No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model

Human Molecular Genetics

Volumn 14, Issue 21, 2005, Pages 3309-3320

  Perrin, Florence E ^a   Boisset, Gaelle ^a   Docquier, Mylene ^a   Schaad, Olivier ^a   Descombes, Patrick ^a   Kato, Ann C ^a,b  

^a Frontiers in Genetics National Center for Competence in Research   (Switzerland)

^b UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; COMPLEMENTARY RNA; CONNEXIN 43; DNA; INTERMEDIATE FILAMENT PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; NEUROMODULIN; VIMENTIN;

AGE DISTRIBUTION; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL GROWTH; CELL LOSS; CONTROLLED STUDY; CYTOPLASM; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE INDUCTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LASER CAPTURE MICRODISSECTION; MOTONEURON; MOUSE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SYMPTOMATOLOGY; TRANSGENIC MOUSE; UPREGULATION;

AGE FACTORS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INCLUSION BODIES; MICE; MICE, TRANSGENIC; MOTOR NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; SUPEROXIDE DISMUTASE; VIMENTIN;

ANIMALIA; MUS MUSCULUS;

EID: 27744542191     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddi357     Document Type: Article

References (43)

1. Bruijn, L.I., Miller, T.M. and Cleveland, D.W. (2004) Unraveling the mechanisms involved in motor neuron degeneration in ALS. Annu. Rev. Neurosci., 27, 723-749.
2. Jiang, Y.M., Yamamoto, M., Kobayashi, Y., Yoshihara, T., Liang, Y., Terao, S., Takeuchi, H., Ishigaki, S., Katsuno, M., Adachi, H. et al. (2005) Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann. Neurol., 57, 236-251.
3. Olsen, M.K., Roberds, S.L., Ellbrock, B.R., Fleck, T.J., McKinley, D.K. and Gurney, M.E. (2004) Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord. Ann. Neurol., 50, 730-740.
4. Yoshihara, T., Ishigaki, S., Yamamoto, M., Liang, Y., Niwa, J., Takeuchi, H., Doyu, M. and Sobue, G. (2002) Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem., 80, 158-167.
5. Gong, Y.H., Parsadanian, A.S., Andreeva, A., Snider, W.D. and Elliott, J.L. (2000) Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration. J. Neurosci., 20, 660-665.
6. Lino, M.M., Schneider, C. and Caroni, P. (2002) Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease. J. Neurosci., 22, 4825-4832.
7. Pramatarova, A., Laganiere, J., Roussel, J., Brisebois, K. and Rouleau, G.A. (2001) Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment. J. Neurosci., 21, 3369-3374.
8. Clement, A.M., Nguyen, M.D., Roberts, E.A., Garcia, M.L., Boillee, S., Rule, M., McMahon, A.P., Doucette, W., Siwek, D., Ferrante, R.J. et al. (2003) Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science, 302, 113-117.
9. Przedborski, S. (2004) Programmed cell death in amyotrophic lateral sclerosis: A mechanism of pathogenic and therapeutic importance. Neurologist, 10, 1-7.
10. Nagase, H. and Woessner, J.F., Jr (1999) Matrix metalloproteinases. J. Biol. Chem., 274, 21491-21494.
11. Yong, V.W., Power, C., Forsyth, P. and Edwards, D.R. (2001) Metalloproteinases in biology and pathology of the nervous system. Nat. Rev. Neurosci., 2, 502-511.
12. Lim, G.P., Backstrom, J.R., Cullen, M.J., Miller, C.A., Atkinson, R.D. and Tokes, Z.A. (1996) Matrix metalloproteinases in the neocortex and spinal cord of amyotrophic lateral sclerosis patients. J. Neurochem., 67, 251-259.
13. Menet, V., Prieto, M., Privat, A. and Ribotta, M. (2003) Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes. Proc. Natl Acad. Sci. USA, 100, 8999-9004.
14. Cochard, P. and Paulin, D. (1984) Initial expression of neurofilaments and vimentin in the central and peripheral nervous system of the mouse embryo in vivo. J. Neurosci., 4, 2080-2094.
15. Tapscott, S.J., Bennett, G.S., Toyama, Y., Kleinbart, F. and Holtzer, H. (1981) Intermediate filament proteins in the developing chick spinal cord. Dev. Biol., 86, 40-54.
16. Fliegner, K.H., Kaplan, M.P., Wood, T.L., Pintar, J.E. and Liem, R.K. (1994) Expression of the gene for the neuronal intermediate filament protein alpha-internexin coincides with the onset of neuronal differentiation in the developing rat nervous system. J. Comp. Neurol., 342, 161-173.
17. Boyne, L.J., Fischer, I. and Shea, T.B. (1996) Role of vimentin in early stages of neuritogenesis in cultured hippocampal neurons. Int. J. Dev. Neurosci., 14, 739-748.
18. Dubey, M., Hoda, S., Chan, W.K., Pimenta, A., Ortiz, D.D. and Shea, T.B. (2004) Reexpression of vimentin in differentiated neuroblastoma cells enhances elongation of axonal neurites. J. Neurosci. Res., 78, 245-249.
19. Perlson, E., Hanz, S., Ben Yaakov, K., Segal-Ruder, Y., Seger, R., and Fainzilber, M. (2005) Vimentin-dependent spatial translocation of an activated MAP kinase in injured nerve. Neuron, 45, 715-726.
