Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: Prevention by mitochondrial-targeted antioxidants

Journal of Neuroscience

Volumn 28, Issue 16, 2008, Pages 4115-4122

  Cassina, Patricia ^a   Cassina, Adriana ^a   Pehar, Mariana ^b   Castellanos, Raquel ^a   Gandelman, Mandi ^a,c   De León, Andrés ^a,c   Robinson, Kristine M ^e   Mason, Ronald P ^d   Beckman, Joseph S ^e   Barbeito, Luis ^a,b,c   Radi, Rafael ^a  

^a DEPARTAMENTO DE BIOQUÍMICA   (Uruguay)

^b INSTITUTO DE INVESTIGACIONES BIOLÓGICAS CLEMENTE ESTABLE   (Uruguay)

^c INSTITUT PASTEUR DE MONTEVIDEO   (Uruguay)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e OREGON STATE UNIVERSITY   (United States)

Author keywords

ALS; Antioxidants; Astrocytes; Free radicals; Mitochondria; SOD1

Indexed keywords

3 NITROTYROSINE; 5,5 DIMETHYL 1 PYRROLINE 1 OXIDE; ADENOSINE DIPHOSPHATE; ANTIMYCIN A1; ANTIOXIDANT; CATION; COPPER ZINC SUPEROXIDE DISMUTASE; FLUOROCITRIC ACID; MITOCARBOXYPROXYLNITROXIDE; MITOCHONDRIAL PROTEIN; MITOUBIQUINONE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHONIUM DERIVATIVE; ROTENONE; SODIUM AZIDE; SUPEROXIDE; TRIPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG; SOD1 G93A PROTEIN; SUPEROXIDE DISMUTASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; ASTROCYTE; CELL COUNT; CELL DEATH; CELL FUNCTION; CELL SURVIVAL; COCULTURE; CONTROLLED STUDY; COVALENT BOND; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG TARGETING; IMMUNOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MOTONEURON; NERVE CELL DEGENERATION; NEWBORN; NONHUMAN; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT; SPINAL CORD; AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL; CELL CULTURE; COMPARATIVE STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; ENZYMOLOGY; GENETICS; METABOLISM; METHODOLOGY; MITOCHONDRION; NERVE DEGENERATION; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; TRANSGENIC ANIMAL;

AMINO ACID SUBSTITUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIOXIDANTS; ASTROCYTES; CELLS, CULTURED; DRUG DELIVERY SYSTEMS; MITOCHONDRIA; MOTOR NEURONS; NERVE DEGENERATION; RATS; RATS, SPRAGUE-DAWLEY; SUPEROXIDE DISMUTASE;

EID: 42949166848     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.5308-07.2008     Document Type: Article

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