j.ceca.2013.01.004
    • Goldman, N., Chandler-Militello, D., Langevin, H. M., Nedergaard, M., and Takano, T. (2013). Purine receptor mediated actin cytoskeleton remodeling of human fibroblasts. Cell Calcium 53, 297-301. doi: 10.1016/j.ceca.2013.01.004
    • (2013) Cell Calcium , vol.53 , pp. 297-301
    • Goldman, N.1    Chandler-Militello, D.2    Langevin, H.M.3    Nedergaard, M.4    Takano, T.5
  • 37
    • 84858825510 scopus 로고    scopus 로고
    • Role of the rumen in copper and thiomolybdate absorption
    • doi: 10.1017/S0954422411000059
    • Gould, L., and Kendall, N. R. (2011). Role of the rumen in copper and thiomolybdate absorption. Nutr. Res. Rev. 24, 176-182. doi: 10.1017/S0954422411000059
    • (2011) Nutr. Res. Rev , vol.24 , pp. 176-182
    • Gould, L.1    Kendall, N.R.2
  • 38
    • 79957973386 scopus 로고    scopus 로고
    • Motor neuron trophic factors: Therapeutic use in ALS?
    • doi: 10.1016/j.brainresrev.2010.10.003
    • Gould, T. W., and Oppenheim, R. W. (2011). Motor neuron trophic factors: therapeutic use in ALS? Brain Res. Rev. 67, 1-39. doi: 10.1016/j.brainresrev.2010.10.003
    • (2011) Brain Res. Rev , vol.67 , pp. 1-39
    • Gould, T.W.1    Oppenheim, R.W.2
  • 39
    • 77950188668 scopus 로고    scopus 로고
    • SAGE analysis of genes differentially expressed in presymptomatic TgSOD1G93A transgenic mice identified cellular processes involved in early stage of ALS pathology
    • doi: 10.1007/s12031-009-9317-1
    • Guipponi, M., Li, Q. X., Hyde, L., Beissbarth, T., Smyth, G. K., Masters, C. L., et al. (2010). SAGE analysis of genes differentially expressed in presymptomatic TgSOD1G93A transgenic mice identified cellular processes involved in early stage of ALS pathology. J. Mol. Neurosci. 41, 172-182. doi: 10.1007/s12031-009-9317-1
    • (2010) J. Mol. Neurosci , vol.41 , pp. 172-182
    • Guipponi, M.1    Li, Q.X.2    Hyde, L.3    Beissbarth, T.4    Smyth, G.K.5    Masters, C.L.6
  • 40
    • 0025304001 scopus 로고
    • Receptor alterations associated with spinal motoneuron degeneration in bovine Akabane disease
    • doi: 10.1002/ana.410270510
    • Gundlach, A. L., Grabara, C. S., Johnston, G. A., and Harper, P. A. (1990). Receptor alterations associated with spinal motoneuron degeneration in bovine Akabane disease. Ann. Neurol. 27, 513-519. doi: 10.1002/ana.410270510
    • (1990) Ann. Neurol , vol.27 , pp. 513-519
    • Gundlach, A.L.1    Grabara, C.S.2    Johnston, G.A.3    Harper, P.A.4
  • 41
    • 0028125281 scopus 로고
    • Transgenic-mouse model of amyotrophic lateral sclerosis
    • doi: 10.1056/NEJM199412223312516
    • Gurney, M. E. (1994). Transgenic-mouse model of amyotrophic lateral sclerosis. N. Engl. J. Med. 331, 1721-1722. doi: 10.1056/NEJM199412223312516
    • (1994) N. Engl. J. Med , vol.331 , pp. 1721-1722
    • Gurney, M.E.1
  • 42
    • 0034785483 scopus 로고    scopus 로고
    • A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2
    • doi: 10.1038/ng1001-166
    • Hadano, S., Hand, C. K., Osuga, H., Yanagisawa, Y., Otomo, A., Devon, R. S., et al. (2001). A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Nat. Genet. 29, 166-173. doi: 10.1038/ng1001-166
    • (2001) Nat. Genet , vol.29 , pp. 166-173
    • Hadano, S.1    Hand, C.K.2    Osuga, H.3    Yanagisawa, Y.4    Otomo, A.5    Devon, R.S.6
  • 43
    • 77956274512 scopus 로고    scopus 로고
    • Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking
    • doi: 10.1371/journal.pone.0009805
    • Hadano, S., Otomo, A., Kunita, R., Suzuki-Utsunomiya, K., Akatsuka, A., Koike, M., et al. (2010). Loss of ALS2/Alsin exacerbates motor dysfunction in a SOD1-expressing mouse ALS model by disturbing endolysosomal trafficking. PLoS ONE 5:e9805. doi: 10.1371/journal.pone.0009805
    • (2010) PLoS ONE , vol.5
    • Hadano, S.1    Otomo, A.2    Kunita, R.3    Suzuki-Utsunomiya, K.4    Akatsuka, A.5    Koike, M.6
  • 44
    • 0037734370 scopus 로고    scopus 로고
    • Mutations in dynein link motor neuron degeneration to defects in retrograde transport
    • doi: 10.1126/science.1083129
    • Hafezparast, M., Klocke, R., Ruhrberg, C., Marquardt, A., Ahmad-Annuar, A., Bowen, S., et al. (2003). Mutations in dynein link motor neuron degeneration to defects in retrograde transport. Science 300, 808-812. doi: 10.1126/science.1083129
    • (2003) Science , vol.300 , pp. 808-812
    • Hafezparast, M.1    Klocke, R.2    Ruhrberg, C.3    Marquardt, A.4    Ahmad-Annuar, A.5    Bowen, S.6
  • 45
    • 0020035894 scopus 로고
    • Degeneration and regeneration of ventral root motor fibers in amyotrophic lateral sclerosis. Morphometric studies of cervical ventral roots
    • doi: 10.1016/0022-510X(82)90173-3
    • Hanyu, N., Oguchi, K., Yanagisawa, N., and Tsukagoshi, H. (1982). Degeneration and regeneration of ventral root motor fibers in amyotrophic lateral sclerosis. Morphometric studies of cervical ventral roots. J. Neurol. Sci. 55, 99-115. doi: 10.1016/0022-510X(82)90173-3
    • (1982) J. Neurol. Sci , vol.55 , pp. 99-115
    • Hanyu, N.1    Oguchi, K.2    Yanagisawa, N.3    Tsukagoshi, H.4
  • 47
    • 0036062628 scopus 로고    scopus 로고
    • Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis
    • doi: 10.1046/j.1471-4159.2002.00968.x