20. Ardley, H.C., Hung, C.C. and Robinson, P.A. (2005) The aggravating role of the ubiquitin-proteasome system in neurodegeneration. FEBS Lett., 579, 571-576.
21. Caughey, B. and Lansbury, P.T. (2003) Protofibrils, pores, fibrils, and neurodegeneration: Separating the responsible protein aggregates from the innocent bystanders. Annu. Rev. Neurosci., 26, 267-298.
22. Soto, C. (2003) Unfolding the role of protein misfolding in neurodegenerative diseases. Nat. Rev. Neurosci., 4, 49-60.
23. Taylor, D.M., Minotti, S., Agar, J.N. and Durham, H.D. (2004) Overexpression of metallothionein protects cultured motor neurons against oxidative stress, but not mutant Cu/Zn-superoxide dismutase toxicity. NeuroToxicology, 25, 779-792.
24. Wood, J.D., Beaujeux, T.P. and Shaw, P.J. (2003) Protein aggregation in motor neurone disorders. Neuropathol. Appl. Neurobiol., 29, 529-545.
25. Johnston, J.A., Dalton, M.J., Gurney, M.E. and Kopito, R.R. (2000) Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 97, 12571-12576.
26. Johnston, J.A., Ward, C.L. and Kopito, R.R. (1998) Aggresomes: A cellular response to misfolded proteins. J. Cell Biol., 143, 1883-1898.
27. Wilczak, N., de Vos, R.A. and De Keyser, J. (2003) Free insulin-like growth factor (IGF)-I and IGF binding proteins 2, 5, and 6 in spinal motor neurons in amyotrophic lateral sclerosis. Lancet, 361, 1007-1011.
28. Christine, P.B., Wilson, E.M., Hwa, V., Oh, Y. and Rosenfeld, R.G. (1999) Binding properties and distribution of insulin-like growth factor binding protein-related protein 3 (IGFBP-rP3/NovH), an additional member of the IGFBP superfamily. J. Clin. Endocrinol. Metab, 84, 1096-1103.
29. Kaspar, B.K., Llado, J., Sherkat, N., Rothstein, J.D. and Gage, F.H. (2003) Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science, 301, 839-842.
30. Malaspina, A. and de Belleroche, J. (2004) Spinal cord molecular profiling provides a better understanding of amyotrophic lateral sclerosis pathogenesis. Brain Res. Rev., 45, 213-229.
31. Alexianu, M.E., Kozovska, M. and Appel, S.H. (2001) Immune reactivity in a mouse model of familial ALS correlates with disease progression. Neurology, 57, 1282-1289.
32. Li, M., Ona, V.O., Gan, C., Chen, M., Jackson-Lewis, V., Andrews, L.J., Olszewski, A.J., Stieg, P.E., Lee, J.P., Przedborski, S. and Friedlander, R.M. (2000) Functional role of caspase-1 and caspase-3 in an ALS transgenic mouse model. Science, 288, 335-339.
33. Pasinelli, P., Houseweart, M.K., Brown, R.H., Jr and Cleveland, D.W. (2000) Caspase-1 and -3 are sequentially activated in motor neuron death in Cu, Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. PNAS, 97, 13901-13906.
34. Vukosavic, S., Stefanis, L., Jackson-Lewis, V., Guegan, C., Romero, N., Chen, C., Dubois-Dauphin, M. and Przedborski, S. (2000) Delaying caspase activation by Bcl-2: A clue to disease retardation in a transgenic mouse model of amyotrophic lateral sclerosis. J. Neurosci., 20, 9119-9125.
35. Vila, M. and Przedborski, S. (2003) Targeting programmed cell death in neurodegenerative diseases. Nat. Rev. Neurosci., 4, 365-375.
36. Perrelet, D., Ferri, A., MacKenzie, A.E., Smith, G.M., Korneluk, R.G., Liston, P., Sagot, Y., Terrado, J., Monnier, D. and Kato, A.C. (2000) IAP family proteins delay motoneuron cell death in vivo. Eur. J. Neurosci., 12, 2059-2067.
37. Perrelet, D., Perrin, F.E., Liston, P., Korneluk, R.G., MacKenzie, A., Ferrer-Alcon, M. and Kato, A.C. (2004) Motoneuron resistance to apoptotic cell death in vivo correlates with the ratio between X-linked inhibitor of apoptosis proteins (XIAPs) and its inhibitor, XIAP-associated factor 1. J. Neurosci., 24, 3777-3785.
38. Malaspina, A., Kaushik, N. and de Belleroche, J. (2001) Differential expression of 14 genes in amyotrophic lateral sclerosis spinal cord detected using gridded cDNA arrays. J. Neurochem., 77, 132-145.
39. Nomura, M., Shimizu, S., Sugiyama, T., Narita, M., Ito, T., Matsuda, H. and Tsujimoto, Y. (2003) 14-3-3 Interacts directly with and negatively regulates Pro-apoptotic Bax. J. Biol. Chem., 278, 2058-2065.
40. Kawamoto, Y., Akiguchi, I., Nakamura, S. and Budka, H. (2004) 14-3-3 Proteins in Lewy body-like hyaline inclusions in patients with sporadic amyotrophic lateral sclerosis. Acta Neuropathol. (Berl), 108, 531-537.
41. Hubbell, E., Liu, W.M. and Mei, R. (2002) Robust estimators for expression analysis. Bioinformatics, 18, 1585-1592.
42. Liu, W.M., Mei, R., Di, X., Ryder, T.B., Hubbell, E., Dee, S., Webster, T.A., Harrington, C.A., Ho, M.H., Baid, J. and Smeekens, S.P. (2002) Analysis of high density expression microarrays with signed-rank call algorithms. Bioinformatics, 18, 1593-1599.
43. Vandesompele, J., De Preter, K., Pattyn, F., Poppe, B., Van Roy, N., De Paepe, A. and Speleman, F. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol., 3, research0034.