Neural-specific deletion of HTRA2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1

PLoS ONE

Volumn 9, Issue 12, 2014, Pages

  Patterson, Victoria L ^a   Zullo, Alfred J ^a   Koenig, Claire ^a   Stoessel, Sean ^a   Jo, Hakryul ^a   Liu, Xinran ^a   Han, Jinah ^a   Choi, Murim ^a   DeWan, Andrew T ^a   Thomas, Jean Leon ^a   Kuan, Chia Yi ^b   Hoh, Josephine ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CHILDREN'S HEALTHCARE OF ATLANTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE; PROTEIN OPA1; SERINE PROTEINASE OMI; UNCLASSIFIED DRUG; MESSENGER RNA; MITOCHONDRIAL PROTEIN; OPA1 PROTEIN (GTPASE), MOUSE; SERINE PROTEINASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ATAXIA; BRAIN MITOCHONDRION; CEREBELLUM DEGENERATION; CONTROLLED STUDY; CORPUS STRIATUM; DEATH; EMBRYO; ENTORHINAL CORTEX; FEMALE; GENE DELETION; HISTOPATHOLOGY; HTRA2 GENE; MALE; MITOCHONDRION SWELLING; MOUSE; NERVE CELL; NONHUMAN; PENETRANCE; PROTEIN PROCESSING; SPLEEN; THYMUS ATROPHY; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; CELL PROLIFERATION; CEREBELLUM; GENETICS; KNOCKOUT MOUSE; METABOLISM; MITOCHONDRION; NERVE DEGENERATION; PARKINSON DISEASE; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EPICOCCUM; MUS; PARKINSONIA;

ANIMALS; APOPTOSIS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CELL PROLIFERATION; CEREBELLUM; FEMALE; GTP PHOSPHOHYDROLASES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; NERVE DEGENERATION; NEURONS; PARKINSON DISEASE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEQUENCE DELETION; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION;

EID: 84919667561     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0115789     Document Type: Article

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