    • Hensley, K., Floyd, R. A., Gordon, B., Mou, S., Pye, Q. N., Stewart, C., et al. (2002). Temporal patterns of cytokine and apoptosis-related gene expression in spinal cords of the G93A-SOD1 mouse model of amyotrophic lateral sclerosis. J. Neurochem. 82, 365-374. doi: 10.1046/j.1471-4159.2002.00968.x
    • (2002) J. Neurochem , vol.82 , pp. 365-374
    • Hensley, K.1    Floyd, R.A.2    Gordon, B.3    Mou, S.4    Pye, Q.N.5    Stewart, C.6
  • 48
    • 33745211703 scopus 로고    scopus 로고
    • Interpreting flow cytometry data: A guide for the perplexed
    • doi: 10.1038/ni0706-681
    • Herzenberg, L. A., Tung, J., Moore, W. A., and Parks, D. R. (2006). Interpreting flow cytometry data: a guide for the perplexed. Nat. Immunol. 7, 681-685. doi: 10.1038/ni0706-681
    • (2006) Nat. Immunol , vol.7 , pp. 681-685
    • Herzenberg, L.A.1    Tung, J.2    Moore, W.A.3    Parks, D.R.4
  • 50
    • 56449107474 scopus 로고    scopus 로고
    • BioVenn-a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams
    • doi: 10.1186/1471-2164-9-488
    • Hulsen, T., De Vlieg, J., and Alkema, W. (2008). BioVenn-a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams. BMC Genomics 9:488. doi: 10.1186/1471-2164-9-488
    • (2008) BMC Genomics , vol.9 , pp. 488
    • Hulsen, T.1    De Vlieg, J.2    Alkema, W.3
  • 51
    • 0033635551 scopus 로고    scopus 로고
    • Mitotic activation: A convergent mechanism for a cohort of neurodegenerative diseases
    • doi: 10.1016/S0197-4580(00)00221-9
    • Husseman, J. W., Nochlin, D., and Vincent, I. (2000). Mitotic activation: a convergent mechanism for a cohort of neurodegenerative diseases. Neurobiol. Aging 21, 815-828. doi: 10.1016/S0197-4580(00)00221-9
    • (2000) Neurobiol. Aging , vol.21 , pp. 815-828
    • Husseman, J.W.1    Nochlin, D.2    Vincent, I.3
  • 52
    • 0028837458 scopus 로고
    • Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis
    • doi: 10.1006/dbio.1995.1026
    • Ito, M., Swanson, B., Sussman, M. A., Kedes, L., and Lyons, G. (1995). Cloning of tropomodulin cDNA and localization of gene transcripts during mouse embryogenesis. Dev. Biol. 167, 317-328. doi: 10.1006/dbio.1995.1026
    • (1995) Dev. Biol , vol.167 , pp. 317-328
    • Ito, M.1    Swanson, B.2    Sussman, M.A.3    Kedes, L.4    Lyons, G.5
  • 53
    • 0842290736 scopus 로고    scopus 로고
    • Axonal defects in mouse models of motoneuron disease
    • doi: 10.1002/neu.10313
    • Jablonka, S., Wiese, S., and Sendtner, M. (2004). Axonal defects in mouse models of motoneuron disease. J. Neurobiol. 58, 272-286. doi: 10.1002/neu.10313
    • (2004) J. Neurobiol , vol.58 , pp. 272-286
    • Jablonka, S.1    Wiese, S.2    Sendtner, M.3
  • 54
    • 19944432585 scopus 로고    scopus 로고
    • Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis
    • doi: 10.1002/ana.20379
    • Jiang, Y. M., Yamamoto, M., Kobayashi, Y., Yoshihara, T., Liang, Y., Terao, S., et al. (2005). Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann. Neurol. 57, 236-251. doi: 10.1002/ana.20379
    • (2005) Ann. Neurol , vol.57 , pp. 236-251
    • Jiang, Y.M.1    Yamamoto, M.2    Kobayashi, Y.3    Yoshihara, T.4    Liang, Y.5    Terao, S.6
  • 55
    • 34447323610 scopus 로고    scopus 로고
    • Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis
    • doi: 10.1097/nen.0b013e318093ece3
    • Jiang, Y. M., Yamamoto, M., Tanaka, F., Ishigaki, S., Katsuno, M., Adachi, H., et al. (2007). Gene expressions specifically detected in motor neurons (dynactin 1, early growth response 3, acetyl-CoA transporter, death receptor 5, and cyclin C) differentially correlate to pathologic markers in sporadic amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 66, 617-627. doi: 10.1097/nen.0b013e318093ece3
    • (2007) J. Neuropathol. Exp. Neurol , vol.66 , pp. 617-627
    • Jiang, Y.M.1    Yamamoto, M.2    Tanaka, F.3    Ishigaki, S.4    Katsuno, M.5    Adachi, H.6
  • 56
    • 69449095509 scopus 로고    scopus 로고
    • Live imaging of amyotrophic lateral sclerosis pathogenesis: Disease onset is characterized by marked induction of GFAP in Schwann cells
    • doi: 10.1002/glia.20836
    • Keller, A. F., Gravel, M., and Kriz, J. (2009). Live imaging of amyotrophic lateral sclerosis pathogenesis: disease onset is characterized by marked induction of GFAP in Schwann cells. Glia 57, 1130-1142. doi: 10.1002/glia.20836
    • (2009) Glia , vol.57 , pp. 1130-1142
    • Keller, A.F.1    Gravel, M.2    Kriz, J.3
  • 58
    • 84868142988 scopus 로고    scopus 로고
    • The nuclear events guiding successful nerve regeneration
    • doi: 10.3389/fnmol.2011.00053
    • Kiryu-Seo, S., and Kiyama, H. (2011). The nuclear events guiding successful nerve regeneration. Front. Mol. Neurosci. 4:53. doi: 10.3389/fnmol.2011.00053
    • (2011) Front. Mol. Neurosci , vol.4 , pp. 53
    • Kiryu-Seo, S.1    Kiyama, H.2
  • 59
    • 23944442778 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene
    • doi: 10.1016/j.tox.2005.05.009
    • Koh, S. H., Roh, H., Lee, S. M., Kim, H. J., Kim, M., Lee, K. W., et al. (2005). Phosphatidylinositol 3-kinase activator reduces motor neuronal cell death induced by G93A or A4V mutant SOD1 gene. Toxicology 213, 45-55. doi: 10.1016/j.tox.2005.05.009
    • (2005) Toxicology , vol.213 , pp. 45-55
    • Koh, S.H.1    Roh, H.2    Lee, S.M.3    Kim, H.J.4    Kim, M.5    Lee, K.W.6
  • 60
    • 84873096554 scopus 로고    scopus 로고
    • Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: Neuroprotective or neurotoxic properties of sirtuins in ALS?
