A metabolic switch toward lipid use in glycolytic muscle is an early pathologic event in a mouse model of amyotrophic lateral sclerosis

EMBO Molecular Medicine

Volumn 7, Issue 5, 2015, Pages 526-546

  Palamiuc, Lavinia ^a,b   Schlagowski, Anna ^c,d   Ngo, Shyuan T ^e,f   Vernay, Aurelia ^a,b   Dirrig Grosch, Sylvie ^a,b   Henriques, Alexandre ^a,b   Boutillier, Anne Laurence ^b   Zoll, Joffrey ^c,d   Echaniz Laguna, Andoni ^a,b,g   Loeffler, Jean Philippe ^a,b   René, Frédérique ^a,b  

^a Laboratoire des Mecanismes Centraux et Peripheriques de la Neurodegenerescence   (France)

^b UNIVERSITÉ DE STRASBOURG   (France)

^c UNIVERSITÉ DE STRASBOURG   (France)

^d UNIVERSITY HOSPITAL OF STRASBOURG   (France)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f UNIVERSITY OF QUEENSLAND   (Australia)

^g HÔPITAL DE HAUTEPIERRE   (France)

Author keywords

Amyotrophic lateral sclerosis; Exercise; Glucose; Lipids; Muscle

Indexed keywords

6 PHOSPHOFRUCTOKINASE; ADENOSINE TRIPHOSPHATE; CD36 ANTIGEN; CITRATE SYNTHASE; DICHLOROACETIC ACID; FATTY ACID; GLUCOSE; GLYCOGEN; GLYCOGEN SYNTHASE; LIPID; LIPOPROTEIN LIPASE; MESSENGER RNA; MITOCHONDRIAL DNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PYRUVATE DEHYDROGENASE KINASE 4; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRANSCRIPTION FACTOR FKHR;

AEROBIC CAPACITY; AMYOTROPHIC LATERAL SCLEROSIS; ANAEROBIC EXERCISE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOGENESIS; CONTROLLED STUDY; DISEASE COURSE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; ENDURANCE TRAINING; ENERGY RESOURCE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; EXHAUSTION; FATTY ACID OXIDATION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE UTILIZATION; GLYCOLYSIS; GRIP STRENGTH; HUMAN; HUMAN TISSUE; LOCOMOTION; MALE; METABOLIC CAPACITY; MOUSE; MUSCLE ATROPHY; MUSCLE DENERVATION; MUSCLE EXERCISE; MUSCLE FUNCTION; MUSCLE METABOLISM; MUSCLE REINNERVATION; MUSCLE TWITCH; NERVE CRUSH; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SOLEUS MUSCLE; TREADMILL EXERCISE; UPREGULATION; WEIGHT GAIN; WEIGHT REDUCTION; ANIMAL; DISEASE MODEL; LIPID METABOLISM; METABOLISM; MUSCLE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; DISEASE MODELS, ANIMAL; GLYCOLYSIS; LIPID METABOLISM; MICE; MUSCLES;

EID: 84928982922     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.15252/emmm.201404433     Document Type: Article

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