    • doi: 10.1159/000338048
    • Korner, S., Boselt, S., Thau, N., Rath, K. J., Dengler, R., and Petri, S. (2013). Differential sirtuin expression patterns in amyotrophic lateral sclerosis (ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS? Neurodegener. Dis. 11, 141-152. doi: 10.1159/000338048
    • (2013) Neurodegener. Dis , vol.11 , pp. 141-152
    • Korner, S.1    Boselt, S.2    Thau, N.3    Rath, K.J.4    Dengler, R.5    Petri, S.6
  • 61
    • 77955034060 scopus 로고    scopus 로고
    • Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: Application to amyotrophic lateral sclerosis
    • doi: 10.1093/hmg/ddq232
    • Kudo, L. C., Parfenova, L., Vi, N., Lau, K., Pomakian, J., Valdmanis, P., et al. (2010). Integrative gene-tissue microarray-based approach for identification of human disease biomarkers: application to amyotrophic lateral sclerosis. Hum. Mol. Genet. 19, 3233-3253. doi: 10.1093/hmg/ddq232
    • (2010) Hum. Mol. Genet , vol.19 , pp. 3233-3253
    • Kudo, L.C.1    Parfenova, L.2    Vi, N.3    Lau, K.4    Pomakian, J.5    Valdmanis, P.6
  • 62
    • 84881131694 scopus 로고    scopus 로고
    • Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis
    • doi: 10.1159/000339529
    • Kuzma-Kozakiewicz, M., Chudy, A., Gajewska, B., Dziewulska, D., Usarek, E., and Baranczyk-Kuzma, A. (2013). Kinesin expression in the central nervous system of humans and transgenic hSOD1G93A mice with amyotrophic lateral sclerosis. Neurodegener. Dis. 12, 71-80. doi: 10.1159/000339529
    • (2013) Neurodegener. Dis , vol.12 , pp. 71-80
    • Kuzma-Kozakiewicz, M.1    Chudy, A.2    Gajewska, B.3    Dziewulska, D.4    Usarek, E.5    Baranczyk-Kuzma, A.6
  • 63
    • 69049112930 scopus 로고    scopus 로고
    • Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin
    • doi: 10.1186/1756-6606-2-23
    • Lai, C., Xie, C., Shim, H., Chandran, J., Howell, B. W., and Cai, H. (2009). Regulation of endosomal motility and degradation by amyotrophic lateral sclerosis 2/alsin. Mol. Brain 2, 23. doi: 10.1186/1756-6606-2-23
    • (2009) Mol. Brain , vol.2 , pp. 23
    • Lai, C.1    Xie, C.2    Shim, H.3    Chandran, J.4    Howell, B.W.5    Cai, H.6
  • 64
    • 0033485920 scopus 로고    scopus 로고
    • Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS)
    • doi: 10.1002/(SICI)1098-1136(199912)28:3<215::AID-GLIA5>3.0.CO;2-C
    • Levine, J. B., Kong, J., Nadler, M., and Xu, Z. (1999). Astrocytes interact intimately with degenerating motor neurons in mouse amyotrophic lateral sclerosis (ALS). Glia 28, 215-224. doi: 10.1002/(SICI)1098-1136(199912)28:3<215::AID-GLIA5>3.0.CO;2-C
    • (1999) Glia , vol.28 , pp. 215-224
    • Levine, J.B.1    Kong, J.2    Nadler, M.3    Xu, Z.4
  • 65
    • 84874497584 scopus 로고    scopus 로고
    • Distinct changes in synaptic protein composition at neuromuscular junctions of extraocular muscles versus limb muscles of ALS donors
    • doi: 10.1371/journal.pone.0057473
    • Liu, J. X., Brannstrom, T., Andersen, P. M., and Pedrosa-Domellof, F. (2013). Distinct changes in synaptic protein composition at neuromuscular junctions of extraocular muscles versus limb muscles of ALS donors. PLoS ONE8:e57473. doi: 10.1371/journal.pone.0057473
    • (2013) PLoS ONE , vol.8
    • Liu, J.X.1    Brannstrom, T.2    Andersen, P.M.3    Pedrosa-Domellof, F.4
  • 66
    • 34250656185 scopus 로고    scopus 로고
    • Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons
    • doi: 10.1073/pnas.0702230104
    • Lobsiger, C. S., Boillee, S., and Cleveland, D. W. (2007). Toxicity from different SOD1 mutants dysregulates the complement system and the neuronal regenerative response in ALS motor neurons. Proc. Natl. Acad. Sci. U.S.A. 104, 7319-7326. doi: 10.1073/pnas.0702230104
    • (2007) Proc. Natl. Acad. Sci. U.S. A , vol.104 , pp. 7319-7326
    • Lobsiger, C.S.1    Boillee, S.2    Cleveland, D.W.3
  • 67
    • 67649874745 scopus 로고    scopus 로고
    • Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons
    • doi: 10.1038/ng.376
    • Lyons, D. A., Naylor, S. G., Scholze, A., and Talbot, W. S. (2009). Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons. Nat. Genet. 41, 854-858. doi: 10.1038/ng.376
    • (2009) Nat. Genet , vol.41 , pp. 854-858
    • Lyons, D.A.1    Naylor, S.G.2    Scholze, A.3    Talbot, W.S.4
  • 68
    • 66749104344 scopus 로고    scopus 로고
    • Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis
    • doi: 10.1089/ARS.2009.2604
    • Magrane, J., and Manfredi, G. (2009). Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis. Antioxid. Redox Signal. 11, 1615-1626. doi: 10.1089/ARS.2009.2604
    • (2009) Antioxid. Redox Signal , vol.11 , pp. 1615-1626
    • Magrane, J.1    Manfredi, G.2
  • 69
    • 77954620620 scopus 로고    scopus 로고
    • Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis
    • doi: 10.1016/j.neuroscience.2010.04.053
    • Malaspina, A., Ngoh, S. F., Ward, R. E., Hall, J. C., Tai, F. W., Yip, P. K., et al. (2010). Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis. Neuroscience 169, 812-827. doi: 10.1016/j.neuroscience.2010.04.053
    • (2010) Neuroscience , vol.169 , pp. 812-827
    • Malaspina, A.1    Ngoh, S.F.2    Ward, R.E.3    Hall, J.C.4    Tai, F.W.5    Yip, P.K.6
  • 70
    • 84907686496 scopus 로고    scopus 로고
    • Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A
    • doi: 10.1016/j.brainres.2013.12.033. [Epub ahead of print]
    • Malmqvist, T., Anthony, K., and Gallo, J. M. (2014). Tau mRNA is present in axonal RNA granules and is associated with elongation factor 1A. Brain Res. doi: 10.1016/j.brainres.2013.12.033. [Epub ahead of print].
    • (2014) Brain Res
    • Malmqvist, T.1    Anthony, K.2    Gallo, J.M.3
  • 71
    • 0036787810 scopus 로고    scopus 로고
    • Inflammatory processes in amyotrophic lateral sclerosis
    • doi: 10.1002/mus.10191
    • McGeer, P. L., and McGeer, E. G. (2002). Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve26, 459-470. doi: 10.1002/mus.10191
    • (2002) Muscle Nerve , vol.26 , pp. 459-470
    • McGeer, P.L.1    McGeer, E.G.2
  • 72
    • 70450188174 scopus 로고    scopus 로고
    • Genetic dissection of myelinated axons in zebrafish
    • doi: 10.1016/j.conb.2009.08.006
    • Monk, K. R., and Talbot, W. S. (2009). Genetic dissection of myelinated axons in zebrafish. Curr. Opin. Neurobiol. 19, 486-490. doi: 10.1016/j.conb.2009.08.006
    • (2009) Curr. Opin. Neurobiol , vol.19 , pp. 486-490
    • Monk, K.R.1    Talbot, W.S.2
  • 73
    • 84878900746 scopus 로고    scopus 로고
    • Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase
    • doi: 10.1371/journal.pone.0065235
    • Morfini, G. A., Bosco, D. A., Brown, H., Gatto, R., Kaminska, A., Song, Y., et al. (2013). Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. PLoS ONE 8:e65235. doi: 10.1371/journal.pone.0065235
    • (2013) PLoS ONE , vol.8
    • Morfini, G.A.1    Bosco, D.A.2    Brown, H.3    Gatto, R.4    Kaminska, A.5    Song, Y.6
  • 74
    • 0028641560 scopus 로고
    • KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria
    • doi: 10.1016/0092-8674(94)90012-4
    • Nangaku, M., Sato-Yoshitake, R., Okada, Y., Noda, Y., Takemura, R., Yamazaki, H., et al. (1994). KIF1B, a novel microtubule plus end-directed monomeric motor protein for transport of mitochondria. Cell 79, 1209-1220. doi: 10.1016/0092-8674(94)90012-4
    • (1994) Cell , vol.79 , pp. 1209-1220
    • Nangaku, M.1    Sato-Yoshitake, R.2    Okada, Y.3    Noda, Y.4    Takemura, R.5    Yamazaki, H.6
  • 75
    • 77952242898 scopus 로고    scopus 로고
    • Novel method to obtain highly enriched cultures of adult rat Schwann cells
    • doi: 10.1007/s10529-010-0230-z
    • Niapour, A., Karamali, F., Karbalaie, K., Kiani, A., Mardani, M., Nasr-Esfahani, M. H., et al. (2010). Novel method to obtain highly enriched cultures of adult rat Schwann cells. Biotechnol. Lett. 32, 781-786. doi: 10.1007/s10529-010-0230-z
    • (2010) Biotechnol. Lett , vol.32 , pp. 781-786
    • Niapour, A.1    Karamali, F.2    Karbalaie, K.3    Kiani, A.4    Mardani, M.5    Nasr-Esfahani, M.H.6
  • 76
    • 79955733724 scopus 로고    scopus 로고
    • The cholinergic system, nerve growth factor and the cytoskeleton
    • doi: 10.1016/j.bbr.2010.02.024
    • Niewiadomska, G., Mietelska-Porowska, A., and Mazurkiewicz, M. (2011). The cholinergic system, nerve growth factor and the cytoskeleton. Behav. Brain Res. 221, 515-526. doi: 10.1016/j.bbr.2010.02.024
    • (2011) Behav. Brain Res , vol.221 , pp. 515-526
    • Niewiadomska, G.1    Mietelska-Porowska, A.2    Mazurkiewicz, M.3
  • 77
    • 6344257200 scopus 로고    scopus 로고
    • A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis
    • doi: 10.1086/425287
    • Nishimura, A. L., Mitne-Neto, M., Silva, H. C., Richieri-Costa, A., Middleton, S., Cascio, D., et al. (2004). A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am. J. Hum. Genet. 75, 822-831. doi: 10.1086/425287
    • (2004) Am. J. Hum. Genet , vol.75 , pp. 822-831
    • Nishimura, A.L.1    Mitne-Neto, M.2    Silva, H.C.3    Richieri-Costa, A.4    Middleton, S.5    Cascio, D.6
  • 78
    • 0033534788 scopus 로고    scopus 로고
    • Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins
    • doi: 10.1006/bbrc.1998.9876
    • Nishimura, Y., Hayashi, M., Inada, H., and Tanaka, T. (1999). Molecular cloning and characterization of mammalian homologues of vesicle-associated membrane protein-associated (VAMP-associated) proteins. Biochem. Biophys. Res. Commun. 254, 21-26. doi: 10.1006/bbrc.1998.9876
    • (1999) Biochem. Biophys. Res. Commun , vol.254 , pp. 21-26
    • Nishimura, Y.1    Hayashi, M.2    Inada, H.3    Tanaka, T.4
  • 79
    • 69249220446 scopus 로고    scopus 로고
    • Spinal cord mRNA profile in patients with ALS: Comparison with transgenic mice expressing the human SOD-1 mutant
    • doi: 10.1007/s12031-007-9004-z
    • Offen, D., Barhum, Y., Melamed, E., Embacher, N., Schindler, C., and Ransmayr, G. (2009). Spinal cord mRNA profile in patients with ALS: comparison with transgenic mice expressing the human SOD-1 mutant. J. Mol. Neurosci. 38, 85-93. doi: 10.1007/s12031-007-9004-z
    • (2009) J. Mol. Neurosci , vol.38 , pp. 85-93
    • Offen, D.1    Barhum, Y.2    Melamed, E.3    Embacher, N.4    Schindler, C.5    Ransmayr, G.6
  • 80
    • 0029051298 scopus 로고
    • The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors
    • doi: 10.1016/0092-8674(95)90538-3
    • Okada, Y., Yamazaki, H., Sekine-Aizawa, Y., and Hirokawa, N. (1995). The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors. Cell81, 769-780. doi: 10.1016/0092-8674(95)90538-3
    • (1995) Cell , vol.81 , pp. 769-780
    • Okada, Y.1    Yamazaki, H.2    Sekine-Aizawa, Y.3    Hirokawa, N.4
  • 81
    • 0035194691 scopus 로고    scopus 로고
    • Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord
    • doi: 10.1002/ana.1252
    • Olsen, M. K., Roberds, S. L., Ellerbrock, B. R., Fleck, T. J., McKinley, D. K., and Gurney, M. E. (2001). Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord. Ann. Neurol. 50, 730-740. doi: 10.1002/ana.1252
    • (2001) Ann. Neurol , vol.50 , pp. 730-740
    • Olsen, M.K.1    Roberds, S.L.2    Ellerbrock, B.R.3    Fleck, T.J.4    McKinley, D.K.5    Gurney, M.E.6
  • 82
    • 0031104891 scopus 로고    scopus 로고
    • A combination of insulin-like growth factor-I and platelet-derived growth factor enhances myelination but diminishes axonal regeneration into Schwann cell grafts in the adult rat spinal cord
    • doi: 10.1002/(SICI)1098-1136(199703)19:3<247::AID-GLIA7>3.0.CO;2-W
    • Oudega, M., Xu, X. M., Guenard, V., Kleitman, N., and Bunge, M. B. (1997). A combination of insulin-like growth factor-I and platelet-derived growth factor enhances myelination but diminishes axonal regeneration into Schwann cell grafts in the adult rat spinal cord. Glia 19, 247-258. doi: 10.1002/(SICI)1098-1136(199703)19:3<247::AID-GLIA7>3.0.CO;2-W
    • (1997) Glia , vol.19 , pp. 247-258
    • Oudega, M.1    Xu, X.M.2    Guenard, V.3    Kleitman, N.4    Bunge, M.B.5
  • 83
    • 34248512129 scopus 로고    scopus 로고
    • Differential expression of molecular motors in the motor cortex of sporadic ALS
    • doi: 10.1016/j.nbd.2007.02.005
    • Pantelidou, M., Zographos, S. E., Lederer, C. W., Kyriakides, T., Pfaffl, M. W., and Santama, N. (2007). Differential expression of molecular motors in the motor cortex of sporadic ALS. Neurobiol. Dis. 26, 577-589. doi: 10.1016/j.nbd.2007.02.005
    • (2007) Neurobiol. Dis , vol.26 , pp. 577-589
    • Pantelidou, M.1    Zographos, S.E.2    Lederer, C.W.3    Kyriakides, T.4    Pfaffl, M.W.5    Santama, N.6
  • 84
    • 39349101214 scopus 로고    scopus 로고
    • Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis
    • doi: 10.1080/17482960701725646
    • Parkhouse, W. S., Cunningham, L., McFee, I., Miller, J. M., Whitney, D., Pelech, S. L., et al. (2008). Neuromuscular dysfunction in the mutant superoxide dismutase mouse model of amyotrophic lateral sclerosis. Amyotroph. Lateral Scler. 9, 24-34. doi: 10.1080/17482960701725646
    • (2008) Amyotroph. Lateral Scler , vol.9 , pp. 24-34
    • Parkhouse, W.S.1    Cunningham, L.2    McFee, I.3    Miller, J.M.4    Whitney, D.5    Pelech, S.L.6
  • 85
    • 33747605320 scopus 로고    scopus 로고
    • Molecular biology of amyotrophic lateral sclerosis: Insights from genetics
    • doi: 10.1038/nrn1971
    • Pasinelli, P., and Brown, R. H. (2006). Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat. Rev. Neurosci. 7, 710-723. doi: 10.1038/nrn1971
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 710-723
    • Pasinelli, P.1    Brown, R.H.2
  • 86
    • 0027337426 scopus 로고
    • Changes in the myelinated axons of femoral nerve in amyotrophic lateral sclerosis
    • doi: 10.1155/2011/718987
    • Perrie, W. T., Lee, G. T., Curtis, E. M., Sparke, J., Buller, J. R., and Rossi, M. L. (1993). Changes in the myelinated axons of femoral nerve in amyotrophic lateral sclerosis. J. Neural Transm. Suppl. 39, 223-233. doi: 10.1155/2011/718987
    • (1993) J. Neural Transm. Suppl , vol.39 , pp. 223-233
    • Perrie, W.T.1    Lee, G.T.2    Curtis, E.M.3    Sparke, J.4    Buller, J.R.5    Rossi, M.L.6
  • 87
    • 27744542191 scopus 로고    scopus 로고
    • No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model
    • doi: 10.1093/hmg/ddi357
    • Perrin, F. E., Boisset, G., Docquier, M., Schaad, O., Descombes, P., and Kato, A. C. (2005). No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model. Hum. Mol. Genet. 14, 3309-3320. doi: 10.1093/hmg/ddi357
    • (2005) Hum. Mol. Genet , vol.14 , pp. 3309-3320
    • Perrin, F.E.1    Boisset, G.2    Docquier, M.3    Schaad, O.4    Descombes, P.5    Kato, A.C.6
  • 88
    • 80055053362 scopus 로고    scopus 로고
    • Muscle gene expression is a marker of amyotrophic lateral sclerosis severity
    • doi: 10.1159/000329723
    • Pradat, P. F., Dubourg, O., De Tapia, M., Di Scala, F., Dupuis, L., Lenglet, T., et al. (2012). Muscle gene expression is a marker of amyotrophic lateral sclerosis severity. Neurodegener. Dis. 9, 38-52. doi: 10.1159/000329723
    • (2012) Neurodegener. Dis , vol.9 , pp. 38-52
    • Pradat, P.F.1    Dubourg, O.2    De Tapia, M.3    Di Scala, F.4    Dupuis, L.5    Lenglet, T.6
  • 89
    • 60849093466 scopus 로고    scopus 로고
    • Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
    • doi: 10.1002/ana.21543
    • Rothstein, J. D. (2009). Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Ann. Neurol. 65(Suppl. 1), S3-S9. doi: 10.1002/ana.21543
    • (2009) Ann. Neurol , vol.65 , Issue.SUPPL. 1
    • Rothstein, J.D.1
  • 90
    • 0035479007 scopus 로고    scopus 로고
    • AIF-1 expression defines a proliferating and alert microglial/macrophage phenotype following spinal cord injury in rats
    • doi: 10.1016/S0165-5728(01)00375-7
    • Schwab, J. M., Frei, E., Klusman, I., Schnell, L., Schwab, M. E., and Schluesener, H. J. (2001). AIF-1 expression defines a proliferating and alert microglial/macrophage phenotype following spinal cord injury in rats. J. Neuroimmunol. 119, 214-222. doi: 10.1016/S0165-5728(01)00375-7
    • (2001) J. Neuroimmunol , vol.119 , pp. 214-222
    • Schwab, J.M.1    Frei, E.2    Klusman, I.3    Schnell, L.4    Schwab, M.E.5    Schluesener, H.J.6
  • 91
    • 77952928969 scopus 로고    scopus 로고
    • The review of the methods to obtain non-neuronal cells to study glial influence on Amyotrophic Lateral Sclerosis pathophysiology at molecular level in vitro
    • doi: 10.1590/S0102-86502010000300011
    • Scorisa, J. M., Duobles, T., Oliveira, G. P., Maximino, J. R., and Chadi, G. (2010). The review of the methods to obtain non-neuronal cells to study glial influence on Amyotrophic Lateral Sclerosis pathophysiology at molecular level in vitro. Acta Cir. Bras. 25, 281-289. doi: 10.1590/S0102-86502010000300011
    • (2010) Acta Cir. Bras , vol.25 , pp. 281-289
    • Scorisa, J.M.1    Duobles, T.2    Oliveira, G.P.3    Maximino, J.R.4    Chadi, G.5
  • 93
    • 0035240305 scopus 로고    scopus 로고
    • Progress in the pathogenesis of amyotrophic lateral sclerosis
    • doi: 10.1007/s11910-001-0078-7
    • Shaw, C. E., Al-Chalabi, A., and Leigh, N. (2001). Progress in the pathogenesis of amyotrophic lateral sclerosis. Curr. Neurol. Neurosci. Rep. 1, 69-76. doi: 10.1007/s11910-001-0078-7
    • (2001) Curr. Neurol. Neurosci. Rep , vol.1 , pp. 69-76
    • Shaw, C.E.1    Al-Chalabi, A.2    Leigh, N.3
  • 94
    • 33644872577 scopus 로고    scopus 로고
    • Limma: Linear models for microarray data
    • in eds V. C. R. Gentleman, S. Dudoit, R. Irizarry, and W. Huber (New York, NY: Springer)
    • Smyth, G. K. (2005). "Limma: linear models for microarray data, " in Bioinformatics and Computational Biology Solutions using R and Bioconductor, eds V. C. R. Gentleman, S. Dudoit, R. Irizarry, and W. Huber (New York, NY: Springer), 397-420.
    • (2005) Bioinformatics and Computational Biology Solutions using R and Bioconductor , pp. 397-420
    • Smyth, G.K.1
  • 95
    • 67650915095 scopus 로고    scopus 로고
    • Gene expression profiles of APP and BACE1 in Tg SOD1G93A cortical cells
    • doi: 10.1007/s10571-009-9356-8
    • Spadoni, O., Crestini, A., Piscopo, P., Malvezzi-Campeggi, L., Carunchio, I., Pieri, M., et al. (2009). Gene expression profiles of APP and BACE1 in Tg SOD1G93A cortical cells. Cell. Mol. Neurobiol. 29, 635-641. doi: 10.1007/s10571-009-9356-8
    • (2009) Cell. Mol. Neurobiol , vol.29 , pp. 635-641
    • Spadoni, O.1    Crestini, A.2    Piscopo, P.3    Malvezzi-Campeggi, L.4    Carunchio, I.5    Pieri, M.6
  • 96
    • 7244239105 scopus 로고    scopus 로고
    • Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis
    • doi: 10.1016/S0002-9440(10)63426-8
    • Strey, C. W., Spellman, D., Stieber, A., Gonatas, J. O., Wang, X., Lambris, J. D., et al. (2004). Dysregulation of stathmin, a microtubule-destabilizing protein, and up-regulation of Hsp25, Hsp27, and the antioxidant peroxiredoxin 6 in a mouse model of familial amyotrophic lateral sclerosis. Am. J. Pathol. 165, 1701-1718. doi: 10.1016/S0002-9440(10)63426-8
    • (2004) Am. J. Pathol , vol.165 , pp. 1701-1718
    • Strey, C.W.1    Spellman, D.2    Stieber, A.3    Gonatas, J.O.4    Wang, X.5    Lambris, J.D.6
  • 97
    • 53049090386 scopus 로고    scopus 로고
    • Interaction of amyotrophic lateral sclerosis (ALS)-related mutant copper-zinc superoxide dismutase with the dynein-dynactin complex contributes to inclusion formation
    • doi: 10.1074/jbc.M800276200
    • Strom, A. L., Shi, P., Zhang, F., Gal, J., Kilty, R., Hayward, L. J., et al. (2008). Interaction of amyotrophic lateral sclerosis (ALS)-related mutant copper-zinc superoxide dismutase with the dynein-dynactin complex contributes to inclusion formation. J. Biol. Chem. 283, 22795-22805. doi: 10.1074/jbc.M800276200
    • (2008) J. Biol. Chem , vol.283 , pp. 22795-22805
    • Strom, A.L.1    Shi, P.2    Zhang, F.3    Gal, J.4    Kilty, R.5    Hayward, L.J.6
  • 98
    • 78650017783 scopus 로고    scopus 로고
    • Reduction in the motoneuron inhibitory/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis
    • doi: 10.1111/j.1750-3639.2010.00417.x
    • Sunico, C. R., Dominguez, G., Garcia-Verdugo, J. M., Osta, R., Montero, F., and Moreno-Lopez, B. (2011). Reduction in the motoneuron inhibitory/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis. Brain Pathol. 21, 1-15. doi: 10.1111/j.1750-3639.2010.00417.x
    • (2011) Brain Pathol , vol.21 , pp. 1-15
    • Sunico, C.R.1    Dominguez, G.2    Garcia-Verdugo, J.M.3    Osta, R.4    Montero, F.5    Moreno-Lopez, B.6
  • 99
    • 84875948762 scopus 로고    scopus 로고
    • Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS
    • doi: 10.1093/hmg/ddt028
    • Taes, I., Timmers, M., Hersmus, N., Bento-Abreu, A., Van Den Bosch, L., Van Damme, P., et al. (2013). Hdac6 deletion delays disease progression in the SOD1G93A mouse model of ALS. Hum. Mol. Genet. 22, 1783-1790. doi: 10.1093/hmg/ddt028
    • (2013) Hum. Mol. Genet , vol.22 , pp. 1783-1790
    • Taes, I.1    Timmers, M.2    Hersmus, N.3    Bento-Abreu, A.4    Van Den Bosch, L.5    Van Damme, P.6
  • 100
    • 84864132492 scopus 로고    scopus 로고
    • Neuropathology and omics in motor neuron diseases
    • doi: 10.1111/j.1440-1789.2011.01281.x
    • Tanaka, F., Ikenaka, K., Yamamoto, M., and Sobue, G. (2012). Neuropathology and omics in motor neuron diseases. Neuropathology 32, 458-462. doi: 10.1111/j.1440-1789.2011.01281.x
    • (2012) Neuropathology , vol.32 , pp. 458-462
    • Tanaka, F.1    Ikenaka, K.2    Yamamoto, M.3    Sobue, G.4
  • 101
    • 34248360224 scopus 로고    scopus 로고
    • Gene expression profiling toward understanding of ALS pathogenesis
    • doi: 10.1196/annals.1377.011
    • Tanaka, F., Niwa, J., Ishigaki, S., Katsuno, M., Waza, M., Yamamoto, M., et al. (2006). Gene expression profiling toward understanding of ALS pathogenesis. Ann. N.Y. Acad. Sci. 1086, 1-10. doi: 10.1196/annals.1377.011
    • (2006) Ann. N.Y. Acad. Sci , vol.1086 , pp. 1-10
    • Tanaka, F.1    Niwa, J.2    Ishigaki, S.3    Katsuno, M.4    Waza, M.5    Yamamoto, M.6
  • 102
    • 77954372835 scopus 로고    scopus 로고
    • Protein aggregation and defective RNA metabolism as mechanisms for motor neuron damage
    • doi: 10.2174/187152710791292585
    • Ticozzi, N., Ratti, A., and Silani, V. (2010). Protein aggregation and defective RNA metabolism as mechanisms for motor neuron damage. CNS Neurol. Disord. Drug Targets 9, 285-296. doi: 10.2174/187152710791292585
    • (2010) CNS Neurol. Disord. Drug Targets , vol.9 , pp. 285-296
    • Ticozzi, N.1    Ratti, A.2    Silani, V.3
  • 103
    • 42049091220 scopus 로고    scopus 로고
    • Molecular insights and therapeutic targets in amyotrophic lateral sclerosis
    • doi: 10.2174/187152708783885110
    • Tripathi, V. B., and Al-Chalabi, A. (2008). Molecular insights and therapeutic targets in amyotrophic lateral sclerosis. CNS Neurol. Disord. Drug Targets 7, 11-19. doi: 10.2174/187152708783885110
    • (2008) CNS Neurol. Disord. Drug Targets , vol.7 , pp. 11-19
    • Tripathi, V.B.1    Al-Chalabi, A.2
  • 104
    • 84862836780 scopus 로고    scopus 로고
    • Pathobiochemical effect of acylated steryl-beta-glucoside on aggregation and cytotoxicity of alpha-synuclein
    • doi: 10.1007/s11064-011-0662-4
    • Usuki, S., Kamitani, T., Matsuo, Y., and Yu, R. K. (2012). Pathobiochemical effect of acylated steryl-beta-glucoside on aggregation and cytotoxicity of alpha-synuclein. Neurochem. Res. 37, 1261-1266. doi: 10.1007/s11064-011-0662-4
    • (2012) Neurochem. Res , vol.37 , pp. 1261-1266
    • Usuki, S.1    Kamitani, T.2    Matsuo, Y.3    Yu, R.K.4
  • 106
    • 59349090605 scopus 로고    scopus 로고
    • Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1
    • doi: 10.1002/jnr.21797
    • Vargas, M. R., Pehar, M., Diaz-Amarilla, P. J., Beckman, J. S., and Barbeito, L. (2008). Transcriptional profile of primary astrocytes expressing ALS-linked mutant SOD1. J Neurosci. Res. 86, 3515-3525. doi: 10.1002/jnr.21797
    • (2008) J Neurosci. Res , vol.86 , pp. 3515-3525
    • Vargas, M.R.1    Pehar, M.2    Diaz-Amarilla, P.J.3    Beckman, J.S.4    Barbeito, L.5
  • 107
    • 84893493940 scopus 로고    scopus 로고
    • Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: Part II, results and discussion
    • doi: 10.1002/brb3.142
    • Vinsant, S., Mansfield, C., Jimenez-Moreno, R., Del Gaizo Moore, V., Yoshikawa, M., Hampton, T. G., et al. (2013). Characterization of early pathogenesis in the SOD1(G93A) mouse model of ALS: part II, results and discussion. Brain Behav. 3, 431-457. doi: 10.1002/brb3.142
    • (2013) Brain Behav , vol.3 , pp. 431-457
    • Vinsant, S.1    Mansfield, C.2    Jimenez-Moreno, R.3    Del Gaizo Moore, V.4    Yoshikawa, M.5    Hampton, T.G.6
  • 108
    • 84880169201 scopus 로고    scopus 로고
    • Targeting mutant KRAS for anticancer therapeutics: A review of novel small molecule modulators
    • doi: 10.1021/jm3017706
    • Wang, Y., Kaiser, C. E., Frett, B., and Li, H. Y. (2013). Targeting mutant KRAS for anticancer therapeutics: a review of novel small molecule modulators. J. Med. Chem. 56, 5219-5230. doi: 10.1021/jm3017706
    • (2013) J. Med. Chem , vol.56 , pp. 5219-5230
    • Wang, Y.1    Kaiser, C.E.2    Frett, B.3    Li, H.Y.4
  • 109
    • 0033585832 scopus 로고    scopus 로고
    • Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene
    • doi: 10.1016/S0006-8993(98)01351-1
    • Warita, H., Itoyama, Y., and Abe, K. (1999). Selective impairment of fast anterograde axonal transport in the peripheral nerves of asymptomatic transgenic mice with a G93A mutant SOD1 gene. Brain Res. 819, 120-131. doi: 10.1016/S0006-8993(98)01351-1
    • (1999) Brain Res , vol.819 , pp. 120-131
    • Warita, H.1    Itoyama, Y.2    Abe, K.3
  • 110
    • 0021089981 scopus 로고
    • Growth properties and biochemical characterization of mouse Schwann cells cultured in vitro
    • doi: 10.1016/0014-4827(83)90198-2
    • White, F. V., Ceccarini, C., Georgieff, I., Matthieu, J. M., and Costantino-Ceccarini, E. (1983). Growth properties and biochemical characterization of mouse Schwann cells cultured in vitro. Exp. Cell. Res. 148, 183-194. doi: 10.1016/0014-4827(83)90198-2
    • (1983) Exp. Cell. Res , vol.148 , pp. 183-194
    • White, F.V.1    Ceccarini, C.2    Georgieff, I.3    Matthieu, J.M.4    Costantino-Ceccarini, E.5
  • 111
    • 0033366384 scopus 로고    scopus 로고
    • Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons
    • doi: 10.1038/4553
    • Williamson, T. L., and Cleveland, D. W. (1999). Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons. Nat. Neurosci. 2, 50-56. doi: 10.1038/4553
    • (1999) Nat. Neurosci , vol.2 , pp. 50-56
    • Williamson, T.L.1    Cleveland, D.W.2
  • 112
    • 33751243629 scopus 로고    scopus 로고
    • Neuronal intermediate filaments and ALS: A new look at an old question
    • doi: 10.1016/j.bbadis.2006.09.003
    • Xiao, S., McLean, J., and Robertson, J. (2006). Neuronal intermediate filaments and ALS: a new look at an old question. Biochim. Biophys. Acta 1762, 1001-1012. doi: 10.1016/j.bbadis.2006.09.003
    • (2006) Biochim. Biophys. Acta , vol.1762 , pp. 1001-1012
    • Xiao, S.1    McLean, J.2    Robertson, J.3
  • 113
    • 39749188753 scopus 로고    scopus 로고
    • Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
    • doi: 10.1038/nn2047
    • Yamanaka, K., Chun, S. J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D. H., et al. (2008). Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat. Neurosci. 11, 251-253. doi: 10.1038/nn2047
    • (2008) Nat. Neurosci , vol.11 , pp. 251-253
    • Yamanaka, K.1    Chun, S.J.2    Boillee, S.3    Fujimori-Tonou, N.4    Yamashita, H.5    Gutmann, D.H.6
  • 114
    • 0034785509 scopus 로고    scopus 로고
    • The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis
    • doi: 10.1038/ng1001-160
    • Yang, Y., Hentati, A., Deng, H. X., Dabbagh, O., Sasaki, T., Hirano, M., et al. (2001). The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat. Genet. 29, 160-165. doi: 10.1038/ng1001-160
    • (2001) Nat. Genet , vol.29 , pp. 160-165
    • Yang, Y.1    Hentati, A.2    Deng, H.X.3    Dabbagh, O.4    Sasaki, T.5    Hirano, M.6
  • 115
    • 0036269810 scopus 로고    scopus 로고
    • Differential expression of inflammation-and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis
    • doi: 10.1046/j.0022-3042.2001.00683.x
    • Yoshihara, T., Ishigaki, S., Yamamoto, M., Liang, Y., Niwa, J., Takeuchi, H., et al. (2002). Differential expression of inflammation-and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem. 80, 158-167. doi: 10.1046/j.0022-3042.2001.00683.x
    • (2002) J. Neurochem , vol.80 , pp. 158-167
    • Yoshihara, T.1    Ishigaki, S.2    Yamamoto, M.3    Liang, Y.4    Niwa, J.5    Takeuchi, H.6


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